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Gene: LOC101955076 (low affinity immunoglobulin gamma Fc region receptor III-A) Ictidomys tridecemlineatus

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Symbol:

LOC101955076 (Ensembl: Fcgr3a)

Name:

low affinity immunoglobulin gamma Fc region receptor III-A

RGD ID:

12631789

Description:

ENCODES a protein that exhibits immune receptor activity (ortholog); low-affinity IgG receptor activity (ortholog); INVOLVED IN calcium-mediated signaling (ortholog); cellular response to lipopolysaccharide (ortholog); macrophage activation (ortholog); ASSOCIATED WITH allergic disease (ortholog); allergic rhinitis (ortholog); ankylosing spondylitis (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog); Fc-gamma receptor III complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

Fc fragment of IgG receptor IIIa; Fc fragment of IgG, low affinity IIIa, receptor (CD16a); Fcgr3a

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	7,523,130 - 7,530,183 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004937131	42,454 - 49,536 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004937131	42,523 - 49,533 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

allergic disease (ISO)

allergic rhinitis (ISO)

ankylosing spondylitis (ISO)

anti-basement membrane glomerulonephritis (ISO)

arthritis (ISO)

asthma (ISO)

autoimmune thrombocytopenic purpura (ISO)

B-Cell Chronic Lymphocytic Leukemia (ISO)

Behcet's disease (ISO)

celiac disease (ISO)

Chemotherapy-Induced Febrile Neutropenia (ISO)

coronary artery disease (ISO)

Crohn's disease (ISO)

Drug-induced Neutropenia (ISO)

epilepsy (ISO)

Experimental Liver Cirrhosis (ISO)

Familial Mixed Cryoglobulinemia (ISO)

glomerulonephritis (ISO)

graft-versus-host disease (ISO)

Heparin-induced Thrombocytopenia (ISO)

human immunodeficiency virus infectious disease (ISO)

IgA glomerulonephritis (ISO)

immunodeficiency 20 (ISO)

lupus nephritis (ISO)

Lupus Vasculitis, Central Nervous System (ISO)

lymphoid leukemia (ISO)

lymphopenia (ISO)

lymphoplasmacytic lymphoma (ISO)

Malarial Anemia (ISO)

multiple sclerosis (ISO)

myelodysplastic syndrome (ISO)

myositis (ISO)

nephritis (ISO)

pneumonia (ISO)

polyneuropathy (ISO)

rheumatoid arthritis (ISO)

systemic lupus erythematosus (ISO)

temporal arteritis (ISO)

Temporomandibular Joint Dysfunction Syndrome (ISO)

thrombocytopenia due to platelet alloimmunization (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antibody-dependent cellular cytotoxicity (IEA)

calcium-mediated signaling (ISO)

cell surface receptor signaling pathway (IEA)

cellular response to lipopolysaccharide (ISO)

dendritic cell antigen processing and presentation (IEA)

Fc receptor-mediated immune complex endocytosis (IEA)

Fc-epsilon receptor signaling pathway (IEA)

Fc-gamma receptor signaling pathway (IEA)

granzyme-mediated programmed cell death signaling pathway (IEA)

immune response (IEA)

immunoglobulin mediated immune response (IEA)

macrophage activation (ISO)

natural killer cell activation (ISO)

natural killer cell degranulation (ISO)

natural killer cell mediated cytotoxicity (ISO)

neutrophil activation (IEA)

phosphatidylinositol 3-kinase/protein kinase B signal transduction (ISO)

positive regulation of bone resorption (IEA)

positive regulation of natural killer cell proliferation (ISO)

positive regulation of tumor necrosis factor production (ISO)

protein import (IEA)

protein transmembrane transport (IEA)

T cell mediated cytotoxicity (IEA)

Cellular Component

cell surface (IEA,ISO)

external side of plasma membrane (IEA)

extracellular space (ISO)

Fc-gamma receptor III complex (ISO)

plasma membrane (IEA)

Molecular Function

IgE receptor activity (IEA)

IgG binding (IEA)

IgG receptor activity (IEA)

immune receptor activity (ISO)

low-affinity IgG receptor activity (ISO)

protein binding (ISO)

transmembrane signaling receptor activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

LOC101955076
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	7,523,130 - 7,530,183 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004937131	42,454 - 49,536 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004937131	42,523 - 49,533 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FCGR3A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	161,541,759 - 161,550,737 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	161,541,759 - 161,550,968 (-)	Ensembl			hg38	GRCh38
GRCh37	1	161,511,549 - 161,520,527 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	159,778,173 - 159,786,442 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	158,324,607 - 158,332,873	NCBI
Cytogenetic Map	1	q23.3	NCBI
HuRef	1	132,836,941 - 132,843,979 (-)	NCBI		HuRef
CHM1_1	1	162,933,382 - 162,942,246 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	160,804,385 - 160,813,363 (-)	NCBI		T2T-CHM13v2.0

Fcgr4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	170,846,495 - 170,857,330 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	170,846,489 - 170,857,330 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	171,018,926 - 171,029,761 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	171,018,920 - 171,029,761 (+)	Ensembl			mm10	GRCm38
MGSCv37	1	172,949,057 - 172,959,892 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	172,855,614 - 172,866,426 (+)	NCBI		MGSCv36	mm8
Celera	1	173,467,124 - 173,477,978 (+)	NCBI		Celera
Cytogenetic Map	1	H3	NCBI
cM Map	1	78.53	NCBI

Fcgr3a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	85,782,636 - 85,792,656 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	85,782,490 - 85,792,651 (+)	Ensembl				GRCr8
mRatBN7.2	13	83,249,905 - 83,259,921 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	83,249,872 - 83,259,921 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	85,869,672 - 85,879,670 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	87,163,159 - 87,173,157 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	84,401,088 - 84,411,091 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	89,385,775 - 89,396,047 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	89,385,859 - 89,396,051 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	94,025,150 - 94,035,170 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	86,867,641 - 86,877,665 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	82,902,506 - 82,912,524 (+)	NCBI		Celera
RGSC_v3.1	13	86,881,828 - 86,891,853 (+)	NCBI
Cytogenetic Map	13	q24	NCBI

FCGR3A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	88,237,392 - 88,246,168 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	87,906,573 - 87,914,574 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	137,027,943 - 137,036,738 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

LOC478984
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	38	21,054,870 - 21,060,948 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	38	21,106,055 - 21,115,738 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	38	21,137,358 - 21,146,800 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
UMICH_Zoey_3.1	38	21,108,977 - 21,118,860 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	38	21,462,756 - 21,472,195 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	38	21,738,473 - 21,748,157 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

FCGR3A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	4	88,948,357 - 88,956,513 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

LOC103223675
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	2,466,492 - 2,475,579 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666038	1,524,719 - 1,533,773 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fcgr3a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624826	51,387 - 59,117 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Fcgr3a
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	10	50,197,313 - 50,207,557 (+)	NCBI		Rrattus_CSIRO_v1

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005342541	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040287307	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000004644 ⟹ ENSSTOP00000004166

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004937131	42,454 - 49,536 (-)	Ensembl

RefSeq Acc Id:

XM_005342541 ⟹ XP_005342598

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	7,523,130 - 7,530,183 (-)	NCBI
SpeTri2.0	NW_004937131	42,523 - 49,533 (-)	NCBI

Sequence:

show sequence

TCTGTGGTGACTCCTTCACGCTAAGTGCAGCAGCAACATGGAACAGCTGTTGCCACCAACGGCT
CTGCTACTTCTAGTTTCAGCTGGCATGCAAGCTGAAGATCTCCCAAAGGCTGTGGTGCTCCTAG
ATCCTCCATGGGACTGGGTGCTCCAGGAAGACAGTGTGACTCTGAAGTGTCAGGGGGCCCAACA
CCCTGAAGACACTTCCACACAGTGGTTCCATAATGGAAACCTCATTCCAAGCCAGGCCTCTAGC
TACTACATTGCAAAAGCCAAAGATAAAGACAGTGGAGAGTACAGGTGCCAGACCAACCTCTCCA
TGCAAAGTGACGCTGTGCATCTAGAAATCCACACTGGCTGGTTGTTGCTCCAGACCTCTAAGCG
GGTGCTCCAGCCCGGGGAGCCTCTCCGGCTGAGATGCCACAGCTGGAAGAATACGCCTGTGCAT
AAGGTCACATATTTACAAGATGGCAGAGGCAAGAAGTATTTTCATCGCAATTCCGAGTTGTACA
TTCCAAAGGCCTCATCCAAGGACAGTGGCTCCTACTTCTGCCGGGGTCTTATTGGGAATCACAA
CCAATCTTCAGAGTCTGTGAACATCATCATTGGAGGTTCAGCATTTCCATCCACCTCCTCAGTT
TTTCTACCTTGGCACCAAATTGCTTTCTGCCTGATGATGGGACTCTTATTTGCAGTGGACACAG
GGCTATATTTTTCTGTGCGAAGAAACCTTCAAAGTTCAGGCGGAGACTGGTCCAAAAACAAAGT
TAGATGGAGCCGGGACCCTCAGGACAAATGACCCATGGGGTAATAAGGGCATTGGCACAGCTTC
TATGAACCTCTCTGTGGATCAACAACCTCATCATCCCCATCAGGCATTTCTTTGAGCAGCAGAA
AAAAAATACAACTCAGAGCCTGGGCCGAGGGCATCTCTCCCAACTCTCTGTTTCCTCCAGGTCT
CTAGTGAAAAGGAAAGGCCAAAAGCAATGCCCTAGTGAGAAGCTGGGGAATTCTCTCAGGAGCT
GAGTGTAGGAGATATATACTTTCTCTGGCTCAACCATTCCCTCACACACTCTGTATAATGAACC
TTTAAACATATAAAAATCTTTCCTGAATACATGAATAACTAGATAAACTATTAACAGTTGAGGA
AGGGCCAGAATGATAGTGGTCTGGTTGCCTTCAGGGGAACCCCAAGCTCCTTCCAGATAGAGGG
TGGGAACTCCTGGGGACCTAGGCAATTCAATAGACCTAATGAAGGGGATGGCTGAGAAAGAGCA
GGGAAGTCCAGAATAGACCCAGGGAGGTATCCACATCTGGACCCAGAGATAAAATTGCCAAAAG
CAGGAGGCATGTTGGAGTCAACAGGCAATTATAGCCATGATATCTAATTGAGTTTTCCAGAGGA
GTATCTATCAAAATTGGAATGGTTTGTGAATATATGATAATGAACCCTTTTAATGCATGAGTAG
GCAATAAGCCTAGGAAGGGGGCTGAAGACTTGGGGGTGGGGTAGAGAGCAGAGGTTGAAAAAGA
AAGCTTAGATCAGACAGACTTGTGTTATGCTAAGTGAAACAGAGACAGTTCACTCTCTGAGCTG
AGAAAAGCATGCAACAAAGAGTCAACCACAAGTTCACAGGAAGGAATGGTCAAGGAATGAAGAC
ACTTGTTGACCAACGTAGTACGAATTAGAGACAAGGAGGAGCAGGGACTTTAAATACAGCTTTT
CTGTTTCAATATCTAATTCAGATATAACTTTGTTCCCATTATACATTGAACAAATGTTGGATAA
CCAACTCTAAATGTCCTGAATTCTACTGACTGAGTTAAATTGTGAAACTTTGAAATCTCTCAGC
CTAACAGTTCCAATGGGTTGGGGGCAGGGAAGGAAAACATTGCTTATGGAAGAAAGCTTTAACT
ATCTCTTTCTGTTCTAGATGTTTTTAACAAAAAACACTTTTGCTTTCAATAAAACATTTTACAA
GA

hide sequence

RefSeq Acc Id:

XM_040287307 ⟹ XP_040143241

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	7,523,130 - 7,530,142 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_005342598	(Get FASTA)	NCBI Sequence Viewer
	XP_040143241	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000004166.3
GenBank Protein	KAG3281128	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005342598 ⟸ XM_005342541
- Peptide Label:	isoform X1
- UniProtKB:	I3M4L9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEQLLPPTALLLLVSAGMQAEDLPKAVVLLDPPWDWVLQEDSVTLKCQGAQHPEDTSTQWFHNG NLIPSQASSYYIAKAKDKDSGEYRCQTNLSMQSDAVHLEIHTGWLLLQTSKRVLQPGEPLRLRC HSWKNTPVHKVTYLQDGRGKKYFHRNSELYIPKASSKDSGSYFCRGLIGNHNQSSESVNIIIGG SAFPSTSSVFLPWHQIAFCLMMGLLFAVDTGLYFSVRRNLQSSGGDWSKNKVRWSRDPQDK hide sequence

RefSeq Acc Id:	XP_040143241 ⟸ XM_040287307
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSSTOP00000004166 ⟸ ENSSTOT00000004644

Protein Domains

Ig-like

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000004650	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000004644.3	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/TrEMBL
InterPro	Ig-like_dom	UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	Ig_Fc_receptor	UniProtKB/TrEMBL
	Ig_sub	UniProtKB/TrEMBL
KEGG Report	iti:101955076	UniProtKB/TrEMBL
NCBI Gene	LOC101955076	ENTREZGENE
PANTHER	IMMUNOGLOBULIN FC RECEPTOR	UniProtKB/TrEMBL
	LOW AFFINITY IMMUNOGLOBULIN GAMMA FC REGION RECEPTOR III-A-RELATED	UniProtKB/TrEMBL
Pfam	Ig_2	UniProtKB/TrEMBL
PROSITE	IG_LIKE	UniProtKB/TrEMBL
SMART	SM00409	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48726	UniProtKB/TrEMBL
UniProt	I3M4L9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-26	LOC101955076	low affinity immunoglobulin gamma Fc region receptor III-A	Fcgr3a	Fc fragment of IgG receptor IIIa	Symbol and/or name change	5135510	APPROVED
2017-07-13	Fcgr3a	Fc fragment of IgG receptor IIIa	LOC101955076	low affinity immunoglobulin gamma Fc region receptor III-A	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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