Cdk2ap2 (cyclin dependent kinase 2 associated protein 2)

Gene: Cdk2ap2 (cyclin dependent kinase 2 associated protein 2) Ictidomys tridecemlineatus

Analyze

Symbol:

Cdk2ap2

Name:

cyclin dependent kinase 2 associated protein 2

RGD ID:

12689930

Description:

INVOLVED IN negative regulation of G1/S transition of mitotic cell cycle (inferred); regulation of microtubule cytoskeleton organization (inferred); regulation of stem cell division (inferred); ASSOCIATED WITH Aicardi-Goutieres Syndrome 3 (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN cytoplasm (inferred); microtubule (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cyclin dependent kinase 2 associated protein 2, transcript variant X1; cyclin dependent kinase 2 associated protein 2, transcript variant X2; cyclin-dependent kinase 2-associated protein 2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	5,815,870 - 5,817,534 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936599	2,257,671 - 2,259,886 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936599	2,257,731 - 2,259,883 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Aicardi-Goutieres Syndrome 3 (ISO)

genetic disease (ISO)

intellectual disability (ISO)

Prostatic Neoplasms (ISO)

Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular Malformations (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of G1/S transition of mitotic cell cycle (IEA)

regulation of microtubule cytoskeleton organization (IEA)

regulation of stem cell division (IEA)

Cellular Component

cytoplasm (IEA)

microtubule (IEA)

nucleus (IEA)

NuRD complex (IEA)

Molecular Function

protein binding (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Cdk2ap2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	5,815,870 - 5,817,534 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936599	2,257,671 - 2,259,886 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936599	2,257,731 - 2,259,883 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CDK2AP2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	67,506,497 - 67,508,162 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	67,506,497 - 67,508,649 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	67,273,968 - 67,275,633 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	67,030,544 - 67,032,678 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	11	64,608,370 - 64,610,504 (-)	NCBI		Celera
Cytogenetic Map	11	q13.2	NCBI
HuRef	11	63,603,170 - 63,605,408 (-)	NCBI		HuRef
CHM1_1	11	67,157,015 - 67,159,253 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	67,501,174 - 67,502,839 (-)	NCBI		T2T-CHM13v2.0

Cdk2ap2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	4,146,204 - 4,149,019 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	4,147,182 - 4,149,019 (+)	Ensembl		GRCm39 Ensembl
GRCm38	19	4,096,206 - 4,099,019 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	4,097,182 - 4,099,019 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	4,097,351 - 4,099,017 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	4,097,351 - 4,099,017 (+)	NCBI		MGSCv36	mm8
Celera	19	3,968,253 - 3,969,919 (+)	NCBI		Celera
Cytogenetic Map	19	A	NCBI
cM Map	19	3.8	NCBI

Cdk2ap2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	210,819,155 - 210,822,604 (+)	NCBI		GRCr8
mRatBN7.2	1	201,391,056 - 201,393,137 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	201,391,466 - 201,393,137 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	209,743,716 - 209,745,384 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	216,836,947 - 216,838,615 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	209,527,960 - 209,529,628 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	219,345,638 - 219,347,709 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	219,345,918 - 219,347,728 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	226,216,312 - 226,218,360 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	206,681,430 - 206,683,098 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	198,935,992 - 198,937,660 (+)	NCBI		Celera
Cytogenetic Map	1	q43	NCBI

Cdk2ap2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	17,981,267 - 17,984,517 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	17,981,267 - 17,983,480 (+)	NCBI	ChiLan1.0	ChiLan1.0

CDK2AP2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	68,734,077 - 68,736,325 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	69,776,660 - 69,778,908 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	62,865,554 - 62,867,756 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	66,176,917 - 66,179,154 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	66,176,917 - 66,179,154 (-)	Ensembl	panpan1.1		panPan2

CDK2AP2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	49,969,630 - 49,971,781 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	49,970,160 - 49,971,457 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	48,580,124 - 48,582,321 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	50,892,011 - 50,894,208 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	50,892,068 - 50,908,430 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	50,105,317 - 50,107,514 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	49,679,848 - 49,682,045 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	50,474,088 - 50,476,285 (+)	NCBI		UU_Cfam_GSD_1.0

