Bfar (bifunctional apoptosis regulator)

Gene: Bfar (bifunctional apoptosis regulator) Ictidomys tridecemlineatus

Analyze

Symbol:

Bfar

Name:

bifunctional apoptosis regulator

RGD ID:

12661364

Description:

ENCODES a protein that exhibits caspase binding (inferred); metal ion binding (inferred); protein-macromolecule adaptor activity (inferred); INVOLVED IN negative regulation of apoptotic process (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN endoplasmic reticulum (inferred); membrane (inferred)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	114,714,164 - 114,741,497 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936501	2,811,907 - 2,841,258 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936501	2,811,967 - 2,839,357 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of apoptotic process (IEA,ISO)

negative regulation of IRE1-mediated unfolded protein response (IEA)

proteasome-mediated ubiquitin-dependent protein catabolic process (IEA)

protein autoubiquitination (IEA)

protein K48-linked ubiquitination (IEA)

protein K63-linked ubiquitination (IEA)

protein polyubiquitination (IEA)

ubiquitin-dependent protein catabolic process (IEA)

Cellular Component

endoplasmic reticulum (IEA)

membrane (IEA)

Molecular Function

caspase binding (IEA)

metal ion binding (IEA)

protein binding (ISO)

protein-macromolecule adaptor activity (IEA)

ubiquitin protein ligase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Bfar
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	114,714,164 - 114,741,497 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936501	2,811,907 - 2,841,258 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936501	2,811,967 - 2,839,357 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BFAR
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	14,632,951 - 14,669,236 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	14,632,931 - 14,669,236 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	14,726,808 - 14,763,093 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	14,634,297 - 14,670,209 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	14,634,296 - 14,670,193	NCBI
Celera	16	14,903,443 - 14,939,870 (+)	NCBI		Celera
Cytogenetic Map	16	p13.12	NCBI
HuRef	16	14,645,522 - 14,682,385 (+)	NCBI		HuRef
CHM1_1	16	14,726,496 - 14,762,923 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	14,670,491 - 14,706,771 (+)	NCBI		T2T-CHM13v2.0

Bfar
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	13,489,722 - 13,521,476 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	13,495,005 - 13,495,835 (+)	Ensembl		GRCm39 Ensembl
GRCm39 Ensembl	16	13,489,722 - 13,521,476 (+)	Ensembl		GRCm39 Ensembl
GRCm38	16	13,671,858 - 13,703,612 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	13,671,929 - 13,678,388 (+)	Ensembl	GRCm38		mm10	GRCm38
GRCm38.p6 Ensembl	16	13,671,858 - 13,703,612 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	13,671,951 - 13,703,705 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	13,585,572 - 13,616,279 (+)	NCBI		MGSCv36	mm8
Celera	16	14,276,844 - 14,308,053 (+)	NCBI		Celera
Cytogenetic Map	16	A1	NCBI
cM Map	16	9.45	NCBI

Bfar
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	2,059,189 - 2,092,207 (+)	NCBI		GRCr8
mRatBN7.2	10	1,552,019 - 1,585,040 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	1,552,072 - 1,585,038 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	6,248,898 - 6,281,870 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	34,283,970 - 34,316,927 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	1,565,910 - 1,599,270 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	1,464,783 - 1,497,653 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	1,464,765 - 1,497,653 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	361,895 - 394,582 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	49 - 13,315 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	613,130 - 645,931 (+)	NCBI		Celera
Cytogenetic Map	10	q11	NCBI

Bfar
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	4,226,756 - 4,255,623 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	4,229,236 - 4,255,623 (-)	NCBI	ChiLan1.0	ChiLan1.0

BFAR
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	15,167,173 - 15,205,284 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	18,950,045 - 18,988,139 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	13,558,912 - 13,597,023 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	14,980,618 - 15,018,310 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	14,980,615 - 15,018,310 (+)	Ensembl	panpan1.1		panPan2

BFAR
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	28,593,931 - 28,624,867 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	28,594,709 - 28,624,759 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	29,957,043 - 29,987,994 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	28,757,093 - 28,788,057 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	28,757,095 - 28,787,932 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	28,560,108 - 28,591,059 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	28,448,363 - 28,479,322 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	28,855,713 - 28,886,664 (-)	NCBI		UU_Cfam_GSD_1.0

BFAR
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	28,573,393 - 28,612,217 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	28,572,789 - 28,612,659 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	29,685,082 - 29,696,890 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BFAR
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	14,092,049 - 14,132,270 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	14,092,097 - 14,133,132 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	15,918,502 - 15,961,414 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Bfar
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624782	3,887,129 - 3,916,858 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624782	3,890,818 - 3,916,920 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005323687	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010004404	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000007562 ⟹ ENSSTOP00000006759

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936501	2,825,193 - 2,838,522 (+)	Ensembl

RefSeq Acc Id:

ENSSTOT00000033682 ⟹ ENSSTOP00000030643

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936501	2,811,907 - 2,841,258 (+)	Ensembl

RefSeq Acc Id:

XM_005323687 ⟹ XP_005323744

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409344	114,714,164 - 114,741,497 (+)	NCBI
SpeTri2.0	NW_004936501	2,811,967 - 2,839,357 (+)	NCBI

Sequence:

show sequence

TAGGCAGCGGGGAGGTCGCGGGGTTGAGGGGGCTGGGAAATGAGTGCGGCCTCTCCTCTATGGT
CGCGGGCCAGGGGTACCCTCCGCAGTCGGTCCTCGGTTACTTCCGGAAGTGAAGCGGTCCAGCT
CCTCCTCCGTTTCCGCGGGGGTCCGTGCGGGGGGCGATGGCCTGGTCGGTCCCGGGGCGAATAG
AATGATTTGATGATGCCTTGCTGCCATCTCCGAAGTCTGAAGTTTTCTGTGTCTGTGGGTCCCA
GAATTTGCTGAAAGATGGAAGAGCCTCAGAAAAATGATGCCACCACAGTGGGCCTGGAAGATGA
CCCTCTCAGAAGCACGGGCCCTCAGATTTCCGTTAGTGAATTTTCCTGCCATTGCTGTTATGAC
ATCCTGGTTAACCCAACAACCTTGAACTGTGGGCACAGCTTCTGCCGGCACTGCCTCGCTTTAT
GGTGGGTGTCTTCAAAGAAAACAGAGTGTCCGGAATGCAGGGAAAAATGGGAAGGTTTCCCCAA
AGTCAACATTCTCCTCAGGGATGCCATTGAAAAGTTATTTCCTGATGCTATTAGGATGAGATTT
GAAGACATTCGACAGAACAATGACATAGTCCAAAGTCTCGCAGCCTTTCAAAAATATGGGAATG
ATCAGATCCCTTTAACTCCCAACACGGGCCGAGTGAATCAGCAGAGAGGAGGGGGCTTCTTTTC
TGGAGTGCTCACAGCTTTAACTGGAGTGGCAGTGGTCCTGCTTGTGTATCACTGGAGCAGCAGG
GAATCTGAGCATGACCTCCTGGTCCATAAGGCTGTGGCCAAATGGACGGCGGAAGAAGTTGTCC
TCTGGCTGGAGCAGCTGGGCCCATGGGCCTCTCTCTACAGAGACAGGTTTTTGTCTGAAAGAGT
GAATGGAAGATTGCTTTTAACTTTGACAGAGGAAGAATTTTCAAGGGCGCCATATACTATAGAA
AACAGCAGCCACAGAAGAGTCATCCTCATGGAGCTGGAGCGTGTCAAGGCACTAGGTGTGAAGC
CCCCCCAGAATCTTTGGGAATATAAGGCCGTGAACCCAGGCAGGTCCCTGTTTCTGCTGTATGC
CCTCAAGAGCTCCCCGAGACTTGGTCTGCTGTACCTGTACCTGTTTGACTACACAGATACCTTC
CTGCCCTTCATCCACACCATCTGCCCTCTGCAGGAAGACAGCTCCGGGGAGGACATCGTCACCA
AGCTTCTGGATCTGAGAGAGCCCACTTGGAAACAGTGGAGGGAATTCCTCGTCAAATACTCCTT
CCTCCCATACCAGCTGATTGCTGAATTTGCCTGGGACTGGCTGGAGGTCCACTACTGGACATCA
CGGTTTCTCATTGTTAACGCCATGCTACTCTCGGTTTTGGAGTTATTTTCTTTTTGGAGGATCT
GGTCAAGAAGTGAGCTCAAGACACTTCCTCAGAGGATGTGGAGCCATTTTTGGAAAGTGTCAAC
ACAGGGGCTTTTTGTGGCCATGTTCTGGCCCCTCATCCCTCAGTTTGTGTGCAACTGTTTGTTT
TACTGGGCCCTGTATTTCAACCCAATCATTAACATTGATCTCGTGGTCAAGGAAGTTCGAAGAC
TGGAAACGCAAGTGTTGTGACTGGCACTGTCCGGGCTCTGAGCGGGTCCTCCAGTCTCCCCAGT
GCCTGAGCGGATGCTTTGGAGGGTGAGGGAAGAGGAGACTTCCTGTTTCTACCCCTGGTAAACA
AGGTGCTGCTTTGTAGGACAAAGGCTTCAACCAGGTCCTCTCTTCTCTGCCTGTGGCACACCGT
GGCAGCACACCAACACCCCAGTACCTGGAGGACTGTCTGTGGCCCACACAGCCGCCGCCTCACA
GGGACCTGGCTGGCTCAGGCCACCATGGCTGGCAGGACTCAGGGTCCTCAGAGGACACAGTGTG
GGTGACGTCAGAAGGCCACCACATCGGCATCTCCCTCCCTGCCTCAGTTAATGACAGGTTCCTA
GAGCCAAGACTAGACTTGTTTGGGCCAGGCCTGTCCTGTACGTCAAGTTTAGGAAGACAGAGAT
AGGGTTTTTGTCATAGGCATAAAAAGTTACACATTTAAAAAAAAAAAAAAAGGGAAAACCCAGA
ATCCAATCAACAATTCTGTCTCCTTGGGTAGTTGCTGGGTTTCAGAGGAAACCTCTAAAATGAT
TCAGTTTGAGATTAGAATGATGGTCGGCTTTTCCTCACTGTTTTTTTGTCATTGTTATTGTTGG
TTGGTTGGTTGGTTTTCTGTTTGGGGTGGGGCTTGAGTGGCTATCTATCGGGCAGCACCCAGAG
CTCCCCTCAGGCTAAGCTGCATCAGGCTGCTTAAAGGCATTGCTTTGGGGTTTTGTTTTGTTTT
GTTTTTCAGAATTTAATCTGTAATATCAGGTTAGACTCTGCATTCATGCATTGAAGGAAACATT
TTATAAATTGACCTCACACTGTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005323744	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000006759.3
	ENSSTOP00000030643.1
GenBank Protein	KAG3259364	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005323744 ⟸ XM_005323687

- UniProtKB:

A0A287DAS3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEEPQKNDATTVGLEDDPLRSTGPQISVSEFSCHCCYDILVNPTTLNCGHSFCRHCLALWWVSS
KKTECPECREKWEGFPKVNILLRDAIEKLFPDAIRMRFEDIRQNNDIVQSLAAFQKYGNDQIPL
TPNTGRVNQQRGGGFFSGVLTALTGVAVVLLVYHWSSRESEHDLLVHKAVAKWTAEEVVLWLEQ
LGPWASLYRDRFLSERVNGRLLLTLTEEEFSRAPYTIENSSHRRVILMELERVKALGVKPPQNL
WEYKAVNPGRSLFLLYALKSSPRLGLLYLYLFDYTDTFLPFIHTICPLQEDSSGEDIVTKLLDL
REPTWKQWREFLVKYSFLPYQLIAEFAWDWLEVHYWTSRFLIVNAMLLSVLELFSFWRIWSRSE
LKTLPQRMWSHFWKVSTQGLFVAMFWPLIPQFVCNCLFYWALYFNPIINIDLVVKEVRRLETQV
L

hide sequence

RefSeq Acc Id:

ENSSTOP00000030643 ⟸ ENSSTOT00000033682

RefSeq Acc Id:

ENSSTOP00000006759 ⟸ ENSSTOT00000007562

Protein Domains

RING-type SAM

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000007564	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000007562.3	UniProtKB/TrEMBL
	ENSSTOT00000033682.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.150.50	UniProtKB/TrEMBL
	3.30.40.10	UniProtKB/TrEMBL
InterPro	SAM	UniProtKB/TrEMBL
	SAM/pointed_sf	UniProtKB/TrEMBL
	Znf_RING	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
	Znf_RING_CS	UniProtKB/TrEMBL
NCBI Gene	Bfar	ENTREZGENE
PANTHER	BIFUNCTIONAL APOPTOSIS REGULATOR	UniProtKB/TrEMBL
	UNCHARACTERIZED	UniProtKB/TrEMBL
Pfam	SAM_1	UniProtKB/TrEMBL
	zf-C3HC4_4	UniProtKB/TrEMBL
PROSITE	SAM_DOMAIN	UniProtKB/TrEMBL
	ZF_RING_1	UniProtKB/TrEMBL
	ZF_RING_2	UniProtKB/TrEMBL
SMART	RING	UniProtKB/TrEMBL
	SAM	UniProtKB/TrEMBL
Superfamily-SCOP	RING/U-box	UniProtKB/TrEMBL
	SSF47769	UniProtKB/TrEMBL
UniProt	A0A287DAS3	ENTREZGENE, UniProtKB/TrEMBL
	I3M9Z5_ICTTR	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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