Pts (6-pyruvoyltetrahydropterin synthase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Pts (6-pyruvoyltetrahydropterin synthase) Ictidomys tridecemlineatus
Analyze
Symbol: Pts
Name: 6-pyruvoyltetrahydropterin synthase
RGD ID: 12677177
Description: ENCODES a protein that exhibits 6-pyruvoyltetrahydropterin synthase activity (ortholog); INVOLVED IN tetrahydrobiopterin biosynthetic process (ortholog); PARTICIPATES IN dopa responsive dystonia pathway; Segawa syndrome pathway; ASSOCIATED WITH BH4-deficient hyperphenylalaninemia A (ortholog); BH4-deficient hyperphenylalaninemia B (ortholog); Chromosome 11, Partial Trisomy 11q (ortholog); FOUND IN cytoplasm (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 6-pyruvoyl tetrahydrobiopterin synthase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494794,451,940 - 94,458,598 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366122,246,878 - 2,253,675 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366122,247,825 - 2,255,277 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
mitochondrion  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Pts
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494794,451,940 - 94,458,598 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366122,246,878 - 2,253,675 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366122,247,825 - 2,255,277 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811112,226,428 - 112,233,973 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11112,226,367 - 112,269,955 (+)EnsemblGRCh38hg38GRCh38
GRCh3711112,097,151 - 112,104,696 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611111,602,309 - 111,609,903 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411111,602,308 - 111,609,903NCBI
Celera11109,250,329 - 109,257,937 (+)NCBICelera
Cytogenetic Map11q23.1NCBI
HuRef11108,022,655 - 108,030,262 (+)NCBIHuRef
CHM1_111111,980,551 - 111,988,158 (+)NCBICHM1_1
T2T-CHM13v2.011112,236,776 - 112,368,893 (+)NCBIT2T-CHM13v2.0
Pts
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39950,432,917 - 50,440,017 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl950,432,917 - 50,440,024 (-)EnsemblGRCm39 Ensembl
GRCm38950,521,617 - 50,528,716 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl950,521,617 - 50,528,724 (-)EnsemblGRCm38mm10GRCm38
MGSCv37950,329,722 - 50,336,746 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36950,273,847 - 50,280,871 (-)NCBIMGSCv36mm8
Celera947,811,421 - 47,818,445 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map927.73NCBI
Pts
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8859,767,234 - 59,774,265 (-)NCBIGRCr8
mRatBN7.2850,870,838 - 50,877,869 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl850,870,841 - 50,877,869 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx856,376,420 - 56,383,401 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0854,655,319 - 54,662,300 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0852,519,589 - 52,526,570 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0854,954,261 - 54,961,271 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl854,954,226 - 54,961,265 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0853,551,584 - 53,558,594 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4853,880,701 - 53,887,711 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1853,899,754 - 53,906,765 (-)NCBI
Celera850,419,474 - 50,426,475 (-)NCBICelera
Cytogenetic Map8q23NCBI
Pts
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541213,880,937 - 13,888,562 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541213,880,937 - 13,888,562 (+)NCBIChiLan1.0ChiLan1.0
PTS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29112,971,384 - 112,978,838 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111114,065,773 - 114,073,257 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011107,107,114 - 107,114,594 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111110,949,714 - 110,957,599 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11110,949,708 - 110,957,599 (+)Ensemblpanpan1.1panPan2
PTS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1520,883,128 - 20,912,318 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl520,896,236 - 20,912,297 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha520,828,713 - 20,835,800 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0520,928,161 - 20,935,247 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl520,919,161 - 20,987,893 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1520,991,102 - 20,998,175 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0520,891,374 - 20,898,446 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0520,917,631 - 20,946,631 (-)NCBIUU_Cfam_GSD_1.0
PTS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl939,920,273 - 39,928,634 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1939,920,157 - 39,927,804 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2944,771,647 - 44,779,304 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11103,574,057 - 103,581,944 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1103,574,451 - 103,582,924 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604322,404,405 - 22,412,377 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pts
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247847,360,344 - 7,370,042 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247847,360,655 - 7,424,357 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000013274   ⟹   ENSSTOP00000011896
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366122,246,878 - 2,253,675 (-)Ensembl
RefSeq Acc Id: XM_005334215   ⟹   XP_005334272
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494794,451,941 - 94,458,598 (+)NCBI
SpeTri2.0NW_0049366122,247,825 - 2,255,277 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040285208   ⟹   XP_040141142
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494794,451,940 - 94,458,598 (+)NCBI
Protein Sequences
Protein RefSeqs XP_005334272 (Get FASTA)   NCBI Sequence Viewer  
  XP_040141142 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000011896.3
Reference Protein Sequences
RefSeq Acc Id: XP_005334272   ⟸   XM_005334215
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_040141142   ⟸   XM_040285208
- Peptide Label: isoform X1
RefSeq Acc Id: ENSSTOP00000011896   ⟸   ENSSTOT00000013274


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000013277 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000013274.3 UniProtKB/TrEMBL
Gene3D-CATH 3.30.479.10 UniProtKB/TrEMBL
InterPro 6-PTP_synth/QueD UniProtKB/TrEMBL
  6-PTP_synth/QueD_sf UniProtKB/TrEMBL
  PTPS_Cys_AS UniProtKB/TrEMBL
  PTPS_His_AS UniProtKB/TrEMBL
NCBI Gene Pts ENTREZGENE
PANTHER 6-PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE UniProtKB/TrEMBL
  PTHR12589 UniProtKB/TrEMBL
Pfam PTPS UniProtKB/TrEMBL
PIRSF PTP_synth UniProtKB/TrEMBL
PROSITE PTPS_1 UniProtKB/TrEMBL
  PTPS_2 UniProtKB/TrEMBL
Superfamily-SCOP Tetrahydrobiopterin biosynthesis enzymes-like UniProtKB/TrEMBL
UniProt I3MKP2_ICTTR UniProtKB/TrEMBL