Zswim2 (zinc finger SWIM-type containing 2)

Gene: Zswim2 (zinc finger SWIM-type containing 2) Ictidomys tridecemlineatus

Analyze

Symbol:

Zswim2

Name:

zinc finger SWIM-type containing 2

RGD ID:

12690133

Description:

ENCODES a protein that exhibits metal ion binding (inferred); ubiquitin protein ligase activity (inferred); ubiquitin-protein transferase activity (inferred); INVOLVED IN positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (ortholog); ASSOCIATED WITH genetic disease (ortholog); Neurodevelopmental Disorders (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

E3 ubiquitin-protein ligase ZSWIM2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	146,187,316 - 146,203,819 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936506	10,634,364 - 10,650,469 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936506	10,634,364 - 10,650,484 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Neurodevelopmental Disorders (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (IEA,ISO)

protein polyubiquitination (IEA)

Molecular Function

metal ion binding (IEA)

protein binding (ISO)

ubiquitin protein ligase activity (IEA)

ubiquitin-protein transferase activity (IEA)

zinc ion binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Zswim2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	146,187,316 - 146,203,819 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936506	10,634,364 - 10,650,469 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936506	10,634,364 - 10,650,484 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ZSWIM2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	186,827,475 - 186,849,170 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	186,827,475 - 186,849,208 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	187,692,202 - 187,713,897 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	187,400,452 - 187,422,142 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	187,518,067 - 187,539,403	NCBI
Celera	2	181,287,838 - 181,310,094 (-)	NCBI		Celera
Cytogenetic Map	2	q32.1	NCBI
HuRef	2	179,552,221 - 179,573,906 (-)	NCBI		HuRef
CHM1_1	2	187,698,209 - 187,719,897 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	187,316,754 - 187,338,450 (-)	NCBI		T2T-CHM13v2.0

Zswim2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	83,745,414 - 83,771,596 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	83,745,423 - 83,771,572 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	83,915,079 - 83,941,226 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	83,915,079 - 83,941,228 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	83,755,236 - 83,781,383 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	83,715,918 - 83,742,065 (-)	NCBI		MGSCv36	mm8
Celera	2	85,573,761 - 85,599,958 (-)	NCBI		Celera
Cytogenetic Map	2	D	NCBI
cM Map	2	49.33	NCBI

Zswim2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	89,401,887 - 89,422,308 (-)	NCBI		GRCr8
mRatBN7.2	3	68,993,422 - 69,015,441 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	68,995,027 - 69,015,411 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	72,383,774 - 72,404,276 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	80,982,424 - 81,002,926 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	78,723,407 - 78,743,872 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	71,274,341 - 71,295,641 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	71,274,337 - 71,295,629 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	77,799,741 - 77,821,020 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	67,101,242 - 67,121,620 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	66,997,614 - 67,017,992 (-)	NCBI
Celera	3	68,365,685 - 68,386,070 (-)	NCBI		Celera
Cytogenetic Map	3	q24	NCBI

Zswim2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	11,479,808 - 11,495,577 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	11,478,682 - 11,494,725 (+)	NCBI	ChiLan1.0	ChiLan1.0

ZSWIM2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	89,505,429 - 89,533,071 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	89,520,409 - 89,548,051 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	74,120,669 - 74,142,560 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	191,921,210 - 191,942,554 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

ZSWIM2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	36	28,989,780 - 29,023,128 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	36	28,989,212 - 29,022,057 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	36	28,888,712 - 28,919,697 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	36	29,216,604 - 29,246,962 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	36	29,216,603 - 29,248,654 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	36	29,273,320 - 29,304,097 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	36	29,208,762 - 29,239,789 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	36	29,376,285 - 29,407,166 (-)	NCBI		UU_Cfam_GSD_1.0

ZSWIM2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	91,840,944 - 91,864,332 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	91,840,694 - 91,865,227 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	101,850,741 - 101,872,225 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ZSWIM2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	72,368,406 - 72,391,943 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	72,368,927 - 72,390,417 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	127,111,072 - 127,133,399 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Zswim2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624899	3,107,902 - 3,129,520 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624899	3,107,362 - 3,129,794 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005324394	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040294565	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000362	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000025588 ⟹ ENSSTOP00000021070

