Rab8a (RAB8A, member RAS oncogene family)

Gene: Rab8a (RAB8A, member RAS oncogene family) Ictidomys tridecemlineatus

Analyze

Symbol:

Rab8a

Name:

RAB8A, member RAS oncogene family

RGD ID:

12636638

Description:

ENCODES a protein that exhibits protein kinase binding (ortholog); protein tyrosine kinase binding (ortholog); INVOLVED IN axonogenesis (ortholog); cellular response to insulin stimulus (ortholog); neurotransmitter receptor transport, endosome to postsynaptic membrane (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; ASSOCIATED WITH genetic disease (ortholog); rheumatoid arthritis (ortholog); FOUND IN cytoplasmic vesicle (ortholog); dendrite (ortholog); exocytic vesicle (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

ras-related protein Rab-8A

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	204,836,649 - 204,854,271 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936596	4,385,772 - 4,403,441 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936596	4,385,788 - 4,403,393 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

rheumatoid arthritis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

axonogenesis (ISO)

cell projection organization (IEA)

cellular response to insulin stimulus (ISO)

cilium assembly (IEA)

endocytic recycling (IEA)

Golgi organization (IEA)

Golgi vesicle fusion to target membrane (IEA)

neurotransmitter receptor transport to postsynaptic membrane (IEA)

neurotransmitter receptor transport, endosome to postsynaptic membrane (ISO)

protein localization to cilium (IEA)

protein localization to plasma membrane (IEA)

protein secretion (IEA)

protein transport (IEA)

regulation of autophagy (IEA)

regulation of exocytosis (IEA)

regulation of long-term neuronal synaptic plasticity (ISO)

regulation of protein localization (ISO)

regulation of protein transport (ISO)

vesicle docking involved in exocytosis (IEA)

vesicle-mediated transport in synapse (ISO)

Cellular Component

centriole (IEA)

centrosome (IEA)

ciliary basal body (IEA)

ciliary base (IEA)

ciliary membrane (IEA)

cilium (IEA)

cytoplasm (IEA)

cytoplasmic vesicle (ISO)

dendrite (ISO)

dendritic spine (IEA)

endosome (IEA)

endosome membrane (IEA)

exocytic vesicle (ISO)

glutamatergic synapse (ISO)

Golgi apparatus (IEA)

membrane (IEA)

midbody (IEA)

neuron projection (IEA)

neuronal cell body (ISO)

non-motile cilium (IEA)

phagocytic vesicle (IEA)

phagocytic vesicle membrane (IEA)

plasma membrane (IEA)

postsynaptic density (ISO)

recycling endosome (IEA)

recycling endosome membrane (IEA)

synapse (ISO)

synaptic vesicle (IEA)

trans-Golgi network transport vesicle (IEA)

Molecular Function

GDP binding (IEA)

GTP binding (IEA)

GTPase activity (IEA)

hydrolase activity (IEA)

myosin V binding (IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein kinase binding (ISO)

protein tyrosine kinase binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

insulin responsive facilitative sugar transporter mediated glucose transport pathway (ISO)

Rab family mediated signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Rab8a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	204,836,649 - 204,854,271 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936596	4,385,772 - 4,403,441 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936596	4,385,788 - 4,403,393 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RAB8A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	16,111,889 - 16,134,234 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	16,111,889 - 16,134,234 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	16,222,699 - 16,245,044 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	16,083,490 - 16,105,445 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	16,083,489 - 16,105,443	NCBI
Celera	19	16,124,417 - 16,146,398 (+)	NCBI		Celera
Cytogenetic Map	19	p13.11	NCBI
HuRef	19	15,793,443 - 15,815,391 (+)	NCBI		HuRef
CHM1_1	19	16,221,978 - 16,243,940 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	16,245,960 - 16,268,300 (+)	NCBI		T2T-CHM13v2.0

Rab8a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	72,915,044 - 72,935,210 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	72,915,044 - 72,937,748 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	72,161,200 - 72,181,366 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	72,161,200 - 72,183,904 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	74,685,099 - 74,705,265 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	75,090,189 - 75,110,355 (+)	NCBI		MGSCv36	mm8
Celera	8	76,516,674 - 76,537,034 (+)	NCBI		Celera
Cytogenetic Map	8	B3.3	NCBI
cM Map	8	34.84	NCBI

Rab8a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	17,688,049 - 17,709,412 (-)	NCBI		GRCr8
mRatBN7.2	16	17,654,027 - 17,675,385 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	17,654,034 - 17,675,678 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	17,713,745 - 17,734,289 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	18,845,873 - 18,866,846 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	17,766,676 - 17,787,222 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	19,355,047 - 19,376,776 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	19,355,048 - 19,376,776 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	19,213,378 - 19,235,107 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	18,078,519 - 18,099,882 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	18,079,199 - 18,089,589 (-)	NCBI
Celera	16	17,868,660 - 17,890,021 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

Rab8a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955524	1,403,811 - 1,416,005 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955524	1,403,811 - 1,416,005 (-)	NCBI	ChiLan1.0	ChiLan1.0

RAB8A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	20,979,867 - 21,002,037 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	19,985,674 - 20,007,842 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	15,598,029 - 15,619,988 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	16,580,720 - 16,602,189 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	16,580,720 - 16,602,189 (+)	Ensembl	panpan1.1		panPan2

RAB8A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	46,334,601 - 46,351,907 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	46,334,601 - 46,351,907 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	46,249,113 - 46,266,419 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	46,823,033 - 46,840,339 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	46,821,781 - 46,864,926 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	46,057,667 - 46,074,969 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	46,469,207 - 46,486,513 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	46,745,524 - 46,762,829 (-)	NCBI		UU_Cfam_GSD_1.0

RAB8A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	61,429,523 - 61,450,413 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	61,430,680 - 61,450,351 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	61,176,944 - 61,196,619 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RAB8A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	14,611,938 - 14,634,086 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	14,611,868 - 14,634,487 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666074	4,859,385 - 4,881,900 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rab8a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624908	1,116,610 - 1,132,111 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624908	1,119,356 - 1,132,029 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005333044	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000177	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000029629 ⟹ ENSSTOP00000021674

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936596	4,385,772 - 4,403,441 (-)	Ensembl

RefSeq Acc Id:

XM_005333044 ⟹ XP_005333101

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405118	204,836,649 - 204,854,271 (-)	NCBI
SpeTri2.0	NW_004936596	4,385,788 - 4,403,393 (-)	NCBI

Sequence:

show sequence

TCCCGTCCGGGAGAGAGTGTAATATGGCGAAGACCTACGATTACCTGTTCAAGCTGCTGCTGAT
CGGGGACTCGGGGGTGGGGAAGACCTGTGTCCTGTTCCGCTTCTCCGAGGACGCCTTCAACTCC
ACTTTCATCTCCACCATAGGAATTGACTTTAAAATCAGGACCATAGAGCTCGATGGCAAGAGGA
TCAAACTGCAGATATGGGACACAGCCGGCCAGGAACGGTTCCGGACGATCACGACGGCCTACTA
CCGGGGAGCCATGGGTATCATGCTGGTCTACGACATCACCAACGAGAAGTCCTTCGACAACATC
CGGAACTGGATTCGGAACATTGAGGAGCACGCCTCTGCAGACGTGGAGAAGATGATACTTGGGA
ACAAGTGTGATGTGAACGACAAGAGACAGGTGTCCAGGGAACGGGGAGAGAAGCTGGCCCTTGA
CTATGGAATCAAGTTCATGGAGACCAGCGCCAAGGCCAACATCAACGTGGAGAACGCATTTTTC
ACTCTCGCCAGAGACATCAAAGCAAAAATGGACAAAAAATTGGAAGGCAACAGCCCCCAGGGCA
GCAGCCAAGGCGTCAAGATCACCCCCGACCAGCAGAAGAGGAGCAGCTTCTTCCGCTGCGCGCT
GGCGTGAGGAGCGCCTTACCTGGGCGCGCCGGCCCAGCTGACTGTGCCTGTCCCCAGCGAGCCT
GGCTCGCGGGGGGCCCTCCCGCTCCAACACCTCGCCCGCCGCGGCCACCGGGCCCTCGGCCACC
AGAACATAATTGAGAAATTATTTTAGTAACTGTCTGATCTTTTTCAACTTTGGAGATGGAAGAA
GAATTCGCTATTTTCCTCTAACGCCCACCAGGACGGCCCACCTGCCCATCTACCAGAGAGAAAG
ATGGGGCCCCGGTGATCCGCAGCCGCCGCAGGCAGACCCCGTCTCGGGGCCTCTCATCCTGGTG
TCACCGCAGCGCCCCACAGAAAGCCTGTCCCGCCGCCGGTGGTGCCAGGCACGTCCGCTCTGCA
CCGAGCAAGTGGCCGATGGCCAGGGCCGGGCGCATTCACACAGGTCTGCCGCCCACATCAGCCT
CCTCTCAGTTTTGGACAAGTGACAAAAACCATTTCCCTCCCGTCTCTTTCACTGTTAAACCAAA
GGGAAGCACAAATCCAAGACGCCCTGCGCGGAGCGCCAGGAGGGAGGACGGGGCGCTCCGACCG
CAGCCAGGTCTTGGTCTGGGCCCACGGGCCTCTGAGCACCCCACTGGAGCAGGGGGGATGCTGT
GCCCGCACAGGTGACCCCAGCATCAGGGCCTCGCGGCCGGGGATCCCCCCTCAGCGGTACCAAA
CGGCCCCCACCCTGTCCTCTCGCCATCTCCAAATCGGACATTCTTTCTAGCTGAGATTTTTTTA
TTTTTCCAGATTTGTAGTGCCATGAAGTGATCTCGTCTTTGATTTCCAGGGGCAGACCCAGGTG
ACGGGAAGCTCGTGCAGCGCCCTGGCCAGAGGTGGCCAGGGGCCGGCAGCACCGTCCACACAGA
GGCCCTGGCACGGCCGGGGCACAGGCATTCCAGGGACAGGCTGGCCGCGCGGCAGCCTGGGTCG
GCTTTTTACTGTCATTATTCAGTTCTGTTTTGATAGCTTTGTCCTCCCGGAGAGACTGCGATTT
GGGACCACTTATCCAGGCGGAGGGCGCCCCACCCCCACCGTTTCTTTGACTCTCCTCCCGCCCC
GCCCCCCGCCGCTGTCAATCCAAGTCATTGACGTCACCTTTCTCCTTTTTTGAATTAAAACGAA
CATACCAGCAATGTCTGCTCTCCCCTGGGGTCTCTAACCTGCTCTGTTTACATCATAAATGCAC
TTAAGGAAAACAGACCAATTAAAGCTCATTCTAAAGTT

hide sequence

Protein Sequences


Protein RefSeqs	XP_005333101	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000021674.1
GenBank Protein	KAG3280004	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005333101 ⟸ XM_005333044

- UniProtKB:

I3NBC7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAKTYDYLFKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGIDFKIRTIELDGKRIKLQIWDT
AGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIRNWIRNIEEHASADVEKMILGNKCDVNDK
RQVSRERGEKLALDYGIKFMETSAKANINVENAFFTLARDIKAKMDKKLEGNSPQGSSQGVKIT
PDQQKRSSFFRCALA

hide sequence

RefSeq Acc Id:

ENSSTOP00000021674 ⟸ ENSSTOT00000029629

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000025380	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000029629.2	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/TrEMBL
InterPro	P-loop_NTPase	UniProtKB/TrEMBL
	Small_GTP-bd_dom	UniProtKB/TrEMBL
	Small_GTPase	UniProtKB/TrEMBL
NCBI Gene	Rab8a	ENTREZGENE
PANTHER	LD44762P	UniProtKB/TrEMBL
	RAS-RELATED PROTEIN RAB-8A	UniProtKB/TrEMBL
Pfam	Ras	UniProtKB/TrEMBL
PRINTS	RASTRNSFRMNG	UniProtKB/TrEMBL
PROSITE	RAB	UniProtKB/TrEMBL
	RAS	UniProtKB/TrEMBL
	RHO	UniProtKB/TrEMBL
SMART	ARF	UniProtKB/TrEMBL
	RAB	UniProtKB/TrEMBL
	RAN	UniProtKB/TrEMBL
	RAS	UniProtKB/TrEMBL
	RHO	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	I3NBC7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

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