Gskip (GSK3B interacting protein)

Gene: Gskip (GSK3B interacting protein) Ictidomys tridecemlineatus

Analyze

Symbol:

Gskip

Name:

GSK3B interacting protein

RGD ID:

12672538

Description:

ENCODES a protein that exhibits beta-catenin binding (ortholog); INVOLVED IN intrinsic apoptotic signaling pathway in response to oxidative stress (inferred); positive regulation of canonical Wnt signaling pathway (inferred); regulation of canonical Wnt signaling pathway (inferred); ASSOCIATED WITH acute myeloid leukemia (ortholog); essential thrombocythemia (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC101958593

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	9,406,837 - 9,424,882 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936604	657,400 - 675,923 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936604	657,602 - 675,702 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (ISO)

essential thrombocythemia (ISO)

genetic disease (ISO)

myelofibrosis (ISO)

myeloid leukemia (ISO)

myeloid neoplasm (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

intrinsic apoptotic signaling pathway in response to oxidative stress (IEA)

positive regulation of canonical Wnt signaling pathway (IEA)

regulation of canonical Wnt signaling pathway (IEA)

regulation of Wnt signaling pathway (IEA)

Cellular Component

cytoplasm (IEA)

nucleus (IEA)

Molecular Function

beta-catenin binding (ISO)

kinase regulator activity (IEA)

protein binding (ISO)

protein kinase A binding (IEA)

protein kinase A regulatory subunit binding (IEA)

protein kinase binding (IEA)

protein kinase inhibitor activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Gskip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	9,406,837 - 9,424,882 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936604	657,400 - 675,923 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936604	657,602 - 675,702 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GSKIP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	96,363,526 - 96,387,290 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	96,363,452 - 96,387,288 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	96,829,863 - 96,853,627 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	95,915,775 - 95,923,321 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	95,899,622 - 95,922,362	NCBI
Celera	14	76,901,748 - 76,909,294 (+)	NCBI		Celera
Cytogenetic Map	14	q32.2	NCBI
HuRef	14	77,014,876 - 77,038,713 (+)	NCBI		HuRef
CHM1_1	14	96,768,634 - 96,792,467 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	90,595,122 - 90,618,884 (+)	NCBI		T2T-CHM13v2.0

Gskip
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	105,651,611 - 105,669,317 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	105,651,088 - 105,669,282 (+)	Ensembl		GRCm39 Ensembl
GRCm38	12	105,685,352 - 105,703,058 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	105,684,829 - 105,703,023 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	106,923,562 - 106,941,268 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	106,086,491 - 106,104,097 (+)	NCBI		MGSCv36	mm8
Celera	12	106,919,875 - 106,937,566 (+)	NCBI		Celera
Cytogenetic Map	12	E	NCBI
cM Map	12	55.92	NCBI

Gskip
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	130,357,241 - 130,373,221 (+)	NCBI		GRCr8
mRatBN7.2	6	124,586,087 - 124,609,106 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	124,586,070 - 124,609,100 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	124,713,904 - 124,729,726 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	125,009,170 - 125,024,993 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	124,370,337 - 124,386,317 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	129,512,950 - 129,536,320 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	129,519,709 - 129,536,221 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	138,706,202 - 138,729,236 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	129,842,160 - 129,858,112 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	129,845,906 - 129,861,859 (+)	NCBI
Celera	6	122,159,593 - 122,175,547 (+)	NCBI		Celera
Cytogenetic Map	6	q32	NCBI

Gskip
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955438	18,153,564 - 18,177,899 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955438	18,153,564 - 18,174,980 (+)	NCBI	ChiLan1.0	ChiLan1.0

GSKIP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	97,523,394 - 97,547,474 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	96,739,898 - 96,763,980 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	76,993,055 - 77,017,142 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	96,331,789 - 96,339,378 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	96,329,936 - 96,339,378 (+)	Ensembl	panpan1.1		panPan2

GSKIP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	65,110,659 - 65,131,205 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	65,111,414 - 65,129,622 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	64,626,310 - 64,647,821 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	65,382,175 - 65,403,816 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	65,383,060 - 65,450,126 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	65,054,862 - 65,076,654 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	65,116,291 - 65,137,874 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	65,439,899 - 65,461,533 (+)	NCBI		UU_Cfam_GSD_1.0

GSKIP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	117,586,764 - 117,607,564 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	117,586,742 - 117,607,575 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	124,844,708 - 124,865,661 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GSKIP
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	74,246,221 - 74,270,608 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	74,246,255 - 74,271,765 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666053	61,397,502 - 61,422,002 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gskip
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624734	7,002,240 - 7,015,194 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624734	7,003,240 - 7,015,215 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005333897	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010003700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000016136 ⟹ ENSSTOP00000014443

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936604	657,400 - 675,923 (+)	Ensembl

RefSeq Acc Id:

XM_005333897 ⟹ XP_005333954

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	9,406,837 - 9,424,882 (-)	NCBI
SpeTri2.0	NW_004936604	657,602 - 675,702 (+)	NCBI

Sequence:

show sequence

GCGGGGGCGGGGCTGGCGCCGCGGGTCGGCTCCAGACGCCCTCGCTGGGAGGAAGAGAAGGACG
GGGCGAGCACAGAATGGAAACAGACTGCAATCCCATGGAGCTAAGCAGTTTGTCGGGGTTCGAG
GAAGGCTCAGAGCTTAATGGCTTTGAAGGAACTGACATGAAAGACATGAGGCTGGAAGCTGAAG
CAGTTGTGAACGACGTTCTCTTTGCTGTGAACAACATGTTTGTCTCAAAAAGCCTACGCTGTGC
AGATGACGTGGCCTATATCAATGTGGAAACAAAGGAAAGGAACAGATACTGCCTGGAGCTCACT
GAAGCAGGACTCAGGGTCGTAGGTTATGCTTTTGACCAGGTGGAGGATCACTTGCAGACTCCCT
ACCACGAAACCGTCTATTCCCTGCTGGACACACTCAGCCCTGCCTACCGGGAGGCGTTTGGAAA
TGCGCTGCTTCAGAGACTAGAAGCTTTGAAAAGGGACGGACAGTCATGACTAAGTTGATTCCTG
TCAGATGGGGCTGCTTCTGGTACAGAATGTCCACATGAAACTTGAAGTTTTTGCACATGGTCAT
AATTGAAAATGCTTCTTCAGTTCTGTGTGTTTATCATTTGCTTCAGATTTAGGCTTTTGGCTTA
GAACATCAGTGACCTAATCAGTTGTCTTAGTTTCTGATTCATTAAGGGAATTCTGAGGCCATTC
TGTGACACCATCATAGGACATCAGATTTCTTCATATAATTTCTCTGCATCTCAGAACCTAATCA
GTATTTCATTCTCTTATTACAGGGCTTTAATGCTGCCAGCACTCTCTTTTACATATGAAATTCT
AGATTTGCACAGTAATAATAGGAATTAGAATTACCTAACTTCAAACATGGATTCAGCCTGCTAA
ATCAGGGGTTTACTACTAGCTTGGACTGACTTTGTAGTGATTATTTTGCTACTGGCCTTATTGG
AAACAAACTATTGACTAGTTTCCCCTGCACAAATTTTGAGATTCACTGCTTCATTTAATCTATT
TATATTGCTAATATGGTTTGAAAAGATGAATGACTTATATGTTCTAGCTAGTATTAAATAAAAA
CAGGGACCGAAGTCGTGCTTGTGCTCCTTGTTTGCAGCAGCCAGCCAGCTAAGCAGAAGATGAA
CCGTTAGCAAATGAATGTAATAACTACTTGTTTCCAAGATATCTAAGCACATAAACAAATATAG
GAACAGGCTTCATTCCCAACAAAAAGCATCCTCAATGTGTGTGATTGAAAAGAAGATTCTGGTT
TCCTAGAAGACAATATTTTGGCCTGTGTTAACTCTTATTCTGAATGTTTGTTTACATAATGTAC
AGTATATATTCAGAAAGTATTTTTGCTTCAACATTTACTTTCTATAACGTAGTGCTTTGGTATT
CCCATGGCACCCCTCCTCCCCAGTAGATGGACAGTGTTCTATCTCAGTGCTAAATGTACAGTGT
AATGTGAGTGCATTGTATGGGTTTGAAACCAAAGGATGAATGAAGCATTCAGAGACTTAATATT
TGAAAAAGAGATACTCTGTATTTTATATTTTACTACAGGTACTAAAATTTATAAACTTAATAAA
ATGTCCAATGCTGCTGCATGTTTTCAAGTATATGTCAAACAATAAGGATTGAGGAATTTTTTTA
ATAGTCACCTAAAGCAGCTACTGTAGAAATATTGAACTAAAATTCTGTTTCCAGACACACCTTC
ATGAATTTGTCATTTGCAGATTTTTTTTTGTCATTATTTGAAAAATAGGCATTTCTAGGTTCCA
AAGATCACATGAGGGCTATGGGTGTATCTCAGTGCTAGAGCAGTACTTGCCTAGCATGTGTGAG
GTCCTGGGGTTCAATCCCCAGCACCAAAAAAGGAAGAAAAAGGATCACTGGACCAGAGCAAATT
AAAGTTAAGTTTTCTGTCATCATCCCTGTCAGAGCTCACTGAAATGTGTGTGATGGATAACGTA
TGTTCACTCTCGACTTTATTTTCAGACGCTTAACTGGGCAGTGAAGTCTAACTTCAGGTTGAAC
TTTCTCATGCTTAATCTCAGGCTAAATGTAAATGATATTTGTAAAGTTTGAATAAAATTCTGTT
TATCATTTTTTGAGTTAAGTATGAAGAAAAGCAATTGTGTTTAAAAATTGAAATTGTTCATTTT
GTGATAAATGATTGATTCCAAAAGC

hide sequence

Protein Sequences


Protein RefSeqs	XP_005333954	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000014443.3
GenBank Protein	KAG3260415	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005333954 ⟸ XM_005333897
- UniProtKB:	I3MQZ3 (UniProtKB/TrEMBL)
- Sequence:	show sequence METDCNPMELSSLSGFEEGSELNGFEGTDMKDMRLEAEAVVNDVLFAVNNMFVSKSLRCADDVA YINVETKERNRYCLELTEAGLRVVGYAFDQVEDHLQTPYHETVYSLLDTLSPAYREAFGNALLQ RLEALKRDGQS hide sequence

RefSeq Acc Id:

ENSSTOP00000014443 ⟸ ENSSTOT00000016136

Protein Domains

GSKIP

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000016136	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000016136.3	UniProtKB/TrEMBL
Gene3D-CATH	3.30.2280.10	UniProtKB/TrEMBL
InterPro	GSKIP	UniProtKB/TrEMBL
	GSKIP_dom	UniProtKB/TrEMBL
	GSKIP_dom_sf	UniProtKB/TrEMBL
NCBI Gene	Gskip	ENTREZGENE
PANTHER	GSK3B-INTERACTING PROTEIN	UniProtKB/TrEMBL
	PTHR12490	UniProtKB/TrEMBL
Pfam	DUF727	UniProtKB/TrEMBL
Superfamily-SCOP	SSF103107	UniProtKB/TrEMBL
UniProt	I3MQZ3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-08-09	Gskip	GSK3B interacting protein	LOC101958593	GSK3B interacting protein	Symbol and/or name change	5135510	APPROVED
2021-03-26	LOC101958593	GSK3B interacting protein	Gskip	GSK3B interacting protein	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD