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Gene: Irs2 (insulin receptor substrate 2) Ictidomys tridecemlineatus

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Symbol:

Irs2

Name:

insulin receptor substrate 2

RGD ID:

12663275

Description:

ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); insulin receptor binding (ortholog); phosphatidylinositol 3-kinase activator activity (ortholog); INVOLVED IN brain development (ortholog); cell migration (ortholog); cell population proliferation (ortholog); PARTICIPATES IN erythropoietin signaling pathway; insulin signaling pathway; insulin-like growth factor signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Anal Atresia, Hypospadias, and Penoscrotal Inversion (ortholog); Diabetic Nephropathies (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	193,155,757 - 193,179,968 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936472	2,772,187 - 2,796,398 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

Anal Atresia, Hypospadias, and Penoscrotal Inversion (ISO)

Diabetic Nephropathies (ISO)

Experimental Diabetes Mellitus (ISO)

factor X deficiency (ISO)

Fetal Growth Retardation (ISO)

hepatocellular carcinoma (ISO)

hyperglycemia (ISO)

Insulin Resistance (ISO)

maturity-onset diabetes of the young type 1 (ISO)

medulloblastoma (ISO)

metabolic dysfunction-associated steatotic liver disease (ISO)

Metabolic Syndrome (ISO)

osteoporosis (ISO)

Stomach Neoplasms (ISO)

type 2 diabetes mellitus (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

brain development (ISO)

cell migration (ISO)

cell population proliferation (ISO)

cellular response to endothelin (ISO)

cellular response to glucose stimulus (ISO)

cellular response to insulin stimulus (ISO)

epithelial cell migration (ISO)

insulin receptor signaling pathway (ISO)

insulin-like growth factor receptor signaling pathway (ISO)

mammary gland development (ISO)

negative regulation of B cell apoptotic process (ISO)

negative regulation of kinase activity (ISO)

negative regulation of long-chain fatty acid import across plasma membrane (ISO)

positive regulation of B cell proliferation (ISO)

positive regulation of cell population proliferation (ISO)

positive regulation of D-glucose import (ISO)

positive regulation of epithelial cell migration (ISO)

positive regulation of fatty acid beta-oxidation (ISO)

positive regulation of glucose metabolic process (ISO)

positive regulation of glycogen biosynthetic process (ISO)

positive regulation of insulin secretion (ISO)

positive regulation of mesenchymal cell proliferation (ISO)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ISO)

positive regulation of type B pancreatic cell proliferation (ISO)

response to glucose (ISO)

type B pancreatic cell proliferation (ISO)

Cellular Component

cytoplasm (ISO)

cytosol (ISO)

plasma membrane (ISO)

Molecular Function

14-3-3 protein binding (ISO)

insulin receptor binding (ISO)

phosphatidylinositol 3-kinase activator activity (ISO)

phosphatidylinositol 3-kinase binding (ISO)

protein binding (ISO)

protein domain specific binding (ISO)

protein kinase binding (ISO)

protein phosphatase binding (ISO)

protein-macromolecule adaptor activity (ISO)

signaling adaptor activity (ISO)

transmembrane receptor protein tyrosine kinase adaptor activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

erythropoietin signaling pathway (ISO)

insulin signaling pathway (ISO)

insulin-like growth factor signaling pathway (ISO)

interleukin-2 signaling pathway (ISO)

interleukin-4 signaling pathway (ISO)

leptin system pathway (ISO)

References

Additional References at PubMed

PMID:25640202	PMID:30032202

Genomics

Comparative Map Data

Irs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	193,155,757 - 193,179,968 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936472	2,772,187 - 2,796,398 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IRS2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	13	109,752,695 - 109,786,583 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	13	109,752,695 - 109,786,583 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	13	110,405,042 - 110,438,930 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	13	109,204,185 - 109,236,915 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	13	109,204,186 - 109,236,915	NCBI
Celera	13	91,250,464 - 91,283,200 (-)	NCBI		Celera
Cytogenetic Map	13	q34	NCBI
HuRef	13	91,005,522 - 91,037,072 (-)	NCBI		HuRef
CHM1_1	13	110,375,378 - 110,407,600 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	13	108,981,231 - 109,015,226 (-)	NCBI		T2T-CHM13v2.0

Irs2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	11,034,681 - 11,058,929 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	11,034,681 - 11,058,458 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	10,984,681 - 11,008,929 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	10,984,681 - 11,008,458 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	10,986,961 - 11,008,430 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	10,986,933 - 11,008,402 (-)	NCBI		MGSCv36	mm8
Celera	8	11,160,160 - 11,181,560 (-)	NCBI		Celera
Cytogenetic Map	8	A1.1	NCBI
cM Map	8	5.35	NCBI

Irs2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	85,190,310 - 85,214,543 (+)	NCBI		GRCr8
mRatBN7.2	16	78,488,249 - 78,512,482 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	78,485,045 - 78,512,482 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	83,768,627 - 83,792,860 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	87,221,312 - 87,245,545 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	82,462,691 - 82,486,908 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	83,824,515 - 83,848,569 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	83,824,430 - 83,848,684 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	83,287,185 - 83,311,239 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	83,379,987 - 83,404,220 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	83,367,312 - 83,368,308 (+)	NCBI
Celera	16	76,286,571 - 76,310,806 (+)	NCBI		Celera
Cytogenetic Map	16	q12.5	NCBI

Irs2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955404	2,531,484 - 2,555,689 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955404	2,531,484 - 2,555,383 (+)	NCBI	ChiLan1.0	ChiLan1.0

IRS2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	14	111,245,626 - 111,277,310 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	13	109,927,626 - 109,959,400 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	13	90,886,095 - 90,917,724 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	13	110,013,214 - 110,044,465 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

IRS2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	22	58,197,016 - 58,229,026 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	22	58,223,387 - 58,227,535 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	22	57,975,030 - 58,001,643 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	22	58,818,940 - 58,849,512 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	22	58,820,310 - 58,850,432 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	22	58,320,760 - 58,351,271 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	22	58,311,744 - 58,342,617 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	22	58,351,225 - 58,377,896 (-)	NCBI		UU_Cfam_GSD_1.0

IRS2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	11	76,626,179 - 76,653,881 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	11	76,626,158 - 76,654,639 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

IRS2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	88,045,439 - 88,076,468 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666046	44,755,670 - 44,786,671 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Irs2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624793	2,614,589 - 2,636,947 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624793	2,615,092 - 2,636,835 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005317130	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_005317130 ⟹ XP_005317187

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404945	193,155,757 - 193,179,968 (-)	NCBI
SpeTri2.0	NW_004936472	2,772,187 - 2,796,398 (+)	NCBI

Sequence:

show sequence

AACCTGAAGCCCAAGGGCCTGGGCCAGAGCAAGAACCTGACGGGCGTGTACCGCCTGTGCCTGT
CGGCGCGCACCATAGGCTTCGTGAAGCTCAATTGCGAGCAGCCGTCGGTGACGCTGCAGCTCAT
GAACATCCGCCGCTGCGGCCATTCGGACAGCTTCTTCTTTATAGAGGTTGGCCGCTCGGCCGTC
ACGGGCCCCGGAGAGCTGTGGATGCAGGCCGACGACTCCGTGGTGGCGCAGAATATCCACGAGA
CCATTCTGGAGGCCATGAAGGCGCTCAAGGAGCTCTTCGAGTTCCGGCCCCGCAGCAAGAGCCA
GTCGTCGGGGTCGTCCGCCACGCACCCTATCAGCGTCCCCGGCGCGCGCCGCCACCATCACCTG
GTCAACTTACCCCCTAGTCAGACAGGCCTGGTGCGCCGCTCGCGCACCGACAGCCTGGCCGCCA
CTCCGCCGGCCACCAAGTGTAGCTCTTGCCGGGTTCGCACTGCCAGTGAGGGCGATGGCGGCGC
TGCAGCCGGGACTGTGGCGGCGGCCGGCAGGCCTGTGTCAGTAGCCGGGAGCCCCCTGAGCCCT
GGGCCCGTGCGCGCGCCCCTGAGCCGCTCGCACACCCTGAGTGGCGGCTGCGGTGGCCGCGGGA
GCAAAGTGACACTGGCACCGGCAGGGGGCGCCCTGCAACACAGCCGCTCCATGTCCATGCCCGT
GGCGCACTCGCCCCCTGCTGCCACCAGTCCTGGCAGCCTGTCGTCCAGCAGCGGGCACGGCTCA
GGCTCCTACCCGCTGCCTCCGGGCCCGCACCCGCACCTGCCTCATCCTTTGCACCACCCCCCAG
GTCAGCGGCCCTCCAGCGGCAGTGCCTCTGCCTCAGGCTCTCCCAGTGACCCTGGCTTCATGTC
ACTGGACGAATACGGCTCTAGCCCTGGTGACCTGAGAGCCTTCTGCAGCCACAGGAGCAACACA
CCGGAGTCCATCGCAGAGACACCCCCGGCCAGGGATGGCAGCGGGGGCGAGTTGTATGGGTACA
TGACTATGGACAGGCCTCTGAGCCACTGTGGCCGGCCATATCGCAGAGTCTCAGGTGATGGGGT
CCAGGACTTGGACAGAGGACTGAGAAAGAGGACTTATTCCTTGACCACACCTGCTCGGCAGCGG
CCAGTGCCCCAGCCCTCCTCTGCCTCTCTGGATGAGTACACCCTGATGCGGGCCACCTTCTCTG
GAAGCTCAGGCCGCCTCTGCCCATCTTTCCCTACATCCTCTCCCAAAATGGCTTACCACCCCTA
TCCAGAGGACTATGGGGACATAGAGATTGGATCCCATAGGAGTTCCAGCAGCAATCTGGGGGCT
GATGATGGCTACATGCCCATGACCCCTGGTGCGGCTCTCATGGGCAGTGGCAGTGGCAGCTGCA
AGAGCGATGACTACATGCCCATGAGCCCCACCAGTGTGTCTGCCCCAAAGCAAATCCTGCAGCC
AAGAGCTGCGCCTGCAGCAGACTTGCCCCCCACCGGAGCAGCAGCAGCGCCTCAGCCCGCCCCT
GTGGCCAACAGGACCTTCCCAGTGAGCGGGAGCGGCTACAAGGCCAGCTCCCCAGCGGAAAGCT
CACCCGAGGATAGCGGGTACATGCGCATGTGGTGTGGCTCCAAGCTGTCCATGGAGAATGCCGA
CCCAAAGCTGCTTCCCAACGGGGACTACCTCAACATGTCCCCCAGCGAAGCGGGCACCGCGGGC
ACGCCTCCCGATTTCTTCTCAGCAGCCTTGCATGGCAGTGGGGAGGTGCTCAAAGGGGTCCCTG
GCTACTGCTACAGTTCCTTGCCCCGCTCCTACAAGGCCCCTTATGCCTGCAGCGGGGACAGTGA
CCAGTATGTGCTCATGAGCTCCCCTGTGGGACGGATCCTGGAAGAGGAGAGGCAGGAGCCCCAG
GCCACCCCAGTAACCTCCCAGTCGGCCAGCACCTTTGGGGTTGGCGGGAGTGGCCACCCCCAGC
CTCCCCATCCAGCAGTGCCTTCACCCATGAGGCCAAGTGGCAGCAATTTCCTGAGCCAGCGCTG
CCGGGCGGTGCGGCCCACACGCCTGTCCCTGGAGGGGCTGCAAACCCTGCCCAGTATGCACGAG
TACCCCGTGCCGCCAGAGCCCAAGAGCCCTGGAGAATACATCAACATTGACTTTGGCGAGGCGG
GTGCCCGCCTCTCACCACCTGCGCCTCCACTGCTGGCATCCGCAGCCTCCTCCTCCTCGCTGCT
GTCCGCCAGTAGCCCAGCTTCGTCCCTGGGCTCGGGCACCCCGGGCACCAGCAGCGACAGCCGG
CAGCGCTCCCCGCTGTCCGATTACATGAACCTGGACTTCAGCTCTCCCAAGTCCCCCAAGCCGG
GCACCCGCAGCGCGGACCCAGTGGGCTCCCTGGATGCCCTGCTCTCGCCTGAGGCTGCTTCCCC
ATACCCACCACTGCCTCCACGTCCTTCTGCCTCGCCCACCTCCCTGCAGCAGCAGCCCCCTGCA
CAGCCTCCTCCAGGGGAGCCCTACCATCTGCCTCCAGCATTGGGCACTGCCACCTCCCAGGGCC
CCAGTGCTGTCTCCTCTACATCCTCTGAGACTGGGGACAATGGTGACTACACCGAGATGGCCTT
TGGTGTGGCTGCCACCCCGCCTCAACCCATCGTGGCCCACCCAAAACCGGAAGGTGCCCGAGTG
ACCAGCCCCACCTCGGGCTTGAAGAGGCTGAGTCTCATGGACCAGCTGTCAGGGGTGGAGGCCT
TCCTGCAGGCCAGTCAGCCCCCCGACCCTCACCGAGGCGCCAAGGTCATCCGCGCAGACCCACA
GGGGGGCCGCCGCCGCCACAGCTCCGAGACCTTCTCCTCAACCACCACGGTCACCCCGGTGTCG
CCGTCCTTTGCCCATAACCCCAAGCGCCACAGCTCAGCCTCTGTGGAAAACGTCTCTCTCAGGA
