Pdgfa (platelet derived growth factor subunit A)

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Gene: Pdgfa (platelet derived growth factor subunit A) Ictidomys tridecemlineatus

Analyze

Symbol:

Pdgfa

Name:

platelet derived growth factor subunit A

RGD ID:

12668754

Description:

ENCODES a protein that exhibits collagen binding (ortholog); growth factor activity (ortholog); identical protein binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); angiogenesis (ortholog); animal organ morphogenesis (ortholog); PARTICIPATES IN ceramide signaling pathway; platelet-derived growth factor signaling pathway; ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); Animal Mammary Neoplasms (ortholog); Brain Injuries (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog); microvillus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Also known as:

platelet-derived growth factor subunit A

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Bonobo

Dog

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	144,181,428 - 144,201,439 (+)	NCBI
SpeTri2.0	NW_004936754	808,894 - 828,554 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amyotrophic lateral sclerosis type 1 (ISO)

Animal Mammary Neoplasms (ISO)

Brain Injuries (ISO)

breast cancer (ISO)

Breast Neoplasms (ISO)

carcinoma (ISO)

Chronic Allograft Nephropathy (ISO)

chronic ulcer of skin (ISO)

Diabetic Nephropathies (ISO)

Endocrine Bone Diseases (ISO)

essential thrombocythemia (ISO)

Experimental Liver Cirrhosis (ISO)

Fetal Growth Retardation (ISO)

high grade glioma (ISO)

leiomyoma (ISO)

Leydig cell tumor (ISO)

lung disease (ISO)

Lymphatic Metastasis (ISO)

Mammary Neoplasms, Experimental (ISO)

Mesothelioma (ISO)

Multicystic Dysplastic Kidney (ISO)

oligohydramnios (ISO)

pancreatitis (ISO)

prostate adenocarcinoma (ISO)

pulmonary fibrosis (ISO)

pulmonary hypertension (ISO)

renovascular hypertension (ISO)

Thyroid Neoplasms (ISO)

Wounds and Injuries (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (ISO)

angiogenesis (ISO)

animal organ morphogenesis (ISO)

bone development (ISO)

cell projection assembly (ISO)

cellular response to transforming growth factor beta stimulus (ISO)

digestive tract development (ISO)

embryonic lung development (ISO)

hair follicle development (ISO)

inner ear development (ISO)

lung alveolus development (ISO)

male gonad development (ISO)

negative chemotaxis (ISO)

negative regulation of phosphatidylinositol biosynthetic process (ISO)

negative regulation of platelet activation (ISO)

platelet-derived growth factor receptor signaling pathway (ISO)

positive regulation of cell migration (ISO)

positive regulation of cell population proliferation (ISO)

positive regulation of ERK1 and ERK2 cascade (ISO)

positive regulation of fibroblast proliferation (ISO)

positive regulation of MAP kinase activity (ISO)

positive regulation of MAPK cascade (ISO)

positive regulation of mesenchymal cell proliferation (ISO)

positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway (ISO)

positive regulation of phosphatidylinositol 3-kinase signaling (ISO)

positive regulation of protein autophosphorylation (ISO)

positive regulation of protein kinase B signaling (ISO)

regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling (ISO)

regulation of DNA biosynthetic process (ISO)

regulation of glomerular mesangial cell proliferation (ISO)

regulation of peptidyl-tyrosine phosphorylation (ISO)

regulation of smooth muscle cell migration (ISO)

response to estradiol (ISO)

response to hypoxia (ISO)

response to inorganic substance (ISO)

response to organic substance (ISO)

response to retinoic acid (ISO)

response to wounding (ISO)

response to xenobiotic stimulus (ISO)

skin development (ISO)

wound healing (ISO)

Cellular Component

cell surface (ISO)

extracellular space (ISO)

microvillus (ISO)

Molecular Function

collagen binding (ISO)

growth factor activity (ISO)

identical protein binding (ISO)

platelet-derived growth factor binding (ISO)

platelet-derived growth factor receptor binding (ISO)

protein binding (ISO)

protein heterodimerization activity (ISO)

protein homodimerization activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

ceramide signaling pathway (ISO)

platelet-derived growth factor signaling pathway (ISO)

References

Genomics

Comparative Map Data

Pdgfa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	144,181,428 - 144,201,439 (+)	NCBI
SpeTri2.0	NW_004936754	808,894 - 828,554 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PDGFA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	7	497,258 - 520,296 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	7	497,245 - 520,668 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	7	536,895 - 559,483 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	503,421 - 526,007 (-)	NCBI	NCBI36		hg18	NCBI36
Celera	7	505,832 - 559,337 (-)	NCBI
Cytogenetic Map	7	p22.3	NCBI
HuRef	7	455,023 - 477,393 (-)	NCBI		HuRef
CHM1_1	7	535,640 - 589,379 (-)	NCBI		CHM1_1
CRA_TCAGchr7v2	7	598,080 - 651,496 (-)	NCBI

Pdgfa
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	138,961,769 - 138,986,336 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	5	138,961,769 - 138,983,125 (-)	Ensembl
GRCm38	5	138,976,014 - 139,000,792 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	138,976,014 - 138,997,370 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	139,452,925 - 139,470,907 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	5	139,230,613 - 139,248,595 (-)	NCBI			mm8
Celera	5	136,032,139 - 136,049,986 (-)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	77.65	NCBI

Pdgfa
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	12	15,645,549 - 15,667,056 (+)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	12	15,645,541 - 15,666,497 (+)	Ensembl
Rnor_6.0	12	17,734,141 - 17,756,186 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	17,734,133 - 17,755,285 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	19,727,672 - 19,749,009 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	16,151,045 - 16,172,412 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	12	16,180,972 - 16,202,334 (+)	NCBI
Celera	12	17,398,134 - 17,419,591 (+)	NCBI		Celera
Cytogenetic Map	12	q11	NCBI

Pdgfa
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955460	8,326,891 - 8,346,550 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955460	8,328,400 - 8,346,755 (-)	NCBI	ChiLan1.0	ChiLan1.0

PDGFA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	7	872,204 - 888,870 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
Mhudiblu_PPA_v0	7	648,722 - 672,023 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

PDGFA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	16,271,082 - 16,293,246 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	16,270,104 - 16,292,396 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	17,743,941 - 17,762,483 (+)	NCBI
ROS_Cfam_1.0	6	16,400,056 - 16,421,423 (+)	NCBI
UMICH_Zoey_3.1	6	16,204,088 - 16,222,628 (+)	NCBI
UNSW_CanFamBas_1.0	6	16,130,433 - 16,148,998 (+)	NCBI
UU_Cfam_GSD_1.0	6	16,420,378 - 16,438,910 (+)	NCBI

PDGFA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	303,311 - 323,036 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	296,399 - 322,967 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	152,233 - 170,626 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PDGFA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	21,044,549 - 21,068,411 (+)	NCBI	ChlSab1.1		chlSab2
ChlSab1.1 Ensembl	28	21,047,219 - 21,069,827 (+)	Ensembl	ChlSab1.1		chlSab2
Vero_WHO_p1.0	NW_023666090	605,283 - 628,542 (-)	NCBI	Vero_WHO_p1.0

Pdgfa
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624740	26,172,808 - 26,191,557 (-)	NCBI	HetGla_female_1.0		hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005339825	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040277138	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010004404	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

XM_005339825 ⟹ XP_005339882

RefSeq Status:

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409344	144,181,911 - 144,201,439 (+)	NCBI
SpeTri2.0	NW_004936754	808,894 - 828,554 (-)	NCBI

Sequence:

show sequence

GGGCCCGGGAGAGGCGAGCCGGCGGCGGCAGCGCTTCTGCGGCGGCCTCCTCCCCTCCCCGCCC
GGTGCCGCAGGATTGCAGCTGGCACTGGAGGGTGGGCAAGCTCGAGGGAGGGGCGCGCGGGGAA
CCCTGCCGCCTGTGCTCGGAGCCGGGCGCCGGGCTTTGATGGATTTGGCTGCCTGCGTGAACGC
GAGTGTGCTCACTGCAGTAGCGGTGGCGGCCTGGCCCTGCCGGGCCCGCAAGACCCCCCGCACG
CTTCCGAGGAGCCCGGCTGGAGCGCCCGCCCTGCGGCCTCTCCTCCCCGCCGAGCCGCCAGCGC
CTCGGGACGCGATGAGGACCTGGGCTTGCCTGCTGCTCCTCGGCTGCGGATACCTCGCCCATGC
CCTGGCCGAGGAAGCTGAGATCCCCCGCGAGCTGATCGAGCGGCTGGCCCGTAGTGAGATCCAC
AGCATCCGCGACCTCCAGCGACTCCTGGAGATAGACTCCGTAGGAGCCGAGGATGCCTTGGGAA
CCAGCCTGAGAGCCCACCGGGCCCACGCCACCAAGCATGCGCCCGAGAAGCGGCCTGTGCCCAT
TCGGAGGAAAAGGAGCATCGAGGAAGCCATTCCTGCAGTCTGCAAGACCAGGACGGTCATTTAC
GAGATACCTCGGAGCCAGGTGGACCCCACGTCTGCCAACTTCCTGATCTGGCCGCCGTGCGTGG
AGGTGAAGCGCTGCACCGGCTGCTGCAACACGAGCAGTGTCAAGTGCCAGCCCTCGCGGGTCCA
CCACCGGAGCGTCAAGGTGGCCAAGGTGGAATACGTCAGGAAGAAGCCACGGTTGAAAGAGGTC
CAGGTGAGGCTGGAGGAGCACTTGGAGTGTGCTTGCGCACCCTCCAGCCTGAGTCCAGACCACC
GGGAAGAGGAGACCGATGTGAGGTGAGGATCAGCAGCAGCCCTCTCCTGGGACACGGATGTACA
TGGCGTGTTACATTCCTGAACCTACTATGTACGGTGCTTTATTGCCGGCGTGCGGTCTTTGTTC
TCCTCCGTGAAAAACTGTGTCCAAGAGCACTCTGGAGAACAAAGAGACAGTGTACATTTGTTCA
GTGTGACAGCAAAGCAAGTATTGTAGCACTCGGAGAAACTGTAAGCTTCCTTGTCAGAGAGAGA
GAGACAGAGAGAGAGAGAGAGAGAGAGAGAGAAAACAAACCACAAAACACGACAAAAAACAAAA
CAAAAAAACAACAAAAAAAAAACGGACTCCAAAACATCTAAGCCTTCGGCGGTAGGGCTGCCCC
GTGCGGGGTGAAGTGCAGTGGGCTCGCGGTGAAGCGCAGTGGGCTCGCGGGTGGATCTGTGTGG
GCCGCGGTGCTTTTGCTGAGTCGGAGCCTGGCGTGGAGAAGCCAGGCTTGGATCACCACGTGGA
CACCCCCTCGCTGCAGCACTCCAGTCTGTGGGACCCTCCTGGGAGCCTTAATGGGTTTTTTTTT
TTACACCGTAAAGTTACGGAGCTTTCCTTTTTACTCTTTGCCTAGCTTTCCCACCCCTCCCCCC
CAACCTTTTTTTAATTATCTCTTGGATGACATTTACGCCGATAACACACGAGGCTGCTGTAACT
GTCAGGACAGAGCGACGGTATTTTTCCTAGCAAGATGCAAACTAATGAGATGTATTAAAATAAA
CGCGGTATACCCACCTATGCATCA

hide sequence

RefSeq Acc Id:

XM_040277138 ⟹ XP_040133072

RefSeq Status:

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409344	144,181,428 - 144,201,439 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005339882	(Get FASTA)	NCBI Sequence Viewer
	XP_040133072	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	KAG3260159	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_005339882 ⟸ XM_005339825

- Peptide Label:

isoform X2

- Sequence:

show sequence

MDLAACVNASVLTAVAVAAWPCRARKTPRTLPRSPAGAPALRPLLPAEPPAPRDAMRTWACLLL
LGCGYLAHALAEEAEIPRELIERLARSEIHSIRDLQRLLEIDSVGAEDALGTSLRAHRAHATKH
APEKRPVPIRRKRSIEEAIPAVCKTRTVIYEIPRSQVDPTSANFLIWPPCVEVKRCTGCCNTSS
VKCQPSRVHHRSVKVAKVEYVRKKPRLKEVQVRLEEHLECACAPSSLSPDHREEETDVR

hide sequence

RefSeq Acc Id:	XP_040133072 ⟸ XM_040277138
- Peptide Label:	isoform X1

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	Pdgfa	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)

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Imported Disease Annotations - CTD

Imported Annotations - PID (archival)