Ung (uracil DNA glycosylase) - Rat Genome Database

Name: Ung
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Ung (uracil DNA glycosylase) Ictidomys tridecemlineatus

Analyze

Symbol:

Ung

Name:

uracil DNA glycosylase

RGD ID:

12664996

Description:

ENCODES a protein that exhibits uracil DNA N-glycosylase activity (ortholog); INVOLVED IN base-excision repair (ortholog); isotype switching (ortholog); negative regulation of apoptotic process (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); Colorectal Neoplasms (ortholog); dysgammaglobulinemia (ortholog); FOUND IN mitochondrion (inferred); nucleoplasm (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

uracil-DNA glycosylase

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	UNG (uracil DNA glycosylase)	NCBI	Ortholog
Mus musculus (house mouse):	Ung (uracil DNA glycosylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Ung (uracil-DNA glycosylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ung (uracil DNA glycosylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	UNG (uracil DNA glycosylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	UNG (uracil DNA glycosylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	UNG (uracil DNA glycosylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	UNG (uracil DNA glycosylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ung (uracil DNA glycosylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	144,553,145 - 144,565,155 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936769	910,838 - 922,726 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936769	911,296 - 922,770 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

Colorectal Neoplasms (ISO)

dysgammaglobulinemia (ISO)

genetic disease (ISO)

hereditary breast ovarian cancer syndrome (ISO)

hyper IgM syndrome (ISO)

immunodeficiency with hyper IgM type 5 (ISO)

X-linked hyper IgM syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

base-excision repair (IEA,ISO)

base-excision repair, AP site formation via deaminated base removal (IEA)

DNA repair (IEA)

isotype switching (IEA,ISO)

negative regulation of apoptotic process (ISO)

somatic hypermutation of immunoglobulin genes (IEA,ISO)

somatic recombination of immunoglobulin gene segments (IEA,ISO)

Cellular Component

mitochondrion (IEA)

nucleoplasm (IEA)

nucleus (IEA)

Molecular Function

damaged DNA binding (IEA)

hydrolase activity (IEA)

protein binding (ISO)

ribosomal small subunit binding (IEA)

uracil DNA N-glycosylase activity (IEA,ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Ung
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	144,553,145 - 144,565,155 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936769	910,838 - 922,726 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936769	911,296 - 922,770 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

UNG
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	109,097,597 - 109,110,992 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	109,097,597 - 109,126,725 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	109,535,402 - 109,548,797 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	108,019,798 - 108,033,181 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	107,998,134 - 108,011,518	NCBI
Celera	12	109,159,338 - 109,172,962 (+)	NCBI		Celera
Cytogenetic Map	12	q24.11	NCBI
HuRef	12	106,553,817 - 106,567,575 (+)	NCBI		HuRef
CHM1_1	12	109,503,049 - 109,516,448 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	109,072,409 - 109,086,041 (+)	NCBI		T2T-CHM13v2.0

Ung
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	114,268,427 - 114,277,382 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	114,268,447 - 114,277,384 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	114,130,366 - 114,139,321 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	114,130,386 - 114,139,323 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	114,580,444 - 114,589,330 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	114,392,199 - 114,418,049 (+)	NCBI		MGSCv36	mm8
Celera	5	111,232,303 - 111,241,182 (+)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	55.97	NCBI

Ung
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	48,145,838 - 48,154,789 (-)	NCBI		GRCr8
mRatBN7.2	12	42,485,276 - 42,494,217 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	42,485,276 - 42,494,206 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	43,652,469 - 43,660,684 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	44,266,059 - 44,274,274 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	43,326,576 - 43,334,791 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	48,246,593 - 48,255,547 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	48,246,569 - 48,254,822 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	50,028,792 - 50,037,127 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	43,520,629 - 43,528,873 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	43,384,016 - 43,392,261 (-)	NCBI
Celera	12	44,089,808 - 44,098,015 (-)	NCBI		Celera
Cytogenetic Map	12	q16	NCBI

Ung
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955455	10,266,989 - 10,282,196 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955455	10,266,989 - 10,282,196 (+)	NCBI	ChiLan1.0	ChiLan1.0