AAAGTGGCGAGGGCAGTGGTGGGGGCGTCCTCGGAGCAGGTGAGGAGCCACCCACGTCCCCAGG
ACAGTCACAGCCATCACTCCCTGTGCCTCCGACCCCGCAGGTGCGGCCGTGGGCCCCGGGCCAG
CCTGGGGGCTTGGTGGGCTGTCCTGGGGCCAGTGGTTCTCCTATGCGAAGAGAGACCTCGGCCG
GTTTCCAGAATGGCCTCAACTACATCGCCATTGACGTGAGAGATGATCCAGGGCTGTCCCCCCA
GATGCAGCATCCGCAGCCAGGAGACAAGAGCTGGGGCCGGACCCGTAGCCTCGGGGGTCTCCTC
AGTGCCGTGGGGGGCAGTGGCACCAGCGGGGTGTGTGGGGGCCCGGGCCCTGGTGCCCTGCCTT
CGGCCAACACCTACGCCAGCATCGACTTCTTGTCCCGTCACTTGAAGGAGGCCACCATCGTGAA
AGAATGAAGCGCCCTCGGGCTGCACCGCCTGGAGGTCGACAGCGGAGATTTCAGCCTATTTCCC
ACCGAAGCTGCATGCGACGTCTGTCGGATCTGGGCCATTCCACTCGGAGACCTCTGAACTGGAC
AGGAACCCACCAGGCCCGAGCGCCTGCCTCTCGCTTGTCCCCGCCGGGGCATGCGTCATTGTGC
AGTGTGTGTTGCATTTTGTTTTATTTTATAACTTAAATTAGCCGAAGAAGTTATTCTGGAGCAA
ATTGGATGTTTTTATTGGCCTTCTTAAATCGTGGCCGGTGTCTTCATTTCTTCTTACTTTTATT
TTGGCAAAGCAGATCTATCCCTCAGCATGCTAGGAGATGCTACCATACCCACCGAAGTGGTAAA
ATCTGGTATTTACTGGCTTACACTCAACTCTACCACAGTCCTACCTCAGTCCAAGGTAACGCCG
GATCACGTGGTCGGGGTGCAGAGGCTTCCTGCACGTCCACCCCAGGGCTCGAGCGTGGCCTTGG
CCTCGCCGACCTGCTCGAGTGGACACAGGTTCCAGTCCAGGTACCTGCGATGTTGACTGGTGCA
CGGAGCCCAGCGTGGGACTGACAGTTCTCCATGGAAGTGAAATCTGGGATCGGACTTCGAAGAT
GGATTCGTAAATAATTCTTATTAAGTGTAACTGAAGCAACCTACTTTTAAAAATCATCAGTTGT
ATTGGGTGGTGGGGTGGGAGGGAGGGGTCCTGGGCGGGTGACTCTCTCTTTTTACCTTTAACAG
GCTTGTCTATCCTTCTCTGTGTAGCTGTTCGTGTAGGTACTTCAAGTTGCAAAAGCCTTTTCTC
CCCTGCAGGAGCTCAGATGCCCTGCTGCCCTGAATCCTGAGCTTACGTTCTCTTAACCAAAACC
TCGTGTAGGCACGCTGGTGGTTCAGGCTGCTGGGGCCTGCAGGCTTCATGTTTGAAAGGTATTA
ACTACTGCTCTCGCGCTGGCCAACAAGGCGGCCCTGAAGAGAGAGAGAGAGAGAGAGAGAGAGA
CGGACAGAGAGAGGCATCGTAGCTAAGCTCCTGTGCTGAGCGGAAAGAGGAGAAAACCAGTCTC
TCACAGTGCACGTCACTTGTCAAAGAAATCCTTGACAGACCACCCTGGTTTCACATTTTCAGTG
TTCTGGAAATTTCAGTGTTGTGGCAATTATCGGTGATCACAGACGTCACCCAGCATGGCTGAGC
GTGCCAGCAGACTGTGGGCCCCTGGTTGCTCCCTCCACACGCTCTGGAGGCTCGGCCTCCCCCA
GTGCCTGTGCCCCTGGTGGTCCTGCAGAGGCTACACTCGTTCTTGGAGATGTGAGTTGTTGGTT
TGTTTGGGGTTTTTTTTGTTGTTGTTTTGTTTCTGTTTGGAGAAAATATATATATATAAATATA
AATATATAGAGATCTATATCACTATAGAGTAATGCATTAATCAAATGAGGCTTTTTAGAGGAAG
ACCAAAAAATTCCATGTCTTAAAAATATATTTAACGGCAATGCAAACGCCTTCCTGCTTCCGTG
CTGAACTCAGAACAGAGGATTGTATTGCAAGACAAAGTTGAATGTAAAGTGATCCCCGAGCATT
CTCCAGGTCTTTCTTTTCTGAAATCACACGTCACCATAACGCAGAGGCCACGCAGTGCTGGTCT
GACCGTCAGCTCCCGAGCGTCCTCGGCACGCGGCGGTAAGATGTATGAAATGCCCTAGAGTTCT
CTCTGGTTGGGGACTAGGAGCCCCCCGTGGTTTGCTGAGACTCCCCCAGCACAGTAGGATGAGG
GGGAACTGCTGGACGCGGCGCTGGAGGAGTCGTGGCACGGACCGGGCGTCATGTCCCTGCTGCC
ACTTAGAAGGAGAAGAACACAAAGTCGATGATGTACTAAATTTTCCTCTATCCTGTACATTTCA
AAAAGAAAAAAAAAGGCATATGCAATATTTACATTTTTAATTTAGTTTACAGAATGGAACCAAA
ATGTGTAAATGTTATGTTTGCTAAAACTTCACAATGTACATTGGGTCTTTGTACATTTTGCCTG
ACTTACCTTAAATTTAAAATATTTTTTTGCTATATGAACTTTAACAGTTATTAAACAGTGTTTT
CTTTGGGTATGTATTGTTTCTGGATATCAAGATGTTAAATATATTTCTCGTGTCGTGTTAGGAC
GAGAGACTCAACCTGCCCTGCTCCGTCTTCCGCTGTACGCTCTGTACAGGGGGTCGACGGGTCG
CTGCTGGAGACGAGAGAAAACTGGACTAGAGTAGCGCATTGTATTTAGTCTGTATTGACCATGG
ATGCCCTCCTTAATAGCCATATGCAATAAAATAAAATACATTATTTATGAAATGAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005317187	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	KAG3293401	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005317187 ⟸ XM_005317130

- Sequence:

show sequence

NLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQLMNIRRCGHSDSFFFIEVGRSAV
TGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRPRSKSQSSGSSATHPISVPGARRHHHL
VNLPPSQTGLVRRSRTDSLAATPPATKCSSCRVRTASEGDGGAAAGTVAAAGRPVSVAGSPLSP
GPVRAPLSRSHTLSGGCGGRGSKVTLAPAGGALQHSRSMSMPVAHSPPAATSPGSLSSSSGHGS
GSYPLPPGPHPHLPHPLHHPPGQRPSSGSASASGSPSDPGFMSLDEYGSSPGDLRAFCSHRSNT
PESIAETPPARDGSGGELYGYMTMDRPLSHCGRPYRRVSGDGVQDLDRGLRKRTYSLTTPARQR
PVPQPSSASLDEYTLMRATFSGSSGRLCPSFPTSSPKMAYHPYPEDYGDIEIGSHRSSSSNLGA
DDGYMPMTPGAALMGSGSGSCKSDDYMPMSPTSVSAPKQILQPRAAPAADLPPTGAAAAPQPAP
VANRTFPVSGSGYKASSPAESSPEDSGYMRMWCGSKLSMENADPKLLPNGDYLNMSPSEAGTAG
TPPDFFSAALHGSGEVLKGVPGYCYSSLPRSYKAPYACSGDSDQYVLMSSPVGRILEEERQEPQ
ATPVTSQSASTFGVGGSGHPQPPHPAVPSPMRPSGSNFLSQRCRAVRPTRLSLEGLQTLPSMHE
YPVPPEPKSPGEYINIDFGEAGARLSPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSSDSR
QRSPLSDYMNLDFSSPKSPKPGTRSADPVGSLDALLSPEAASPYPPLPPRPSASPTSLQQQPPA
QPPPGEPYHLPPALGTATSQGPSAVSSTSSETGDNGDYTEMAFGVAATPPQPIVAHPKPEGARV
TSPTSGLKRLSLMDQLSGVEAFLQASQPPDPHRGAKVIRADPQGGRRRHSSETFSSTTTVTPVS
PSFAHNPKRHSSASVENVSLRKSGEGSGGGVLGAGEEPPTSPGQSQPSLPVPPTPQVRPWAPGQ
PGGLVGCPGASGSPMRRETSAGFQNGLNYIAIDVRDDPGLSPQMQHPQPGDKSWGRTRSLGGLL
SAVGGSGTSGVCGGPGPGALPSANTYASIDFLSRHLKEATIVKE

hide sequence

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	Irs2	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)

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