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Gene: Dpysl4 (dihydropyrimidinase like 4) Ictidomys tridecemlineatus

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Symbol:

Dpysl4

Name:

dihydropyrimidinase like 4

RGD ID:

12629712

Description:

ENCODES a protein that exhibits phosphoprotein binding (ortholog); INVOLVED IN neuron development (ortholog); ASSOCIATED WITH distal 10q deletion syndrome (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

dihydropyrimidinase-related protein 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	6,961,004 - 6,977,631 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936486	18,583,611 - 18,600,279 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936486	18,583,663 - 18,600,297 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

distal 10q deletion syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

neuron development (ISO)

Cellular Component

cytoplasm (IEA)

cytosol (IEA)

Molecular Function

filamin binding (IEA)

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds (IEA)

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides (IEA)

phosphoprotein binding (ISO)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Dpysl4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	6,961,004 - 6,977,631 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936486	18,583,611 - 18,600,279 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936486	18,583,663 - 18,600,297 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DPYSL4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	132,186,948 - 132,205,759 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	132,186,948 - 132,205,759 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	134,000,452 - 134,019,263 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	133,850,394 - 133,869,256 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	133,850,393 - 133,869,256	NCBI
Celera	10	127,645,533 - 127,664,406 (+)	NCBI		Celera
Cytogenetic Map	10	q26.3	NCBI
HuRef	10	127,552,157 - 127,570,704 (+)	NCBI		HuRef
CHM1_1	10	134,282,639 - 134,301,323 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	133,128,313 - 133,148,570 (+)	NCBI		T2T-CHM13v2.0

Dpysl4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	138,665,917 - 138,681,711 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	138,665,917 - 138,682,620 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	139,085,981 - 139,101,795 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	139,086,001 - 139,102,704 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	146,271,900 - 146,287,694 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	138,937,393 - 138,953,088 (+)	NCBI		MGSCv36	mm8
Celera	7	138,881,350 - 138,897,146 (+)	NCBI		Celera
Cytogenetic Map	7	F4	NCBI
cM Map	7	83.92	NCBI

Dpysl4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	203,312,646 - 203,328,523 (+)	NCBI		GRCr8
mRatBN7.2	1	193,883,039 - 193,898,916 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	193,883,106 - 193,898,914 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	202,253,464 - 202,269,243 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	209,388,259 - 209,403,801 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	202,061,741 - 202,077,555 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	211,423,022 - 211,438,533 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	211,423,022 - 211,438,531 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	218,349,771 - 218,365,282 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	198,866,034 - 198,881,902 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	199,016,163 - 199,031,892 (+)	NCBI
Celera	1	191,572,026 - 191,587,830 (+)	NCBI		Celera
Cytogenetic Map	1	q41	NCBI

Dpysl4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955477	9,828,766 - 9,845,002 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955477	9,828,766 - 9,844,975 (+)	NCBI	ChiLan1.0	ChiLan1.0

DPYSL4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	144,153,315 - 144,173,837 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	144,158,676 - 144,179,194 (+)	NCBI		NHGRI_mPanPan1
PanPan1.1	10	133,083,764 - 133,099,349 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	133,082,886 - 133,099,349 (+)	Ensembl	panpan1.1		panPan2

DPYSL4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	40,171,461 - 40,185,910 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	40,171,239 - 40,185,481 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	40,235,701 - 40,250,040 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	40,816,840 - 40,831,202 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	40,818,236 - 40,831,201 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	40,300,771 - 40,315,112 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	40,288,656 - 40,302,623 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	40,687,937 - 40,702,309 (+)	NCBI		UU_Cfam_GSD_1.0

DPYSL4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	140,497,457 - 140,511,733 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	140,497,457 - 140,511,740 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	152,331,352 - 152,344,998 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DPYSL4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	124,778,082 - 124,795,738 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	124,778,156 - 124,795,806 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	86,262,725 - 86,280,751 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dpysl4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624737	14,606,176 - 14,623,490 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624737	14,606,176 - 14,623,498 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005320778	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040272207	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010002273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000004237 ⟹ ENSSTOP00000003804

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936486	18,583,611 - 18,600,279 (+)	Ensembl

RefSeq Acc Id:

XM_005320778 ⟹ XP_005320835

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	6,961,004 - 6,977,631 (-)	NCBI
SpeTri2.0	NW_004936486	18,583,663 - 18,600,297 (+)	NCBI

Sequence:

show sequence

GCGCCCCGCGCGCTCGCACTCAGCGGCTCCGCGCCCCACGCTCACGCTGTTCACCGCGCGTGTC
CCCGCTCGCTCGCCCACGCTCGCGCTGCCCCTGCCAGGATCGGGCCAGCCTGCAGAACAGGATG
TCCTTCCAGGGCAAGAAGAGCATCCCCCGGATCACGAGTGACCGCCTCCTGATCAAAGGTGGGA
AGATTGTGAATGACGACCAGTCCTTTTATGCTGATTTGTATGTGGAAGACGGTTTGATTAAACA
AATTGGAGAAAACCTCATTGTCCCTGGGGGCATTAAAACCATTGATGCCCATGGCCTCATGGTC
CTGCCTGGCGGAGTCGATGTCCACACGAGACTGCAGATGCCTGTCCTGGGCATGACGCCGGCTG
ATGACTTCTGTCAAGGCACCAAGGCAGCCCTGGCAGGAGGGACCACCATGATACTGGACCACGT
GTTCCCGGACACGGGGGTGAGCCTGCTGGCAGCCTACGAGCAGTGGCGGGAGTGGGCGGACAGC
GCAGCGTGCTGTGACTACTCTCTGCATGTGGACGTGCCCCGCTGGCACGAGAGCACCAAGGAGG
AGCTGGAGGCCCTGGTCAGGGACAAGGGTGTGAACTCCTTCCTGGTCTTCATGTCATATAAGGA
CAGGTGCCAGTGTACTGACGGCCAGATGTATGAGATCTTCAGCATCATCCGGGACCTGGGAGCG
GTGGCCCAGGTGCACGCAGAGAACGGGGACATCGTGGAGGAGGAGCAGAAGCGCCTGCTGGAGC
GAGGTATCACCGGCCCCGAGGGCCACGTGCTCAGCCACCCCGAGGAGGTGGAGGCCGAGGCTGT
GTACCGAGCTGTCACCATCGCCAAGCAGGCCAACTGCCCACTGTATGTCACCAAGGTGATGAGC
AGGAGTGCAGCCGATGTGATCGCCCAAGCCAAGCGCAGGGGATTGGTTGTGTTTGGGGAGCCCA
TCGCTGCCAGCCTGGGCGCTGACGGCACACACTACTGGAGCAAGAACTGGGCGAAGGCTGCGGC
GTTTGTCACCTCACCCCCCATCAACCCGGACCCCACCACTGCAGACCACCTCACCTCCCTGCTA
TCCAGTGGGGACCTCCAGGTGACGGGCAGTGCCCACTGCACCTTCACCACTGCCCAGAAGGCTG
TTGGCAAAGATAACTTCACGCTGATCCCCGAGGGCACCAACGGTGTGGAGGAGCGCATGTCTGT
AGTCTGGGAAAAATGCGTGGCCTCCGGGAAGATGGATGAGAATGAATTTGTTGCCGTGACCAGT
ACAAATGCTGCCAAAATCTTCAATTTTTACCCAAGGAAGGGGCGCGTGGCTGTAGGCTCCGATG
CTGACCTGGTGATCTGGAACCCCAGGGCCTCGAAGATCCTCTCTGCCAAGAGCCACAGCTCGAA
CGTGGAGTACAACATCTTTGAAGGATCCGAGTGCCGAGGAGGCCCCTCCGTGGTCATAAGTCAG
GGCAGAGTGGTGCTGGAGGACGGGAACCTGTGTGCCACTCCGGGGGCTGGCCGCTTCATTCCTC
GGAAAACATTCCCAGACTTCGTCTATAAGAGAATAAAAGCTCGCAACAGGCTGGCAGAGATCCA
CGGTGTGCCCCGGGGCCTCTATGATGGGCCGGTCCATGAGGTGGTGGTGCCTGCCAAGACAGGA
GGTGGCACCCAGGCCCGCGCATCCTGCCCAGGCAAGATCTCCGTGCCCCCCGTGCGCAACCTGC
ACCAGTCGGGATTCAGCCTGTCTGGGTCGCAGGCTGACGACCACATCGCCAGGCGCACAGCCCA
GAAGATCATGGCGCCCCCCGGTGGACGCTCCAACATCACCTCTCTCTCTTAGACCCCATTCCCG
CTGGCGGCTGCTGTGGGGGCCGGTGGCCTCAGTTAGCTCTTTCCTTTGTAGAAGTCACTTTGAA
AGGTGCTCAACCTTGCCTTCCCTCCCCCTCAACAAAGCTCTCCTTTGGGGTCCCGGGTCCCACT
GCGAGGAGCCCCTTCAAGAGGGCTGAATGTGGGGAGACCTCACTGCCAGGACCAGGAGCTAGAT
GAGGCAGCGACAGCTCAGGCGGCCCCTAGCCCACATGCCAGGTGACCCAGTGCCTGCCTGGCCC
CACTAGGGTGCTGAAACCCCCAGGTGCTCACTGTGGAGTAGTGGCTGGGGCTGGGAGCCCAGGC
TCTGAGCTGGAGTCTGGGCGGGCGGGTGTCTGCCGCTTCCTTCCCGTGGGAATCACTGCCCTTC
CAAGTCCCCAGCCTCCCACCTGCCCGTGGCACTAGGTGCGGCCGTCCTTCCAGGGGATGTCACG
ATGTTCGCCCAGCACAGGTAGGGGACAGGCATGGAGCCTCGGCCTCTAGAGCTGCTGTGACTTC
AGGGATCCACCAGGAATTTAGCATGGGCAGCTCCCCCCGTAGGGACTCACTGGTACCCACTCAA
GGACCAAGCCTGAGCTTCCCCAGGGCCCTTCCAGGAAGCTTCACGACCCTTTAGCTCAGATGCC
CCCCTTTTACTACAGGACGAGTCCTTCCACAGGGCCATTAGAGTAGCAGATTTGTAGAGTGAGG
AAACCGTAGCCAGGAACCTGCATGCCACCACCCTGGACGGCAGGTGGCCGTCTGAGCCTGATTC
GTCGGGTGGATTAAAGACGTCTCTGGGTTAGAAGCT

hide sequence

RefSeq Acc Id:

XM_040272207 ⟹ XP_040128141

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	6,961,004 - 6,977,316 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_005320835	(Get FASTA)	NCBI Sequence Viewer
	XP_040128141	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000003804.2
GenBank Protein	KAG3263837	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005320835 ⟸ XM_005320778
- Peptide Label:	isoform X1
- UniProtKB:	I3M3V5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSFQGKKSIPRITSDRLLIKGGKIVNDDQSFYADLYVEDGLIKQIGENLIVPGGIKTIDAHGLM VLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWREWAD SAACCDYSLHVDVPRWHESTKEELEALVRDKGVNSFLVFMSYKDRCQCTDGQMYEIFSIIRDLG AVAQVHAENGDIVEEEQKRLLERGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVM SRSAADVIAQAKRRGLVVFGEPIAASLGADGTHYWSKNWAKAAAFVTSPPINPDPTTADHLTSL LSSGDLQVTGSAHCTFTTAQKAVGKDNFTLIPEGTNGVEERMSVVWEKCVASGKMDENEFVAVT STNAAKIFNFYPRKGRVAVGSDADLVIWNPRASKILSAKSHSSNVEYNIFEGSECRGGPSVVIS QGRVVLEDGNLCATPGAGRFIPRKTFPDFVYKRIKARNRLAEIHGVPRGLYDGPVHEVVVPAKT GGGTQARASCPGKISVPPVRNLHQSGFSLSGSQADDHIARRTAQKIMAPPGGRSNITSLS hide sequence

RefSeq Acc Id:	XP_040128141 ⟸ XM_040272207
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSSTOP00000003804 ⟸ ENSSTOT00000004237

Protein Domains

Amidohydrolase-related

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000004242	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000004237.3	UniProtKB/TrEMBL
Gene3D-CATH	2.30.40.10	UniProtKB/TrEMBL
	Metal-dependent hydrolases	UniProtKB/TrEMBL
InterPro	Amidohydro-rel	UniProtKB/TrEMBL
	Hydantoinase/dihydroPyrase	UniProtKB/TrEMBL
	Metal-dep_hydrolase_composite	UniProtKB/TrEMBL
	Metal_Hydrolase	UniProtKB/TrEMBL
	Metallo-dep_Hydrolases_sf	UniProtKB/TrEMBL
NCBI Gene	Dpysl4	ENTREZGENE
PANTHER	HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER	UniProtKB/TrEMBL
	PTHR11647:SF55	UniProtKB/TrEMBL
Pfam	Amidohydro_1	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51338	UniProtKB/TrEMBL
	SSF51556	UniProtKB/TrEMBL
UniProt	I3M3V5	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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