Clic3 (chloride intracellular channel 3)

Gene: Clic3 (chloride intracellular channel 3) Ictidomys tridecemlineatus

Analyze

Symbol:

Clic3

Name:

chloride intracellular channel 3

RGD ID:

12670461

Description:

ENCODES a protein that exhibits protein-disulfide reductase (glutathione) activity (ortholog); INVOLVED IN positive regulation of sprouting angiogenesis (ortholog); ASSOCIATED WITH Adams-Oliver Syndrome 5 (ortholog); autosomal dominant intellectual developmental disorder 8 (ortholog); autosomal dominant nocturnal frontal lobe epilepsy 5 (ortholog); FOUND IN extracellular matrix (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

chloride intracellular channel protein 3

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	202,424,519 - 202,427,338 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936669	948,667 - 950,539 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936669	947,743 - 950,539 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Adams-Oliver Syndrome 5 (ISO)

autosomal dominant intellectual developmental disorder 8 (ISO)

autosomal dominant nocturnal frontal lobe epilepsy 5 (ISO)

developmental and epileptic encephalopathy 14 (ISO)

epilepsy (ISO)

genetic disease (ISO)

Joubert syndrome 1 (ISO)

Kleefstra syndrome 1 (ISO)

Leigh disease (ISO)

primary coenzyme Q10 deficiency 7 (ISO)

Rafiq syndrome (ISO)

tuberous sclerosis 1 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chloride transmembrane transport (IEA)

chloride transport (IEA)

monoatomic ion transmembrane transport (IEA)

positive regulation of sprouting angiogenesis (ISO)

Cellular Component

chloride channel complex (IEA)

cytoplasm (IEA)

extracellular matrix (ISO)

membrane (IEA)

nuclear body (IEA)

nucleus (IEA)

Molecular Function

chloride channel activity (IEA)

protein binding (ISO)

protein-disulfide reductase (glutathione) activity (ISO)

References

Genomics

Comparative Map Data

Clic3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	202,424,519 - 202,427,338 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936669	948,667 - 950,539 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936669	947,743 - 950,539 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CLIC3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	136,994,608 - 136,996,568 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	136,994,608 - 136,996,568 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	139,889,060 - 139,891,020 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	139,008,881 - 139,010,845 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	137,164,896 - 137,166,861	NCBI
Celera	9	110,401,370 - 110,403,334 (-)	NCBI		Celera
Cytogenetic Map	9	q34.3	NCBI
HuRef	9	109,348,166 - 109,350,130 (-)	NCBI		HuRef
CHM1_1	9	140,037,817 - 140,039,781 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	149,229,019 - 149,230,979 (-)	NCBI		T2T-CHM13v2.0

Clic3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	25,346,855 - 25,348,789 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	25,346,850 - 25,348,788 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	25,456,843 - 25,458,777 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	25,456,838 - 25,458,776 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	25,312,363 - 25,314,292 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	25,278,852 - 25,280,781 (+)	NCBI		MGSCv36	mm8
Celera	2	25,184,332 - 25,186,261 (+)	NCBI		Celera
Cytogenetic Map	2	A3	NCBI
cM Map	2	17.27	NCBI

Clic3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	28,670,176 - 28,672,166 (+)	NCBI		GRCr8
mRatBN7.2	3	8,271,416 - 8,274,023 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	8,272,097 - 8,274,018 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	11,377,185 - 11,379,096 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	19,963,409 - 19,965,320 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	18,153,257 - 18,155,168 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	2,675,732 - 2,678,248 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	2,676,296 - 2,680,565 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	2,657,743 - 2,659,664 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	3,622,894 - 3,624,805 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	3,623,545 - 3,624,807 (+)	NCBI
Celera	3	3,097,212 - 3,099,123 (+)	NCBI		Celera
Cytogenetic Map	3	p13	NCBI

Clic3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955513	5,020,144 - 5,021,936 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955513	5,020,105 - 5,022,000 (-)	NCBI	ChiLan1.0	ChiLan1.0

CLIC3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	2,401,954 - 2,404,212 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	2,404,606 - 2,406,683 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	108,054,934 - 108,057,100 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	137,023,465 - 137,025,522 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	137,023,505 - 137,025,361 (-)	Ensembl	panpan1.1		panPan2

CLIC3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	48,634,061 - 48,637,083 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	48,634,878 - 48,637,015 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	47,848,449 - 47,850,740 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	49,512,882 - 49,515,171 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	49,512,968 - 49,515,955 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	48,289,095 - 48,291,384 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	48,587,812 - 48,590,101 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	48,635,170 - 48,637,460 (+)	NCBI		UU_Cfam_GSD_1.0

CLIC3
(Sus scrofa - pig)

No map positions available.

CLIC3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	1,198,192 - 1,200,296 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	1,198,387 - 1,200,246 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666058	4,101,042 - 4,103,201 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Clic3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	911,145 - 912,951 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624760	911,124 - 912,922 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005336914	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040286688	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000027742 ⟹ ENSSTOP00000021515

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936669	948,667 - 950,539 (+)	Ensembl

RefSeq Acc Id:

XM_005336914 ⟹ XP_005336971

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404947	202,424,519 - 202,426,467 (-)	NCBI
SpeTri2.0	NW_004936669	947,743 - 950,539 (+)	NCBI

Sequence:

show sequence

CCTCACACACCCATCACCACCACCACCACCACGGAAGGAACACCAAGCTGTGGATTCCGGAGGA
GCTGGAAGTCCCGGGCAGAGGGGCAGGTATGCATCTGTGGGGCCATTTGCCCTGCCCCGGTCTT
TCCTTCCTGCTACTCTGCCAGTCCCCTAGGCCAGCAGGTTGTGCCTTATGTCCCCTGGTGCTGT
TCAGAGGCTTAGCAGTCAAGAGGGTAGGAAACCTGCCCCAAGCCAGGGGCAGGATGGGACGGAG
CCCAGGGCTGCCCACACAGCTGGTTAAACACCAGGCAGGCTACCTGCCTCCAGCATGTCGGGAA
TGTGGAGCCGCCCTGGAGAGGGAGGGGTCGCCAGCCTGGCTCTCCGTGGGTGGGAGGAGAGTCT
CTGGAGGTGGGCTCCTCATCTGGTAATGTCCTGATAGGTAGGAGGGAACCAAGCAGAGTGCAGA
GTCACCTGCTGGCCCCCCAGGCTGGGGACTTAGACCGTGGGGCATGCACTGCAGGGAGGGCTGT
GAGCAGGTTCTGAGCCCAGATCATGGAGCATCAGTCCAGACCCAGAGCTGCCCCTCCAGGCTGG
CACCCCACCTCACCCCACCCCTTCTGGACCCTGGGCTCTTCGGGCCTCTCTACCCTCTGGTCTG
CCTACACACTGGCTCCCCAGTGAGCACACACCAGGAGCCAGTCTTCTGGCATGAGCCAGCCTCG
CACACTTACTGCCAGCCCCCAAGATTCAGGCCCCCATGGCCGGTCATGCTCGGACACCCTGACA
GACCCACCTCACACAGGCAGCCAGCTCTGCGCCCTGATTCATCTGCCCGCCTAGGTGGCTCATG
GGGCGGGCCCCAGGCTGGGGAGGGCGGGGCACCCAGGGAGACTTAAAGAGTTCCCAGGTCTGGG
CCCAGTGCCCTGCACCTGATGCCGCAGCTCCACCATGGCAGAGACCACCAAGCTCCAGCTCTTT
GTGAAGGCCAGTGAGGACGGGGAGAGCGTGGGGCACTGCCCTTCCTGCCAGCGGCTCTTCATGG
TCCTGCTCCTCAAGGGTGTTCCCTTCACACTCACCACCGTGGACACACGCAGGGCACTGGACGT
GCTGAAGGACTTTGCGCCAGGCTCACAGCTGCCCATTCTGCTCTATGATGGGGACGCCAAGACA
GACACGCTGCAGATTGAAGAGTTCCTGGAGGAGACACTTGGGCCACCCAACTTTCCCAGCCTGG
CACCCCGTTACAGGGAGTCCAACACAGCGGGCAACGACGTCTTCCACAAGTTCTCGGCATTCAT
TAAGAACCCAGCGCCAGGGCAGGATGATGCCCTGTACCAGCAGCTGCTGCGCGCACTAGCCAGG
CTGGACAGCTACCTGCGCACACCCCTGGAGCATGAGCGGGAGCAGGAACCACAGCTGCGCGAGT
CCCGCCGTCGCTTTCTGGACGGTGATCAGCTGACGCTGGCCGACTGCAGCCTGCTGCCCAAGCT
GCACATTGTGGATACTGTGTGTGCGCACTTCCGCCAGGCACCCATCCCTGCAGAGCTGCATGGC
GTCCGCCGCTACTTGGACAGCGCGCTGCAGGAGAAGGAGTTCAAGTACACGTGTCCCCACAGCG
CCGAGATCCTGGCAGCATACCGGCCCGCTGTGCGCCCCCGTTAGCGCCCCGGCCTCGTCCCAAC
CCATTCTCGCGTATATAGCCCCATAAAGGTATCTCTGCCCCCA

hide sequence

RefSeq Acc Id:

XM_040286688 ⟹ XP_040142622

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404947	202,424,519 - 202,427,338 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_005336971	(Get FASTA)	NCBI Sequence Viewer
	XP_040142622	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000021515.2
GenBank Protein	KAG3288414	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005336971 ⟸ XM_005336914
- Peptide Label:	isoform X1
- UniProtKB:	I3NAW8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAETTKLQLFVKASEDGESVGHCPSCQRLFMVLLLKGVPFTLTTVDTRRALDVLKDFAPGSQLP ILLYDGDAKTDTLQIEEFLEETLGPPNFPSLAPRYRESNTAGNDVFHKFSAFIKNPAPGQDDAL YQQLLRALARLDSYLRTPLEHEREQEPQLRESRRRFLDGDQLTLADCSLLPKLHIVDTVCAHFR QAPIPAELHGVRRYLDSALQEKEFKYTCPHSAEILAAYRPAVRPR hide sequence

RefSeq Acc Id:	XP_040142622 ⟸ XM_040286688
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSSTOP00000021515 ⟸ ENSSTOT00000027742

Protein Domains

GST N-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000023657	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000027742.2	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1050.10	UniProtKB/TrEMBL
	Glutaredoxin	UniProtKB/TrEMBL
InterPro	CLIC	UniProtKB/TrEMBL
	Glutathione-S-Trfase_C_sf	UniProtKB/TrEMBL
	Glutathione_S-Trfase	UniProtKB/TrEMBL
	Glutathione_S-Trfase_N	UniProtKB/TrEMBL
	Thioredoxin-like_sf	UniProtKB/TrEMBL
NCBI Gene	Clic3	ENTREZGENE
PANTHER	CHLORIDE INTRACELLULAR CHANNEL PROTEIN	UniProtKB/TrEMBL
	CHLORIDE INTRACELLULAR CHANNEL PROTEIN 6-RELATED	UniProtKB/TrEMBL
Pfam	GST_C_2	UniProtKB/TrEMBL
	GST_N_2	UniProtKB/TrEMBL
PRINTS	INTCLCHANNEL	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47616	UniProtKB/TrEMBL
	SSF52833	UniProtKB/TrEMBL
UniProt	I3NAW8	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar