Nuak1 (NUAK family kinase 1) - Rat Genome Database

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Gene: Nuak1 (NUAK family kinase 1) Ictidomys tridecemlineatus
Analyze
Symbol: Nuak1
Name: NUAK family kinase 1
RGD ID: 12655573
Description: ENCODES a protein that exhibits ATP binding (inferred); nucleotide binding (inferred); p53 binding (inferred); INVOLVED IN intracellular signal transduction (inferred); regulation of cell adhesion (inferred); regulation of cellular senescence (inferred); ASSOCIATED WITH COVID-19 (ortholog); genetic disease (ortholog); multiple myeloma (ortholog); FOUND IN cytoplasm (inferred); fibrillar center (inferred); microtubule cytoskeleton (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: NUAK family SNF1-like kinase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494515,699,625 - 15,764,456 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364928,710,039 - 8,775,112 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364928,710,039 - 8,774,870 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Nuak1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494515,699,625 - 15,764,456 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364928,710,039 - 8,775,112 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364928,710,039 - 8,774,870 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUAK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812106,063,345 - 106,138,954 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12106,063,345 - 106,138,954 (-)EnsemblGRCh38hg38GRCh38
GRCh3712106,457,123 - 106,532,732 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612104,981,255 - 105,057,941 (-)NCBINCBI36Build 36hg18NCBI36
Celera12106,122,505 - 106,199,131 (-)NCBICelera
Cytogenetic Map12q23.3NCBI
HuRef12103,517,880 - 103,594,537 (-)NCBIHuRef
CHM1_112106,422,717 - 106,499,407 (-)NCBICHM1_1
T2T-CHM13v2.012106,026,098 - 106,101,716 (-)NCBIT2T-CHM13v2.0
Nuak1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391084,206,764 - 84,282,028 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1084,206,769 - 84,276,461 (-)EnsemblGRCm39 Ensembl
GRCm381084,370,900 - 84,440,668 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1084,370,905 - 84,440,597 (-)EnsemblGRCm38mm10GRCm38
MGSCv371083,834,056 - 83,903,216 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361083,801,110 - 83,870,270 (-)NCBIMGSCv36mm8
Celera1086,350,008 - 86,419,314 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1041.42NCBI
Nuak1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8721,217,729 - 21,289,608 (+)NCBIGRCr8
mRatBN7.2719,330,034 - 19,401,918 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl719,329,933 - 19,401,913 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx721,290,632 - 21,360,457 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0723,453,310 - 23,523,126 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0723,230,282 - 23,300,102 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0725,039,336 - 25,111,118 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl725,039,335 - 25,113,664 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0725,184,054 - 25,253,032 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4721,461,413 - 21,529,068 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1721,481,448 - 21,548,614 (+)NCBI
Celera716,538,758 - 16,608,089 (+)NCBICelera
Cytogenetic Map7q13NCBI
Nuak1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540540,153,747 - 40,188,145 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540540,156,316 - 40,188,144 (-)NCBIChiLan1.0ChiLan1.0
NUAK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210114,130,583 - 114,206,322 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112114,126,980 - 114,202,690 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012103,642,744 - 103,720,352 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112107,037,632 - 107,113,163 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12107,037,627 - 107,113,163 (-)Ensemblpanpan1.1panPan2
NUAK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11032,463,845 - 32,537,425 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1032,464,123 - 32,536,650 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1032,383,951 - 32,457,600 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01033,305,053 - 33,378,753 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1033,306,774 - 33,378,743 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11033,041,000 - 33,114,539 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01033,329,739 - 33,403,411 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01033,517,685 - 33,591,445 (+)NCBIUU_Cfam_GSD_1.0
NUAK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl514,102,006 - 14,177,584 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1514,089,584 - 14,177,584 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2514,165,755 - 14,290,617 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NUAK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111101,282,483 - 101,362,618 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11101,282,347 - 101,360,602 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037143,676,111 - 143,753,398 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nuak1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247503,141,441 - 3,197,514 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247503,141,442 - 3,197,821 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005322450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000023353   ⟹   ENSSTOP00000018829
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364928,710,039 - 8,775,112 (+)Ensembl
RefSeq Acc Id: XM_005322450   ⟹   XP_005322507
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494515,699,625 - 15,764,456 (+)NCBI
SpeTri2.0NW_0049364928,710,039 - 8,774,870 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005322507 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000018829.2
GenBank Protein KAG3291107 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005322507   ⟸   XM_005322450
- UniProtKB: I3N383 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000018829   ⟸   ENSSTOT00000023353
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000027258 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000023353.2 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Nuak1 ENTREZGENE
PANTHER MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/TrEMBL
  NUAK FAMILY SNF1-LIKE KINASE 1 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt I3N383 ENTREZGENE, UniProtKB/TrEMBL