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Gene: Tax1bp3 (Tax1 binding protein 3) Ictidomys tridecemlineatus

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Symbol:

Tax1bp3

Name:

Tax1 binding protein 3

RGD ID:

12654532

Description:

ENCODES a protein that exhibits beta-catenin binding (ortholog); INVOLVED IN activation of GTPase activity (ortholog); negative regulation of cell population proliferation (ortholog); negative regulation of protein localization to cell surface (ortholog); ASSOCIATED WITH Abderhalden-Kaufmann-Lignac Syndrome (ortholog); arrhythmogenic right ventricular cardiomyopathy (ortholog); Canavan disease (ortholog); FOUND IN actin cytoskeleton (ortholog); fibrillar center (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

tax1-binding protein 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	55,533,701 - 55,539,675 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936677	361,300 - 367,234 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Abderhalden-Kaufmann-Lignac Syndrome (ISO)

arrhythmogenic right ventricular cardiomyopathy (ISO)

Canavan disease (ISO)

cystinosis (ISO)

Cystinosis, Late-Onset Juvenile or Adolescent Nephropathic Type (ISO)

Cystinosis, Ocular Nonnephropathic (ISO)

dilated cardiomyopathy 1B (ISO)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of GTPase activity (ISO)

cell-cell adhesion (IEA)

establishment or maintenance of epithelial cell apical/basal polarity (IEA)

negative regulation of cell population proliferation (ISO)

negative regulation of protein localization to cell surface (ISO)

negative regulation of Wnt signaling pathway (ISO)

neurotransmitter receptor transport postsynaptic membrane to endosome (IEA)

neurotransmitter receptor transport, endosome to postsynaptic membrane (IEA)

receptor clustering (IEA)

Rho protein signal transduction (ISO)

Wnt signaling pathway (IEA)

Cellular Component

actin cytoskeleton (ISO)

adherens junction (IEA)

basolateral plasma membrane (IEA)

cytoplasm (IEA)

fibrillar center (ISO)

intracellular membrane-bounded organelle (IEA)

membrane (IEA)

nucleus (IEA)

plasma membrane (IEA)

postsynaptic density (IEA)

postsynaptic membrane (IEA)

Molecular Function

beta-catenin binding (ISO)

protein binding (ISO)

protein kinase binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Tax1bp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	55,533,701 - 55,539,675 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936677	361,300 - 367,234 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TAX1BP3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	3,662,895 - 3,668,578 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	3,662,895 - 3,668,679 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	3,566,189 - 3,571,872 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	3,512,938 - 3,518,722 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	3,512,938 - 3,518,722	NCBI
Celera	17	3,579,928 - 3,585,715 (-)	NCBI		Celera
Cytogenetic Map	17	p13.2	NCBI
HuRef	17	3,457,894 - 3,463,683 (-)	NCBI		HuRef
CHM1_1	17	3,576,823 - 3,582,609 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	3,551,947 - 3,557,633 (-)	NCBI		T2T-CHM13v2.0

Tax1bp3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	73,067,909 - 73,072,872 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	73,067,909 - 73,073,988 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	73,177,083 - 73,182,046 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	73,177,083 - 73,183,162 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	72,990,585 - 72,995,548 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	72,993,278 - 72,998,241 (+)	NCBI		MGSCv36	mm8
Celera	11	80,714,177 - 80,719,138 (+)	NCBI		Celera
Cytogenetic Map	11	B4	NCBI
cM Map	11	45.25	NCBI

Tax1bp3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	58,294,357 - 58,298,875 (+)	NCBI		GRCr8
mRatBN7.2	10	57,795,845 - 57,800,363 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	57,795,382 - 57,800,363 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	62,451,524 - 62,456,041 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	61,939,983 - 61,944,500 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	57,439,136 - 57,443,653 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	59,743,356 - 59,748,063 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	59,743,544 - 59,748,062 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	59,482,530 - 59,487,239 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	60,054,096 - 60,058,595 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	60,067,718 - 60,072,217 (+)	NCBI
Celera	10	56,918,760 - 56,923,259 (+)	NCBI		Celera
Cytogenetic Map	10	q24	NCBI

Tax1bp3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955467	13,146,527 - 13,151,109 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955467	13,146,527 - 13,151,109 (+)	NCBI	ChiLan1.0	ChiLan1.0

TAX1BP3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	11,274,594 - 11,280,369 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	13,240,101 - 13,245,815 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	3,713,211 - 3,718,959 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	3,709,600 - 3,715,342 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	3,709,600 - 3,715,342 (-)	Ensembl	panpan1.1		panPan2

TAX1BP3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	47,492,371 - 47,497,298 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	47,493,069 - 47,497,203 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	46,654,625 - 46,659,564 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	48,337,717 - 48,342,666 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	48,337,720 - 48,342,619 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	47,115,492 - 47,120,433 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	47,404,610 - 47,409,549 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	47,460,236 - 47,465,179 (-)	NCBI		UU_Cfam_GSD_1.0

TAX1BP3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	49,754,166 - 49,759,412 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	49,754,162 - 49,759,026 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	51,614,252 - 51,619,116 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TAX1BP3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	3,166,151 - 3,171,292 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666059	18,658,710 - 18,663,867 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tax1bp3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624786	6,318,879 - 6,323,816 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624786	6,318,879 - 6,323,835 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005337302	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000662	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_005337302 ⟹ XP_005337359

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405602	55,533,701 - 55,539,675 (+)	NCBI
SpeTri2.0	NW_004936677	361,300 - 367,234 (-)	NCBI

Sequence:

show sequence

TTAACCAGAGAGGGCGCGGCCGCTGGCATTCTCACTGCGGGCTTCTCTCAGCTGTACTTCGTTG
CTAGATCGGGTCGAGATGTCTTACATCCCGGGCCAGCCGGTCACCGCCGTGGTGCAAAGAGTTG
AAATTCACAAGCTGCGTCAAGGTGAGAACTTAATCTTGGGCTTCAGCATTGGAGGTGGAATTGA
CCAGGATCCCTCTCAAAATCCCTTCTCAGAAGATAAGACAGACAAGGGCATTTATGTCACACGT
GTGTCTGAAGGAGGTCCTGCTGAAATTGCTGGGCTGCAGATTGGAGACAAAATCATGCAGGTGA
ATGGCTGGGACATGACCATGGTCACACATGACCAGGCCCGGAAACGGCTCACCAAGCGCTCAGA
GGAGGTGGTGCGCCTGCTGGTGACGCGGCAGTCGCTGCAGAAGGCCGTGCAGCAGTCCATGCTG
TCCTAGCAGCCCACCTGTGATCCTTACCTTGTGCCTACCTGCCTATTTGTACAGCGACACCACT
TCCACGCTCTCTGCTCCTCCATCCTGGCTTCTGCTGCATGCTGGGTTCCAGCTCAGAAGGGTGA
CAGCTGATCCCAGAGGCCTGAGCCAGTCCTGTTTCCCCTCCCACTCTAGCCCGAGGCTCTGGGA
CCAGTTCTGTCTCTGGGATACTGAGGATTGGAAATAAGGGCCTGGAGCTGAATGAAGCCAGTCT
GCAATGACCAAAGCTCAACCCACTGCTGCTTCAGCAGTGCCTGGGTGAGCAGAAAACACCACTT
TCTGAGAGCTGCCAAAGCTGGGAAATGCCACTCGGGGCTGGCTTTCCCTCATTTGCCCCGGCTG
CAGGGCTTGGCCCTGCCTTCCTATGTCACTTCCACAGTGCCCAAGCCACATGCTGTCCACCCCG
ACATTGCCCAGTGGGGGGCTAGACCCCCCACACGCCTGGAGGCACTAAGAAGGTTCATCTGGAT
GGCAGCTGGTAGCCTCCCATGCACCCTCACTTCCCTGAGGGGTGCTGGCCTCCCCAGGGTTTGC
CTACTTACAGGATTTAGCTGAGGTTCAAACTGACATTTCAGGGCAGCTCTCAGGATTGCCATTT
TTCTCTATGCCTGTGGTTTTACCTTTTGTATTTTTTTACTCACAACTTTGATACACAGTGTTTT
TACCTTACTATTTGGAGATGCCAGTTCTAGTTTTGAGTTTAGCTTACTAATTCACATGTGGGAG
CAACTACTCTTAGCATGTGACCAGCCTTACTTTGGTTACCAAGGAAATGGGGCAGTATGATGCT
GCCCCACTCCCAACATCTCATGTCCAATAAAGATCGCTGGAATTCATGAGGGATCCTTGCTGAG
ACATGGAGTGGAATGGGACAAGTGCTTTGGTTTTAAGGATGGCTAACATGTCTCCCACTGTTCT
GGGACAAAGCCCAACTCTTTTTAGGCCCACCTGCCCGGGAAAGTGTGTGGCTGGTGTTGCCTTA
GAAGCTTTAGTGAGGGCTGAAGTTATAGTGGTAAAGTGCTTCCTGGCACAGGGGAAGCCCTGGT
CCCAGCTCTAGTACCGTGGTGGGTGGTGGAGCCTCAGTGGAAACACCCTGTATGTGGCAAAGGC
CACATCTATGTCTGGGTATACCTTCACTGCAATTAAGGTGAGGAACCTGGGGTGTCACTGTGAA
GCTAGGTTACATAAAGGAAGTTGGGGGTACTTCAGTGTAACCTACCTTCAGTTCCCACCTGAGA
GGGGCCTCATGGGCACTCTAGGGTTCATGGGAAAAGCATCTGCCCCTGAGACTCTAGACAGTTT
TGATCCACAGCCAGGGACATAACCCTGGATGTTCCCACAAGTCGAGAGTAGCTAGGTAGTAAGC
AGTGAGTGTCTAGTCCTCTGCCTACTAGCTCTGAGAAGGTGCTGCCACTTCTGGATCCACCTTA
CATTGCCAAATCAGATTTGTGAAGGAAAGTCCAGAATTTGAAATCTCCTATTTTTAAAGTGCAA
TACCCAAGGACATATTTTATAAAAATCTCTGGGTGGCCTAAATAAAACCGGTCTATAGGT

hide sequence

Protein Sequences


Protein RefSeqs	XP_005337359	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000017212.2
	ENSSTOP00000027677.1
GenBank Protein	KAG3270166	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005337359 ⟸ XM_005337302
- UniProtKB:	A0A287D2C6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSYIPGQPVTAVVQRVEIHKLRQGENLILGFSIGGGIDQDPSQNPFSEDKTDKGIYVTRVSEGG PAEIAGLQIGDKIMQVNGWDMTMVTHDQARKRLTKRSEEVVRLLVTRQSLQKAVQQSMLS hide sequence

Protein Domains

PDZ

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000022920	UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000022394.2	UniProtKB/TrEMBL
	ENSSTOT00000031606.1	UniProtKB/TrEMBL
Gene3D-CATH	2.30.42.10	UniProtKB/TrEMBL
InterPro	PDZ	UniProtKB/TrEMBL
	PDZ_sf	UniProtKB/TrEMBL
	Synaptic_Scaffolding_LAP-MAGUK	UniProtKB/TrEMBL
	Tax1-binding_p3	UniProtKB/TrEMBL
NCBI Gene	Tax1bp3	ENTREZGENE
PANTHER	DISCS LARGE	UniProtKB/TrEMBL
	PDZ DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
Pfam	PDZ	UniProtKB/TrEMBL
PIRSF	Tax1-binding_p3	UniProtKB/TrEMBL
PROSITE	PDZ	UniProtKB/TrEMBL
SMART	PDZ	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50156	UniProtKB/TrEMBL
UniProt	A0A287D2C6	ENTREZGENE, UniProtKB/TrEMBL
	I3MYL6_ICTTR	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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