Kcnj5 (potassium inwardly rectifying channel subfamily J member 5) - Rat Genome Database

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Gene: Kcnj5 (potassium inwardly rectifying channel subfamily J member 5) Ictidomys tridecemlineatus
Analyze
Symbol: Kcnj5
Name: potassium inwardly rectifying channel subfamily J member 5
RGD ID: 12675326
Description: ENCODES a protein that exhibits inward rectifier potassium channel activity (ortholog); INVOLVED IN membrane repolarization during atrial cardiac muscle cell action potential (inferred); monoatomic ion transmembrane transport (inferred); potassium ion import across plasma membrane (inferred); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH adenoma (ortholog); Andersen-Tawil syndrome (ortholog); atrial fibrillation (ortholog); FOUND IN external side of plasma membrane (ortholog); T-tubule (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: G protein-activated inward rectifier potassium channel 4; potassium inwardly-rectifying channel, subfamily J, member 5; potassium voltage-gated channel subfamily J member 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947111,076,299 - 111,103,302 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365723,344,937 - 3,373,747 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365723,344,942 - 3,373,690 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Kcnj5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947111,076,299 - 111,103,302 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365723,344,937 - 3,373,747 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365723,344,942 - 3,373,690 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNJ5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811128,891,356 - 128,921,163 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11128,891,356 - 128,921,163 (+)EnsemblGRCh38hg38GRCh38
GRCh3711128,761,251 - 128,791,058 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611128,266,523 - 128,293,174 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411128,266,522 - 128,293,174NCBI
Celera11125,929,625 - 125,956,261 (+)NCBICelera
Cytogenetic Map11q24.3NCBI
HuRef11124,711,137 - 124,737,786 (+)NCBIHuRef
CHM1_111128,647,771 - 128,674,425 (+)NCBICHM1_1
T2T-CHM13v2.011128,926,287 - 128,956,088 (+)NCBIT2T-CHM13v2.0
Kcnj5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39932,226,002 - 32,255,640 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl932,226,003 - 32,255,646 (-)EnsemblGRCm39 Ensembl
GRCm38932,314,706 - 32,344,380 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl932,314,707 - 32,344,350 (-)EnsemblGRCm38mm10GRCm38
MGSCv37932,122,368 - 32,151,822 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36932,064,348 - 32,093,802 (-)NCBIMGSCv36mm8
Celera929,575,909 - 29,607,555 (-)NCBICelera
Cytogenetic Map9A4NCBI
cM Map917.65NCBI
Kcnj5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8838,981,598 - 39,011,197 (-)NCBIGRCr8
mRatBN7.2830,724,923 - 30,753,083 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl830,724,925 - 30,753,518 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx834,797,358 - 34,825,231 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0833,091,766 - 33,119,639 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0830,954,588 - 30,982,520 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0833,435,493 - 33,463,410 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl833,433,905 - 33,463,467 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0833,488,649 - 33,510,083 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4832,082,866 - 32,104,412 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1831,320,012 - 32,113,178 (-)NCBI
Celera832,183,024 - 32,204,559 (-)NCBICelera
Cytogenetic Map8q21NCBI
Kcnj5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541229,850,097 - 29,874,213 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541229,850,097 - 29,874,213 (+)NCBIChiLan1.0ChiLan1.0
KCNJ5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29129,573,968 - 129,607,177 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111130,681,522 - 130,714,740 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011123,705,361 - 123,735,370 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111127,602,663 - 127,637,326 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11127,606,208 - 127,634,213 (+)Ensemblpanpan1.1panPan2
KCNJ5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.155,736,544 - 5,760,705 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl55,740,176 - 5,760,866 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha55,799,513 - 5,820,774 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.055,699,117 - 5,704,382 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.155,758,951 - 5,780,195 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.055,736,878 - 5,758,109 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.055,770,917 - 5,792,183 (-)NCBIUU_Cfam_GSD_1.0
KCNJ5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl955,836,701 - 55,864,941 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1955,836,777 - 55,861,288 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2961,927,955 - 61,952,450 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNJ5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11120,025,238 - 120,098,006 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1120,025,300 - 120,057,023 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660436,035,256 - 6,065,531 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnj5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248123,213,774 - 3,244,012 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248123,213,619 - 3,243,514 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000023348   ⟹   ENSSTOP00000018254
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365723,344,937 - 3,373,747 (-)Ensembl
RefSeq Acc Id: XM_005330740   ⟹   XP_005330797
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947111,076,300 - 111,103,302 (+)NCBI
SpeTri2.0NW_0049365723,344,942 - 3,373,690 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021730135   ⟹   XP_021585810
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947111,076,299 - 111,103,302 (+)NCBI
SpeTri2.0NW_0049365723,344,942 - 3,373,690 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005330797 (Get FASTA)   NCBI Sequence Viewer  
  XP_021585810 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000018254.1
Reference Protein Sequences
RefSeq Acc Id: XP_005330797   ⟸   XM_005330740
- Peptide Label: isoform X1
- UniProtKB: I3N1K8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021585810   ⟸   XM_021730135
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSSTOP00000018254   ⟸   ENSSTOT00000023348
Protein Domains
Inward rectifier potassium channel C-terminal   Potassium channel inwardly rectifying transmembrane


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000021749 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000023348.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  2.60.40.1400 UniProtKB/TrEMBL
InterPro Ig_E-set UniProtKB/TrEMBL
  IRK_C UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir3.4 UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir_cyto UniProtKB/TrEMBL
  Kir_TM UniProtKB/TrEMBL
NCBI Gene Kcnj5 ENTREZGENE
PANTHER G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4 UniProtKB/TrEMBL
  PTHR11767 UniProtKB/TrEMBL
Pfam IRK UniProtKB/TrEMBL
  IRK_C UniProtKB/TrEMBL
PIRSF GIRK_kir UniProtKB/TrEMBL
PRINTS KIR34CHANNEL UniProtKB/TrEMBL
  KIRCHANNEL UniProtKB/TrEMBL
Superfamily-SCOP SSF81296 UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt I3N1K8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-23 Kcnj5  potassium inwardly rectifying channel subfamily J member 5  Kcnj5  potassium voltage-gated channel subfamily J member 5  Symbol and/or name change 5135510 APPROVED