Degs2 (delta 4-desaturase, sphingolipid 2)

Gene: Degs2 (delta 4-desaturase, sphingolipid 2) Ictidomys tridecemlineatus

Analyze

Symbol:

Degs2

Name:

delta 4-desaturase, sphingolipid 2

RGD ID:

12640828

Description:

ENCODES a protein that exhibits oxidoreductase activity (inferred); oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (inferred); sphingolipid delta-4 desaturase activity (inferred); INVOLVED IN sphinganine metabolic process (ortholog); sphingolipid biosynthetic process (ortholog); PARTICIPATES IN Fabry disease pathway; Gaucher's disease pathway; Krabbe disease pathway; ASSOCIATED WITH genetic disease (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

sphingolipid delta(4)-desaturase/C4-hydroxylase DES2; sphingolipid delta(4)-desaturase/C4-monooxygenase DES2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	6,211,662 - 6,260,794 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936604	3,817,886 - 3,839,986 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936604	3,821,672 - 3,839,975 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

ceramide biosynthetic process (IEA)

lipid metabolic process (IEA)

sphinganine metabolic process (IEA,ISO)

sphingolipid biosynthetic process (IEA,ISO)

Cellular Component

endoplasmic reticulum (IEA)

endoplasmic reticulum membrane (IEA)

membrane (IEA)

Molecular Function

oxidoreductase activity (IEA)

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (IEA)

sphingolipid delta-4 desaturase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

Fabry disease pathway (ISO)

Gaucher's disease pathway (ISO)

Krabbe disease pathway (ISO)

metachromatic leukodystrophy pathway (ISO)

sphingolipid metabolic pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Degs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	6,211,662 - 6,260,794 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936604	3,817,886 - 3,839,986 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936604	3,821,672 - 3,839,975 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DEGS2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	100,143,957 - 100,166,886 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	100,143,957 - 100,159,645 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	100,610,294 - 100,625,982 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	99,682,509 - 99,695,712 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	99,682,509 - 99,695,712	NCBI
Celera	14	80,667,585 - 80,680,837 (-)	NCBI		Celera
Cytogenetic Map	14	q32.2	NCBI
HuRef	14	80,794,810 - 80,808,042 (-)	NCBI		HuRef
CHM1_1	14	100,550,475 - 100,563,702 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	94,377,005 - 94,399,934 (-)	NCBI		T2T-CHM13v2.0

Degs2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	108,653,051 - 108,668,561 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	108,644,970 - 108,668,570 (-)	Ensembl		GRCm39 Ensembl
GRCm38	12	108,686,792 - 108,702,306 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	108,678,711 - 108,702,315 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	109,925,002 - 109,940,516 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	109,138,034 - 109,150,097 (-)	NCBI		MGSCv36	mm8
Celera	12	109,922,978 - 109,938,475 (-)	NCBI		Celera
Cytogenetic Map	12	F1	NCBI
cM Map	12	59.46	NCBI

Degs2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	133,360,449 - 133,377,677 (-)	NCBI		GRCr8
mRatBN7.2	6	127,596,063 - 127,613,293 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	127,596,071 - 127,613,293 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	127,720,188 - 127,736,719 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	128,015,247 - 128,031,780 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	127,373,386 - 127,390,379 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	132,591,968 - 132,608,600 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	132,591,969 - 132,608,600 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	141,762,044 - 141,778,676 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	133,021,596 - 133,037,633 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	133,028,029 - 133,043,753 (-)	NCBI
Celera	6	125,151,076 - 125,165,766 (-)	NCBI		Celera
Cytogenetic Map	6	q32	NCBI

Degs2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955438	21,300,118 - 21,313,330 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955438	21,300,118 - 21,313,330 (-)	NCBI	ChiLan1.0	ChiLan1.0

DEGS2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	101,300,362 - 101,314,035 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	100,516,856 - 100,530,535 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	80,767,334 - 80,813,506 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	100,086,782 - 100,100,741 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	100,086,782 - 100,100,741 (-)	Ensembl	panpan1.1		panPan2

DEGS2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	68,461,461 - 68,483,685 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	68,462,555 - 68,533,062 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	67,982,593 - 68,003,272 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	68,746,674 - 68,768,529 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	68,745,809 - 68,810,392 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	68,408,727 - 68,430,548 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	68,474,055 - 68,496,021 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	68,871,727 - 68,893,581 (-)	NCBI		UU_Cfam_GSD_1.0

DEGS2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	121,058,105 - 121,076,328 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	121,058,102 - 121,131,612 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	128,592,520 - 128,599,969 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DEGS2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	78,114,950 - 78,128,766 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	78,115,292 - 78,127,831 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666053	65,248,542 - 65,263,548 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Degs2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624734	3,913,169 - 3,926,156 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624734	3,913,159 - 3,925,309 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005333911	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040276246	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010003700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000004479 ⟹ ENSSTOP00000004019

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936604	3,817,886 - 3,839,986 (-)	Ensembl

RefSeq Acc Id:

XM_005333911 ⟹ XP_005333968

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	6,242,481 - 6,260,794 (+)	NCBI
SpeTri2.0	NW_004936604	3,821,672 - 3,839,975 (-)	NCBI

