Slc2a5 (solute carrier family 2 member 5)

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Gene: Slc2a5 (solute carrier family 2 member 5) Ictidomys tridecemlineatus

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Symbol:

Slc2a5

Name:

solute carrier family 2 member 5

RGD ID:

12638001

Description:

ENCODES a protein that exhibits fructose binding (ortholog); INVOLVED IN D-glucose transmembrane transport (ortholog); fructose transmembrane transport (ortholog); metanephric proximal tubule development (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); chromosome 1p36 deletion syndrome (ortholog); long QT syndrome (ortholog); FOUND IN apical plasma membrane (inferred); membrane (inferred); plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

solute carrier family 2, facilitated glucose transporter member 5

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	32,741,273 - 32,767,573 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936623	3,226,515 - 3,249,914 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936623	3,226,533 - 3,249,909 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Breast Neoplasms (ISO)

chromosome 1p36 deletion syndrome (ISO)

long QT syndrome (ISO)

Neurodevelopmental Disorders (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to fructose stimulus (IEA)

D-glucose import (IEA)

D-glucose transmembrane transport (ISO)

dehydroascorbic acid transport (IEA)

fructose import across plasma membrane (IEA)

fructose transmembrane transport (IEA,ISO)

metanephric proximal tubule development (ISO)

regulation of systemic arterial blood pressure mediated by a chemical signal (IEA)

response to fructose (IEA)

Cellular Component

apical plasma membrane (IEA)

membrane (IEA)

plasma membrane (IEA)

sarcolemma (IEA)

Molecular Function

D-glucose transmembrane transporter activity (IEA)

fructose binding (ISO)

fructose transmembrane transporter activity (IEA)

hexose transmembrane transporter activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Slc2a5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	32,741,273 - 32,767,573 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936623	3,226,515 - 3,249,914 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936623	3,226,533 - 3,249,909 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC2A5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	9,035,106 - 9,094,195 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	9,035,106 - 9,088,478 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	9,095,165 - 9,132,318 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	9,019,594 - 9,052,257 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	9,031,272 - 9,063,936	NCBI
Celera	1	8,205,681 - 8,257,881 (-)	NCBI		Celera
Cytogenetic Map	1	p36.23	NCBI
HuRef	1	8,246,781 - 8,279,898 (-)	NCBI		HuRef
CHM1_1	1	9,086,735 - 9,120,070 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	8,568,756 - 8,627,452 (-)	NCBI		T2T-CHM13v2.0

Slc2a5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	150,203,801 - 150,228,625 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	150,203,740 - 150,228,626 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	150,119,344 - 150,144,168 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	150,119,283 - 150,144,169 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	149,493,453 - 149,518,277 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	148,963,144 - 148,987,968 (+)	NCBI		MGSCv36	mm8
Celera	4	152,395,331 - 152,418,947 (+)	NCBI		Celera
Cytogenetic Map	4	E2	NCBI
cM Map	4	80.97	NCBI

Slc2a5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	165,857,412 - 165,892,928 (+)	NCBI		GRCr8
mRatBN7.2	5	160,583,055 - 160,609,994 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	160,583,234 - 160,611,106 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	163,299,711 - 163,326,461 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	165,121,924 - 165,148,813 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	165,078,270 - 165,105,019 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	167,142,182 - 167,174,203 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	167,141,875 - 167,174,310 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	170,782,871 - 170,808,467 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	167,240,442 - 167,285,761 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	167,250,629 - 167,295,948 (+)	NCBI
Celera	5	158,844,838 - 158,869,525 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

Slc2a5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955486	4,194,833 - 4,211,377 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955486	4,194,568 - 4,208,568 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLC2A5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	219,145,117 - 219,196,791 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	217,789,862 - 217,841,544 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	7,792,361 - 7,840,634 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	9,028,790 - 9,078,509 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	9,028,790 - 9,078,509 (-)	Ensembl	panpan1.1		panPan2

LOC489640
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	62,417,234 - 62,444,903 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	62,417,591 - 62,442,922 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	62,434,685 - 62,454,581 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	62,644,215 - 62,664,060 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	62,644,215 - 62,664,372 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	62,642,371 - 62,662,203 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	62,506,640 - 62,526,482 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	62,910,582 - 62,930,423 (-)	NCBI		UU_Cfam_GSD_1.0

SLC2A5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	69,507,830 - 69,535,371 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	69,507,829 - 69,535,794 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

SLC2A5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	122,669,220 - 122,714,708 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	122,683,373 - 122,716,540 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	26,700,362 - 26,733,757 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc2a5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624818	3,135,422 - 3,155,698 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624818	3,132,345 - 3,156,184 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005334791	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040287892	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000012068 ⟹ ENSSTOP00000010821

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936623	3,227,062 - 3,243,284 (-)	Ensembl

Ensembl Acc Id:

ENSSTOT00000034353 ⟹ ENSSTOP00000025900

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936623	3,226,515 - 3,249,914 (-)	Ensembl

RefSeq Acc Id:

XM_005334791 ⟹ XP_005334848

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	32,741,273 - 32,767,573 (-)	NCBI
SpeTri2.0	NW_004936623	3,226,533 - 3,249,909 (-)	NCBI

Sequence:

show sequence

CGGCACGTTGTCCCTGCAGCGCAGAGATGGAGAGTTCCAATGAAGAGAAGAAGGAAGGGAGGCT
CACGCTCCTGCTTGCCCTGGCCACCCTGATCGCCTCCTTCGGCTCCTCCTTCCAATATGGGTAC
AACGTGGCCGTGGTCAACTCCCCGTCAGAGTTCATGAAGCAGTTTTACAACGACACCTACGGTG
ACAGAACTGGAGAGCTCATTGACACCTTCGCTTTGACCTTGCTGTGGTCTGTGACAGTGTCCAT
GTTCCCCTTCGGAGGCTTTATCGGGTCCCTCCTGGTTGGCCCCCTGGTGAATAATTTGGGCAGG
AAAGGAACCTTGCTGTTCAACAACATCTTTTCCATTGTGCCCGCCATCTTCATGGGTTGCAGTA
AAATCGCCAAGGCCTTTGAGCTTATCATTATTTCCAGATTTTTAGTGGGAATATGCGCAGGTGT
GTCTTCCAATGTGGTCCCTATGTACTTAGGGGAGCTGGCCCCTAAAAACCTGCGGGGGGCCCTC
GGGGTGGTGCCCCAGCTCTTCATCACCATCGGCATCCTTGTAGCCCAGCTGCTTGGTCTTCGGA
GTATCCTCGCCAACGAAGAAGGCTGGCCCATCCTCCTGGCGCTGACCGCGGTCCCCGCCGTGCT
GCAGGTCCTGCTGCTCCCCTTCTTCCCCGAGAGCCCCCGGTACCTGCTGATTCAGAAGAAAAAC
GAAGAAGCTGCCAGGAAAGCCCTGCGGCGGGTGCGCGGCTGGGACGAGGTGGACGAGGAGGTGG
AGGAGATCCGGCGGGAGGACGAGGCGGAGCGGGCGGCGGGCTTCATCTCGGTGCGGAAGCTGTT
CCACCTCAAGTCCCTGCGCTGGCAGCTCATCTCCATCATCACCCTCATGGCCGGCCAGCAGCTG
TCCGGCGTGAACGCGATCTACTACTACGCGGACCAGATCTACCTGAGCGCCGGCGTGGAGGCCA
ACGACGTCCAGTACGTGACGGCCGGCACCGGGGCCGTCAACGTGTTCATGACCGTGTGCACTGT
GTTAGTGGTGGAGCTCTGGGGCAGGAGGCGTCTGCTGCTCCTGGGCTTCTCCACCTGCTTCATG
GCCTGCGCTGTGCTGACCGTGGCTCTGGCACTGCAGGACACCGTCTCCTGGATGCCCTATGTCA
GCATTGCCTGCGTCATCATCTATGTCATAGGACATGCCGTCGGGCCCAGTCCCATCCCTGCGCT
GATCATCACTGAGGTCTTCCTGCAGTCCTCCAGGCCAGCTGCCTTCATGATCGGGGGCAGTGTC
CACTGGCTGTCCAACTTCACTGTGGGCTTGATCTTCCCCTTCATTCAAGTGGGCCTTGGTGCTT
ACAGCTTCATCATCTTTGCCATAGTATGTCTCCTCACCACCGTCTACACCTTCTTCATTGTCCC
CGAGACCAAGAACAAGACCTTCATCGAGATCAATCAGATCTTCGCCAATTTGAACAAGGTGTCG
GGAATCCACCCGGAGAAGGAGGAGCTGAAAACCTTTCCATCGGACACTTCAAAGCAGCAGTGAA
GAGGAGCCCGTGGAGCAGGTCTGCGTGGAGCCTCCTCCCAGGACTTTCCCCTGACTTCTGTTTG
CCTGTGACGTCCAGAAACGGAACGAGTCTGGTGTGGAACACAGGTCTCAGGCTGACCTCCCCGC
CCAGAGGGACAGTCCAGGGGCCTCCATGCTGTTCTCCCCCCGGGTCACCTCTGCCCAGCCCTGT
GTCTGCACACCGTCATTCCTCACCTGCTGGGCCAGCTGCTGTGGGGCTCTTTTCTAACAAAAAT
AGGTACTACAGGGACAGATGGGAGGAATCCAATTTTGTCAGTGAAACTAACTCTCTTCTGGGGC
CCCACGGACCTCCTGGGGCCACCAGCACTGTGGAAAGCCGAATTCATCCTCTGATCCCACCCTT
CTCCTGACTTGCAAAGAGTGGTATCAAGAATAATGACTTAGAGAAAGCTGGAGAAGGGTCCCTG
GGGATATATTACCTGAGTTCAAATTGATGATCCTAAATTATATTGCTAGGGGAAATGGAATTGC
TTCTGTATAGTTAATA

hide sequence

RefSeq Acc Id:

XM_040287892 ⟹ XP_040143826

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	32,741,273 - 32,767,573 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_005334848	(Get FASTA)	NCBI Sequence Viewer
	XP_040143826	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000010821.3
	ENSSTOP00000025900.1
GenBank Protein	KAG3282070	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005334848 ⟸ XM_005334791
- Peptide Label:	isoform X1
- UniProtKB:	I3MIH7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MESSNEEKKEGRLTLLLALATLIASFGSSFQYGYNVAVVNSPSEFMKQFYNDTYGDRTGELIDT FALTLLWSVTVSMFPFGGFIGSLLVGPLVNNLGRKGTLLFNNIFSIVPAIFMGCSKIAKAFELI IISRFLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITIGILVAQLLGLRSILANEEGW PILLALTAVPAVLQVLLLPFFPESPRYLLIQKKNEEAARKALRRVRGWDEVDEEVEEIRREDEA ERAAGFISVRKLFHLKSLRWQLISIITLMAGQQLSGVNAIYYYADQIYLSAGVEANDVQYVTAG TGAVNVFMTVCTVLVVELWGRRRLLLLGFSTCFMACAVLTVALALQDTVSWMPYVSIACVIIYV IGHAVGPSPIPALIITEVFLQSSRPAAFMIGGSVHWLSNFTVGLIFPFIQVGLGAYSFIIFAIV CLLTTVYTFFIVPETKNKTFIEINQIFANLNKVSGIHPEKEELKTFPSDTSKQQ hide sequence

RefSeq Acc Id:	XP_040143826 ⟸ XM_040287892
- Peptide Label:	isoform X2
- UniProtKB:	I3MIH7 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSSTOP00000025900 ⟸ ENSSTOT00000034353

Ensembl Acc Id:

ENSSTOP00000010821 ⟸ ENSSTOT00000012068

Protein Domains

Major facilitator superfamily (MFS) profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000012057	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000012068.3	UniProtKB/TrEMBL
	ENSSTOT00000034353.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1250.20	UniProtKB/TrEMBL
InterPro	Fru_transpt_5	UniProtKB/TrEMBL
	GLUT	UniProtKB/TrEMBL
	MFS_dom	UniProtKB/TrEMBL
	MFS_sugar_transport-like	UniProtKB/TrEMBL
	MFS_trans_sf	UniProtKB/TrEMBL
	Sugar/inositol_transpt	UniProtKB/TrEMBL
	Sugar_transporter_CS	UniProtKB/TrEMBL
NCBI Gene	Slc2a5	ENTREZGENE
PANTHER	PTHR23503	UniProtKB/TrEMBL
	SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 5	UniProtKB/TrEMBL
Pfam	Sugar_tr	UniProtKB/TrEMBL
PRINTS	GLUCTRSPORT5	UniProtKB/TrEMBL
	SUGRTRNSPORT	UniProtKB/TrEMBL
PROSITE	MFS	UniProtKB/TrEMBL
	SUGAR_TRANSPORT_1	UniProtKB/TrEMBL
	SUGAR_TRANSPORT_2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF103473	UniProtKB/TrEMBL
UniProt	A0A287CX47_ICTTR	UniProtKB/TrEMBL
	I3MIH7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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