Rpe65 (retinoid isomerohydrolase RPE65)

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Gene: Rpe65 (retinoid isomerohydrolase RPE65) Ictidomys tridecemlineatus

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Symbol:

Rpe65

Name:

retinoid isomerohydrolase RPE65

RGD ID:

12677040

Description:

ENCODES a protein that exhibits all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity (ortholog); cardiolipin binding (ortholog); phosphatidylcholine binding (ortholog); INVOLVED IN camera-type eye development (ortholog); circadian rhythm (ortholog); neural retina development (ortholog); PARTICIPATES IN altered retinoid cycle metabolic pathway; retinitis pigmentosa pathway; retinoid cycle metabolic pathway; ASSOCIATED WITH adrenocorticotropic hormone deficiency (ortholog); autistic disorder (ortholog); basal cell carcinoma (ortholog); FOUND IN cell body (ortholog); membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

retinal pigment epithelium-specific protein 65kDa; retinoid isomerohydrolase; RPE65, retinoid isomerohydrolase; RPE65, retinoid isomerohydrolase, transcript variant X1; RPE65, retinoid isomerohydrolase, transcript variant X2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	81,055,133 - 81,142,276 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936591	3,347,272 - 3,368,015 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936591	3,347,346 - 3,368,062 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adrenocorticotropic hormone deficiency (ISO)

autistic disorder (ISO)

basal cell carcinoma (ISO)

blindness (ISO)

cone-rod dystrophy (ISO)

cone-rod dystrophy 15 (ISO)

congenital nystagmus (ISO)

Developmental Disabilities (ISO)

Experimental Autoimmune Uveitis (ISO)

Experimental Diabetes Mellitus (ISO)

Eye Abnormalities (ISO)

fundus dystrophy (ISO)

genetic disease (ISO)

globe disease (ISO)

Hereditary Eye Diseases (ISO)

intellectual disability (ISO)

Joubert syndrome 9 (ISO)

Leber congenital amaurosis (ISO)

Leber congenital amaurosis 2 (ISO)

Leber hereditary optic neuropathy (ISO)

Neurodevelopmental Disorders (ISO)

pathologic nystagmus (ISO)

retinal degeneration (ISO)

retinitis pigmentosa (ISO)

retinitis pigmentosa 20 (ISO)

retinitis pigmentosa 87 (ISO)

squamous cell carcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

camera-type eye development (ISO)

circadian rhythm (ISO)

detection of light stimulus involved in visual perception (IEA)

neural retina development (ISO)

response to light stimulus (ISO)

retina homeostasis (IEA)

retinal metabolic process (IEA,ISO)

retinoid metabolic process (IEA)

retinol metabolic process (IEA,ISO)

visual perception (IEA)

zeaxanthin biosynthetic process (IEA)

Cellular Component

cell body (ISO)

cytoplasm (IEA)

endoplasmic reticulum membrane (IEA)

membrane (IEA,ISS)

nucleus (IEA)

plasma membrane (IEA)

Molecular Function

all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity (IEA,ISO,ISS)

all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity (IEA)

beta-carotene 15,15'-dioxygenase activity (IEA)

cardiolipin binding (ISS)

isomerase activity (IEA)

metal ion binding (IEA)

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (IEA)

phosphatidylcholine binding (ISS)

phosphatidylserine binding (ISS)

protein binding (ISO)

retinol isomerase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

altered retinoid cycle metabolic pathway (ISO)

retinitis pigmentosa pathway (ISO)

retinoid cycle metabolic pathway (ISO)

retinol metabolic pathway (ISO)

vitamin A deficiency pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Rpe65
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	81,055,133 - 81,142,276 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936591	3,347,272 - 3,368,015 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936591	3,347,346 - 3,368,062 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RPE65
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	68,428,822 - 68,449,954 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	68,428,822 - 68,451,103 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	68,894,505 - 68,915,637 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	68,667,095 - 68,688,230 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	68,606,465 - 68,627,663	NCBI
Celera	1	67,184,748 - 67,205,854 (-)	NCBI		Celera
Cytogenetic Map	1	p31.3	NCBI
HuRef	1	67,004,313 - 67,025,452 (-)	NCBI		HuRef
CHM1_1	1	69,009,866 - 69,031,001 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	68,306,207 - 68,327,339 (-)	NCBI		T2T-CHM13v2.0