CDK2AP2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	5,025,600 - 5,027,764 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	5,025,256 - 5,027,766 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	3,743,767 - 3,746,277 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CDK2AP2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	6,756,853 - 6,759,087 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	6,756,909 - 6,759,090 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	104,034,694 - 104,036,928 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cdk2ap2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624767	19,027,912 - 19,030,835 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624767	19,028,442 - 19,030,580 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005333339	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021731741	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000022572 ⟹ ENSSTOP00000016275

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936599	2,257,671 - 2,259,886 (+)	Ensembl

RefSeq Acc Id:

XM_005333339 ⟹ XP_005333396

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404947	5,815,870 - 5,817,534 (+)	NCBI
SpeTri2.0	NW_004936599	2,257,731 - 2,259,883 (+)	NCBI

Sequence:

show sequence

AGAGAAGGGAAGGCACGCGCGACGGCGACGACCGCAGCTCCGGCCGGACCGAGACCGGGCGGTG
CGGAGCGGACGCGCAAGGCGACGCGAGCAAGGCGGGAGGGCGGCGCCCGCGTCCGAGAAGACCC
CCTCGTCACGAACCGCGGCTGCCGGGACCCCGGTCCCCGCTTCCGAGGCCCCGCCTCTCGGGTC
TTGGGACTAATCGGATTGAGAGCGCGCCGGCCGGGGCCGCGAACTCGCCAATTGCGAAGGGAGG
CAGCCACCGCCCAATCCGGAGCAGACAGGTGCGAGGTCCGGAAGGCACAAACCAATCGGCTGTA
GTTGCGACCTGTGGGGGCAGGCCTCGGCCAATAAGGAGGCTCGAGTGACGTCTTTGAGCGCCAA
TAGGGAGTGACGGAGCTTGCGTGCCCGCCCACCCTTCCGGCCGGAGCTCTATTTACCAGGGGCG
TGCAGCGCGTCTGCCAATCGGAGCGCGGCTGAGCGGCCCGGCAGCCAACCCCGGAGGAGCGGCC
GGCTGGCGTCCGCCGCACCCAGGAGTTGGGGATGTCCTACAAACCCATCGCTCCCGCCCCCAGC
AGCACCCCCGGCTCCAGCACCCCTGGGCCAGGCACCCCGGTACCTACAGCCGGAAGTGTTCCAT
CGCCGTCGGGCTCAGTGCCAGGAGCCGCTGCCCCTTTCAGACCACTCTTTAATGACTTTGGACC
TCCCTCCATGGGCTATGTGCAGACGATGAAGCCACCTGGTACCCAGGGCTCTCAGAGCACCTAT
ACGGACCTGCTATCCGTCATAGAGGAGATGGGTAAAGAGATTCGGCCCACCTATGCTGGGAGCA
AGAGCGCCATGGAGCGCCTGAAAAGAGGCATCATCCATGCCCGGGCCCTGGTCAGAGAGTGCCT
GGCAGAGACAGAGAGAAACGCTCGCACGTAACAGGAAGCACCTTGGCCTCAGCGTCTGGACCTT
TCCGGCCACTGCAGAGCACCTGCTTCTCCCTGGCCTTTGCCCCAAGTTGCACCTCCTATCCTGG
GCTTCCTGTCTTGTCCCTTGGTGGGTGCCCTCCAGGAACCAGGGATCGACTTTCACTCCAGTGG
GCAACGCTAACTGGGCTCCTCCCCCTGCAAGAGTTAGCTGCCAGGTCACTGTGAGTCCCACCCA
CGACCTGCCAGCAGCAGTGTTGGTCCCACTGGAGCGTTCTCCTTTCTTGGCCCCCATTACTCTG
CACTTACTTCTCACCACTTTGTCCCAGGCCTTCTCTTCCAGAAGGAGCTTAGAAGGCCTGTCAC
CTCCCTGCCTTGTCTCTGGGGCCATATTGACTCTTTTCTCAGTGTATCTTTTGCTAAATATGCC
CTTTTTATATAAATAAAAAGATGATTTGGAGTTGTTCTCTCA

hide sequence

RefSeq Acc Id:

XM_021731741 ⟹ XP_021587416

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404947	5,816,009 - 5,817,534 (+)	NCBI
SpeTri2.0	NW_004936599	2,258,364 - 2,259,883 (+)	NCBI

Sequence:

show sequence

CCAGCTCCACCCCTGCTCGCCTACCGGGGCTGTCGAGGTCTTGAAGAGAAGACGGCCTGAGTTC
TACAATACTGGGCCTGCCGCCTATAGCCTCGCTGAGCCTCAGTTTGCTGGCCTGTGAAGTGGGC
GTGGTCACCCGGAAGTGTTCCATCGCCGTCGGGCTCAGTGCCAGGAGCCGCTGCCCCTTTCAGA
CCACTCTTTAATGACTTTGGACCTCCCTCCATGGGCTATGTGCAGACGATGAAGCCACCTGGTA
CCCAGGGCTCTCAGAGCACCTATACGGACCTGCTATCCGTCATAGAGGAGATGGGTAAAGAGAT
TCGGCCCACCTATGCTGGGAGCAAGAGCGCCATGGAGCGCCTGAAAAGAGGCATCATCCATGCC
CGGGCCCTGGTCAGAGAGTGCCTGGCAGAGACAGAGAGAAACGCTCGCACGTAACAGGAAGCAC
CTTGGCCTCAGCGTCTGGACCTTTCCGGCCACTGCAGAGCACCTGCTTCTCCCTGGCCTTTGCC
CCAAGTTGCACCTCCTATCCTGGGCTTCCTGTCTTGTCCCTTGGTGGGTGCCCTCCAGGAACCA
GGGATCGACTTTCACTCCAGTGGGCAACGCTAACTGGGCTCCTCCCCCTGCAAGAGTTAGCTGC
CAGGTCACTGTGAGTCCCACCCACGACCTGCCAGCAGCAGTGTTGGTCCCACTGGAGCGTTCTC
CTTTCTTGGCCCCCATTACTCTGCACTTACTTCTCACCACTTTGTCCCAGGCCTTCTCTTCCAG
AAGGAGCTTAGAAGGCCTGTCACCTCCCTGCCTTGTCTCTGGGGCCATATTGACTCTTTTCTCA
GTGTATCTTTTGCTAAATATGCCCTTTTTATATAAATAAAAAGATGATTTGGAGTTGTTCTCTC
A

hide sequence

Protein Sequences


Protein RefSeqs	XP_005333396	(Get FASTA)	NCBI Sequence Viewer
	XP_021587416	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000016275.1
GenBank Protein	KAG3284553	(Get FASTA)	NCBI Sequence Viewer
	KAG3284554	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005333396 ⟸ XM_005333339
- Peptide Label:	isoform X1
- UniProtKB:	I3MVY0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSYKPIAPAPSSTPGSSTPGPGTPVPTAGSVPSPSGSVPGAAAPFRPLFNDFGPPSMGYVQTMK PPGTQGSQSTYTDLLSVIEEMGKEIRPTYAGSKSAMERLKRGIIHARALVRECLAETERNART hide sequence

RefSeq Acc Id:	XP_021587416 ⟸ XM_021731741
- Peptide Label:	isoform X2
- Sequence:	show sequence MGYVQTMKPPGTQGSQSTYTDLLSVIEEMGKEIRPTYAGSKSAMERLKRGIIHARALVRECLAE TERNART hide sequence

RefSeq Acc Id:

ENSSTOP00000016275 ⟸ ENSSTOT00000022572

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000024042	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000022572.2	UniProtKB/TrEMBL
Gene3D-CATH	6.10.140.1300	UniProtKB/TrEMBL
InterPro	DOC_1/2	UniProtKB/TrEMBL
NCBI Gene	Cdk2ap2	ENTREZGENE
PANTHER	CYCLIN-DEPENDENT KINASE 2-ASSOCIATED PROTEIN 2	UniProtKB/TrEMBL
	PTHR22607	UniProtKB/TrEMBL
Pfam	CDK2AP	UniProtKB/TrEMBL
PIRSF	CDK2-associated_p2	UniProtKB/TrEMBL
UniProt	I3MVY0	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD