Clic5 (chloride intracellular channel 5) - Rat Genome Database

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Gene: Clic5 (chloride intracellular channel 5) Ictidomys tridecemlineatus
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Symbol: Clic5
Name: chloride intracellular channel 5
RGD ID: 12661688
Description: ENCODES a protein that exhibits chloride channel activity (ortholog); INVOLVED IN auditory receptor cell stereocilium organization (ortholog); diet induced thermogenesis (ortholog); inner ear receptor cell stereocilium organization (ortholog); ASSOCIATED WITH autosomal recessive nonsyndromic deafness (ortholog); autosomal recessive nonsyndromic deafness 103 (ortholog); genetic disease (ortholog); FOUND IN apical plasma membrane (ortholog); Golgi apparatus (ortholog); stereocilium (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: chloride intracellular channel 5, transcript variant X1; chloride intracellular channel 5, transcript variant X2; chloride intracellular channel protein 5; LOC110597486; uncharacterized LOC110597486
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494649,578,625 - 49,741,329 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647614,283,006 - 14,381,634 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647614,234,447 - 14,381,582 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
Clic5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494649,578,625 - 49,741,329 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647614,283,006 - 14,381,634 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647614,234,447 - 14,381,582 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLIC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38645,880,827 - 46,129,819 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl645,880,827 - 46,080,348 (-)EnsemblGRCh38hg38GRCh38
GRCh37645,866,188 - 46,097,556 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36645,974,171 - 46,091,553 (-)NCBINCBI36Build 36hg18NCBI36
Build 34645,977,485 - 46,091,545NCBI
Celera647,419,073 - 47,600,603 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef645,589,507 - 45,771,107 (-)NCBIHuRef
CHM1_1645,869,674 - 46,051,333 (-)NCBICHM1_1
T2T-CHM13v2.0645,716,118 - 45,964,907 (-)NCBIT2T-CHM13v2.0
Clic5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391744,445,671 - 44,591,059 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1744,445,659 - 44,591,059 (+)EnsemblGRCm39 Ensembl
GRCm381744,134,762 - 44,280,169 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1744,188,584 - 44,280,172 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl1744,134,768 - 44,280,172 (+)EnsemblGRCm38mm10GRCm38
MGSCv371744,325,521 - 44,417,117 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361743,651,627 - 43,743,223 (+)NCBIMGSCv36mm8
Celera1747,604,897 - 47,706,768 (+)NCBICelera
Cytogenetic Map17B3NCBI
cM Map1720.53NCBI
Clic5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8924,208,455 - 24,310,964 (-)NCBIGRCr8
mRatBN7.2916,710,980 - 16,813,502 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl916,710,980 - 16,813,427 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx925,300,548 - 25,400,082 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0930,374,783 - 30,474,345 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0928,663,965 - 28,763,534 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0919,121,676 - 19,372,673 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl919,121,677 - 19,372,673 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0918,203,018 - 18,251,818 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0918,004,699 - 18,049,825 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4912,370,341 - 12,472,969 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1912,367,663 - 12,470,290 (-)NCBI
Celera914,441,285 - 14,540,691 (-)NCBICelera
Cytogenetic Map9q13NCBI
Clic5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543711,053,885 - 11,118,255 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543711,053,885 - 11,118,150 (-)NCBIChiLan1.0ChiLan1.0
CLIC5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2560,387,381 - 60,505,130 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1656,253,426 - 56,371,209 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0645,474,797 - 45,592,407 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1646,753,007 - 46,934,100 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl646,753,013 - 46,934,100 (-)Ensemblpanpan1.1panPan2
CLIC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11214,160,524 - 14,318,174 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1214,144,390 - 14,318,582 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1214,193,104 - 14,350,325 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01214,660,621 - 14,818,027 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1214,644,744 - 14,818,385 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11214,177,139 - 14,334,394 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01214,265,255 - 14,422,839 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01214,361,798 - 14,519,297 (-)NCBIUU_Cfam_GSD_1.0
CLIC5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl740,682,907 - 40,863,886 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1740,683,044 - 40,808,017 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2746,946,099 - 47,128,142 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CLIC5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11726,231,192 - 26,364,076 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1726,231,728 - 26,343,346 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604445,867,551 - 46,089,886 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clic5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475414,370,425 - 14,434,269 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475414,335,173 - 14,433,721 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000022287   ⟹   ENSSTOP00000020453
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647614,283,006 - 14,381,634 (+)Ensembl
RefSeq Acc Id: XM_005318615   ⟹   XP_005318672
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494649,578,625 - 49,725,922 (-)NCBI
SpeTri2.0NW_00493647614,234,447 - 14,381,582 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005318616   ⟹   XP_005318673
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494649,578,625 - 49,677,205 (-)NCBI
SpeTri2.0NW_00493647614,283,020 - 14,381,582 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040282746   ⟹   XP_040138680
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494649,578,625 - 49,741,329 (-)NCBI
Protein Sequences
Protein RefSeqs XP_005318672 (Get FASTA)   NCBI Sequence Viewer  
  XP_005318673 (Get FASTA)   NCBI Sequence Viewer  
  XP_040138680 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000020453.2
GenBank Protein KAG3289574 (Get FASTA)   NCBI Sequence Viewer  
  KAG3289575 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005318672   ⟸   XM_005318615
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005318673   ⟸   XM_005318616
- Peptide Label: isoform X2
- UniProtKB: I3N7V7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040138680   ⟸   XM_040282746
- Peptide Label: isoform X3
RefSeq Acc Id: ENSSTOP00000020453   ⟸   ENSSTOT00000022287
Protein Domains
GST C-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000028761 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000022287.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1050.10 UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/TrEMBL
InterPro CLIC UniProtKB/TrEMBL
  CLIC5_C_GST UniProtKB/TrEMBL
  Glutathione-S-Trfase_C-like UniProtKB/TrEMBL
  Glutathione-S-Trfase_C_sf UniProtKB/TrEMBL
  Glutathione_S-Trfase UniProtKB/TrEMBL
  Glutathione_S-Trfase_N UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
NCBI Gene Clic5 ENTREZGENE
PANTHER CHLORIDE INTRACELLULAR CHANNEL PROTEIN 6-RELATED UniProtKB/TrEMBL
  PTHR45476:SF4 UniProtKB/TrEMBL
Pfam GST_C_2 UniProtKB/TrEMBL
  GST_N_2 UniProtKB/TrEMBL
PRINTS INTCLCHANNEL UniProtKB/TrEMBL
PROSITE GST_CTER UniProtKB/TrEMBL
Superfamily-SCOP SSF47616 UniProtKB/TrEMBL
  SSF52833 UniProtKB/TrEMBL
UniProt I3N7V7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-25 Clic5  chloride intracellular channel 5  LOC110597486  uncharacterized LOC110597486  Data merged from RGD:13197831 737654 PROVISIONAL