Diaph2 (diaphanous related formin 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Diaph2 (diaphanous related formin 2) Ictidomys tridecemlineatus
Analyze
Symbol: Diaph2
Name: diaphanous related formin 2
RGD ID: 12681192
Description: ENCODES a protein that exhibits actin binding (inferred); small GTPase binding (inferred); INVOLVED IN actin filament polymerization (ortholog); axon midline choice point recognition (ortholog); ephrin receptor signaling pathway (ortholog); ASSOCIATED WITH amenorrhea (ortholog); autistic disorder (ortholog); developmental and epileptic encephalopathy 9 (ortholog); FOUND IN actin filament (inferred); endoplasmic reticulum (inferred); intracellular membrane-bounded organelle (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X66,474,564 - 67,266,088 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365842,287,288 - 3,076,788 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365842,286,919 - 3,081,652 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Diaph2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X66,474,564 - 67,266,088 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365842,287,288 - 3,076,788 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365842,286,919 - 3,081,652 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DIAPH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X96,684,842 - 97,604,997 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX96,684,712 - 97,604,997 (+)EnsemblGRCh38hg38GRCh38
GRCh37X95,939,841 - 96,859,996 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X95,826,365 - 96,746,652 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X95,745,855 - 96,666,137NCBI
CeleraX96,458,012 - 97,373,277 (+)NCBICelera
Cytogenetic MapXq21.33NCBI
HuRefX85,739,952 - 86,659,936 (+)NCBIHuRef
CHM1_1X95,832,371 - 96,748,951 (+)NCBICHM1_1
T2T-CHM13v2.0X95,124,162 - 96,044,467 (+)NCBIT2T-CHM13v2.0
Diaph2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X128,650,409 - 129,366,583 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX128,650,491 - 129,366,583 (+)EnsemblGRCm39 Ensembl
GRCm38X129,749,668 - 130,465,834 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX129,749,742 - 130,465,834 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X126,284,278 - 126,995,733 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X125,096,143 - 125,675,204 (+)NCBIMGSCv36mm8
CeleraX112,642,958 - 113,350,873 (+)NCBICelera
Cytogenetic MapXE3NCBI
cM MapX52.36NCBI
Diaph2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X96,700,535 - 97,528,080 (+)NCBIGRCr8
mRatBN7.2X92,395,189 - 93,234,521 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX92,395,251 - 93,229,869 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X99,722,910 - 100,363,228 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX99,852,198 - 100,057,439 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0X99,553,986 - 100,197,417 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X116,641,770 - 117,258,314 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX93,552,263 - 94,180,770 (+)NCBICelera
Cytogenetic MapXq31NCBI
Diaph2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555032,325,103 - 2,835,656 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555032,324,934 - 3,132,466 (+)NCBIChiLan1.0ChiLan1.0
DIAPH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X96,304,030 - 97,225,531 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X96,307,680 - 97,224,783 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X85,916,356 - 86,837,858 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X96,067,252 - 96,979,830 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX96,066,870 - 96,979,462 (+)Ensemblpanpan1.1panPan2
DIAPH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X69,994,674 - 71,044,178 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX69,994,650 - 71,043,198 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX60,804,704 - 61,857,429 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X71,343,583 - 72,392,960 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X69,016,716 - 70,066,386 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X70,624,006 - 71,673,290 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X70,255,069 - 71,304,928 (+)NCBIUU_Cfam_GSD_1.0
DIAPH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX78,602,390 - 79,520,428 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X78,602,385 - 79,520,441 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X85,891,093 - 85,978,699 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DIAPH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X85,130,928 - 86,035,944 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606510,174,929 - 10,906,218 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Diaph2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248513,291,888 - 4,329,285 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000014787   ⟹   ENSSTOP00000013247
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365842,287,288 - 3,076,788 (+)Ensembl
RefSeq Acc Id: XM_040283675   ⟹   XP_040139609
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2X66,474,564 - 67,266,088 (-)NCBI
RefSeq Acc Id: XM_040283676   ⟹   XP_040139610
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2X66,474,564 - 67,266,088 (-)NCBI
RefSeq Acc Id: XM_040283677   ⟹   XP_040139611
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2X66,607,646 - 67,266,088 (-)NCBI
RefSeq Acc Id: XM_040283678   ⟹   XP_040139612
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2X66,474,564 - 67,266,088 (-)NCBI
RefSeq Acc Id: XM_040283680   ⟹   XP_040139614
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2X66,474,564 - 67,266,088 (-)NCBI
RefSeq Acc Id: XR_005733169
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2X66,649,898 - 67,266,087 (-)NCBI
Protein Sequences
Protein RefSeqs XP_040139609 (Get FASTA)   NCBI Sequence Viewer  
  XP_040139610 (Get FASTA)   NCBI Sequence Viewer  
  XP_040139611 (Get FASTA)   NCBI Sequence Viewer  
  XP_040139612 (Get FASTA)   NCBI Sequence Viewer  
  XP_040139614 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000013247.3
GenBank Protein KAG3272634 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_040139614   ⟸   XM_040283680
- Peptide Label: isoform X4
- UniProtKB: I3MNK2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139612   ⟸   XM_040283678
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040139610   ⟸   XM_040283676
- Peptide Label: isoform X1
RefSeq Acc Id: XP_040139609   ⟸   XM_040283675
- Peptide Label: isoform X1
RefSeq Acc Id: XP_040139611   ⟸   XM_040283677
- Peptide Label: isoform X2
RefSeq Acc Id: ENSSTOP00000013247   ⟸   ENSSTOT00000014787
Protein Domains
DAD   FH2   GBD/FH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000014769 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000014787.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.20.40 UniProtKB/TrEMBL
  1.20.58.2220 UniProtKB/TrEMBL
  1.20.58.630 UniProtKB/TrEMBL
  1.25.10.10 UniProtKB/TrEMBL
  6.10.30.30 UniProtKB/TrEMBL
  Formin, FH3 diaphanous domain UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  DAD_dom UniProtKB/TrEMBL
  DIA_GBD_sf UniProtKB/TrEMBL
  FH2_Formin UniProtKB/TrEMBL
  FH2_Formin_sf UniProtKB/TrEMBL
  FH3_dom UniProtKB/TrEMBL
  GBD/FH3_dom UniProtKB/TrEMBL
  GTPase-bd UniProtKB/TrEMBL
NCBI Gene Diaph2 ENTREZGENE
PANTHER PROTEIN DIAPHANOUS UniProtKB/TrEMBL
  PTHR45691:SF3 UniProtKB/TrEMBL
Pfam Drf_FH3 UniProtKB/TrEMBL
  Drf_GBD UniProtKB/TrEMBL
  FH2 UniProtKB/TrEMBL
PROSITE DAD UniProtKB/TrEMBL
  FH2 UniProtKB/TrEMBL
  GBD_FH3 UniProtKB/TrEMBL
SMART Drf_FH3 UniProtKB/TrEMBL
  Drf_GBD UniProtKB/TrEMBL
  FH2 UniProtKB/TrEMBL
Superfamily-SCOP Formin homology 2 domain (FH2 domain) UniProtKB/TrEMBL
  SSF48371 UniProtKB/TrEMBL
UniProt I3MNK2 ENTREZGENE, UniProtKB/TrEMBL