Ovol2 (ovo like zinc finger 2) - Rat Genome Database

Name: Ovol2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Ovol2 (ovo like zinc finger 2) Ictidomys tridecemlineatus

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Symbol:

Ovol2

Name:

ovo like zinc finger 2

RGD ID:

12653642

Description:

ENCODES a protein that exhibits transcription cis-regulatory region binding (ortholog); INVOLVED IN angiogenesis (ortholog); cell population proliferation (ortholog); dorsal/ventral pattern formation (ortholog); ASSOCIATED WITH congenital dyserythropoietic anemia type II (ortholog); familial hyperinsulinemic hypoglycemia 1 (ortholog); pilomatrixoma (ortholog); FOUND IN nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

ovo-like 2; transcription factor Ovo-like 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	OVOL2 (ovo like zinc finger 2)	NCBI	Ortholog
Mus musculus (house mouse):	Ovol2 (ovo like zinc finger 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Ovol2 (ovo-like zinc finger 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ovol2 (ovo like zinc finger 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	OVOL2 (ovo like zinc finger 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	OVOL2 (ovo like zinc finger 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	OVOL2 (ovo like zinc finger 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	OVOL2 (ovo like zinc finger 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ovol2 (ovo like zinc finger 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	153,663,620 - 153,696,671 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936485	2,096,495 - 2,128,540 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936485	2,096,495 - 2,128,002 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital dyserythropoietic anemia type II (ISO)

familial hyperinsulinemic hypoglycemia 1 (ISO)

pilomatrixoma (ISO)

posterior polymorphous corneal dystrophy 1 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

angiogenesis (IEA,ISO)

cell population proliferation (IEA,ISO)

dorsal/ventral pattern formation (IEA,ISO)

embryonic digestive tract morphogenesis (IEA,ISO)

endocardium formation (IEA,ISO)

epidermal cell differentiation (IEA)

epidermis development (IEA,ISO)

heart development (IEA,ISO)

heart looping (IEA,ISO)

heart trabecula formation (IEA,ISO)

labyrinthine layer blood vessel development (IEA,ISO)

negative regulation of cell population proliferation (IEA,ISO)

negative regulation of epithelial to mesenchymal transition (IEA)

negative regulation of gene expression (IEA)

negative regulation of keratinocyte differentiation (ISO)

negative regulation of Notch signaling pathway (ISO)

negative regulation of SMAD protein signal transduction (IEA)

negative regulation of stem cell proliferation (IEA,ISO)

negative regulation of transcription by competitive promoter binding (ISO)

negative regulation of transcription by RNA polymerase II (IEA)

negative regulation of transforming growth factor beta receptor signaling pathway (IEA)

neural crest cell migration (IEA,ISO)

neural fold formation (IEA,ISO)

positive regulation of gene expression (IEA)

positive regulation of keratinocyte differentiation (IEA,ISO)

positive regulation of transcription by RNA polymerase II (IEA)

regulation of cell cycle (ISO)

regulation of keratinocyte proliferation (IEA)

regulation of transcription by RNA polymerase II (IEA)

Cellular Component

nucleus (IEA)

Molecular Function

chromatin binding (IEA)

DNA binding (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IEA)

DNA-binding transcription repressor activity, RNA polymerase II-specific (IEA)

metal ion binding (IEA)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IEA)

sequence-specific double-stranded DNA binding (IEA)

transcription cis-regulatory region binding (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Ovol2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	153,663,620 - 153,696,671 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936485	2,096,495 - 2,128,540 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936485	2,096,495 - 2,128,002 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

OVOL2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	18,024,152 - 18,059,188 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	17,956,979 - 18,059,188 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	18,004,796 - 18,039,832 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	17,952,796 - 17,986,521 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	17,952,795 - 17,986,521	NCBI
Celera	20	18,079,347 - 18,113,079 (-)	NCBI		Celera
Cytogenetic Map	20	p11.23	NCBI
HuRef	20	17,967,242 - 18,001,367 (-)	NCBI		HuRef
CHM1_1	20	18,004,853 - 18,038,551 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	18,075,263 - 18,110,299 (-)	NCBI		T2T-CHM13v2.0

Ovol2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	144,147,095 - 144,174,000 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	144,147,095 - 144,174,066 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	144,305,175 - 144,332,080 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	144,305,175 - 144,332,146 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	144,130,911 - 144,157,816 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	143,996,616 - 144,023,521 (-)	NCBI		MGSCv36	mm8
Celera	2	145,493,569 - 145,520,509 (-)	NCBI		Celera
Cytogenetic Map	2	G1	NCBI
cM Map	2	70.99	NCBI

Ovol2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	152,130,767 - 152,160,487 (-)	NCBI		GRCr8
mRatBN7.2	3	131,677,391 - 131,707,123 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	131,677,391 - 131,708,359 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	135,601,228 - 135,630,393 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	144,185,320 - 144,214,479 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	141,888,510 - 141,917,671 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	138,433,990 - 138,464,511 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	138,433,990 - 138,462,063 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	144,867,735 - 144,898,199 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	132,842,267 - 132,871,206 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	132,747,836 - 132,777,519 (-)	NCBI
Celera	3	130,572,320 - 130,601,420 (-)	NCBI		Celera
Cytogenetic Map	3	q41	NCBI

Ovol2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	26,825,284 - 26,843,438 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955415	26,825,284 - 26,843,438 (-)	NCBI	ChiLan1.0	ChiLan1.0

OVOL2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	18,914,381 - 18,950,868 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	18,911,219 - 18,947,699 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	17,983,277 - 18,019,441 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	17,961,749 - 17,996,364 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	17,962,123 - 17,994,486 (-)	Ensembl	panpan1.1		panPan2

OVOL2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	5,020,608 - 5,050,487 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	5,020,813 - 5,050,309 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	4,949,757 - 4,980,761 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	5,427,079 - 5,458,074 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	5,428,834 - 5,457,893 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	5,039,068 - 5,070,261 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	5,133,467 - 5,164,662 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	5,409,939 - 5,440,959 (+)	NCBI		UU_Cfam_GSD_1.0

OVOL2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	26,417,795 - 26,451,928 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	26,417,793 - 26,451,707 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	29,918,120 - 29,956,051 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

OVOL2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	47,082,294 - 47,118,880 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	47,082,167 - 47,117,521 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666078	1,750,940 - 1,797,786 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ovol2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624741	18,995,246 - 19,012,910 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624741	18,994,689 - 19,012,381 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005320446	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010003700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000028405 ⟹ ENSSTOP00000018022

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936485	2,096,495 - 2,128,540 (+)	Ensembl

RefSeq Acc Id:

XM_005320446 ⟹ XP_005320503

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	153,663,620 - 153,696,671 (+)	NCBI
SpeTri2.0	NW_004936485	2,096,495 - 2,128,002 (+)	NCBI

Sequence:

show sequence

AAACTTTTTTCCCGGCGTGGTCTCACCCGCGATTTAAGGCTTAGGTGTCGCCAAGCCCAGAGGC
TGGGAGTCTCCGGGAGTGCGGGGGAGAGGCCCGGGCAACGCCGCGGCGGGGGGGAGAGGAAGAG
GGCAGGCGAGGCGGGAAGGTGGGCTCTGACCGCCGGGAGCTGGGGACCCAGCCGCCACCTCAGC
CCCTAGCGGGAAGCAGTCGAGAGGAGGGGGCCTCAGCCTGGCAAAGGGACCCCACCATGCCCAA
AGTCTTCCTGGTGAAGAGGAGGAGCCCGGGAGTCACGGTCCGCAGCTGGGATGAGCTCCCGGAT
GAAAAAAGGGCAGACGCTTACATCCCAGTGGTCCTGGGCTGTCTGCTCCACGATCCCCCCGAGG
ACTGCCGCAGCGACGGCGGCAGCAGCAGCGGCGGCGGCAGCAGCAGCAGCGCCGGGGAACCTGG
AGGCGCCGAGAGCAGCTTGTCCCCGCGCGCCCTGGAGCGCGAAACCCCCGAGCCCCGCGACGCC
GAGGACCCAGATGGACACTTGGCAGCAAAGCAGCGCCCGGTTGCCAGGTCAAAAATCAAGTACA
CCACAGGCACGTGCAATGATTCAGTGATTCACAGCTGTGACCTGTGTGGCAAAGGCTTCCGCCT
GCAGCGCATGCTCAACCGTCACCTCAAGTGCCACAACCAGGTAAAGAGACACCTGTGCACCTTC
TGTGGCAAGGGCTTCAACGACACCTTTGACCTGAAGAGGCATGTCCGCACACACACAGGCATCC
GCCCCTACAAATGTGACATCTGCAACAAAGCCTTCACCCAGCGCTGCTCCCTGGAGTCCCACCT
GAAGAAAATCCACGGGGTGCAGCAGCAGTATGCCTACAAGCAACGTCGGGACAAACTCTACGTC
TGTGAGGATTGTGGCTACACAGGCCCCACGCAGGAGGACCTGTACCTCCACGTGAACAGTGCCC
ACCCGGGCAGCACGTTTCTCAAAAAGACATCCAAAAAGTTGGCAGCCCTTTTGCAGAGCAAGCT
GATGTCCACACACCAGGAAAATACCCTCCTGAGTGGGGAAGAGGAGAAGAAATGAGGAGGATGA
GGAAGGGAAAGAGAAATGCTAGTGCCGCCATGTTTATTGGGACTTGGTTTGGAGGCTGTCATAC
CCTCCCTTCATCCAACTGGCT

hide sequence

Protein Sequences


Protein RefSeqs	XP_005320503	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000018022.1
GenBank Protein	KAG3262799	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005320503 ⟸ XM_005320446

- UniProtKB:

I3N0X6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPKVFLVKRRSPGVTVRSWDELPDEKRADAYIPVVLGCLLHDPPEDCRSDGGSSSGGGSSSSAG
EPGGAESSLSPRALERETPEPRDAEDPDGHLAAKQRPVARSKIKYTTGTCNDSVIHSCDLCGKG
FRLQRMLNRHLKCHNQVKRHLCTFCGKGFNDTFDLKRHVRTHTGIRPYKCDICNKAFTQRCSLE
SHLKKIHGVQQQYAYKQRRDKLYVCEDCGYTGPTQEDLYLHVNSAHPGSTFLKKTSKKLAALLQ
SKLMSTHQENTLLSGEEEKK

hide sequence

Ensembl Acc Id:

ENSSTOP00000018022 ⟸ ENSSTOT00000028405

Protein Domains

C2H2-type

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000024979	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000028405.2	UniProtKB/TrEMBL
Gene3D-CATH	Classic Zinc Finger	UniProtKB/TrEMBL
InterPro	Ovo-like	UniProtKB/TrEMBL
	Znf_C2H2_sf	UniProtKB/TrEMBL
	Znf_C2H2_type	UniProtKB/TrEMBL
NCBI Gene	Ovol2	ENTREZGENE
PANTHER	PTHR10032	UniProtKB/TrEMBL
	TRANSCRIPTION FACTOR OVO-LIKE 2	UniProtKB/TrEMBL
Pfam	zf-C2H2	UniProtKB/TrEMBL
	zf-C2H2_4	UniProtKB/TrEMBL
	zf-C2H2_6	UniProtKB/TrEMBL
PROSITE	ZINC_FINGER_C2H2_1	UniProtKB/TrEMBL
	ZINC_FINGER_C2H2_2	UniProtKB/TrEMBL
SMART	ZnF_C2H2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57667	UniProtKB/TrEMBL
UniProt	I3N0X6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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