Uros (uroporphyrinogen III synthase) - Rat Genome Database

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Gene: Uros (uroporphyrinogen III synthase) Ictidomys tridecemlineatus
Analyze
Symbol: Uros
Name: uroporphyrinogen III synthase
RGD ID: 12651030
Description: ENCODES a protein that exhibits folic acid binding (ortholog); uroporphyrinogen-III synthase activity (ortholog); INVOLVED IN cellular response to amine stimulus (ortholog); cellular response to arsenic-containing substance (ortholog); porphyrin-containing compound biosynthetic process (ortholog); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; heme biosynthetic pathway; ASSOCIATED WITH cutaneous porphyria (ortholog); FOUND IN cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: uroporphyrinogen III synthase, transcript variant X1; uroporphyrinogen III synthase, transcript variant X2; uroporphyrinogen-III synthase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721311,744,646 - 11,770,000 (+)NCBI
SpeTri2.0NW_00493648613,792,354 - 13,816,744 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (ISO)

Molecular Function

References

Genomics

Comparative Map Data
Uros
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721311,744,646 - 11,770,000 (+)NCBI
SpeTri2.0NW_00493648613,792,354 - 13,816,744 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UROS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810125,784,980 - 125,823,258 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl10125,784,980 - 125,823,258 (-)EnsemblGRCh38hg38GRCh38
GRCh3710127,473,549 - 127,511,827 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610127,467,142 - 127,501,757 (-)NCBINCBI36hg18NCBI36
Build 3410127,467,141 - 127,501,757NCBI
Celera10121,252,582 - 121,287,272 (-)NCBI
Cytogenetic Map10q26.2NCBI
HuRef10121,166,434 - 121,201,129 (-)NCBIHuRef
CHM1_110127,758,882 - 127,793,568 (-)NCBICHM1_1
T2T-CHM13v2.010126,667,433 - 126,705,719 (-)NCBI
Uros
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397133,287,871 - 133,312,176 (-)NCBIGRCm39mm39
GRCm39 Ensembl7133,287,972 - 133,311,801 (-)Ensembl
GRCm387133,686,142 - 133,710,467 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7133,686,243 - 133,710,072 (-)EnsemblGRCm38mm10GRCm38
MGSCv377140,878,013 - 140,900,978 (-)NCBIGRCm37mm9NCBIm37
MGSCv367133,524,673 - 133,547,638 (-)NCBImm8
Celera7133,491,254 - 133,514,229 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map777.26NCBI
Uros
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21188,490,832 - 188,513,659 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1188,490,323 - 188,512,249 (-)Ensembl
Rnor_6.01205,755,766 - 205,778,170 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1205,756,640 - 205,777,167 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01212,704,834 - 212,727,235 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41193,184,946 - 193,205,475 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11193,334,828 - 193,355,356 (-)NCBI
Celera1186,229,349 - 186,249,866 (-)NCBICelera
Cytogenetic Map1q41NCBI
Uros
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554773,673,532 - 3,707,760 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554773,673,583 - 3,707,761 (-)NCBIChiLan1.0ChiLan1.0
UROS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110126,610,621 - 126,648,363 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10126,613,732 - 126,648,363 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v010122,346,072 - 122,384,405 (-)NCBIMhudiblu_PPA_v0panPan3
UROS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12834,952,074 - 34,983,532 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2834,948,003 - 34,983,532 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2835,010,678 - 35,042,131 (-)NCBI
ROS_Cfam_1.02835,509,930 - 35,540,636 (-)NCBI
ROS_Cfam_1.0 Ensembl2835,504,435 - 35,540,634 (-)Ensembl
UMICH_Zoey_3.12835,063,739 - 35,095,183 (-)NCBI
UNSW_CanFamBas_1.02835,055,275 - 35,086,722 (-)NCBI
UU_Cfam_GSD_1.02835,315,163 - 35,346,614 (-)NCBI
UROS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14135,055,538 - 135,131,074 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114135,101,609 - 135,131,082 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214146,730,875 - 146,760,513 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UROS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19118,405,674 - 118,450,544 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl9118,410,802 - 118,440,915 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604879,769,188 - 79,808,154 (-)NCBIVero_WHO_p1.0
Uros
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473721,340,193 - 21,383,452 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005320763   ⟹   XP_005320820
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721311,744,646 - 11,769,099 (+)NCBI
SpeTri2.0NW_00493648613,792,354 - 13,816,742 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013356603   ⟹   XP_013212057
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721311,744,646 - 11,769,099 (+)NCBI
SpeTri2.0NW_00493648613,792,354 - 13,816,744 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040272422   ⟹   XP_040128356
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721311,750,027 - 11,770,000 (+)NCBI
RefSeq Acc Id: XM_040272423   ⟹   XP_040128357
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721311,750,027 - 11,770,000 (+)NCBI
RefSeq Acc Id: XM_040272424   ⟹   XP_040128358
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721311,744,646 - 11,762,787 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_013212057   ⟸   XM_013356603
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005320820   ⟸   XM_005320763
- Peptide Label: isoform X1
- UniProtKB: I3MI16 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040128358   ⟸   XM_040272424
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040128356   ⟸   XM_040272422
- Peptide Label: isoform X1
RefSeq Acc Id: XP_040128357   ⟸   XM_040272423
- Peptide Label: isoform X2
Protein Domains
HEM4


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000011820 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000010599 ENTREZGENE, UniProtKB/TrEMBL
  ENSSTOP00000027953 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000011818 UniProtKB/TrEMBL
  ENSSTOT00000032611 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10090 UniProtKB/TrEMBL
InterPro 4pyrrol_syn_uPrphyn_synt_sf UniProtKB/TrEMBL
  4pyrrol_synth_uPrphyn_synth UniProtKB/TrEMBL
  UROS/Hem4 UniProtKB/TrEMBL
NCBI Gene Uros ENTREZGENE
PANTHER PTHR12390 UniProtKB/TrEMBL
Pfam HEM4 UniProtKB/TrEMBL
Superfamily-SCOP SSF69618 UniProtKB/TrEMBL
UniProt A0A287D323_ICTTR UniProtKB/TrEMBL
  I3MI16 ENTREZGENE, UniProtKB/TrEMBL