Rpe65
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	159,304,712 - 159,330,944 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	159,304,812 - 159,330,958 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	159,599,075 - 159,625,307 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	159,599,175 - 159,625,321 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	159,262,145 - 159,288,271 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	159,534,526 - 159,560,092 (+)	NCBI		MGSCv36	mm8
Celera	3	166,038,618 - 166,064,587 (+)	NCBI		Celera
Cytogenetic Map	3	H4	NCBI
cM Map	3	82.52	NCBI

Rpe65
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	251,425,228 - 251,457,209 (+)	NCBI		GRCr8
mRatBN7.2	2	248,766,497 - 248,798,403 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	248,766,612 - 248,798,403 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	256,482,408 - 256,514,178 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	254,375,936 - 254,407,703 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	249,342,889 - 249,374,020 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	266,141,581 - 266,169,197 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	266,141,581 - 266,169,197 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	284,774,159 - 284,804,254 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.1	2	257,860,998 - 257,893,921 (+)	NCBI
Celera	2	240,512,281 - 240,537,640 (+)	NCBI		Celera
Cytogenetic Map	2	q45	NCBI

Rpe65
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955423	23,183,937 - 23,208,282 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955423	23,184,326 - 23,208,206 (+)	NCBI	ChiLan1.0	ChiLan1.0

RPE65
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	158,421,347 - 158,442,454 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	157,581,121 - 157,602,228 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	67,666,784 - 67,687,891 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	69,623,775 - 69,644,894 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	69,623,775 - 69,644,904 (-)	Ensembl	panpan1.1		panPan2

RPE65
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	76,887,399 - 76,911,133 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	76,887,399 - 76,911,131 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	79,498,666 - 79,521,615 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	77,481,101 - 77,504,927 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	77,481,101 - 77,504,925 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	77,031,835 - 77,055,739 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	76,935,191 - 76,959,205 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	77,422,281 - 77,446,314 (+)	NCBI		UU_Cfam_GSD_1.0

RPE65
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	144,206,078 - 144,229,467 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	144,206,078 - 144,229,471 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	133,491,901 - 133,514,217 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RPE65
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	64,662,777 - 64,684,178 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	64,664,358 - 64,683,211 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	52,929,980 - 52,950,761 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rpe65
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624742	27,302,453 - 27,319,203 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624742	27,302,222 - 27,319,549 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005332357	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021731077	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040288835	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000001659 ⟹ ENSSTOP00000001488

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936591	3,347,272 - 3,368,015 (+)	Ensembl

RefSeq Acc Id:

XM_005332357 ⟹ XP_005332414

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	81,119,205 - 81,142,276 (-)	NCBI
SpeTri2.0	NW_004936591	3,347,346 - 3,368,062 (+)	NCBI

Sequence:

show sequence

AAAGCCCCTGGCTGAGGACTTGCTCCCTCATTCCTCAGTCGGTGCCAGAATTCTTGATCCTGCA
CTGGGAGAAAATGTCTATCCAAGTGGAACACCCAGCTGGTGGCTACAAGAAGCTATTTGAAACT
GTAGAGGAACTGTCCTCACCACTCACAGCTCACGTGACAGGCAGGATCCCTGTCTGGCTCACCG
GCAGTCTCCTTCGATGTGGGCCAGGACTCTTTGAAGTTGGATCTGAGCCATTTTACCACCTGTT
TGACGGGCAAGCCCTCCTTCACAAGTTTGACTTTAAAGAAGGACATGTCACATACCACAGAAGG
TTCATCCGCACTGATGCCTACGTGCGTGCAATGACTGAGAAAAGGATTGTCATAACAGAATTTG
GCACCTGTGCTTTCCCAGACCCCTGCAAGAATATATTCTCCAGGTTTTTTTCCTACTTTAGAGG
AGTGGAGGTTACCGACAATGCCCTTGTAAATGTCTACCCAGTGGGGGAAGATTACTATGCCTGC
ACAGAGACCAACTTTATTACAAAGATTAATCCAGAGACCTTAGAGACAATTAAGCAGGTTGACC
TTTGCAACTATGTCTCAGTCAACGGAGCCACTGCCCACCCCCACATTGAAAGTGATGGAACCGT
TTACAACATTGGTAATTGCTTTGGGAAAAACTTTTCAATTGCCTACAATATTGTAAAGATTCCT
CCACTGCAAGCAGACAAGGAAGATCCAATAAGCAAGTCAGAGATCGTTGTACAATTCCCCTGCA
GTGACCGATTCAAGCCATCTTACGTCCATAGTTTTGGTCTGACCCCCAATTACATCGTTTTTGT
GGAGACACCAGTCAAAATTAACTTGTTCAAGTTCCTTTCTTCATGGAGTCTTTGGGGAGCCAAC
TACATGGACTGTTTTGAGTCCAATGAAACCATGGGGGTTTGGCTTCATATTGCTGACAAAAAAA
GAAGAAAATACCTTAATAATAAATACAGAACCTCTTCCTTCAACCTCTTCCATCACATCAACAC
CTATGAAGACAGTGGGTTTCTGATTGTGGACCTCTGTTGCTGGAAAGGATTTGAATTCGTCTAT
AATTACTTATATTTAGCTAATTTACGTGAGAACTGGGAAGAGGTAAAAAAAAATGCCAGAAAGG
CTCCTCAACCGGAAGTTAGAAGATATGTACTACCTTTGAATATCGACAAGGCTGACACAGGCAA
GAATTTGATCACACTCCCCAACACAACAGCCACAGCGATTCTGTGCAGCGATGAGACCATCTGG
CTGGAACCTGAGGTTCTCTTCTCAGGGCCTCGTCAAGCATTTGAGTTTCCTCAGATCAATTACC
AGAAGTATGGTGGGAAACCTTATACGTACGCCTATGGACTTGGCTTGAATCACTTTGTTCCAGA
CAGGCTCTGTAAGCTGAATGTCAAAACTAAAGAAATTTGGGTATGGCAAGAGCCGGATTCATAT
CCATCAGAACCCATCTTTGTTTCTCACCCAGAGGCCTTGGAAGAAGATGATGGTGTAGTTCTGA
GTGTGGTGGTGAGCCCCGGGGCAGGACAAAAGCCTGCATACCTCCTGATTCTGAATGCCAAGGA
TTTGAGTGAAGTTGCCAGGGCTGAAGTGGAGATTAACATCCCTGTTACCTTTCATGGACTGTTC
AAAAAATCCTGAGCATAAGATGTGTTTATGGTGACAAAACTAAGAAAACTAGCTTCAGTTCTGC
AATCAAATTTGTTCAATTTTAGCCTGCTATATGTTGTGTTTTTAACTTGCACATGCACACAATT
TTTCAATGTCTTATAGAAGATATCTGACCAAACAATCTCTTTAGAAAAAAGTATTTTCTTGATA
AAATAGACCATAACTGAAAAATTCTTTTAATATTTAGCAATCAAATAAGAAATTAATGTGGACT
TATTAAACTGATTTTTGTTCCTATATAAAAGATAATTTTAGCTATCTGCTCTAATGTTTTTTTT
TTTAACATTTAAAACCCAAAGTCTTCTACATACCTTATTTGTATGTAGCTTTGCTGAGTCAAGG
CAAAAAGGCTTAATTACTAAAGTAAAACCAAAATTTCCAGGGACTATCATTTAAGAGTACATAG
CAATTGCTCTGTGTATATGTAACTGCTTAAAGATCCTTAATGAACTTTAATCTCTTTGTTCAAT
TTTTTTCAATTCCATGCTTAATTCCATTAAATATTGGCAGTTGCTACCACTTCTGA

hide sequence

RefSeq Acc Id:

XM_021731077 ⟹ XP_021586752

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	81,119,205 - 81,142,273 (-)	NCBI
SpeTri2.0	NW_004936591	3,347,346 - 3,368,062 (+)	NCBI

Sequence:

show sequence

AAAGCCCCTGGCTGAGGACTTGCTCCCTCATTCCTCAGTCGGTGCCAGAATTCTTGATCCTGCA
CTGGGAGAAAATGTCTATCCAGAGCCAGAGGAACGAGTCTCCCCATGAGGCCAGAAAGTCAATG
ATGCATTCAGCAGAGAGTGTCAATAGGGCAGGAGTGGAACACCCAGCTGGTGGCTACAAGAAGC
TATTTGAAACTGTAGAGGAACTGTCCTCACCACTCACAGCTCACGTGACAGGCAGGATCCCTGT
CTGGCTCACCGGCAGTCTCCTTCGATGTGGGCCAGGACTCTTTGAAGTTGGATCTGAGCCATTT
TACCACCTGTTTGACGGGCAAGCCCTCCTTCACAAGTTTGACTTTAAAGAAGGACATGTCACAT
ACCACAGAAGGTTCATCCGCACTGATGCCTACGTGCGTGCAATGACTGAGAAAAGGATTGTCAT
AACAGAATTTGGCACCTGTGCTTTCCCAGACCCCTGCAAGAATATATTCTCCAGGTTTTTTTCC
TACTTTAGAGGAGTGGAGGTTACCGACAATGCCCTTGTAAATGTCTACCCAGTGGGGGAAGATT
ACTATGCCTGCACAGAGACCAACTTTATTACAAAGATTAATCCAGAGACCTTAGAGACAATTAA
GCAGGTTGACCTTTGCAACTATGTCTCAGTCAACGGAGCCACTGCCCACCCCCACATTGAAAGT
GATGGAACCGTTTACAACATTGGTAATTGCTTTGGGAAAAACTTTTCAATTGCCTACAATATTG
TAAAGATTCCTCCACTGCAAGCAGACAAGGAAGATCCAATAAGCAAGTCAGAGATCGTTGTACA
ATTCCCCTGCAGTGACCGATTCAAGCCATCTTACGTCCATAGTTTTGGTCTGACCCCCAATTAC
ATCGTTTTTGTGGAGACACCAGTCAAAATTAACTTGTTCAAGTTCCTTTCTTCATGGAGTCTTT
GGGGAGCCAACTACATGGACTGTTTTGAGTCCAATGAAACCATGGGGGTTTGGCTTCATATTGC
TGACAAAAAAAGAAGAAAATACCTTAATAATAAATACAGAACCTCTTCCTTCAACCTCTTCCAT
CACATCAACACCTATGAAGACAGTGGGTTTCTGATTGTGGACCTCTGTTGCTGGAAAGGATTTG
AATTCGTCTATAATTACTTATATTTAGCTAATTTACGTGAGAACTGGGAAGAGGTAAAAAAAAA
TGCCAGAAAGGCTCCTCAACCGGAAGTTAGAAGATATGTACTACCTTTGAATATCGACAAGGCT
GACACAGGCAAGAATTTGATCACACTCCCCAACACAACAGCCACAGCGATTCTGTGCAGCGATG
AGACCATCTGGCTGGAACCTGAGGTTCTCTTCTCAGGGCCTCGTCAAGCATTTGAGTTTCCTCA
GATCAATTACCAGAAGTATGGTGGGAAACCTTATACGTACGCCTATGGACTTGGCTTGAATCAC
TTTGTTCCAGACAGGCTCTGTAAGCTGAATGTCAAAACTAAAGAAATTTGGGTATGGCAAGAGC
CGGATTCATATCCATCAGAACCCATCTTTGTTTCTCACCCAGAGGCCTTGGAAGAAGATGATGG
TGTAGTTCTGAGTGTGGTGGTGAGCCCCGGGGCAGGACAAAAGCCTGCATACCTCCTGATTCTG
AATGCCAAGGATTTGAGTGAAGTTGCCAGGGCTGAAGTGGAGATTAACATCCCTGTTACCTTTC
ATGGACTGTTCAAAAAATCCTGAGCATAAGATGTGTTTATGGTGACAAAACTAAGAAAACTAGC
TTCAGTTCTGCAATCAAATTTGTTCAATTTTAGCCTGCTATATGTTGTGTTTTTAACTTGCACA
TGCACACAATTTTTCAATGTCTTATAGAAGATATCTGACCAAACAATCTCTTTAGAAAAAAGTA
TTTTCTTGATAAAATAGACCATAACTGAAAAATTCTTTTAATATTTAGCAATCAAATAAGAAAT
TAATGTGGACTTATTAAACTGATTTTTGTTCCTATATAAAAGATAATTTTAGCTATCTGCTCTA
ATGTTTTTTTTTTTAACATTTAAAACCCAAAGTCTTCTACATACCTTATTTGTATGTAGCTTTG
CTGAGTCAAGGCAAAAAGGCTTAATTACTAAAGTAAAACCAAAATTTCCAGGGACTATCATTTA
AGAGTACATAGCAATTGCTCTGTGTATATGTAACTGCTTAAAGATCCTTAATGAACTTTAATCT
CTTTGTTCAATTTTTTTCAATTCCATGCTTAATTCCATTAAATATTGGCAGTTGCTACCACTTC
TGA

hide sequence

RefSeq Acc Id:

XM_040288835 ⟹ XP_040144769

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	81,055,133 - 81,142,274 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_005332414	(Get FASTA)	NCBI Sequence Viewer
	XP_021586752	(Get FASTA)	NCBI Sequence Viewer
	XP_040144769	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000001488.2
GenBank Protein	KAG3283362	(Get FASTA)	NCBI Sequence Viewer
	KAG3283363	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005332414 ⟸ XM_005332357
- Peptide Label:	isoform X2
- UniProtKB:	I3LZ03 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSIQVEHPAGGYKKLFETVEELSSPLTAHVTGRIPVWLTGSLLRCGPGLFEVGSEPFYHLFDGQ ALLHKFDFKEGHVTYHRRFIRTDAYVRAMTEKRIVITEFGTCAFPDPCKNIFSRFFSYFRGVEV TDNALVNVYPVGEDYYACTETNFITKINPETLETIKQVDLCNYVSVNGATAHPHIESDGTVYNI GNCFGKNFSIAYNIVKIPPLQADKEDPISKSEIVVQFPCSDRFKPSYVHSFGLTPNYIVFVETP VKINLFKFLSSWSLWGANYMDCFESNETMGVWLHIADKKRRKYLNNKYRTSSFNLFHHINTYED SGFLIVDLCCWKGFEFVYNYLYLANLRENWEEVKKNARKAPQPEVRRYVLPLNIDKADTGKNLI TLPNTTATAILCSDETIWLEPEVLFSGPRQAFEFPQINYQKYGGKPYTYAYGLGLNHFVPDRLC KLNVKTKEIWVWQEPDSYPSEPIFVSHPEALEEDDGVVLSVVVSPGAGQKPAYLLILNAKDLSE VARAEVEINIPVTFHGLFKKS hide sequence

RefSeq Acc Id:

XP_021586752 ⟸ XM_021731077

- Peptide Label:

isoform X1

- Sequence:

show sequence

MSIQSQRNESPHEARKSMMHSAESVNRAGVEHPAGGYKKLFETVEELSSPLTAHVTGRIPVWLT
GSLLRCGPGLFEVGSEPFYHLFDGQALLHKFDFKEGHVTYHRRFIRTDAYVRAMTEKRIVITEF
GTCAFPDPCKNIFSRFFSYFRGVEVTDNALVNVYPVGEDYYACTETNFITKINPETLETIKQVD
LCNYVSVNGATAHPHIESDGTVYNIGNCFGKNFSIAYNIVKIPPLQADKEDPISKSEIVVQFPC
SDRFKPSYVHSFGLTPNYIVFVETPVKINLFKFLSSWSLWGANYMDCFESNETMGVWLHIADKK
RRKYLNNKYRTSSFNLFHHINTYEDSGFLIVDLCCWKGFEFVYNYLYLANLRENWEEVKKNARK
APQPEVRRYVLPLNIDKADTGKNLITLPNTTATAILCSDETIWLEPEVLFSGPRQAFEFPQINY
QKYGGKPYTYAYGLGLNHFVPDRLCKLNVKTKEIWVWQEPDSYPSEPIFVSHPEALEEDDGVVL
SVVVSPGAGQKPAYLLILNAKDLSEVARAEVEINIPVTFHGLFKKS

hide sequence

RefSeq Acc Id:	XP_040144769 ⟸ XM_040288835
- Peptide Label:	isoform X3

Ensembl Acc Id:

ENSSTOP00000001488 ⟸ ENSSTOT00000001659

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000001659	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000001659.3	UniProtKB/TrEMBL
InterPro	Carotenoid_Oase	UniProtKB/TrEMBL
NCBI Gene	Rpe65	ENTREZGENE
PANTHER	PTHR10543	UniProtKB/TrEMBL
	RETINOID ISOMEROHYDROLASE	UniProtKB/TrEMBL
Pfam	RPE65	UniProtKB/TrEMBL
UniProt	I3LZ03	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-01-29	Rpe65	retinoid isomerohydrolase RPE65		RPE65, retinoid isomerohydrolase	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB