Kcnip2 (potassium voltage-gated channel interacting protein 2) - Rat Genome Database

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Gene: Kcnip2 (potassium voltage-gated channel interacting protein 2) Ictidomys tridecemlineatus
Analyze
Symbol: Kcnip2
Name: potassium voltage-gated channel interacting protein 2
RGD ID: 12624969
Description: ENCODES a protein that exhibits A-type (transient outward) potassium channel activity (ortholog); calcium ion binding (ortholog); identical protein binding (ortholog); INVOLVED IN clustering of voltage-gated potassium channels (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH Cardiac Arrhythmias (ortholog); FOUND IN dendrite (ortholog); plasma membrane (ortholog); voltage-gated potassium channel complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Kv channel-interacting protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721332,337,576 - 32,371,125 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366003,940,813 - 3,961,803 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366003,940,806 - 3,974,455 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
alfentanil pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway   (ISO)
calcium/calcium-mediated signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Kcnip2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721332,337,576 - 32,371,125 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366003,940,813 - 3,961,803 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366003,940,806 - 3,974,455 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNIP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810101,825,974 - 101,843,800 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10101,825,974 - 101,843,920 (-)EnsemblGRCh38hg38GRCh38
GRCh3710103,585,731 - 103,603,557 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610103,575,721 - 103,593,667 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410103,575,721 - 103,593,667NCBI
Celera1097,324,471 - 97,342,415 (-)NCBICelera
Cytogenetic Map10q24.32NCBI
HuRef1097,216,464 - 97,234,410 (-)NCBIHuRef
CHM1_110103,869,314 - 103,887,271 (-)NCBICHM1_1
T2T-CHM13v2.010102,709,458 - 102,727,289 (-)NCBIT2T-CHM13v2.0
Kcnip2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391945,780,785 - 45,804,948 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1945,780,278 - 45,804,500 (-)EnsemblGRCm39 Ensembl
GRCm381945,792,346 - 45,816,422 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1945,791,839 - 45,816,061 (-)EnsemblGRCm38mm10GRCm38
MGSCv371945,868,160 - 45,890,293 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361945,846,981 - 45,869,114 (-)NCBIMGSCv36mm8
Celera1946,555,638 - 46,577,688 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.75NCBI
Kcnip2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81254,590,172 - 254,614,437 (-)NCBIGRCr8
mRatBN7.21244,641,147 - 244,664,939 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1244,641,150 - 244,664,874 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1252,782,586 - 252,806,733 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01259,480,725 - 259,504,561 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01252,132,599 - 252,156,275 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01265,549,610 - 265,573,393 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1265,549,593 - 265,573,409 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1262,892,545 - 262,916,361 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01270,337,725 - 270,361,519 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41251,008,676 - 251,032,402 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1240,448,191 - 240,472,276 (-)NCBICelera
Cytogenetic Map1q54NCBI
Kcnip2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554858,467,207 - 8,470,950 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554858,468,117 - 8,472,220 (+)NCBIChiLan1.0ChiLan1.0
KCNIP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28113,712,657 - 113,730,573 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110113,717,971 - 113,735,894 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01098,428,619 - 98,446,581 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110101,899,898 - 101,918,691 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10101,899,898 - 101,918,691 (-)Ensemblpanpan1.1panPan2
KCNIP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12814,409,526 - 14,425,641 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2814,409,526 - 14,425,641 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2814,578,242 - 14,596,662 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02814,877,733 - 14,896,184 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2814,859,845 - 14,896,560 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12814,424,193 - 14,442,591 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02814,463,755 - 14,482,179 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02814,596,080 - 14,614,481 (-)NCBIUU_Cfam_GSD_1.0
KCNIP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14112,857,062 - 112,876,439 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114112,857,058 - 112,876,469 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214122,709,372 - 122,726,785 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNIP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1994,854,024 - 94,873,655 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl994,855,403 - 94,873,312 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604855,930,976 - 55,951,582 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnip2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248311,301,598 - 1,319,572 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248311,301,840 - 1,319,487 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000029706   ⟹   ENSSTOP00000017281
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366003,940,821 - 3,961,803 (+)Ensembl
Ensembl Acc Id: ENSSTOT00000040249   ⟹   ENSSTOP00000024733
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366003,945,943 - 3,961,803 (+)Ensembl
Ensembl Acc Id: ENSSTOT00000040753   ⟹   ENSSTOP00000029203
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366003,940,821 - 3,961,803 (+)Ensembl
Ensembl Acc Id: ENSSTOT00000041408   ⟹   ENSSTOP00000032041
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366003,940,813 - 3,961,803 (+)Ensembl
RefSeq Acc Id: XM_005333642   ⟹   XP_005333699
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721332,337,581 - 32,358,582 (+)NCBI
SpeTri2.0NW_0049366003,940,815 - 3,961,807 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005333643   ⟹   XP_005333700
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721332,337,581 - 32,357,503 (+)NCBI
SpeTri2.0NW_0049366003,940,816 - 3,961,807 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005333644   ⟹   XP_005333701
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721332,341,829 - 32,357,503 (+)NCBI
SpeTri2.0NW_0049366003,945,418 - 3,961,807 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005333645   ⟹   XP_005333702
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721332,348,388 - 32,358,582 (+)NCBI
SpeTri2.0NW_0049366003,953,167 - 3,961,807 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005333647   ⟹   XP_005333704
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721332,337,584 - 32,357,503 (+)NCBI
SpeTri2.0NW_0049366003,940,814 - 3,961,807 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021731867   ⟹   XP_021587542
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721332,337,576 - 32,371,125 (+)NCBI
SpeTri2.0NW_0049366003,940,806 - 3,974,453 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021731868   ⟹   XP_021587543
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721332,341,819 - 32,371,125 (+)NCBI
SpeTri2.0NW_0049366003,945,408 - 3,974,453 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021731869   ⟹   XP_021587544
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721332,337,577 - 32,371,125 (+)NCBI
SpeTri2.0NW_0049366003,940,807 - 3,974,450 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021731871   ⟹   XP_021587546
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721332,337,576 - 32,371,125 (+)NCBI
SpeTri2.0NW_0049366003,941,038 - 3,974,455 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040273595   ⟹   XP_040129529
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721332,337,577 - 32,371,125 (+)NCBI
RefSeq Acc Id: XR_005728575
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721332,337,580 - 32,370,959 (+)NCBI
RefSeq Acc Id: XP_005333704   ⟸   XM_005333647
- Peptide Label: isoform X9
- UniProtKB: A0A287DEU7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005333699   ⟸   XM_005333642
- Peptide Label: isoform X6
- UniProtKB: I3MYT5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005333700   ⟸   XM_005333643
- Peptide Label: isoform X7
- UniProtKB: A0A287D6N2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005333701   ⟸   XM_005333644
- Peptide Label: isoform X8
- UniProtKB: A0A287CTY1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005333702   ⟸   XM_005333645
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_021587542   ⟸   XM_021731867
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_021587544   ⟸   XM_021731869
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_021587546   ⟸   XM_021731871
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_021587543   ⟸   XM_021731868
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_040129529   ⟸   XM_040273595
- Peptide Label: isoform X3
Ensembl Acc Id: ENSSTOP00000032041   ⟸   ENSSTOT00000041408
Ensembl Acc Id: ENSSTOP00000017281   ⟸   ENSSTOT00000029706
Ensembl Acc Id: ENSSTOP00000024733   ⟸   ENSSTOT00000040249
Ensembl Acc Id: ENSSTOP00000029203   ⟸   ENSSTOT00000040753
Protein Domains
EF-hand


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000021030 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000029706.2 UniProtKB/TrEMBL
  ENSSTOT00000040249.1 UniProtKB/TrEMBL
  ENSSTOT00000040753.1 UniProtKB/TrEMBL
  ENSSTOT00000041408.1 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  Recoverin UniProtKB/TrEMBL
NCBI Gene Kcnip2 ENTREZGENE
PANTHER KV CHANNEL-INTERACTING PROTEIN 2 UniProtKB/TrEMBL
  PTHR23055 UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/TrEMBL
  EF-hand_8 UniProtKB/TrEMBL
PRINTS RECOVERIN UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A0A287CTY1 ENTREZGENE, UniProtKB/TrEMBL
  A0A287D6N2 ENTREZGENE, UniProtKB/TrEMBL
  A0A287DEU7 ENTREZGENE, UniProtKB/TrEMBL
  I3MYT5 ENTREZGENE, UniProtKB/TrEMBL