Epha2 (EPH receptor A2) - Rat Genome Database

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Pathways
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Gene: Epha2 (EPH receptor A2) Ictidomys tridecemlineatus
Analyze
Symbol: Epha2
Name: EPH receptor A2
RGD ID: 12649622
Description: ENCODES a protein that exhibits molecular function activator activity (ortholog); INVOLVED IN axial mesoderm formation (ortholog); blood vessel development (ortholog); blood vessel endothelial cell proliferation involved in sprouting angiogenesis (ortholog); PARTICIPATES IN E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH cataract (ortholog); cataract 6 multiple types (ortholog); chromosome 1p36 deletion syndrome (ortholog); FOUND IN cell surface (inferred); dendrite (inferred); focal adhesion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ephrin type-A receptor 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505837,823,596 - 37,849,129 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364743,648,550 - 3,673,861 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364743,648,395 - 3,673,856 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axial mesoderm formation  (IEA,ISO)
axon guidance  (IEA)
blood vessel development  (IEA,ISO)
blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IEA,ISO)
blood vessel morphogenesis  (IEA,ISO)
bone remodeling  (IEA)
branching involved in mammary gland duct morphogenesis  (IEA)
cAMP metabolic process  (IEA)
cell chemotaxis  (IEA)
cell migration  (IEA)
cell motility  (IEA)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA)
defense response to Gram-positive bacterium  (IEA,ISO)
ephrin receptor signaling pathway  (IEA,ISO)
inflammatory response  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (IEA)
keratinocyte differentiation  (IEA)
lens fiber cell morphogenesis  (IEA)
mammary gland epithelial cell proliferation  (IEA)
negative regulation of angiogenesis  (IEA,ISO)
negative regulation of chemokine production  (IEA,ISO)
negative regulation of cytokine production  (IEA,ISO)
negative regulation of lymphangiogenesis  (IEA,ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
neural tube development  (IEA,ISO)
neuron differentiation  (IEA,ISO)
notochord cell development  (IEA,ISO)
notochord formation  (IEA,ISO)
notochord morphogenesis  (IEA,ISO)
osteoblast differentiation  (IEA)
osteoclast differentiation  (IEA)
pericyte cell differentiation  (IEA,ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of bicellular tight junction assembly  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of protein localization to plasma membrane  (IEA)
post-anal tail morphogenesis  (IEA,ISO)
protein localization to plasma membrane  (IEA)
regulation of angiogenesis  (IEA)
regulation of blood vessel endothelial cell migration  (IEA)
regulation of cell adhesion mediated by integrin  (IEA)
regulation of ERK1 and ERK2 cascade  (IEA)
regulation of lamellipodium assembly  (IEA)
response to growth factor  (IEA)
skeletal system development  (IEA,ISO)
vasculogenesis  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Epha2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505837,823,596 - 37,849,129 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364743,648,550 - 3,673,861 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364743,648,395 - 3,673,856 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPHA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38116,124,337 - 16,156,069 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl116,124,337 - 16,156,069 (-)EnsemblGRCh38hg38GRCh38
GRCh37116,450,832 - 16,482,564 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,323,419 - 16,355,151 (-)NCBINCBI36Build 36hg18NCBI36
Build 34116,196,138 - 16,227,870NCBI
Celera114,930,817 - 14,962,560 (-)NCBICelera
Cytogenetic Map1p36.13NCBI
HuRef114,968,749 - 15,000,153 (-)NCBIHuRef
CHM1_1116,249,454 - 16,281,203 (-)NCBICHM1_1
T2T-CHM13v2.0115,565,745 - 15,597,465 (-)NCBIT2T-CHM13v2.0
Epha2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394141,028,532 - 141,056,695 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4141,028,551 - 141,056,695 (+)EnsemblGRCm39 Ensembl
GRCm384141,301,221 - 141,329,384 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4141,301,240 - 141,329,384 (+)EnsemblGRCm38mm10GRCm38
MGSCv374140,857,155 - 140,885,293 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364140,573,316 - 140,601,454 (+)NCBIMGSCv36mm8
Celera4143,116,872 - 143,145,199 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map473.67NCBI
Epha2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85158,888,629 - 158,917,100 (+)NCBIGRCr8
mRatBN7.25153,605,644 - 153,634,115 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5153,605,644 - 153,634,117 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5156,294,648 - 156,322,973 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05158,067,931 - 158,096,260 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05158,057,120 - 158,085,441 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05159,845,773 - 159,874,203 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5159,845,774 - 159,874,206 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05163,558,669 - 163,586,206 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45160,185,143 - 160,214,727 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15160,190,327 - 160,224,048 (+)NCBI
Celera5151,971,932 - 152,000,092 (+)NCBICelera
Cytogenetic Map5q36NCBI
Epha2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555272,120,266 - 2,152,781 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555272,120,447 - 2,151,932 (+)NCBIChiLan1.0ChiLan1.0
EPHA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21210,765,451 - 210,798,549 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11210,014,072 - 210,047,154 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0115,259,915 - 15,292,983 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1116,253,509 - 16,284,787 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl116,253,513 - 16,284,787 (-)Ensemblpanpan1.1panPan2
EPHA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1281,534,130 - 81,561,722 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl281,534,125 - 81,561,725 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,070,108 - 78,097,636 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0282,179,960 - 82,207,481 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl282,179,892 - 82,207,484 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1278,933,025 - 78,960,551 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0279,950,185 - 79,977,704 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0281,018,093 - 81,045,632 (+)NCBIUU_Cfam_GSD_1.0
EPHA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl675,251,467 - 75,279,314 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1675,251,465 - 75,279,364 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2669,567,147 - 69,595,017 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EPHA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120116,147,077 - 116,178,647 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20116,147,040 - 116,178,644 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605419,643,306 - 19,675,426 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Epha2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247642,264,945 - 2,296,197 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247642,265,114 - 2,296,032 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000003096   ⟹   ENSSTOP00000002767
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364743,648,550 - 3,673,861 (-)Ensembl
RefSeq Acc Id: XM_040289150   ⟹   XP_040145084
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505837,823,596 - 37,849,129 (-)NCBI
Protein Sequences
Protein RefSeqs XP_040145084 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000002767.3
GenBank Protein KAG3282237 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_040145084   ⟸   XM_040289150
- UniProtKB: I3M1N8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000002767   ⟸   ENSSTOT00000003096
Protein Domains
Eph LBD   Fibronectin type-III   Protein kinase   SAM


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000003080 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000003096.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  ephrin a2 ectodomain UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/TrEMBL
  Single helix bin UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
  Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/TrEMBL
InterPro Eph_TM UniProtKB/TrEMBL
  EphA2_rcpt_lig-bd UniProtKB/TrEMBL
  Ephrin_rcpt_lig-bd_dom UniProtKB/TrEMBL
  FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_ephrin_rcpt UniProtKB/TrEMBL
  Tyr_kinase_rcpt_V_CS UniProtKB/TrEMBL
NCBI Gene Epha2 ENTREZGENE
PANTHER EPH RECEPTOR A5 UniProtKB/TrEMBL
  EPHRIN TYPE-A RECEPTOR 3 UniProtKB/TrEMBL
Pfam EphA2_TM UniProtKB/TrEMBL
  Ephrin_lbd UniProtKB/TrEMBL
  fn3 UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  SAM_1 UniProtKB/TrEMBL
PIRSF TyrPK_ephrin_receptor UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE EPH_LBD UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_V_1 UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_V_2 UniProtKB/TrEMBL
  SAM_DOMAIN UniProtKB/TrEMBL
SMART EPH_lbd UniProtKB/TrEMBL
  Ephrin_rec_like UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF47769 UniProtKB/TrEMBL
  SSF49265 UniProtKB/TrEMBL
  SSF49785 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt I3M1N8 ENTREZGENE, UniProtKB/TrEMBL