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Gene: Ahr^em2Sage (aryl hydrocarbon receptor; ZFN induced mutant2, Sage) Rattus norvegicus

Symbol:	Ahr^em2Sage
Name:	aryl hydrocarbon receptor; ZFN induced mutant2, Sage
RGD ID:	126790510
Description:	ZFN constructs were designed to target exon 2 which contains the DNA binding bHLH motif of the AHR gene. The ZFN system was injected to embryos from outbred Sprague Dawle from Harlan and one founder contained a 29-bp deletion in the rat Ahr gene. The deletion resulted in a premature stop codon within exon 2. ASSOCIATED WITH abnormal kidney medullary ray morphology; abnormal urothelium morphology; absent ductus venosus
Type:	allele of Ahr
Previously known as:	Ahr^[em2Sage]
Is Marker For:	Strains: SD-Ahr^em2Sage
Latest Assembly:	GRCr8 - GRCr8 Assembly
Position:	No map positions available.

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated

#	Reference Title	Reference Citation
1.	Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice.	Harrill JA, etal., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13.
2.	Role of Glucocorticoid Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor Nuclear Translocator and NADPH-Cytochrome P450 Oxidoreductase.	Hunter SR, etal., Drug Metab Dispos. 2017 Feb;45(2):118-129. doi: 10.1124/dmd.116.073833. Epub 2016 Nov 16.
3.	Aryl hydrocarbon receptor is indispensable for β-naphthoflavone-induced novel food avoidance and may be involved in LiCl-triggered conditioned taste aversion in rats.	Pohjanvirta R and Mahiout S, Physiol Behav. 2019 May 15;204:58-64. doi: 10.1016/j.physbeh.2019.02.014. Epub 2019 Feb 12.

Genomics

Related Rat Strains

The following Strains have been annotated to Ahr^em2Sage

SD-Ahr^em2Sage

Expression

RNA-SEQ Expression

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Sequence

Nucleotide Sequences

Additional Information

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