UNG
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	117,163,347 - 117,176,365 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	117,159,745 - 117,172,766 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	106,674,073 - 106,687,054 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	110,067,882 - 110,080,891 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	110,067,879 - 110,080,891 (+)	Ensembl	panpan1.1		panPan2

UNG
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	17,900,354 - 17,911,126 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	17,901,357 - 17,911,288 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	17,889,919 - 17,901,192 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	18,244,407 - 18,255,900 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	18,242,974 - 18,255,885 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	18,099,207 - 18,110,426 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	18,235,026 - 18,246,514 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	18,253,824 - 18,265,113 (-)	NCBI		UU_Cfam_GSD_1.0

UNG
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	41,746,502 - 41,757,807 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	41,746,498 - 41,757,841 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	44,311,840 - 44,323,500 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

UNG
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	104,302,507 - 104,325,160 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666037	140,779,094 - 140,801,492 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ung
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	12,261,623 - 12,274,859 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	12,261,546 - 12,275,229 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005340106	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000177	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000006891 ⟹ ENSSTOP00000006161

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936769	910,838 - 921,840 (+)	Ensembl

RefSeq Acc Id:

ENSSTOT00000031653 ⟹ ENSSTOP00000028628

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936769	911,349 - 922,726 (+)	Ensembl

RefSeq Acc Id:

XM_005340106 ⟹ XP_005340163

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405118	144,553,145 - 144,565,155 (-)	NCBI
SpeTri2.0	NW_004936769	911,296 - 922,770 (+)	NCBI

Sequence:

show sequence

GCCACGTGGGGACGCTTGCCGCGGATCCCGCAGGGCGGGGCGCCTGAGTGAGTCTCAGGACCCC
GCGGGGTTCTCGGAGTTCGGACCCCAAAGCTCTGCACTGGCTCCACCCCGAGCCCTGGAGTCAA
ATTGTCTGATTTGGCTCGCACCCGCCTTCGCCATGGGCGTCTGTAGCCGACCGCTGGTGGGTTT
GGCCCGGAAGCTGCGGGCGCCCGGGAAGCGGCCTGTGCGGTTGGTGACCCGCCTCTGCGGGGAC
TCGTTGCAGGACCATCCCACCAAGAAGGCCCGGGTCGGGCAGGAGGAGCCCGACACGCCGCCCT
CCTCGCCGCTGAGCCAGGAGCAGCTGGTCCGCATCCAGAGAAACAAGGCCGCGGCGCTGCTCAG
ACTCGCGGCCCGCAACGTGCCCGTGGGCTTCGGCGAGAGCTGGAGGAAGCCCCTGGGCGCCGAG
TTCGGGAAGCCGTATTTCATCAAGCTAATGGGATTCGTTGCAGAAGAAAGAAAACGTTACACTG
TTTACCCGCCTCCACACCAAGTCTTCACATGGACCCAAACATGTGACATAAAAGATGTGAAGGT
TGTCATCCTGGGACAAGATCCTTATCATGGACCCAATCAAGCTCATGGGCTCTGCTTTAGCGTC
CAAAGACCTGTTCCACCTCCACCCAGTTTGGAAAACATTTATAAAGAGCTGTCTACAGACATAG
ATGGTTTTGTTCATCCTGGCCATGGAGATCTATCAGGATGGGCCAAACAAGGTGTCCTCCTGCT
CAACGCCGTGCTCACTGTCCGGGCCCATCAAGCCAATTCCCACAAGGAGAGGGGTTGGGAGGAG
TTCACCGACGCAGTCGTGTCCTGGCTGAATCAGAACTTGAACGGCCTTGTCTTCCTGCTCTGGG
GCTCATACGCCCAGAAGAAGGGCATTGCCATCGACAGGAAGCGGCACCATGTACTGCAGACTGC
TCATCCCTCCCCGCTGTCAGTGTATAGAGGGTTCTTTGGGTGTAGACATTTTTCTAAAGCTAAT
GAGCTGCTGCAGAAATCTGGCAAGAAGCCCATCGACTGGAAGGAGCTGTGACCTTGTACTGAGA
GGGGGTCTCTTCTCTGGGGGGTGGTTTTTGAGAAGCTGCTGCTGAAGTATTTGTCAATTGTGAA
GTCGTTGAAAATTTCCTTATTCTTAAGTGCCTTGCCTAAGAGGAGAGAGCTTCCATTCAACAGC
AGAGAGCCAGGCTGCCCAGCCAGGGACAGCAGAGATACAGCACTGTGACCATTTCTGTATTTGA
ACCCTCCAGGCACAATAAGATGAGGCCCAAGGGTGGCAAAGGTGGCTCTGCCTGAAATAAGCAC
ACTTCTCTCCAGTGAGGTCAGGTTCTGGTCCTGTCCAGCCTCTTACCTCTTTGGTTCAAAATGG
AAGAGATGCACCTTTTTGGGACGGCTGTTTGGTCTTGCTGCTAGCATTTTTAGCTGATAGGTTA
GACTTTAGGTTACAAGGTATTTGGTGGCTTGGCTTGGAAAAGCCCCTTAAATTTGTGAATCTTC
AGGCCATTTCCTAGAAGAATCTGGAGGACCTTTTGCAAGCCTCTAGGAATCTGTCCCAAAAGCT
AAGGATCAGAGTTTCCTGATTATAGTAAAGGCCAGGATCCCTGAGGATCACACCCTCAGTGTGA
GCCTCAGTGTGATCCTCAGACTGGATGAAGAAGCAGTCTGGAATGATGGGTGAACAGAGAAGAA
GGTTCTGTTTTGTTTTCATGCTGGGTGGGAGACTTTCTCCTAGGGTCATCAGTTGAGGTGTTTT
AAGGAGGGACAGATTGCCAGATTCTATTTTTATGGACTTGGATTTTTTTTTTTTTCATCACTGG
AGATTTTTACATTTTTGTAAGATACGCAGATACATATTTTTTTTTTTTAAAGACAGTGGTTTTT
GCTGTTAGCTGGGTTAAAGAGTTAACCCTTATAAGTTTGGTAATAAAAGATCTAACCCGTTGAA
GTTTTGCTTCCTGTCCCCTCT

hide sequence

Protein Sequences


Protein RefSeqs	XP_005340163	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000006161.2
	ENSSTOP00000028628.1
GenBank Protein	KAG3278859	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005340163 ⟸ XM_005340106

- UniProtKB:

I3M8Q6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGVCSRPLVGLARKLRAPGKRPVRLVTRLCGDSLQDHPTKKARVGQEEPDTPPSSPLSQEQLVR
IQRNKAAALLRLAARNVPVGFGESWRKPLGAEFGKPYFIKLMGFVAEERKRYTVYPPPHQVFTW
TQTCDIKDVKVVILGQDPYHGPNQAHGLCFSVQRPVPPPPSLENIYKELSTDIDGFVHPGHGDL
SGWAKQGVLLLNAVLTVRAHQANSHKERGWEEFTDAVVSWLNQNLNGLVFLLWGSYAQKKGIAI
DRKRHHVLQTAHPSPLSVYRGFFGCRHFSKANELLQKSGKKPIDWKEL

hide sequence

RefSeq Acc Id:

ENSSTOP00000006161 ⟸ ENSSTOT00000006891

RefSeq Acc Id:

ENSSTOP00000028628 ⟸ ENSSTOT00000031653

Protein Domains

Uracil-DNA glycosylase-like

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000006894	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000006891.2	UniProtKB/TrEMBL
	ENSSTOT00000031653.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.470.10	UniProtKB/TrEMBL
InterPro	UDG_fam1	UniProtKB/TrEMBL
	Ura-DNA_Glyclase_AS	UniProtKB/TrEMBL
	Uracil-DNA_glycosylase-like	UniProtKB/TrEMBL
	Uracil-DNA_glycosylase-like_sf	UniProtKB/TrEMBL
NCBI Gene	Ung	ENTREZGENE
PANTHER	PTHR11264	UniProtKB/TrEMBL
	URACIL-DNA GLYCOSYLASE	UniProtKB/TrEMBL
Pfam	UDG	UniProtKB/TrEMBL
PROSITE	U_DNA_GLYCOSYLASE	UniProtKB/TrEMBL
SMART	UDG	UniProtKB/TrEMBL
	UreE_C	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52141	UniProtKB/TrEMBL
UniProt	A0A287D4Z8_ICTTR	UniProtKB/TrEMBL
	I3M8Q6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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