Tspo (translocator protein) - Rat Genome Database
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Gene: Tspo (translocator protein) Ictidomys tridecemlineatus
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Symbol: Tspo
Name: translocator protein
RGD ID: 12630390
Description: ENCODES a protein that exhibits androgen binding (ortholog); benzodiazepine receptor activity (ortholog); ion channel binding (ortholog); INVOLVED IN adrenal gland development (ortholog); aging (ortholog); behavioral response to pain (ortholog); PARTICIPATES IN heme biosynthetic pathway; ASSOCIATED WITH COVID-19 (ortholog); End Stage Liver Disease (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cytosol (ortholog); intracellular membrane-bounded organelle (ortholog); mitochondrial outer membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936718992,301 - 995,172 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
aging  (ISO)
behavioral response to pain  (ISO)
cellular hypotonic response  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to zinc ion  (ISO)
chloride transport  (ISO)
contact inhibition  (ISO)
establishment of protein localization to mitochondrion  (ISO)
glial cell migration  (ISO)
ion transport  (ISO)
maintenance of protein location in mitochondrion  (ISO)
negative regulation of ATP metabolic process  (ISO)
negative regulation of autophagy of mitochondrion  (ISO)
negative regulation of glial cell proliferation  (ISO)
negative regulation of mitochondrion organization  (ISO)
negative regulation of nitric oxide biosynthetic process  (ISO)
negative regulation of protein ubiquitination  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
peripheral nervous system axon regeneration  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of calcium ion transport  (ISO)
positive regulation of glial cell proliferation  (ISO)
positive regulation of mitochondrial depolarization  (ISO)
positive regulation of necrotic cell death  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
regulation of steroid biosynthetic process  (ISO)
response to axon injury  (ISO)
response to drug  (ISO)
response to manganese ion  (ISO)
response to pain  (ISO)
response to progesterone  (ISO)
response to testosterone  (ISO)
response to vitamin B1  (ISO)
steroid biosynthetic process  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Tspo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936718992,301 - 995,172 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TSPO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2243,151,547 - 43,163,242 (+)EnsemblGRCh38hg38GRCh38
GRCh382243,151,559 - 43,163,242 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372243,547,565 - 43,559,248 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh372243,547,520 - 43,559,248 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362241,877,479 - 41,889,192 (+)NCBINCBI36hg18NCBI36
Build 342241,872,050 - 41,883,745NCBI
Celera2227,457,910 - 27,469,623 (+)NCBI
Cytogenetic Map22q13.2NCBI
HuRef2226,505,727 - 26,517,455 (+)NCBIHuRef
CHM1_12243,507,104 - 43,518,509 (+)NCBICHM1_1
Tspo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391583,447,774 - 83,458,404 (+)NCBIGRCm39mm39
GRCm381583,563,573 - 83,574,203 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1583,563,592 - 83,574,203 (+)EnsemblGRCm38mm10GRCm38
MGSCv371583,394,003 - 83,404,633 (+)NCBIGRCm37mm9NCBIm37
MGSCv361583,391,377 - 83,401,962 (+)NCBImm8
Celera1585,689,315 - 85,701,021 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1539.4NCBI
Tspo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27114,720,188 - 114,730,450 (+)NCBI
Rnor_6.0 Ensembl7124,460,358 - 124,470,609 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07124,460,358 - 124,470,610 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07124,449,361 - 124,459,090 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47121,597,084 - 121,599,342 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17121,631,313 - 121,633,572 (+)NCBI
Celera7111,031,561 - 111,041,788 (+)NCBICelera
RH 3.4 Map7906.4RGD
Cytogenetic Map7q34NCBI
Tspo
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541328,308,658 - 28,315,075 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541328,309,105 - 28,315,075 (+)NCBIChiLan1.0ChiLan1.0
TSPO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12242,233,186 - 42,244,930 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2242,233,619 - 42,244,930 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02224,034,918 - 24,046,370 (+)NCBIMhudiblu_PPA_v0panPan3
TSPO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1022,274,405 - 22,399,297 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11022,388,498 - 22,399,329 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
TSPO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl55,723,186 - 5,735,128 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.155,723,190 - 5,735,097 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.253,145,792 - 3,157,669 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TSPO
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11925,678,602 - 25,690,556 (+)NCBI
ChlSab1.1 Ensembl1925,686,981 - 25,690,768 (+)Ensembl
Tspo
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247525,814,784 - 5,820,250 (-)NCBI


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_013364397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AGTP01098780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_013364397   ⟹   XP_013219851
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_004936718992,301 - 995,172 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013219851 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013219851   ⟸   XM_013364397
- UniProtKB: I3M198 (UniProtKB/TrEMBL)
- Sequence:


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000002875 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000002569 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000002871 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.20.1260.100 UniProtKB/TrEMBL
InterPro TSPO UniProtKB/TrEMBL
  TspO/MBR-related_sf UniProtKB/TrEMBL
  TspO_MBR UniProtKB/TrEMBL
NCBI Gene Tspo ENTREZGENE
PANTHER PTHR10057 UniProtKB/TrEMBL
  PTHR10057:SF5 UniProtKB/TrEMBL
Pfam TspO_MBR UniProtKB/TrEMBL
PIRSF PBR UniProtKB/TrEMBL
UniProt I3M198 ENTREZGENE, UniProtKB/TrEMBL