Gem (GTP binding protein overexpressed in skeletal muscle)

Gene: Gem (GTP binding protein overexpressed in skeletal muscle) Ictidomys tridecemlineatus

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Symbol:

Gem

Name:

GTP binding protein overexpressed in skeletal muscle

RGD ID:

12639659

Description:

ENCODES a protein that exhibits calcium channel regulator activity (inferred); calmodulin binding (inferred); GDP binding (inferred); INVOLVED IN chromosome organization (inferred); metaphase chromosome alignment (inferred); mitotic cell cycle (inferred); ASSOCIATED WITH genetic disease (ortholog); glaucoma (ortholog); megacolon (ortholog); FOUND IN cytoplasmic side of plasma membrane (inferred); midbody (inferred); mitotic spindle (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

GTP-binding protein GEM

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	40,516,800 - 40,530,076 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936544	7,262,629 - 7,275,910 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936544	7,262,629 - 7,275,860 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

glaucoma (ISO)

megacolon (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chromosome organization (IEA)

metaphase chromosome alignment (IEA)

mitotic cell cycle (IEA)

Cellular Component

cytoplasmic side of plasma membrane (IEA)

midbody (IEA)

mitotic spindle (IEA)

nucleus (IEA)

plasma membrane (IEA)

spindle midzone (IEA)

Molecular Function

calcium channel regulator activity (IEA)

calmodulin binding (IEA)

GDP binding (IEA)

GTP binding (IEA)

GTPase activity (IEA)

magnesium ion binding (IEA)

nucleotide binding (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Gem
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	40,516,800 - 40,530,076 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936544	7,262,629 - 7,275,910 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936544	7,262,629 - 7,275,860 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GEM
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	94,249,253 - 94,262,319 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	94,249,253 - 94,262,350 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	95,261,481 - 95,274,547 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	95,330,657 - 95,343,733 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	95,330,662 - 95,343,733	NCBI
Celera	8	91,447,594 - 91,460,660 (-)	NCBI		Celera
Cytogenetic Map	8	q22.1	NCBI
HuRef	8	90,470,565 - 90,483,631 (-)	NCBI		HuRef
CHM1_1	8	95,301,787 - 95,314,853 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	95,374,122 - 95,387,192 (-)	NCBI		T2T-CHM13v2.0

Gem
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	11,702,379 - 11,714,993 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	11,704,457 - 11,714,752 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	11,704,447 - 11,714,993 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	11,704,457 - 11,714,752 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	11,631,594 - 11,642,140 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	11,631,604 - 11,641,899 (+)	NCBI		MGSCv36	mm8
Celera	4	11,515,538 - 11,526,084 (+)	NCBI		Celera
Cytogenetic Map	4	A1	NCBI
cM Map	4	5.34	NCBI

Gem
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	30,011,641 - 30,022,554 (+)	NCBI		GRCr8
mRatBN7.2	5	25,214,309 - 25,225,222 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	25,214,309 - 25,225,222 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	27,339,200 - 27,350,185 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	28,931,944 - 28,942,929 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	28,874,165 - 28,885,140 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	25,339,479 - 25,353,661 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	25,349,928 - 25,353,661 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	30,050,664 - 30,062,666 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	25,809,543 - 26,008,249 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	26,004,470 - 26,008,270 (+)	NCBI
Celera	5	24,546,414 - 24,557,484 (+)	NCBI		Celera
Cytogenetic Map	5	q13	NCBI

Gem
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955417	10,475,822 - 10,487,825 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955417	10,475,967 - 10,486,879 (-)	NCBI	ChiLan1.0	ChiLan1.0

GEM
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	111,582,105 - 111,595,278 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	87,119,098 - 87,132,234 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	90,872,855 - 90,885,969 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	92,817,028 - 92,830,133 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	92,817,028 - 92,830,133 (-)	Ensembl	panpan1.1		panPan2

GEM
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	29	39,016,543 - 39,037,761 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	29	39,025,483 - 39,037,403 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	29	39,177,842 - 39,199,013 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	29	39,220,477 - 39,241,164 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	29	39,229,312 - 39,239,841 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	29	39,234,088 - 39,255,249 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	29	39,229,276 - 39,250,433 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	29	39,670,894 - 39,692,020 (-)	NCBI		UU_Cfam_GSD_1.0

GEM
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	42,458,466 - 42,471,929 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	42,458,591 - 42,471,941 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	45,876,630 - 45,889,986 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GEM
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	89,219,484 - 89,232,788 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	89,218,782 - 89,232,753 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	51,615,735 - 51,629,058 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gem
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624763	1,654,130 - 1,666,540 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624763	1,654,369 - 1,666,538 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005328655	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000362	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000010782 ⟹ ENSSTOP00000009674

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936544	7,262,629 - 7,275,910 (-)	Ensembl

RefSeq Acc Id:

XM_005328655 ⟹ XP_005328712

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405303	40,516,800 - 40,530,076 (+)	NCBI
SpeTri2.0	NW_004936544	7,262,629 - 7,275,860 (-)	NCBI

Sequence:

show sequence

GCGGCTGCAGGCTGCAGGCTCGGACGGCGGGCACAGCGGAGTCTCCCCGTGCTCAGCGGCCCCG
GCATCCCAACGCGGACCCACTCAAGGACGCCCACCCTGCCGGCCCCGCGGAGCCAAGATCCCAC
GATGACTCTAAATAATGTCACCATGCGCCAGGGCACTGTGGGCATGCAGCCACAGCAGCAGCGC
TGGAGCATCCCAGCCGATGGCAGGCATCTGATGGTCCAGAAAGAGCCCCACCCATACAACCATC
GCAACCACCACTCTGCCAACCCTGAGGACCACTGCCGGCGGAGCTGGTCCTCTGACTCTACAGA
CTCTGTCATCTCCTCTGAGTCAGGGAACACCTACTACCGCGTGGTGCTCATAGGGGAGCAGGGG
GTAGGCAAGTCCACCCTGGCCAACATCTTTGCAGGCGTGCACGACAGCCTGGACAGCGACTGCG
AGGTGCTGGGAGAAGATACATATGAGCGCACCCTGATTGTTGATGGGGAAAGTGCCACAATTAT
ACTGCTGGACATGTGGGAAAATAAGGGAGAGAATGAATGGCTCCAAGACCACTGCATGCAAGTC
GGGGACGCCTACCTGATTGTCTACTCCATCACAGATCGAGCGAGCTTTGAGAAGGCATCTGAGT
TGCGAATACAGCTCCGCAGGGCCCGGCAGACAGAGGACATTCCTATCATTTTAGTTGGCAACAA
AAGTGACCTAGTCCGGTGCCGGGAGGTGTCTGTATCAGAAGGGAGAGCATGTGCTGTGGTGTTC
GACTGCAAGTTCATTGAGACCTCAGCGGCTGTCCAGCACAACGTGAAGGAGCTGTTCGAGGGCA
TCGTGCGGCAGGTCCGCCTACGTCGGGACAGCAAGGAGAAAAATGAGCGGCGGCTGGCTTACCA
GAAACGGAGAGAGAGCATCCCCAGGAAAGCTCGGCGCTTCTGGGGCAAGATCGTGGCCAAAAAC
AACAAGAACATGGCCTTCAAGCTCAAGTCCAAATCTTGCCACGACCTCTCTGTGCTCTAGACAC
CAAGCATCACCCAGATGTCCTCCTGATGGACATCGTCAAAGGCCACTGGGACCAATAATCTATA
TTAGATTGAATACTTAAGTATTGTTAGATGTGGCTTCCCTCAATGCAGCTGGGAATGAATATGT
TAGCCTCATGGGCAACAAAATGCATGGGAAATGAAAGATCTTTGTAAACAATTAGTATTTATTT
ATGGAAAAAGGCTGACTTTGCTAAGTGGACACTTAATGCTCTTTATGGGACATGTTTGGTGTTC
ACATGAGTTTTTTTTTTTTTTTTTTTTTTTGCTCCTTTGGATAGTAGAGACTCAAAGCTTACAA
AAGAATGCCTAGAACAAGAGCTTTTCATCACTAAAATTTTGCCCAGTGTTCTTGTGAATTCGAG
GCCATTGGGTGATAAACGAACATGGGAACACTGAAAGGATTTATACAAAGGGGGAGAACTGTCC
ATGTACCTTATCTCCATGGAGCTAGAATTGTAAGAACTGGGCTCATCATGGTCATGACTATCAG
TGCTCCATCAAACTGTGAAAAGAAATGATGGATCTTGCTGGAAACTAAAGCTTAAGCTAACAAT
TTTTGTGTAATGCTTACAGAGATTTGTGGTATTGGGAACTAATGTGTGTACCATTTATAGGTTC
AAAACATGTATCTTATGTGTCTTACAATTTTTTATTTAGGGGAAGGTTATTTTCAACAAATTCT
ACTTAGTAAAATCACCTTTTGTGTTTCATTGTTTTTGAAATCATGGAGCTAACATAAAAATATT
TTTAAAATCTGAATTATTGATAACCTGGAGTATAAAATGCCAAATTTTTAAATAGAAGCAAAGG
CTAAATTTTTATAAAATATATAAAAACTTCCAGTATTTTGAGTTAGCCCTTGTATGCTACAGCT
CTGCTCTATTTATTATTATTTTGCAAAATAACCATTTTAACATTTGATAAAGCATATTTATGAA
CATATTTCTTAATAAGAAAAATGTCCATTTTATTACCATTTTCTATCTTTTTCAAAATATACAA
GTTTTTACCTTATATGTCTTATAATAAAAGAAATAAAATCTTTGAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005328712	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000009674.2
GenBank Protein	KAG3273893	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005328712 ⟸ XM_005328655

- UniProtKB:

I3MG39 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTLNNVTMRQGTVGMQPQQQRWSIPADGRHLMVQKEPHPYNHRNHHSANPEDHCRRSWSSDSTD
SVISSESGNTYYRVVLIGEQGVGKSTLANIFAGVHDSLDSDCEVLGEDTYERTLIVDGESATII
LLDMWENKGENEWLQDHCMQVGDAYLIVYSITDRASFEKASELRIQLRRARQTEDIPIILVGNK
SDLVRCREVSVSEGRACAVVFDCKFIETSAAVQHNVKELFEGIVRQVRLRRDSKEKNERRLAYQ
KRRESIPRKARRFWGKIVAKNNKNMAFKLKSKSCHDLSVL

hide sequence

RefSeq Acc Id:

ENSSTOP00000009674 ⟸ ENSSTOT00000010782

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000010786	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000010782.3	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/TrEMBL
InterPro	P-loop_NTPase	UniProtKB/TrEMBL
	RGK	UniProtKB/TrEMBL
	Small_GTP-bd_dom	UniProtKB/TrEMBL
	Small_GTPase	UniProtKB/TrEMBL
NCBI Gene	Gem	ENTREZGENE
PANTHER	GTP-BINDING PROTEIN GEM	UniProtKB/TrEMBL
	RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C	UniProtKB/TrEMBL
Pfam	Ras	UniProtKB/TrEMBL
PIRSF	GTP-binding_GEM	UniProtKB/TrEMBL
PRINTS	RASTRNSFRMNG	UniProtKB/TrEMBL
PROSITE	RAB	UniProtKB/TrEMBL
	RAS	UniProtKB/TrEMBL
SMART	RAB	UniProtKB/TrEMBL
	RAS	UniProtKB/TrEMBL
	RHO	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	I3MG39	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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