Mpc1 (mitochondrial pyruvate carrier 1)

Gene: Mpc1 (mitochondrial pyruvate carrier 1) Ictidomys tridecemlineatus

Analyze

Symbol:

Mpc1

Name:

mitochondrial pyruvate carrier 1

RGD ID:

12632990

Description:

ENCODES a protein that exhibits pyruvate transmembrane transporter activity (ortholog); INVOLVED IN acetyl-CoA biosynthetic process from pyruvate (ortholog); cellular response to leukemia inhibitory factor (ortholog); mitochondrial pyruvate transmembrane transport (ortholog); PARTICIPATES IN citric acid cycle pathway; fructose-1,6-bisphosphatase deficiency pathway; fumaric aciduria pathway; ASSOCIATED WITH Fraser syndrome 3 (ortholog); genetic disease (ortholog); mitochondrial pyruvate carrier deficiency (ortholog); FOUND IN mitochondrial inner membrane (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	148,927,328 - 148,929,837 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936489	16,179,810 - 16,184,020 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936489	16,179,321 - 16,181,991 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Fraser syndrome 3 (ISO)

genetic disease (ISO)

mitochondrial pyruvate carrier deficiency (ISO)

substance-related disorder (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acetyl-CoA biosynthetic process from pyruvate (ISO)

cellular response to leukemia inhibitory factor (ISO)

mitochondrial pyruvate transmembrane transport (IEA,ISO)

Cellular Component

mitochondrial inner membrane (IEA,ISO)

mitochondrion (IEA)

Molecular Function

protein binding (ISO)

pyruvate transmembrane transporter activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

citric acid cycle pathway (ISO)

fructose-1,6-bisphosphatase deficiency pathway (ISO)

fumaric aciduria pathway (ISO)

gluconeogenesis pathway (ISO)

glycogen storage disease type Ia pathway (ISO)

glycogen storage disease type Ib pathway (ISO)

mitochondrial complex II deficiency pathway (ISO)

phosphoenolpyruvate carboxykinase deficiency pathway (ISO)

pyruvate dehydrogenase E2 deficiency pathway (ISO)

pyruvate dehydrogenase E3 deficiency pathway (ISO)

triosephosphate isomerase deficiency pathway (ISO)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Mpc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	148,927,328 - 148,929,837 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936489	16,179,810 - 16,184,020 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936489	16,179,321 - 16,181,991 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MPC1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	166,364,919 - 166,382,940 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	166,364,919 - 166,383,013 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	166,778,407 - 166,796,428 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	166,698,397 - 166,716,476 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	166,748,820 - 166,766,897	NCBI
Celera	6	167,517,772 - 167,535,855 (-)	NCBI		Celera
Cytogenetic Map	6	q27	NCBI
HuRef	6	164,249,365 - 164,267,463 (-)	NCBI		HuRef
CHM1_1	6	167,042,136 - 167,060,235 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	167,741,850 - 167,759,859 (-)	NCBI		T2T-CHM13v2.0

Mpc1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	8,502,590 - 8,516,499 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	8,501,736 - 8,516,493 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	8,283,787 - 8,297,667 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	8,282,904 - 8,297,661 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	8,476,678 - 8,490,526 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	8,121,987 - 8,135,835 (+)	NCBI		MGSCv36	mm8
Celera	12	112,049,395 - 112,049,996 (-)	NCBI		Celera
Cytogenetic Map	17	A1	NCBI
cM Map	17	4.92	NCBI

Mpc1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	54,985,305 - 54,996,979 (-)	NCBI		GRCr8
mRatBN7.2	1	52,437,745 - 52,449,399 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	52,437,741 - 52,449,400 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	53,139,229 - 53,150,880 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	59,130,934 - 59,142,585 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	53,214,825 - 53,226,476 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	53,026,608 - 53,038,229 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	53,026,608 - 53,038,229 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	54,275,046 - 54,286,667 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	47,077,723 - 47,089,344 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	47,080,667 - 47,092,289 (-)	NCBI
Celera	1	48,200,723 - 48,212,344 (-)	NCBI		Celera
Cytogenetic Map	1	q12	NCBI

Mpc1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955439	15,516,090 - 15,531,116 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955439	15,515,966 - 15,531,618 (+)	NCBI	ChiLan1.0	ChiLan1.0

MPC1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	186,572,971 - 186,591,196 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	184,468,871 - 184,487,160 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	164,331,604 - 164,349,747 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	169,313,271 - 169,318,685 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

MPC1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	54,379,195 - 54,395,697 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	55,167,961 - 55,184,449 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	54,557,931 - 54,574,673 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	54,557,928 - 54,574,770 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	54,455,224 - 54,471,730 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	54,304,263 - 54,320,827 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	54,928,921 - 54,945,422 (-)	NCBI		UU_Cfam_GSD_1.0

MPC1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	1	2,541,475 - 2,552,864 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	3,681,075 - 3,692,480 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MPC1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	94,080,417 - 94,100,149 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666040	65,907,418 - 65,927,150 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mpc1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624785	12,877,077 - 12,891,914 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624785	12,876,942 - 12,892,417 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005321436	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000024969 ⟹ ENSSTOP00000018886

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936489	16,179,810 - 16,184,020 (-)	Ensembl

RefSeq Acc Id:

XM_005321436 ⟹ XP_005321493

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404946	148,927,328 - 148,929,837 (-)	NCBI
SpeTri2.0	NW_004936489	16,179,321 - 16,181,991 (-)	NCBI

Sequence:

show sequence

CTGCCTACTCATATGAAAGCCCTTGAACAATCACACAATGATAACCACCCATGAATTAACCCAG
TGAACCTGCAGCATGTAAAGATGAAGATTGAGGAAGATTGCACCTGTTCATGGCTCTACCTTAA
CTCTTCCCTCTCTTCTTCTCTCATGTTTTGTAGCACTTCTGGGGCCCAGTAGCCAACTGGGGTC
TCCCCATTGCTGCCATCAATGACATGAAGAAGTCTCCAGAGATCATCAGTGGACGAATGACATT
TGCCCTCTGTTGCTATTCTTTGACATTCATGAGATTTGCCTACAAGGTGCAGCCTCGAAACTGG
CTTCTCTTTGCGTGCCATGCAACAAACGAAGTAGCCCAGCTCATTCAGGGAGGACGGCTTATCA
GATATGAGATGACTAAAAAGGCATCTGCATAGAAGTGGAAGGAACAAGCTCTTGAAAGGACAGC
ACCCCAGCTACTGCTGCAGAGTCACAGATTCCATCAGCATGAATAGGAGGAAATGTGGAATGCT
ATTTTTACTAACTGTACCATTTTTATAGATATAGCTGGGAGTCCCTAAACAAATTCTCTGCTGC
CTTACAAGTACTGAATATTTTTTCTTCATAGAGTAGCTCAAAATATGCAATTAACTTAATAATT
TCCAATGATGGTTTTATCTGTATTCATACACATATTATCTGTTGGGATTTGCTTAATGAAAAAC
TGAACAGCAAAATTTTATAATACTCACATTTAAATACTCAGACTTCTTGACTTTAATGACTGCA
AGATATCCAACAACTTAACACATACCTAAAATCTGATCTTCAGTGTTTGAAAAACTGTCTTGTA
TTTCCATGCAGTATGTACATTGAGATGCTGTAACTTAAATGGCAATAAATGATTTAAATATTTG
TTATATGAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005321493	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000018886.2
GenBank Protein	KAG3290561	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005321493 ⟸ XM_005321436
- Sequence:	show sequence MKKSPEIISGRMTFALCCYSLTFMRFAYKVQPRNWLLFACHATNEVAQLIQGGRLIRYEMTKKA SA hide sequence

RefSeq Acc Id:

ENSSTOP00000018886 ⟸ ENSSTOT00000024969

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000024720	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000024969.2	UniProtKB/TrEMBL
InterPro	MPC	UniProtKB/TrEMBL
NCBI Gene	Mpc1	ENTREZGENE
PANTHER	MITOCHONDRIAL PYRUVATE CARRIER 1	UniProtKB/TrEMBL
	UPF0041 BRAIN PROTEIN 44-RELATED	UniProtKB/TrEMBL
Pfam	MPC	UniProtKB/TrEMBL
UniProt	I3N3E0_ICTTR	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB