Plk1 (polo like kinase 1) - Rat Genome Database

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Gene: Plk1 (polo like kinase 1) Ictidomys tridecemlineatus
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Symbol: Plk1
Name: polo like kinase 1
RGD ID: 12624493
Description: ENCODES a protein that exhibits anaphase-promoting complex binding (inferred); ATP binding (inferred); identical protein binding (inferred); INVOLVED IN peptidyl-serine phosphorylation (ortholog); polar body extrusion after meiotic divisions (ortholog); positive regulation of ubiquitin protein ligase activity (ortholog); ASSOCIATED WITH Breast Cancer, Familial (ortholog); breast carcinoma (ortholog); COVID-19 (ortholog); FOUND IN centrosome (ortholog); spindle midzone (ortholog); spindle pole (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine/threonine-protein kinase PLK1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344120,223,455 - 120,234,564 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365018,321,305 - 8,332,424 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365018,321,415 - 8,332,414 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell division  (IEA)
centrosome cycle  (IEA)
double-strand break repair  (IEA)
double-strand break repair via alternative nonhomologous end joining  (IEA)
establishment of mitotic spindle orientation  (IEA)
establishment of protein localization  (IEA)
female meiosis chromosome segregation  (IEA)
G2/M transition of mitotic cell cycle  (IEA)
homologous chromosome segregation  (IEA)
microtubule bundle formation  (IEA)
mitotic cell cycle  (IEA)
mitotic cytokinesis  (IEA)
mitotic G2 DNA damage checkpoint signaling  (IEA)
mitotic sister chromatid segregation  (IEA)
mitotic spindle assembly checkpoint signaling  (IEA)
mitotic spindle organization  (IEA)
negative regulation of apoptotic process  (IEA)
negative regulation of double-strand break repair via homologous recombination  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
nuclear membrane disassembly  (IEA)
peptidyl-serine phosphorylation  (ISO)
polar body extrusion after meiotic divisions  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA)
positive regulation of proteolysis  (IEA)
positive regulation of ubiquitin protein ligase activity  (ISO)
positive regulation of ubiquitin-protein transferase activity  (ISO)
protein destabilization  (IEA)
protein localization to chromatin  (IEA)
protein localization to nuclear envelope  (IEA)
protein phosphorylation  (ISO)
protein ubiquitination  (IEA)
regulation of cytokinesis  (IEA)
regulation of mitotic cell cycle  (IEA)
regulation of mitotic metaphase/anaphase transition  (IEA)
regulation of mitotic spindle assembly  (IEA)
regulation of protein localization to cell cortex  (IEA)
synaptonemal complex disassembly  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Plk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344120,223,455 - 120,234,564 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365018,321,305 - 8,332,424 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365018,321,415 - 8,332,414 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381623,678,889 - 23,690,367 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1623,677,656 - 23,690,367 (+)EnsemblGRCh38hg38GRCh38
GRCh371623,690,210 - 23,701,688 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361623,597,702 - 23,609,189 (+)NCBINCBI36Build 36hg18NCBI36
Build 341623,597,701 - 23,609,191NCBI
Celera1622,468,373 - 22,479,857 (+)NCBICelera
Cytogenetic Map16p12.2NCBI
HuRef1621,779,829 - 21,791,312 (+)NCBIHuRef
CHM1_11624,701,920 - 24,713,407 (+)NCBICHM1_1
T2T-CHM13v2.01623,954,691 - 23,966,171 (+)NCBIT2T-CHM13v2.0
Plk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397121,758,658 - 121,769,107 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7121,758,662 - 121,769,096 (+)EnsemblGRCm39 Ensembl
GRCm387122,159,435 - 122,169,884 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7122,159,439 - 122,169,873 (+)EnsemblGRCm38mm10GRCm38
MGSCv377129,302,951 - 129,313,389 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367121,950,641 - 121,961,011 (+)NCBIMGSCv36mm8
Celera7122,049,692 - 122,060,205 (+)NCBICelera
Cytogenetic Map7F2NCBI
cM Map765.52NCBI
Plk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81186,147,658 - 186,157,637 (+)NCBIGRCr8
mRatBN7.21176,716,420 - 176,726,400 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1176,716,420 - 176,726,400 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1185,044,423 - 185,054,396 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01192,230,379 - 192,240,352 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,914,429 - 184,924,412 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01192,115,990 - 192,125,969 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1192,115,966 - 192,125,989 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01199,178,259 - 199,188,238 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41181,002,811 - 181,012,741 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11181,142,728 - 181,152,656 (+)NCBI
Celera1174,424,809 - 174,434,922 (+)NCBICelera
Cytogenetic Map1q36NCBI
Plk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554932,206,353 - 2,217,231 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554932,206,353 - 2,217,231 (+)NCBIChiLan1.0ChiLan1.0
PLK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21825,083,709 - 25,101,117 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11629,600,211 - 29,620,577 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01614,420,972 - 14,432,821 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11623,928,773 - 23,940,779 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1623,928,773 - 23,940,779 (+)Ensemblpanpan1.1panPan2
PLK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1622,165,338 - 22,176,847 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl622,165,338 - 22,176,441 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha623,732,161 - 23,743,926 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0622,309,120 - 22,320,926 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl622,309,120 - 22,341,941 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1622,112,754 - 22,124,540 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0622,014,857 - 22,026,662 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0622,410,301 - 22,422,125 (-)NCBIUU_Cfam_GSD_1.0
PLK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl322,537,831 - 22,552,380 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1322,537,814 - 22,550,901 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PLK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1521,388,957 - 21,408,574 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl521,396,204 - 21,410,718 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660688,388,349 - 8,407,454 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247828,811,616 - 8,826,749 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247828,811,593 - 8,823,060 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005323755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010004404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSTOT00000012406   ⟹   ENSSTOP00000011115
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365018,321,305 - 8,332,424 (+)Ensembl
RefSeq Acc Id: XM_005323755   ⟹   XP_005323812
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024409344120,223,455 - 120,234,564 (+)NCBI
SpeTri2.0NW_0049365018,321,415 - 8,332,414 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005323812 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000011115.3
GenBank Protein KAG3259502 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005323812   ⟸   XM_005323755
- UniProtKB: I3MJ33 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000011115   ⟸   ENSSTOT00000012406
Protein Domains
POLO box   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000012407 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000012406.3 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1120.30 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  PLK1_cat UniProtKB/TrEMBL
  POLO_box_1 UniProtKB/TrEMBL
  POLO_box_2 UniProtKB/TrEMBL
  POLO_box_dom UniProtKB/TrEMBL
  POLO_box_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Plk1 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE PLK UniProtKB/TrEMBL
  SERINE_THREONINE-PROTEIN KINASE PLK1 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
  POLO_box UniProtKB/TrEMBL
PROSITE POLO_BOX UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Polo-box domain UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt I3MJ33 ENTREZGENE, UniProtKB/TrEMBL