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936506	10,634,364 - 10,650,469 (+)	Ensembl

RefSeq Acc Id:

XM_005324394 ⟹ XP_005324451

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405303	146,187,316 - 146,203,814 (-)	NCBI
SpeTri2.0	NW_004936506	10,634,364 - 10,650,484 (+)	NCBI

Sequence:

show sequence

ATGCTTCGCGGAGGCTCCCGGCCCTCTGAAAGGCGAAGATTCTTGAACGACAGCCTCAGCTGGC
AACAAGACCAGGCGTTGAACAGCAGCATCTACCTCCTACGACAGATGGGCCCCACCGGCTTCCT
GCTGAGGGAGGAAGAGCCAGAGAACAGGGATTTCCGAGTTTTTCTAGGAAATCCTCATGTTTGT
AACTGTTCCACATTTCTGAAAAAAGGGGAGCTTTGTAAGCATATATGCTGGGTCTTATTGAAAA
AATTCAAGCTTCCAAGGAATCATGAATCTGCTTTCCAGTTAGGTCTTGTAGAAGGAGAAATAAA
TGACTTGCTACGGGGAATACATCAAGTTCAAACTCCCCAACCAGGAACAAGTGAAAATGCACAT
GTGAAAGAAGATGGGTATATTAAACAGAAGGAAATTGATTCAGAGGATATCTGCTCTATTTGTC
AAGAGGTGCTTTTACAGAAAAGGCTGCCTGTCACCTTTTGCAGATTTGGCTGTGGCAATAATTT
CCATATAAAATGCATGAAGATCTTAGCTAATTATCAGAATACAGTATCAAACACTTCCACGTTG
AAATGTCCTCTGTGCAGGAAGGAGTTTGCACCACTGAAACTTATTTTGGAAGAATTCCAAAATG
CTAGCAAACTTGTGACTGCAGCTGAGAAAGAACGACTGAACAAACACCTTGGAATTCCCTGTAA
TAACTGTAAACAATTTCCAATTGAGGGGAAGTGTTATAAGTGTACCGAATGTATAGAATACCAC
TTATGCCAGGAATGCTTTGATAGCTACTGCCATCTTTCTCACACATTTACATTCCGTGAGAAGA
GAAACCAAAGATGGAGATCATTAGACAAGAGACTGGATGAAGGTATAAAATATTTAAATGTTAA
AAATGAGATAGAAGAAGAAGAGATGCTACATGTTCAGGAAAAGCAAGGTCAGGTTTATACACCA
AAACACGTTGTAAAGTCACTACCTCTCCTACTAATTACAAAAAATAGTAAGCTGCTTGCTCCAG
GGTACCAGTGTCGACTTTGTTTGAAGTCATTTCATCTTGGTCAACATGTAAGACTGCTACCATG
TATTCATAAGTTTCATAGGAAGTGTATTGACAACTGGTTATTCCACAAGTGCAATTCATGCCCT
ATTGATGGACAAGTTATATATAACCCTTTATTATGGAACAGTACAGCAATGAATGGACAAGCCC
ATCAGTCTGCTTCAAACATAGACATCGCCCATCTGTCAAAGCAAGAAGAACCAAAACTTTTTGT
TCCTGGTACTGGATTAGTCCTAAAGACAAATGAACTTAGAATCTTACCTAACATATCTCAATGT
AGTTTTGAAAAGTTAAATACACTTCCAAGTCCAATAGATACTTATCAGAACATAACAATAGATG
ATCTATGCTCAGTCAAATTAAGTGATTCAAATTCAAGAAAATTAATCTATAAACATAAAATTAG
CCAACATTTCCCCAGTCATCTTCAAGATTTACCCACTGGACCTTTTGGAGAAATATCTCAAACA
TTCCTTCCTTCTATTGCAAAAAAGAATATTATGTGTCCCACTAGAATAGAAAGCCCATGTAACA
ATGAAAAGTGCCACGCTGGTCAAAATCAAAAGATGGCCAAAAGCCGTAAACATATTACCCTTGA
TCCAAAGAAGACTCTTGGTACTAAAATAAGGGAAGACAACAGGAAATCAAATACTTTACTTCCA
GAAGATTTAAATCTTATTATCAATTGGGGTAAAACTAAACTTAGTTCACCTAAAAGGTATAATA
ATTGTATGGGGAAAATTAGAAAAAGATGTAGTCATCTATCAAGACAACCTGTATCTCGCCCTTT
AAATACAAAAAGTACTGAGCTATCTCTAATAATGGAAGGAGTTCAGTTGTAAAAAAGTATTTTT
GAT

hide sequence

RefSeq Acc Id:

XM_040294565 ⟹ XP_040150499

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405303	146,187,316 - 146,203,819 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_005324451	(Get FASTA)	NCBI Sequence Viewer
	XP_040150499	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000021070.1
GenBank Protein	KAG3274842	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005324451 ⟸ XM_005324394
- Peptide Label:	isoform X1
- UniProtKB:	I3N9M4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLRGGSRPSERRRFLNDSLSWQQDQALNSSIYLLRQMGPTGFLLREEEPENRDFRVFLGNPHVC NCSTFLKKGELCKHICWVLLKKFKLPRNHESAFQLGLVEGEINDLLRGIHQVQTPQPGTSENAH VKEDGYIKQKEIDSEDICSICQEVLLQKRLPVTFCRFGCGNNFHIKCMKILANYQNTVSNTSTL KCPLCRKEFAPLKLILEEFQNASKLVTAAEKERLNKHLGIPCNNCKQFPIEGKCYKCTECIEYH LCQECFDSYCHLSHTFTFREKRNQRWRSLDKRLDEGIKYLNVKNEIEEEEMLHVQEKQGQVYTP KHVVKSLPLLLITKNSKLLAPGYQCRLCLKSFHLGQHVRLLPCIHKFHRKCIDNWLFHKCNSCP IDGQVIYNPLLWNSTAMNGQAHQSASNIDIAHLSKQEEPKLFVPGTGLVLKTNELRILPNISQC SFEKLNTLPSPIDTYQNITIDDLCSVKLSDSNSRKLIYKHKISQHFPSHLQDLPTGPFGEISQT FLPSIAKKNIMCPTRIESPCNNEKCHAGQNQKMAKSRKHITLDPKKTLGTKIREDNRKSNTLLP EDLNLIINWGKTKLSSPKRYNNCMGKIRKRCSHLSRQPVSRPLNTKSTELSLIMEGVQL hide sequence

RefSeq Acc Id:	XP_040150499 ⟸ XM_040294565
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSSTOP00000021070 ⟸ ENSSTOT00000025588

Protein Domains

RING-type SWIM-type ZZ-type

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000021223	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000025588.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.40.10	UniProtKB/TrEMBL
	3.30.60.90	UniProtKB/TrEMBL
InterPro	Znf_RING	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
	Znf_SWIM	UniProtKB/TrEMBL
	Znf_ZZ	UniProtKB/TrEMBL
	Znf_ZZ_sf	UniProtKB/TrEMBL
	Zswim2	UniProtKB/TrEMBL
NCBI Gene	Zswim2	ENTREZGENE
PANTHER	E3 UBIQUITIN-PROTEIN LIGASE ZSWIM2	UniProtKB/TrEMBL
	PTHR21540	UniProtKB/TrEMBL
Pfam	PF00569	UniProtKB/TrEMBL
	SWIM	UniProtKB/TrEMBL
	zf-RING_2	UniProtKB/TrEMBL
PROSITE	ZF_RING_2	UniProtKB/TrEMBL
	ZF_SWIM	UniProtKB/TrEMBL
	ZF_ZZ_1	UniProtKB/TrEMBL
	ZF_ZZ_2	UniProtKB/TrEMBL
SMART	RING	UniProtKB/TrEMBL
Superfamily-SCOP	RING/U-box	UniProtKB/TrEMBL
UniProt	I3N9M4	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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