Pdgfa (platelet derived growth factor subunit A) - Rat Genome Database

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Gene: Pdgfa (platelet derived growth factor subunit A) Ictidomys tridecemlineatus
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Symbol: Pdgfa
Name: platelet derived growth factor subunit A
RGD ID: 12668754
Description: ENCODES a protein that exhibits collagen binding (ortholog); growth factor activity (ortholog); identical protein binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); angiogenesis (ortholog); animal organ morphogenesis (ortholog); PARTICIPATES IN ceramide signaling pathway; platelet-derived growth factor signaling pathway; ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); Animal Mammary Neoplasms (ortholog); Brain Injuries (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog); microvillus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: platelet-derived growth factor subunit A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344144,181,428 - 144,201,439 (+)NCBI
SpeTri2.0NW_004936754808,894 - 828,554 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
angiogenesis  (ISO)
animal organ morphogenesis  (ISO)
bone development  (ISO)
cell projection assembly  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
digestive tract development  (ISO)
embryonic lung development  (ISO)
hair follicle development  (ISO)
inner ear development  (ISO)
lung alveolus development  (ISO)
male gonad development  (ISO)
negative chemotaxis  (ISO)
negative regulation of phosphatidylinositol biosynthetic process  (ISO)
negative regulation of platelet activation  (ISO)
platelet-derived growth factor receptor signaling pathway  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of protein autophosphorylation  (ISO)
positive regulation of protein kinase B signaling  (ISO)
regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling  (ISO)
regulation of DNA biosynthetic process  (ISO)
regulation of glomerular mesangial cell proliferation  (ISO)
regulation of peptidyl-tyrosine phosphorylation  (ISO)
regulation of smooth muscle cell migration  (ISO)
response to estradiol  (ISO)
response to hypoxia  (ISO)
response to inorganic substance  (ISO)
response to organic substance  (ISO)
response to retinoic acid  (ISO)
response to wounding  (ISO)
response to xenobiotic stimulus  (ISO)
skin development  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Pdgfa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344144,181,428 - 144,201,439 (+)NCBI
SpeTri2.0NW_004936754808,894 - 828,554 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDGFA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7497,258 - 520,296 (-)EnsemblGRCh38hg38GRCh38
GRCh387497,245 - 520,668 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377536,895 - 559,483 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367503,421 - 526,007 (-)NCBINCBI36hg18NCBI36
Celera7505,832 - 559,337 (-)NCBI
Cytogenetic Map7p22.3NCBI
HuRef7455,023 - 477,393 (-)NCBIHuRef
CHM1_17535,640 - 589,379 (-)NCBICHM1_1
CRA_TCAGchr7v27598,080 - 651,496 (-)NCBI
Pdgfa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395138,961,769 - 138,986,336 (-)NCBIGRCm39mm39
GRCm39 Ensembl5138,961,769 - 138,983,125 (-)Ensembl
GRCm385138,976,014 - 139,000,792 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5138,976,014 - 138,997,370 (-)EnsemblGRCm38mm10GRCm38
MGSCv375139,452,925 - 139,470,907 (-)NCBIGRCm37mm9NCBIm37
MGSCv365139,230,613 - 139,248,595 (-)NCBImm8
Celera5136,032,139 - 136,049,986 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map577.65NCBI
Pdgfa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21215,645,549 - 15,667,056 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1215,645,541 - 15,666,497 (+)Ensembl
Rnor_6.01217,734,141 - 17,756,186 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,734,133 - 17,755,285 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,727,672 - 19,749,009 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41216,151,045 - 16,172,412 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11216,180,972 - 16,202,334 (+)NCBI
Celera1217,398,134 - 17,419,591 (+)NCBICelera
Cytogenetic Map12q11NCBI
Pdgfa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554608,326,891 - 8,346,550 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554608,328,400 - 8,346,755 (-)NCBIChiLan1.0ChiLan1.0
PDGFA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17872,204 - 888,870 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v07648,722 - 672,023 (-)NCBIMhudiblu_PPA_v0panPan3
PDGFA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1616,271,082 - 16,293,246 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl616,270,104 - 16,292,396 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha617,743,941 - 17,762,483 (+)NCBI
ROS_Cfam_1.0616,400,056 - 16,421,423 (+)NCBI
UMICH_Zoey_3.1616,204,088 - 16,222,628 (+)NCBI
UNSW_CanFamBas_1.0616,130,433 - 16,148,998 (+)NCBI
UU_Cfam_GSD_1.0616,420,378 - 16,438,910 (+)NCBI
PDGFA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3303,311 - 323,036 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13296,399 - 322,967 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23152,233 - 170,626 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDGFA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12821,044,549 - 21,068,411 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2821,047,219 - 21,069,827 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666090605,283 - 628,542 (-)NCBIVero_WHO_p1.0
Pdgfa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474026,172,808 - 26,191,557 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005339825   ⟹   XP_005339882
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024409344144,181,911 - 144,201,439 (+)NCBI
SpeTri2.0NW_004936754808,894 - 828,554 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040277138   ⟹   XP_040133072
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024409344144,181,428 - 144,201,439 (+)NCBI
Protein Sequences
Protein RefSeqs XP_005339882 (Get FASTA)   NCBI Sequence Viewer  
  XP_040133072 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein KAG3260159 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005339882   ⟸   XM_005339825
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_040133072   ⟸   XM_040277138
- Peptide Label: isoform X1


Additional Information

Database Acc Id Source(s)
NCBI Gene Pdgfa ENTREZGENE