Ube2a (ubiquitin conjugating enzyme E2 A)

Gene: Ube2a (ubiquitin conjugating enzyme E2 A) Ictidomys tridecemlineatus

Analyze

Symbol:

Ube2a

Name:

ubiquitin conjugating enzyme E2 A

RGD ID:

12627964

Description:

ENCODES a protein that exhibits ATP binding (inferred); histone ubiquitin ligase activity (inferred); transferase activity (inferred); INVOLVED IN blastocyst hatching (ortholog); in utero embryonic development (ortholog); maternal process involved in female pregnancy (ortholog); ASSOCIATED WITH autistic disorder (ortholog); genetic disease (ortholog); syndromic X-linked intellectual disability 14 (ortholog); FOUND IN chromatin (ortholog); XY body (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

ubiquitin-conjugating enzyme E2 A

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	90,647,228 - 90,656,829 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936479	10,330,632 - 10,340,367 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936479	10,330,666 - 10,340,268 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

genetic disease (ISO)

syndromic X-linked intellectual disability 14 (ISO)

syndromic X-linked intellectual disability Cabezas type (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

syndromic X-linked intellectual disability Nascimento type (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blastocyst hatching (ISO)

chromatin remodeling (IEA)

DNA repair (IEA)

G2/M transition of mitotic cell cycle (IEA)

in utero embryonic development (ISO)

maternal process involved in female pregnancy (ISO)

positive regulation of mitophagy (ISO)

proteasome-mediated ubiquitin-dependent protein catabolic process (IEA)

protein K11-linked ubiquitination (IEA)

protein K48-linked ubiquitination (IEA)

protein polyubiquitination (IEA)

protein ubiquitination (ISO)

response to UV (IEA)

Cellular Component

chromatin (ISO)

HULC complex (IEA)

XY body (ISO)

Molecular Function

ATP binding (IEA)

histone ubiquitin ligase activity (IEA)

protein binding (ISO)

transferase activity (IEA)

ubiquitin conjugating enzyme activity (IEA)

ubiquitin protein ligase binding (IEA)

ubiquitin-protein transferase activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Ube2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	90,647,228 - 90,656,829 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936479	10,330,632 - 10,340,367 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936479	10,330,666 - 10,340,268 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

UBE2A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	119,574,563 - 119,584,423 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	119,474,802 - 119,591,083 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	118,708,526 - 118,718,386 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	118,592,527 - 118,602,409 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	118,496,179 - 118,500,259	NCBI
Celera	X	119,163,202 - 119,173,086 (+)	NCBI		Celera
Cytogenetic Map	X	q24	NCBI
HuRef	X	108,201,952 - 108,211,764 (+)	NCBI		HuRef
CHM1_1	X	118,619,785 - 118,629,669 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	117,952,276 - 117,962,139 (+)	NCBI		T2T-CHM13v2.0

Ube2a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	36,137,948 - 36,147,875 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	36,064,828 - 36,147,875 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	36,874,295 - 36,884,222 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	36,873,900 - 36,884,222 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	34,414,361 - 34,424,217 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	33,305,811 - 33,315,667 (+)	NCBI		MGSCv36	mm8
Celera	X	23,598,009 - 23,607,867 (+)	NCBI		Celera
Cytogenetic Map	X	A3.3	NCBI
cM Map	X	21.28	NCBI

Ube2a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	120,979,993 - 120,990,773 (+)	NCBI		GRCr8
mRatBN7.2	X	116,114,339 - 116,125,076 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	116,113,875 - 116,125,070 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	118,217,786 - 118,228,455 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	121,786,920 - 121,797,590 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	119,333,079 - 119,343,748 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	123,486,988 - 123,497,726 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	123,486,989 - 123,497,726 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	123,631,932 - 123,642,667 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	7,981,683 - 7,992,372 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	7,987,239 - 7,997,928 (-)	NCBI
Celera	X	115,344,617 - 115,355,306 (+)	NCBI		Celera
Cytogenetic Map	X	q34	NCBI

Ube2a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955534	409,947 - 421,888 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955534	411,602 - 485,964 (-)	NCBI	ChiLan1.0	ChiLan1.0

UBE2A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	118,952,772 - 118,966,003 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	118,958,856 - 118,969,606 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	108,606,271 - 108,617,000 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	119,034,235 - 119,044,162 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	119,034,235 - 119,049,655 (+)	Ensembl	panpan1.1		panPan2

UBE2A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	91,608,936 - 91,617,993 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	91,529,855 - 91,617,086 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	77,683,723 - 77,693,214 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	93,348,047 - 93,357,539 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	93,269,313 - 93,357,780 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	90,800,735 - 90,810,228 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	92,559,455 - 92,567,715 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	92,288,649 - 92,298,142 (+)	NCBI		UU_Cfam_GSD_1.0

UBE2A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	97,925,131 - 98,012,278 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	97,925,136 - 98,007,551 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	113,657,314 - 113,666,926 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

UBE2A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Vero_WHO_p1.0	NW_023666065	32,327,496 - 32,337,450 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ube2a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624895	3,544,410 - 3,553,981 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005319376	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000614	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000011581 ⟹ ENSSTOP00000010395

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936479	10,331,786 - 10,340,072 (-)	Ensembl

RefSeq Acc Id:

ENSSTOT00000042058 ⟹ ENSSTOP00000028407

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936479	10,330,632 - 10,340,367 (-)	Ensembl

RefSeq Acc Id:

ENSSTOT00000042838 ⟹ ENSSTOP00000031261

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936479	10,331,901 - 10,340,072 (-)	Ensembl

RefSeq Acc Id:

XM_005319376 ⟹ XP_005319433

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	X	90,647,228 - 90,656,829 (+)	NCBI
SpeTri2.0	NW_004936479	10,330,666 - 10,340,268 (-)	NCBI

Sequence:

show sequence

GGTTGGTTCAGCCCCCGTCTACTCCGGGGTGGTGCTTAGCCGGCGCCAGACCGACCCTCGACTT
CGGAGAGGCAGTGCTGTTCCTCTGGGTGCTTCCTCCACATCTTCTTCAGCTTCTTCAGTCTCCT
CGGCCTCCTTACCGACCGCGGGGACCCGAGACTCTGGTGTATGCCCCACCCCTGACCCTGCTAG
AGATATGTCCACCCCGGCTCGGCGGCGCCTCATGCGGGACTTCAAGAGGTTGCAGGAGGATCCT
CCGGCTGGAGTCAGTGGGGCTCCGTCTGAGAACAACATAATGGTTTGGAACGCGGTCATTTTTG
GGCCTGAAGGGACCCCATTTGAGGATGGAACATTTAAACTTACAATAGAATTCACTGAAGAATA
TCCGAATAAACCACCTACTGTTAGATTTGTCTCTAAGATGTTTCATCCAAATGTCTATGCAGAT
GGTAGTATATGTCTGGATATACTTCAGAACCGTTGGAGTCCAACCTATGATGTGTCTTCCATTT
TAACATCCATACAGTCTCTATTGGATGAACCCAATCCCAATAGTCCTGCAAACAGCCAAGCTGC
TCAGCTGTACCAGGAGAACAAGCGGGAATATGAAAAGCGTGTTTCTGCCATAGTAGAACAGAGC
TGGCGCGACTGTTGACTGAAGGTGGAACAAAGGAAGAGGCTGGGCATAAGAAAAATATATATTG
ATGTGTTTATCACCTTCTTATTCCTCAATGTCATTACATTTACTTTATTAAAAGCAAAATAGCT
GTTCTGCTGTTTCCATCTTCCCTTGCCAAGCTTTTCCTACCCCTTCTACTCTCTTGTTGAACAT
CAGAAAACACGCTCTATGAAATCAAATGTACTGTACCTGGGTTACTTGCAAAAATTACTAATGC
TTAACTCTTTTTTTGTTGTATCTCATCTCCAGCCTTCGGGCATTTATTTGTGTTACTGTACTTT
ACACTAAGCTTTTAAGATGCATTGTTATACAAATGGTTCTTATGTATAGTTTGAAGACCAGGAT
TTTATTTTTAACAGAATGATTACCAAAGTGTTTCATACTGGCTGGTCCTTCCCTTGTGTTGGGA
CTTAGATGTGAATGTGTTTAGAATACAGCCAGCCTGTTTGAGGACAGGGAAACAAATCCACTGT
AAACAGTTCTTTGATGCTAATGTCTTGTAATATGAATTACAAGATGGTATTTACTGGTAGAAAA
TGTTGGAAGGCTTCAGCCAAGGGAGCGCAGCAGGAACTGACATCTACTCCTAGCAAGATACCAA
CAGCTCACATATATTAGATTTCAGAATATTGGTCTTCTAAGGTTTCTTTTGTTTTGGTTTTTTT
CTTAAAGAGGTGTAGGAGCAAAGGAATGGAAACAATCAACAGTTTTTGAGCTAGGGAAAGGTGA
AAATCCTTTCATATTTTTAAAGGAGAAGTGTTGCCCTAGAAAAAACTTACAATCCTCCATCTTG
TTTTTTAGTTTTAATTCAAGGGCACATATATGTGGCAAACTATTTTCTACTGAAATCTTGAGTT
ATTGCTGCATACTTTAGTTTCTTCTCGTTCAGTGTTATGAGAACCTTAAAGCCTATGTCTACAA
TCTTTCTTTGGATATTTACACTTTTAGATATACAAAGCTTATAAGTGAGTTGTCTAATGTTTCA
TTGTTACCTTTTTGGATTTATTGCTGTTTGAAGTCTAATGTTGCACAAGTAACCCATGTAAAAA
AATGTACATTTTTCAAAACTTGTAAATAAAAATAACCTTAAAATTTT

hide sequence

Protein Sequences


Protein RefSeqs	XP_005319433	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000010395.3
	ENSSTOP00000028407.1
	ENSSTOP00000031261.1
GenBank Protein	KAG3272812	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005319433 ⟸ XM_005319376
- UniProtKB:	A0A287D4F9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSTPARRRLMRDFKRLQEDPPAGVSGAPSENNIMVWNAVIFGPEGTPFEDGTFKLTIEFTEEYP NKPPTVRFVSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQ LYQENKREYEKRVSAIVEQSWRDC hide sequence

RefSeq Acc Id:

ENSSTOP00000010395 ⟸ ENSSTOT00000011581

RefSeq Acc Id:

ENSSTOP00000028407 ⟸ ENSSTOT00000042058

RefSeq Acc Id:

ENSSTOP00000031261 ⟸ ENSSTOT00000042838

Protein Domains

UBC core

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000011583	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000011581.3	UniProtKB/TrEMBL
	ENSSTOT00000042058.1	UniProtKB/TrEMBL
	ENSSTOT00000042838.1	UniProtKB/TrEMBL
Gene3D-CATH	3.10.110.10	UniProtKB/TrEMBL
InterPro	UBQ-conjugat_E2	UniProtKB/TrEMBL
	UBQ-conjugating_AS	UniProtKB/TrEMBL
	UBQ-conjugating_enzyme/RWD	UniProtKB/TrEMBL
NCBI Gene	Ube2a	ENTREZGENE
PANTHER	UBIQUITIN-CONJUGATING ENZYME E2	UniProtKB/TrEMBL
	UBIQUITIN-CONJUGATING ENZYME E2 A	UniProtKB/TrEMBL
	UBIQUITIN-CONJUGATING ENZYME E2-17 KDA	UniProtKB/TrEMBL
Pfam	UQ_con	UniProtKB/TrEMBL
PROSITE	UBC_1	UniProtKB/TrEMBL
	UBC_2	UniProtKB/TrEMBL
SMART	UBCc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54495	UniProtKB/TrEMBL
UniProt	A0A287D4F9	ENTREZGENE, UniProtKB/TrEMBL
	A0A287DCP6_ICTTR	UniProtKB/TrEMBL
	I3MHL8_ICTTR	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM