Mapkapk5 (MAPK activated protein kinase 5) - Rat Genome Database

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Gene: Mapkapk5 (MAPK activated protein kinase 5) Ictidomys tridecemlineatus
Analyze
Symbol: Mapkapk5
Name: MAPK activated protein kinase 5
RGD ID: 12670836
Description: ENCODES a protein that exhibits ATP binding (inferred); calcium-dependent protein serine/threonine kinase activity (inferred); calmodulin binding (inferred); INVOLVED IN positive regulation of dendritic spine development (ortholog); PARTICIPATES IN p38 MAPK signaling pathway; ASSOCIATED WITH genetic disease (ortholog); NEUROCARDIOFACIODIGITAL SYNDROME (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: MAP kinase-activated protein kinase 5; mitogen-activated protein kinase-activated protein kinase 5; mitogen-activated protein kinase-activated protein kinase 5, transcript variant X1; mitogen-activated protein kinase-activated protein kinase 5, transcript variant X2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118155,030,940 - 155,065,143 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365584,414,277 - 4,451,291 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365584,414,283 - 4,448,291 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mapkapk5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118155,030,940 - 155,065,143 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365584,414,277 - 4,451,291 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365584,414,283 - 4,448,291 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPKAPK5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812111,842,228 - 111,902,222 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12111,842,013 - 111,902,222 (+)EnsemblGRCh38hg38GRCh38
GRCh3712112,280,032 - 112,340,026 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612110,764,662 - 110,815,611 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412110,742,998 - 110,793,947NCBI
Celera12111,905,742 - 111,956,689 (+)NCBICelera
Cytogenetic Map12q24.12-q24.13NCBI
HuRef12109,293,372 - 109,344,645 (+)NCBIHuRef
CHM1_112112,247,967 - 112,299,159 (+)NCBICHM1_1
T2T-CHM13v2.012111,819,139 - 111,879,131 (+)NCBIT2T-CHM13v2.0
Mapkapk5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395121,663,114 - 121,683,955 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5121,663,101 - 121,683,968 (-)EnsemblGRCm39 Ensembl
GRCm385121,525,051 - 121,545,892 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5121,525,038 - 121,545,905 (-)EnsemblGRCm38mm10GRCm38
MGSCv375121,975,060 - 121,995,901 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365121,785,668 - 121,806,509 (-)NCBIMGSCv36mm8
Celera5118,614,887 - 118,635,774 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map561.84NCBI
Mapkapk5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81240,654,220 - 40,673,740 (+)NCBIGRCr8
mRatBN7.21234,993,520 - 35,013,059 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,994,092 - 35,013,052 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1236,166,747 - 36,185,867 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01236,777,956 - 36,797,075 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,830,405 - 35,849,524 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01240,510,378 - 40,529,332 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1240,510,378 - 40,529,338 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01242,377,614 - 42,396,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41236,128,538 - 36,147,493 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1236,658,764 - 36,677,720 (+)NCBICelera
Cytogenetic Map12q16NCBI
Mapkapk5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554828,409,192 - 8,434,907 (+)NCBIChiLan1.0ChiLan1.0
MAPKAPK5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210119,911,213 - 119,966,539 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112119,907,604 - 119,962,960 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012109,416,610 - 109,471,729 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112112,812,764 - 112,868,846 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12112,812,769 - 112,863,595 (+)Ensemblpanpan1.1panPan2
MAPKAPK5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1269,380,551 - 9,420,564 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl269,319,180 - 9,419,236 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha269,542,771 - 9,581,769 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0269,640,243 - 9,679,215 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl269,640,197 - 9,679,147 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,595,507 - 9,634,501 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0269,658,467 - 9,697,479 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0269,611,599 - 9,650,628 (+)NCBIUU_Cfam_GSD_1.0
MAPKAPK5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1439,849,413 - 39,886,455 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11439,852,537 - 39,885,898 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21442,329,054 - 42,362,471 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAPKAPK5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111107,084,117 - 107,126,360 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11107,084,366 - 107,124,710 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037137,965,646 - 138,009,993 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapkapk5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474720,344,078 - 20,384,894 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474720,344,078 - 20,384,880 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000029645   ⟹   ENSSTOP00000023927
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365584,414,277 - 4,451,291 (+)Ensembl
RefSeq Acc Id: ENSSTOT00000032796   ⟹   ENSSTOP00000031720
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365584,414,406 - 4,448,188 (+)Ensembl
RefSeq Acc Id: ENSSTOT00000036315   ⟹   ENSSTOP00000027816
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365584,414,406 - 4,436,175 (+)Ensembl
RefSeq Acc Id: ENSSTOT00000038400   ⟹   ENSSTOP00000024812
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365584,424,774 - 4,448,188 (+)Ensembl
RefSeq Acc Id: XM_005329630   ⟹   XP_005329687
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118155,030,940 - 155,065,143 (-)NCBI
SpeTri2.0NW_0049365584,414,283 - 4,448,291 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005329631   ⟹   XP_005329688
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118155,030,940 - 155,065,143 (-)NCBI
SpeTri2.0NW_0049365584,414,283 - 4,448,291 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040289448   ⟹   XP_040145382
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118155,030,940 - 155,065,143 (-)NCBI
RefSeq Acc Id: XM_040289449   ⟹   XP_040145383
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118155,030,940 - 155,065,143 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005329687   ⟸   XM_005329630
- Peptide Label: isoform X1
- UniProtKB: A0A287CU49 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005329688   ⟸   XM_005329631
- Peptide Label: isoform X2
- UniProtKB: I3NHT0 (UniProtKB/TrEMBL),   A0A287CU49 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040145383   ⟸   XM_040289449
- Peptide Label: isoform X4
- UniProtKB: A0A287CU49 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040145382   ⟸   XM_040289448
- Peptide Label: isoform X3
- UniProtKB: A0A287CU49 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000024812   ⟸   ENSSTOT00000038400
RefSeq Acc Id: ENSSTOP00000027816   ⟸   ENSSTOT00000036315
RefSeq Acc Id: ENSSTOP00000023927   ⟸   ENSSTOT00000029645
RefSeq Acc Id: ENSSTOP00000031720   ⟸   ENSSTOT00000032796
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000026731 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000029645.2 UniProtKB/TrEMBL
  ENSSTOT00000032796.1 UniProtKB/TrEMBL
  ENSSTOT00000036315.1 UniProtKB/TrEMBL
  ENSSTOT00000038400.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.1170.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  MAPKAPK_C UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Mapkapk5 ENTREZGENE
PANTHER MAP KINASE-ACTIVATED PROTEIN KINASE 5 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A287CU49 ENTREZGENE, UniProtKB/TrEMBL
  A0A287D2K7_ICTTR UniProtKB/TrEMBL
  A0A287DDS3_ICTTR UniProtKB/TrEMBL
  I3NHT0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-16 Mapkapk5  MAPK activated protein kinase 5    mitogen-activated protein kinase-activated protein kinase 5  Symbol and/or name change 5135510 APPROVED