Cdk8 (cyclin dependent kinase 8) - Rat Genome Database

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Gene: Cdk8 (cyclin dependent kinase 8) Ictidomys tridecemlineatus
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Symbol: Cdk8
Name: cyclin dependent kinase 8
RGD ID: 12645045
Description: ENCODES a protein that exhibits ubiquitin protein ligase activity (ortholog); INVOLVED IN negative regulation of triglyceride metabolic process (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); protein ubiquitination (ortholog); PARTICIPATES IN RNA polymerase II transcription pathway; ASSOCIATED WITH dilated cardiomyopathy (ortholog); Ebstein anomaly (ortholog); genetic disease (ortholog); FOUND IN CKM complex (ortholog); cyclin-dependent protein kinase holoenzyme complex (ortholog); mediator complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cyclin dependent kinase 8, transcript variant X1; cyclin dependent kinase 8, transcript variant X10; cyclin dependent kinase 8, transcript variant X2; cyclin dependent kinase 8, transcript variant X6; cyclin dependent kinase 8, transcript variant X7; cyclin dependent kinase 8, transcript variant X8; cyclin dependent kinase 8, transcript variant X9; cyclin-dependent kinase 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945114,926,309 - 115,028,565 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493694891,578 - 236,051 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Cdk8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945114,926,309 - 115,028,565 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493694891,578 - 236,051 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDK8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381326,254,129 - 26,405,238 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1326,254,104 - 26,420,982 (+)EnsemblGRCh38hg38GRCh38
GRCh371326,828,266 - 26,979,375 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361325,726,756 - 25,876,569 (+)NCBINCBI36Build 36hg18NCBI36
Build 341325,726,755 - 25,876,569NCBI
Celera137,896,857 - 8,046,682 (+)NCBICelera
Cytogenetic Map13q12.13NCBI
HuRef137,646,374 - 7,796,038 (+)NCBIHuRef
CHM1_11326,796,796 - 26,946,621 (+)NCBICHM1_1
T2T-CHM13v2.01325,467,904 - 25,619,002 (+)NCBIT2T-CHM13v2.0
Cdk8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395146,167,432 - 146,239,684 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5146,168,040 - 146,239,684 (+)EnsemblGRCm39 Ensembl
GRCm385146,230,795 - 146,302,874 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5146,231,230 - 146,302,874 (+)EnsemblGRCm38mm10GRCm38
MGSCv375147,043,251 - 147,114,450 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365146,535,913 - 146,607,053 (+)NCBIMGSCv36mm8
Celera5144,210,649 - 144,281,842 (+)NCBICelera
Cytogenetic Map5G3NCBI
cM Map585.19NCBI
Cdk8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81213,851,024 - 13,919,017 (-)NCBIGRCr8
mRatBN7.2128,737,198 - 8,805,026 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl128,737,262 - 8,804,177 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx129,534,947 - 9,601,599 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01210,158,140 - 10,224,798 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,181,585 - 9,248,239 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01210,496,273 - 10,561,335 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01212,597,402 - 12,663,842 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4129,215,964 - 9,254,015 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1210,565,691 - 10,631,673 (-)NCBICelera
Cytogenetic Map12p11NCBI
Cdk8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554975,781,237 - 5,908,374 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554975,781,237 - 5,908,072 (+)NCBIChiLan1.0ChiLan1.0
CDK8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21425,853,105 - 26,004,531 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11316,962,029 - 17,112,677 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0137,546,922 - 7,698,079 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11325,895,353 - 26,046,120 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1325,895,705 - 26,046,120 (+)Ensemblpanpan1.1panPan2
CDK8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12513,043,949 - 13,179,752 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2513,045,343 - 13,179,656 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2513,114,192 - 13,250,035 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02513,179,325 - 13,315,182 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2513,180,701 - 13,315,567 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12513,063,086 - 13,198,906 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02513,055,645 - 13,191,566 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02513,106,469 - 13,242,317 (-)NCBIUU_Cfam_GSD_1.0
CDK8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl114,054,442 - 4,161,481 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1114,054,442 - 4,161,501 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2113,493,422 - 3,545,124 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDK8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.135,505,532 - 5,652,527 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl35,505,625 - 5,651,366 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605738,774,603 - 38,922,173 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdk8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477612,157,892 - 12,325,081 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477612,114,277 - 12,324,481 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: XM_005342040   ⟹   XP_005342097
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404945114,926,314 - 115,028,565 (+)NCBI
SpeTri2.0NW_00493694891,578 - 193,676 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005342041   ⟹   XP_005342098
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404945114,926,312 - 115,028,565 (+)NCBI
SpeTri2.0NW_00493694891,578 - 193,676 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013366050   ⟹   XP_013221504
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404945114,926,832 - 115,028,565 (+)NCBI
SpeTri2.0NW_00493694892,180 - 192,956 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013366052   ⟹   XP_013221506
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404945114,949,574 - 115,028,565 (+)NCBI
SpeTri2.0NW_004936948114,840 - 192,956 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021721268   ⟹   XP_021576943
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404945114,926,731 - 115,028,565 (+)NCBI
SpeTri2.0NW_00493694891,593 - 192,956 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021721269   ⟹   XP_021576944
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404945114,926,841 - 115,028,565 (+)NCBI
SpeTri2.0NW_00493694892,149 - 192,956 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021721270   ⟹   XP_021576945
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404945114,926,309 - 115,028,565 (+)NCBI
SpeTri2.0NW_00493694891,578 - 193,676 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040281267   ⟹   XP_040137201
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404945114,990,883 - 115,028,565 (+)NCBI
RefSeq Acc Id: XM_040281268   ⟹   XP_040137202
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404945114,990,878 - 115,028,565 (+)NCBI
RefSeq Acc Id: XM_040281269   ⟹   XP_040137203
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404945114,989,113 - 115,028,565 (+)NCBI
RefSeq Acc Id: XP_005342097   ⟸   XM_005342040
- Peptide Label: isoform X1
- UniProtKB: I3MRT5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005342098   ⟸   XM_005342041
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013221504   ⟸   XM_013366050
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_013221506   ⟸   XM_013366052
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_021576945   ⟸   XM_021721270
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_021576943   ⟸   XM_021721268
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_021576944   ⟸   XM_021721269
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_040137203   ⟸   XM_040281269
- Peptide Label: isoform X5
RefSeq Acc Id: XP_040137202   ⟸   XM_040281268
- Peptide Label: isoform X5
RefSeq Acc Id: XP_040137201   ⟸   XM_040281267
- Peptide Label: isoform X5
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000016568 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000016571.3 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Cdk8 ENTREZGENE
PANTHER CELL DIVISION PROTEIN KINASE UniProtKB/TrEMBL
  CYCLIN-DEPENDENT KINASE 8 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt I3MRT5 ENTREZGENE, UniProtKB/TrEMBL