Nedd4l (NEDD4 like E3 ubiquitin protein ligase) - Rat Genome Database

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Gene: Nedd4l (NEDD4 like E3 ubiquitin protein ligase) Ictidomys tridecemlineatus
Analyze
Symbol: Nedd4l
Name: NEDD4 like E3 ubiquitin protein ligase
RGD ID: 12660294
Description: ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN establishment of localization in cell (ortholog); negative regulation of sodium ion transport (ortholog); negative regulation of systemic arterial blood pressure (ortholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); cleft palate (ortholog); Developmental Disease (ortholog); FOUND IN glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 ubiquitin-protein ligase NEDD4-like; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494430,867,247 - 31,171,348 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364976,106,268 - 6,318,354 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364976,106,284 - 6,318,339 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
establishment of localization in cell  (ISO)
negative regulation of potassium ion transmembrane transport  (IEA)
negative regulation of protein localization to cell surface  (IEA)
negative regulation of sodium ion transmembrane transport  (IEA)
negative regulation of sodium ion transport  (ISO)
negative regulation of systemic arterial blood pressure  (ISO)
positive regulation of caveolin-mediated endocytosis  (ISO)
positive regulation of dendrite extension  (IEA)
positive regulation of protein catabolic process  (ISO)
positive regulation of sodium ion transport  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IEA)
protein K48-linked ubiquitination  (IEA)
protein monoubiquitination  (ISO)
protein polyubiquitination  (IEA)
protein ubiquitination  (IEA)
regulation of bicellular tight junction assembly  (ISO)
regulation of dendrite morphogenesis  (IEA)
regulation of membrane depolarization  (IEA)
regulation of membrane potential  (IEA)
regulation of membrane repolarization  (IEA)
regulation of monoatomic ion transmembrane transport  (IEA)
regulation of postsynaptic neurotransmitter receptor internalization  (ISO)
regulation of protein stability  (IEA)
regulation of sodium ion transmembrane transport  (IEA)
regulation of sodium ion transport  (ISO)
regulation protein catabolic process at postsynapse  (ISO)
response to salt stress  (ISO)
sodium ion transport  (ISO)
ubiquitin-dependent protein catabolic process  (IEA)
ventricular cardiac muscle cell action potential  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Nedd4l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494430,867,247 - 31,171,348 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364976,106,268 - 6,318,354 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364976,106,284 - 6,318,339 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEDD4L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381858,044,226 - 58,401,540 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1858,044,226 - 58,401,540 (+)EnsemblGRCh38hg38GRCh38
GRCh371855,711,458 - 56,068,772 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361853,862,778 - 54,216,369 (+)NCBINCBI36Build 36hg18NCBI36
Build 341853,862,777 - 54,216,369NCBI
Celera1852,429,273 - 52,785,147 (+)NCBICelera
Cytogenetic Map18q21.31NCBI
HuRef1852,421,551 - 52,777,135 (+)NCBIHuRef
CHM1_11855,707,037 - 56,063,999 (+)NCBICHM1_1
T2T-CHM13v2.01858,244,126 - 58,602,300 (+)NCBIT2T-CHM13v2.0
Nedd4l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391865,017,551 - 65,350,888 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1865,020,776 - 65,350,899 (+)EnsemblGRCm39 Ensembl
GRCm381864,884,480 - 65,217,826 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1864,887,705 - 65,217,828 (+)EnsemblGRCm38mm10GRCm38
MGSCv371865,047,410 - 65,377,480 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361865,149,263 - 65,338,676 (+)NCBIMGSCv36mm8
Celera1866,271,347 - 66,493,213 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1837.57NCBI
Nedd4l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81860,663,918 - 60,996,824 (+)NCBIGRCr8
mRatBN7.21858,393,759 - 58,726,709 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1858,393,509 - 58,723,137 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1860,487,918 - 60,820,828 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01861,186,393 - 61,519,168 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01859,015,711 - 59,343,901 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01860,392,376 - 60,719,720 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1860,392,376 - 60,719,720 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01859,595,643 - 59,921,504 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41861,134,242 - 61,477,040 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11861,528,414 - 61,549,290 (+)NCBI
Celera1856,529,040 - 56,853,871 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
Nedd4l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540242,339,380 - 42,688,714 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540242,339,380 - 42,688,661 (+)NCBIChiLan1.0ChiLan1.0
NEDD4L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21775,577,762 - 75,942,886 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11861,270,375 - 61,635,499 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01851,428,077 - 51,792,995 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11854,762,516 - 55,122,236 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1854,867,149 - 55,123,423 (+)Ensemblpanpan1.1panPan2
NEDD4L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1117,629,163 - 17,858,471 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl117,633,591 - 17,950,072 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha118,613,069 - 18,951,799 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0117,509,482 - 17,848,443 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl117,509,487 - 17,849,053 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1117,567,699 - 17,905,982 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0117,465,765 - 17,804,137 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0117,733,960 - 18,072,781 (-)NCBIUU_Cfam_GSD_1.0
NEDD4L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1162,364,057 - 162,513,718 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11162,364,053 - 162,736,515 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NEDD4L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11821,326,276 - 21,683,817 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1821,327,567 - 21,683,905 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660603,882,156 - 4,244,040 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nedd4l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247923,553,004 - 3,902,468 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247923,553,185 - 3,903,288 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_013357607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013357608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021724971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021724972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021724973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021724974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021724975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040272594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040272601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040272608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040272613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040272621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040272635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040272639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040272640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000012844   ⟹   ENSSTOP00000011509
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364976,111,029 - 6,318,354 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000043097   ⟹   ENSSTOP00000024391
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364976,106,268 - 6,318,342 (-)Ensembl
RefSeq Acc Id: XM_013357607   ⟹   XP_013213061
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494430,867,247 - 31,001,545 (-)NCBI
SpeTri2.0NW_0049364976,111,029 - 6,242,793 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013357608   ⟹   XP_013213062
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494430,871,571 - 31,079,304 (-)NCBI
SpeTri2.0NW_0049364976,110,606 - 6,318,339 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021724971   ⟹   XP_021580646
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494430,867,247 - 31,001,530 (-)NCBI
SpeTri2.0NW_0049364976,106,284 - 6,242,793 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021724974   ⟹   XP_021580649
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494430,871,571 - 31,079,304 (-)NCBI
SpeTri2.0NW_0049364976,110,469 - 6,318,339 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040272594   ⟹   XP_040128528
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494430,867,247 - 31,001,548 (-)NCBI
RefSeq Acc Id: XM_040272601   ⟹   XP_040128535
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494430,867,247 - 31,001,525 (-)NCBI
RefSeq Acc Id: XM_040272608   ⟹   XP_040128542
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494430,871,571 - 31,001,494 (-)NCBI
RefSeq Acc Id: XM_040272613   ⟹   XP_040128547
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494430,867,247 - 31,001,553 (-)NCBI
RefSeq Acc Id: XM_040272621   ⟹   XP_040128555
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494430,867,247 - 31,001,720 (-)NCBI
RefSeq Acc Id: XM_040272635   ⟹   XP_040128569
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494430,867,247 - 31,053,842 (-)NCBI
RefSeq Acc Id: XM_040272639   ⟹   XP_040128573
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494430,867,247 - 31,010,322 (-)NCBI
RefSeq Acc Id: XM_040272640   ⟹   XP_040128574
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494430,867,247 - 31,171,348 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_013213062   ⟸   XM_013357608
- Peptide Label: isoform X8
- UniProtKB: A0A287CSX0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013213061   ⟸   XM_013357607
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_021580646   ⟸   XM_021724971
- Peptide Label: isoform X2
- UniProtKB: A0A287CSX0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021580649   ⟸   XM_021724974
- Peptide Label: isoform X9
- UniProtKB: A0A287CSX0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040128574   ⟸   XM_040272640
- Peptide Label: isoform X10
- UniProtKB: A0A287CSX0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040128569   ⟸   XM_040272635
- Peptide Label: isoform X10
- UniProtKB: A0A287CSX0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040128573   ⟸   XM_040272639
- Peptide Label: isoform X10
- UniProtKB: A0A287CSX0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040128555   ⟸   XM_040272621
- Peptide Label: isoform X6
RefSeq Acc Id: XP_040128547   ⟸   XM_040272613
- Peptide Label: isoform X5
- UniProtKB: A0A287CSX0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040128528   ⟸   XM_040272594
- Peptide Label: isoform X1
- UniProtKB: A0A287CSX0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040128535   ⟸   XM_040272601
- Peptide Label: isoform X3
- UniProtKB: A0A287CSX0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040128542   ⟸   XM_040272608
- Peptide Label: isoform X4
- UniProtKB: A0A287CSX0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000011509   ⟸   ENSSTOT00000012844
RefSeq Acc Id: ENSSTOP00000024391   ⟸   ENSSTOT00000043097
Protein Domains
C2   HECT   WW


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000012833 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000012844.3 UniProtKB/TrEMBL
  ENSSTOT00000043097.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.70.10 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  E3_ub_ligase_SMURF1 UniProtKB/TrEMBL
  HECT_dom UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
  WW_dom UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
NCBI Gene Nedd4l ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE NEDD4-LIKE UniProtKB/TrEMBL
  HECT DOMAIN UBIQUITIN-PROTEIN LIGASE UniProtKB/TrEMBL
Pfam HECT UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  PF00397 UniProtKB/TrEMBL
PIRSF E3_ub_ligase_SMURF1 UniProtKB/TrEMBL
PRINTS C2DOMAIN UniProtKB/TrEMBL
PROSITE HECT UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
SMART HECTc UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
  SM00456 UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/TrEMBL
  SSF51045 UniProtKB/TrEMBL
  SSF56204 UniProtKB/TrEMBL
UniProt A0A287CSX0 ENTREZGENE, UniProtKB/TrEMBL
  I3MJW6_ICTTR UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-09 Nedd4l  NEDD4 like E3 ubiquitin protein ligase    neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase  Symbol and/or name change 5135510 APPROVED