Rab5c (RAB5C, member RAS oncogene family)

Gene: Rab5c (RAB5C, member RAS oncogene family) Ictidomys tridecemlineatus

Analyze

Symbol:

Rab5c

Name:

RAB5C, member RAS oncogene family

RGD ID:

12695074

Description:

ENCODES a protein that exhibits GDP binding (inferred); GTP binding (inferred); GTPase activity (inferred); INVOLVED IN endosome organization (ortholog); regulation of endocytosis (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN endocytic vesicle (ortholog); exocytic vesicle (ortholog); synaptic vesicle membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

RAB5C, member RAS oncogene family, transcript variant X1; RAB5C, member RAS oncogene family, transcript variant X2; ras-related protein Rab-5C

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	20,090,127 - 20,112,346 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936490	16,960,917 - 16,985,022 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936490	16,962,793 - 16,985,006 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

endosome organization (ISO)

plasma membrane to endosome transport (IEA)

regulation of endocytosis (ISO)

Cellular Component

cytoplasmic vesicle (IEA)

early endosome membrane (IEA)

endocytic vesicle (ISO)

endosome (IEA)

exocytic vesicle (ISO)

Golgi apparatus (IEA)

lipid droplet (IEA)

plasma membrane (IEA)

synaptic vesicle membrane (ISO)

Molecular Function

GDP binding (IEA)

GTP binding (IEA)

GTPase activity (IEA)

nucleotide binding (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Rab5c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	20,090,127 - 20,112,346 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936490	16,960,917 - 16,985,022 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936490	16,962,793 - 16,985,006 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RAB5C
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	42,124,979 - 42,154,989 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	42,124,978 - 42,155,044 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	40,276,997 - 40,307,007 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	37,530,523 - 37,560,548 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	37,530,523 - 37,560,548	NCBI
Celera	17	36,932,032 - 36,962,339 (-)	NCBI		Celera
Cytogenetic Map	17	q21.2	NCBI
HuRef	17	36,042,066 - 36,072,281 (-)	NCBI		HuRef
CHM1_1	17	40,512,765 - 40,542,811 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	42,981,483 - 43,011,474 (-)	NCBI		T2T-CHM13v2.0

Rab5c
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	100,605,829 - 100,629,041 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	100,605,835 - 100,629,041 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	100,715,003 - 100,738,215 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	100,715,009 - 100,738,215 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	100,576,580 - 100,599,444 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	100,531,101 - 100,554,280 (-)	NCBI		MGSCv36	mm8
Celera	11	111,331,770 - 111,354,674 (-)	NCBI		Celera
Cytogenetic Map	11	D	NCBI
cM Map	11	63.54	NCBI

Rab5c
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	86,142,872 - 86,166,449 (-)	NCBI		GRCr8
mRatBN7.2	10	85,642,553 - 85,666,142 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	85,642,809 - 85,666,103 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	90,679,016 - 90,702,641 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	90,157,856 - 90,181,452 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	85,550,796 - 85,574,373 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	88,621,924 - 88,645,364 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	88,621,925 - 88,645,364 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	88,416,137 - 88,439,534 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	89,652,342 - 89,675,787 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	89,666,711 - 89,690,155 (-)	NCBI
Celera	10	84,358,238 - 84,381,583 (-)	NCBI		Celera
Cytogenetic Map	10	q31	NCBI

Rab5c
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955451	16,200,442 - 16,215,583 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955451	16,200,442 - 16,215,583 (-)	NCBI	ChiLan1.0	ChiLan1.0

RAB5C
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	22,829,028 - 22,858,920 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	24,719,145 - 24,748,445 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	15,160,965 - 15,190,840 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	15,382,729 - 15,412,693 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	15,382,729 - 15,412,693 (+)	Ensembl	panpan1.1		panPan2

RAB5C
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	20,754,264 - 20,776,941 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	20,754,293 - 20,776,125 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	20,215,485 - 20,237,010 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	21,473,165 - 21,495,660 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	21,473,201 - 21,495,660 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	20,258,591 - 20,280,121 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	20,525,710 - 20,547,250 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	20,628,754 - 20,650,284 (+)	NCBI		UU_Cfam_GSD_1.0

RAB5C
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	20,613,996 - 20,636,073 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	20,613,991 - 20,635,952 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	20,904,150 - 20,926,107 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RAB5C
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	64,115,658 - 64,142,905 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	64,115,059 - 64,143,207 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	34,929,789 - 34,959,450 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rab5c
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624795	1,775,649 - 1,780,978 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624795	1,764,536 - 1,779,284 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005321871	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021724241	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040268769	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000662	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000006607 ⟹ ENSSTOP00000005907

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936490	16,963,598 - 16,967,050 (-)	Ensembl

RefSeq Acc Id:

ENSSTOT00000040910 ⟹ ENSSTOP00000027419

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936490	16,960,917 - 16,985,022 (-)	Ensembl

RefSeq Acc Id:

XM_005321871 ⟹ XP_005321928

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405602	20,090,127 - 20,112,346 (+)	NCBI
SpeTri2.0	NW_004936490	16,962,793 - 16,985,006 (-)	NCBI

Sequence:

show sequence

GAGCATGGAGGGGCGGGGCGGAGGTGGAGATCCGGATCCGGAGCGGCTGAAAGGCGGAAGTGGA
GGCCGGAGCCTGGGACACCGCCGGCGGGGGGGAGAGGAGCGGAGTCTGTCCGAGCCCCGGCCCC
AAGTAACGCCGCCGCCCCGGAGCCGCGTTGGAGGCCCCCTCCCCACTAAGTGCCTCCTTGCCTA
GCACCAGCCCCCATCCGCACGCTCACTGGTACTACTTCGGCAGGACGGGCCATGGCGGGTCGGG
GAGGAGCAGCACGGCCCAACGGACCAGCCGCTGGGAACAAGATTTGTCAGTTTAAGCTGGTTCT
GCTAGGGGAGTCTGCAGTGGGCAAATCCAGTCTCGTCCTCCGCTTTGTCAAGGGACAATTCCAT
GAGTACCAGGAGAGCACAATTGGAGCGGCCTTCCTTACACAGACTGTCTGCTTGGACGACACAA
CAGTCAAGTTTGAGATCTGGGACACAGCTGGACAGGAGCGGTATCACAGCCTGGCCCCCATGTA
CTACCGGGGGGCCCAGGCTGCCATCGTGGTCTATGACATCACCAACACAGATACATTTGCACGG
GCCAAGAACTGGGTGAAGGAGTTACAGAGGCAGGCCAGCCCCAACATCGTCATTGCACTTGCGG
GTAACAAGGCAGACCTGGCCAGCAAGAGAGCCGTGGAGTTCCAGGAAGCACAGGCCTATGCAGA
TGACAACAGTTTGCTGTTCATGGAGACATCAGCAAAGACTGCAATGAACGTGAATGAAATTTTC
ATGGCAATAGCTAAGAAGCTTCCCAAGAACGAGCCTCAGAATGCAGCTGGTGCTCCAGGCGGGA
CCCGAGGGGTGAACCTCCAGGAGAGCAACCCAGCCAGCCGGAGCCAGTGCTGCAGCAACTGAGC
CCCCCTTGCCTGCCACTGCCCCCACCTCCTCCGCCTGAATGACCCGACTGGAATCCACTCTAAC
CAATCGCACTTAACGACTCGGGCCACCACTGGGGGCAGGGGAGGGGTCCACCATGATTTCTCAG
TATAACTTTGATCCTAGGCCGGAGGGAGTTATTCCACCTGCACCTTTCTGTACAAATACTAATT
CAATTTTAAGTCTTAAGTCACTTTTTTAATATATATGATCTTCTGCTCTTCCCACTTCCCCCCT
TTCTACTATACTCTCCCATTTGTCCTTTGCTGGTAGTAGCCACATGCTCCTGCCCCCCACCCCC
TTGTCTGTGGGGTCGGGGCTTGGAACAGTTACCCCTCCCTTCCCTTCCCTTCCCTCTTGCTGAA
GAGCAGCCTTAGCAAGAGCATCCACATCCTTACCTTGTTGGGAGTGGTCTTAGTCTGGGGTGGT
GGGCAGGCCCTGGGCTGGGAAGGGGACAGGCAGCTCTGCCCTCAGCTGGCTGTCATCAGGCTGC
AGCCTCCTTCCCACCCAACTCCCAGCTGGGAGAGAAAACGCAGCATTACCGCAGCATCATTGTG
ACAGCCATGCATCCATTGCCCATGACCCCTCCACCCTCGGTCACCTGACCTCTGGCTCTGAGCC
CTGTTCTGACCAAATCACGATGATGAGTATTTGGGGGTGGGTGGGTAAGGGGGGGAGTGGGAGG
GGATGGAACCAACTTTTTCTGTATTTTGTATTGTATGTTTTCTTCAACATGTAACCAATCAGTA
TCTTGTCAATATAGTCAGCCGATCGATCGACCTCA

hide sequence

RefSeq Acc Id:

XM_040268769 ⟹ XP_040124703

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405602	20,091,142 - 20,112,346 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005321928	(Get FASTA)	NCBI Sequence Viewer
	XP_040124703	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000005907.3
	ENSSTOP00000027419.1
GenBank Protein	KAG3268924	(Get FASTA)	NCBI Sequence Viewer
	KAG3268925	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005321928 ⟸ XM_005321871

- UniProtKB:

A0A287D1K5 (UniProtKB/TrEMBL), I3M882 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAGRGGAARPNGPAAGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTVC
LDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNTDTFARAKNWVKELQRQASPNIV
IALAGNKADLASKRAVEFQEAQAYADDNSLLFMETSAKTAMNVNEIFMAIAKKLPKNEPQNAAG
APGGTRGVNLQESNPASRSQCCSN

hide sequence

RefSeq Acc Id:	XP_040124703 ⟸ XM_040268769
- UniProtKB:	A0A287D1K5 (UniProtKB/TrEMBL), I3M882 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSSTOP00000005907 ⟸ ENSSTOT00000006607

RefSeq Acc Id:

ENSSTOP00000027419 ⟸ ENSSTOT00000040910

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000006620	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000006607.3	UniProtKB/TrEMBL
	ENSSTOT00000040910.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/TrEMBL
InterPro	P-loop_NTPase	UniProtKB/TrEMBL
	Small_GTP-bd_dom	UniProtKB/TrEMBL
	Small_GTPase	UniProtKB/TrEMBL
NCBI Gene	Rab5c	ENTREZGENE
PANTHER	PTHR47978	UniProtKB/TrEMBL
	RAB43, MEMBER RAS ONCOGENE FAMILY	UniProtKB/TrEMBL
Pfam	Ras	UniProtKB/TrEMBL
PRINTS	RASTRNSFRMNG	UniProtKB/TrEMBL
PROSITE	RAB	UniProtKB/TrEMBL
	RAS	UniProtKB/TrEMBL
	RHO	UniProtKB/TrEMBL
SMART	RAB	UniProtKB/TrEMBL
	RAN	UniProtKB/TrEMBL
	RAS	UniProtKB/TrEMBL
	RHO	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	A0A287D1K5	ENTREZGENE, UniProtKB/TrEMBL
	I3M882	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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