Slc23a1 (solute carrier family 23 member 1)

Gene: Slc23a1 (solute carrier family 23 member 1) Ictidomys tridecemlineatus

Analyze

Symbol:

Slc23a1

Name:

solute carrier family 23 member 1

RGD ID:

12665791

Description:

ENCODES a protein that exhibits L-ascorbate:sodium symporter activity (ortholog); INVOLVED IN L-ascorbic acid transmembrane transport (ortholog); ASSOCIATED WITH autosomal dominant intellectual developmental disorder 31 (ortholog); cholestasis (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN brush border (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	153,138,372 - 153,159,132 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936531	8,457,957 - 8,471,258 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936531	8,457,779 - 8,471,244 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant intellectual developmental disorder 31 (ISO)

cholestasis (ISO)

Experimental Liver Cirrhosis (ISO)

familial adenomatous polyposis 1 (ISO)

genetic disease (ISO)

Hereditary Neoplastic Syndromes (ISO)

Intracranial Hemorrhages (ISO)

Neurodevelopmental Disorders (ISO)

respiratory failure (ISO)

STING-associated vasculopathy with onset in infancy (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

brain development (IEA)

dehydroascorbic acid transport (IEA)

L-ascorbic acid transmembrane transport (IEA,ISO)

lung development (IEA)

organic substance transport (IEA)

response to toxic substance (IEA)

sodium ion transmembrane transport (IEA)

sodium ion transport (IEA)

transmembrane transport (IEA)

urate transport (IEA)

Cellular Component

apical plasma membrane (IEA)

basal plasma membrane (IEA)

brush border (ISO)

cytoplasm (IEA)

intracellular organelle (IEA)

membrane (IEA)

plasma membrane (IEA)

Molecular Function

dehydroascorbic acid transmembrane transporter activity (IEA)

L-ascorbate:sodium symporter activity (IEA,ISO)

L-ascorbic acid transmembrane transporter activity (IEA)

protein binding (ISO)

sodium ion transmembrane transporter activity (IEA)

transmembrane transporter activity (IEA)

urate transmembrane transporter activity (IEA)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Slc23a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	153,138,372 - 153,159,132 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936531	8,457,957 - 8,471,258 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936531	8,457,779 - 8,471,244 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC23A1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	139,367,196 - 139,385,676 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	139,367,196 - 139,384,553 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	138,702,885 - 138,718,986 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	138,730,787 - 138,746,900 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	138,730,787 - 138,746,900	NCBI
Celera	5	134,824,593 - 134,840,618 (-)	NCBI		Celera
Cytogenetic Map	5	q31.2	NCBI
HuRef	5	133,892,618 - 133,908,788 (-)	NCBI		HuRef
CHM1_1	5	138,135,498 - 138,151,676 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	139,893,271 - 139,911,881 (-)	NCBI		T2T-CHM13v2.0

Slc23a1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	35,747,657 - 35,762,900 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	35,747,657 - 35,760,297 (-)	Ensembl		GRCm39 Ensembl
GRCm38	18	35,604,224 - 35,629,845 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	35,614,604 - 35,627,244 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	35,774,258 - 35,786,881 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	35,740,578 - 35,753,192 (-)	NCBI		MGSCv36	mm8
MGSCv36	18	35,794,115 - 35,806,597 (-)	NCBI		MGSCv36	mm8
Celera	18	36,070,745 - 36,083,392 (-)	NCBI		Celera
Cytogenetic Map	18	B2	NCBI
cM Map	18	19.17	NCBI

Slc23a1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	27,490,549 - 27,504,563 (-)	NCBI		GRCr8
mRatBN7.2	18	27,214,940 - 27,230,564 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	27,216,281 - 27,230,697 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	27,343,879 - 27,355,815 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	28,106,018 - 28,117,920 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	27,440,904 - 27,452,806 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	28,413,910 - 28,428,133 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	28,414,009 - 28,428,117 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	28,127,118 - 28,141,110 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	28,238,953 - 28,250,889 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	28,265,423 - 28,277,535 (-)	NCBI
Celera	18	26,950,004 - 26,961,940 (-)	NCBI		Celera
Cytogenetic Map	18	p11	NCBI

Slc23a1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955418	1,176,000 - 1,186,940 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955418	1,176,390 - 1,192,270 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLC23A1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	134,638,723 - 134,649,462 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	132,775,959 - 132,789,014 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	134,737,344 - 134,756,153 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	140,859,975 - 140,877,214 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	140,859,984 - 140,877,214 (-)	Ensembl	panpan1.1		panPan2

SLC23A1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	34,694,064 - 34,708,498 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	34,698,838 - 34,708,412 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	31,801,133 - 31,809,319 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	35,148,002 - 35,162,589 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	35,152,908 - 35,162,973 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	32,205,366 - 32,213,552 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	33,071,664 - 33,079,850 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	33,823,283 - 33,831,469 (-)	NCBI		UU_Cfam_GSD_1.0

SLC23A1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	141,258,323 - 141,276,442 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	141,258,318 - 141,277,555 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	147,081,831 - 147,107,402 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC23A1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	42,040,163 - 42,056,593 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	42,044,590 - 42,055,831 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	35,832,046 - 35,861,341 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc23a1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624743	32,174,922 - 32,186,697 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624743	32,169,051 - 32,186,618 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005327267	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040272180	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010002273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000014762 ⟹ ENSSTOP00000013225

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936531	8,457,957 - 8,471,258 (-)	Ensembl

RefSeq Acc Id:

XM_005327267 ⟹ XP_005327324

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	153,138,372 - 153,159,132 (+)	NCBI
SpeTri2.0	NW_004936531	8,457,779 - 8,471,244 (-)	NCBI

Sequence:

show sequence

ATGAGGGCTCAGACGGATCCCGAGGGCCGGACACAGCATGAGTCTCCCAGCTCAACAGGAAATT
CCACCAGGGATCCACAGATGCCCCTGCCCACGGAGCCCAAATTTGACATGTTGTATAAGATTGA
GGATGTGCCACCTTGGTACCTGTGTATCCTGCTTGGCTTCCAGCATTACCTGACATGCTTTAGC
GGCACCATCGCTGTTCCCTTCCTCCTGGCCGAGGCACTGTGTGTGGGCCAAGACCAGAACATGA
TCAGCCAGCTCATCGGCACCATCTTCGTGTGTGTGGGTATCACCACTCTCATCCAGACCACACT
GGGCATCCGGCTGCCACTGTTCCAGGCCAGTGCCTTTGCGTTTTTGGTTCCAGCCAAAGCCATC
CTGGCCCTGGAGAAATGGAAATGTCCCCCAGAAGAGGAGATCTACGGTAACTGGAGTCAGCCCT
TGAACACCTCTCATATCTGGCACCCACGGATTCGAGAGGTCCAGGGTGCAATCATGGTGGCCAG
TGTGGTGGAGGTGGTGATTGGGCTGATGGGGCTGCCTGGGGCCCTGCTCAGCTACATTGGGCCT
CTCACAGTCACCCCTACTGTCTCACTCATTGGCCTGTCTGTCTTCCAAGCTGCTGGTGATCGAG
CAGGCTCCCATTGGGGCATCTCAGCTTGCTCCATTCTCCTGATCATCCTCTTCTCCCAGTACCT
GCGCAATGTCACCTTCCTGCTGCCTGTCTACCGCTGGGGCAAGGGCCTCACTCTCTTCCGAATC
CAGATCTTCAAGATGTTTCCCATTGTGCTGGCCATCATGACTGTGTGGCTGCTCTGCTACGTGC
TGACCCTGACAGATGTGCTGCCTAAAGACCCAACAGCCTATGGCTACCAGGCACGAACTGATGC
CCGTGGAGACATCATGAGTATTTCACCCTGGATCCGCATTCCATACCCCTGTCAGTGGGGCCTG
CCTACAGTGACTGTGGCTGCTGTGTTGGGAATGTTCAGTGCCACACTGGCAGGCATCATCGAGT
CCATTGGTGATTACTATGCTTGTGCCCGCCTGGCTGGTGCACCACCCCCTCCAGTACATGCTAT
CAATAGGGGTATCTTCACCGAAGGCATCTGCTGCATTATCGCGGGGCTACTGGGCACAGGCAAC
GGGTCCACCTCGTCCAGTCCCAACATTGGCGTCCTAGGGATTACCAAGGTGGGCAGCCGTCGCG
TGGTGCAGTACGGTGCCGGTATCATGCTGGTCCTGGGTGCCATCGGCAAGTTCACAGCTCTCTT
TGCCTCGCTCCCCGACCCTATCCTGGGGGGCATGTTCTGCACCCTTTTCGGTATGATCACGGCT
GTGGGGCTCTCCAACCTGCAGTTCGTGGACATGAACTCCTCCCGCAACCTCTTTGTGCTTGGAT
TTTCCATGTTCTTCGGGCTCACACTGCCCAACTATCTGGATTCCAACCCTGGCGCTATCGACAC
AGGTGTTGCTGAAATTGACCAGATTCTGACTGTGCTGCTGACCACCGAGATGTTTGTGGGCGGA
TGCCTTGCTTTCATTCTGGATAACACAGTGCCAGGCAGTCCAGAGGAACGAGGCCTGATACAGT
GGAAAGCTGGGGCCCATGCCAACAGTGAGACATCTGCCAGCCTGAAGAGCTATGACTTTCCCAT
TGGGATGGGTACAGTAAAAAGGATTGCGTTTCTGAAATACATTCCTGTCTGCCCAGTCTTCAAA
GGATTTTCTTCAAGGTCAAAAACTCAGTCTCGTGTTCCAGAAGACATTCCAGAAAATATAGAAA
CTGGGTCTGGGTGCACCAAGGTCTGAACATTACTTTGAAAAAAGGTAGGAAGTCTCTATGGTTT
TTGTGGGAAGGTTGAACAAAACATTCTTATGTTTCAACAAAAGAAAACCCAAACTATTAAGTTC
CCATTTTTATGACCTATTTGAGGATCTTCAAGGGAAAAGTGGACTAAAGTCAACATATGGGCTG
GGCACAGTGGTT

hide sequence

RefSeq Acc Id:

XM_040272180 ⟹ XP_040128114

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	153,138,372 - 153,159,132 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005327324	(Get FASTA)	NCBI Sequence Viewer
	XP_040128114	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000013225.3
GenBank Protein	KAG3266194	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005327324 ⟸ XM_005327267
- Peptide Label:	isoform X1
- UniProtKB:	I3MNI8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRAQTDPEGRTQHESPSSTGNSTRDPQMPLPTEPKFDMLYKIEDVPPWYLCILLGFQHYLTCFS GTIAVPFLLAEALCVGQDQNMISQLIGTIFVCVGITTLIQTTLGIRLPLFQASAFAFLVPAKAI LALEKWKCPPEEEIYGNWSQPLNTSHIWHPRIREVQGAIMVASVVEVVIGLMGLPGALLSYIGP LTVTPTVSLIGLSVFQAAGDRAGSHWGISACSILLIILFSQYLRNVTFLLPVYRWGKGLTLFRI QIFKMFPIVLAIMTVWLLCYVLTLTDVLPKDPTAYGYQARTDARGDIMSISPWIRIPYPCQWGL PTVTVAAVLGMFSATLAGIIESIGDYYACARLAGAPPPPVHAINRGIFTEGICCIIAGLLGTGN GSTSSSPNIGVLGITKVGSRRVVQYGAGIMLVLGAIGKFTALFASLPDPILGGMFCTLFGMITA VGLSNLQFVDMNSSRNLFVLGFSMFFGLTLPNYLDSNPGAIDTGVAEIDQILTVLLTTEMFVGG CLAFILDNTVPGSPEERGLIQWKAGAHANSETSASLKSYDFPIGMGTVKRIAFLKYIPVCPVFK GFSSRSKTQSRVPEDIPENIETGSGCTKV hide sequence

RefSeq Acc Id:	XP_040128114 ⟸ XM_040272180
- Peptide Label:	isoform X2
- UniProtKB:	I3MNI8 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSSTOP00000013225 ⟸ ENSSTOT00000014762

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000014761	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000014762.3	UniProtKB/TrEMBL
InterPro	NCS2	UniProtKB/TrEMBL
NCBI Gene	Slc23a1	ENTREZGENE
PANTHER	PTHR11119:SF21	UniProtKB/TrEMBL
	XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER	UniProtKB/TrEMBL
Pfam	Xan_ur_permease	UniProtKB/TrEMBL
UniProt	I3MNI8	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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