Sequence:

show sequence

CGCGGGCGCCGCGGCAGGTGGAGCAGTTCCGAGCCGCGCGCTGCGCTCCCGGACGCACGATGGG
CAACTGCGCGGGCCGCAGCGACTTCGAGTGGGTCTACACCGACCAGCCGCACACGCAGCGGCGC
AAGGAGATGCTGGCCAAGTACCCGGCCATCAAGGACCTGATGCGGCCAGACCCATATATCAAGT
GGACAGTGACAGGGCTGGTGCTGTCACAGCTGCTGGCCTGCTGGCTGGTGCAGGGGCTGGCCTG
GCGCTGGCTCTTCTTCTGGGCCTATGCCTTTGGCGGCTGCGTGAACCACTCCCTGACGCTGGCC
ATCCACGACATCTCCCACAACACTGCCTTCGGCACCGGCCGCCCTGCCCACAACCGCTGGTTCG
CCATCTTCGCCAACCTGCCCATGGGCGTGCCCTACTCGGCCTCCTTCAAGAAGTACCACGTGGA
CCACCACCGCTACCTGGGCGGCGATGGGCTGGACGTGGACATCCCCACGCGCCTGGAGGGCTGG
CTCTTCTGCACGCCGGCCCGCAAGCTGCTGTGGCTGGTGCTGCAGCCCTTCTTCTACTCGCTGC
GGCCGCTCTGTGTCAACCCCAAGGCCGTGACCCGCATGGAGGTGCTCAACACCCTGGTGCAGCT
GCTGGTCGACGCCGCCATCTTTGCCCTTTGGGGCATCAAGCCTGTGGCCTACCTTCTGGCCAGC
TCCCTGCTGGGCCTGGGCCTGCACCCCATCTCCGGCCACTTCGTGGCTGAGCACTACATGTTCC
TCAAGGGCCACGAGACCTACTCCTACTACGGGCCCCTCAACTGGATCACCTTCAACGTGGGCTA
CCACATGGAGCACCACGACTTCCCCAGCATCCCGGGCTGCAACCTGCCCCTGGTGCGGAAGATC
GCGCCCGAGTACTACGACCACCTGCCGCAGCACCACTCGTGGGTGAAGGTGCTCTGGGATTTTG
TGTTCGAGGACTCCCTGGGACCCTATGCCAGGGTGAAGCGGGTGTGCAAGCTGGCAGAGGACCG
CCTGTGAGCCCTGCCAGGGAGCCTGCGACCCGACCCCGCCCACACTGCCCGGCTGGCTGCTGCT
TCCCCCGTGCCCATGGGCAGTGCCCCAGACGGGTTTGGCTGCTGCATACCCCGTGCGAATGGGC
AGTGCCCCAGTCGGGTTTGGCTGCTGCATCCCCCGTGCCCATGGGCAGTGCCCCAGACGGGTTT
GGCTGCTGCATCCCCCGTGCGCATGGGCAGTGCCCCCAGATGGGTTTGGCTGCATCGATTCTGG
CTTTTGTCCGCAGAGCCCTGGGAGTTGCCATTAGCAGCCATGCCTGTCAACAGTGGGCCCAGGC
TGCATCCTGCTCTGCACAGGGACTCTCAGTGGACCTTTTTGGGCTCAATGGGCAAGGCCTGGCT
CTGCCACCTGGACCAGGGTGCCCTGGGCCCATGATCCCCACGGAGCTGACTTCTCTGGATTCTT
GTGCCCTAAATTAAACCCAGTGCTTGTTTTCATA

hide sequence

RefSeq Acc Id:

XM_040276246 ⟹ XP_040132180

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	6,211,662 - 6,260,794 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005333968	(Get FASTA)	NCBI Sequence Viewer
	XP_040132180	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000004019.2
GenBank Protein	KAG3260375	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005333968 ⟸ XM_005333911
- Peptide Label:	isoform X1
- UniProtKB:	I3M4B7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGNCAGRSDFEWVYTDQPHTQRRKEMLAKYPAIKDLMRPDPYIKWTVTGLVLSQLLACWLVQGL AWRWLFFWAYAFGGCVNHSLTLAIHDISHNTAFGTGRPAHNRWFAIFANLPMGVPYSASFKKYH VDHHRYLGGDGLDVDIPTRLEGWLFCTPARKLLWLVLQPFFYSLRPLCVNPKAVTRMEVLNTLV QLLVDAAIFALWGIKPVAYLLASSLLGLGLHPISGHFVAEHYMFLKGHETYSYYGPLNWITFNV GYHMEHHDFPSIPGCNLPLVRKIAPEYYDHLPQHHSWVKVLWDFVFEDSLGPYARVKRVCKLAE DRL hide sequence

RefSeq Acc Id:	XP_040132180 ⟸ XM_040276246
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSSTOP00000004019 ⟸ ENSSTOT00000004479

Protein Domains

Sphingolipid delta4-desaturase N-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000004491	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000004479.3	UniProtKB/TrEMBL
InterPro	DES1/DES2	UniProtKB/TrEMBL
	FA_desaturase_dom	UniProtKB/TrEMBL
	Sphingolipid_d4-desaturase_N	UniProtKB/TrEMBL
NCBI Gene	Degs2	ENTREZGENE
PANTHER	SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2	UniProtKB/TrEMBL
	SPHINGOLIPID DELTA(4)-DESATURASE/C4-MONOOXYGENASE DES2	UniProtKB/TrEMBL
Pfam	FA_desaturase	UniProtKB/TrEMBL
	Lipid_DES	UniProtKB/TrEMBL
PIRSF	Sphnglp_dlt4_des	UniProtKB/TrEMBL
SMART	Lipid_DES	UniProtKB/TrEMBL
UniProt	I3M4B7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB

Send us a Message

Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB