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Gene: Fscn3 (fascin actin-bundling protein 3) Ictidomys tridecemlineatus

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Symbol:

Fscn3

Name:

fascin actin-bundling protein 3

RGD ID:

12620310

Description:

ENCODES a protein that exhibits actin binding (inferred); actin filament binding (inferred); protein-macromolecule adaptor activity (inferred); INVOLVED IN actin filament bundle assembly (inferred); actin filament organization (inferred); cell migration (inferred); ASSOCIATED WITH hypospadias (ortholog); pleomorphic xanthoastrocytoma (ortholog); FOUND IN actin cytoskeleton (inferred); cell projection membrane (inferred); cytoplasm (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

fascin homolog 3, actin-bundling protein, testicular; fascin-3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	53,671,359 - 53,680,429 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936479	14,795,129 - 14,801,401 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936479	14,794,876 - 14,803,549 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hypospadias (ISO)

pleomorphic xanthoastrocytoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament bundle assembly (IEA)

actin filament organization (IEA)

cell migration (IEA)

establishment or maintenance of cell polarity (IEA)

Cellular Component

actin cytoskeleton (IEA)

cell projection membrane (IEA)

cytoplasm (IEA)

cytoskeleton (IEA)

filopodium (IEA)

growth cone (IEA)

lamellipodium (IEA)

microvillus (IEA)

ruffle (IEA)

Molecular Function

actin binding (IEA)

actin filament binding (IEA)

protein-macromolecule adaptor activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Fscn3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	53,671,359 - 53,680,429 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936479	14,795,129 - 14,801,401 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936479	14,794,876 - 14,803,549 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FSCN3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	127,593,736 - 127,602,144 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	127,591,409 - 127,602,144 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	127,233,790 - 127,242,198 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	127,020,925 - 127,029,079 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	126,827,639 - 126,835,794	NCBI
Celera	7	122,037,417 - 122,045,564 (+)	NCBI		Celera
Cytogenetic Map	7	q32.1	NCBI
HuRef	7	121,594,759 - 121,602,743 (+)	NCBI		HuRef
CHM1_1	7	127,166,986 - 127,175,152 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	128,905,415 - 128,913,829 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	126,617,134 - 126,625,289 (+)	NCBI

Fscn3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	28,427,888 - 28,438,621 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	28,427,788 - 28,438,621 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	28,427,870 - 28,438,622 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	28,427,789 - 28,438,622 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	28,377,901 - 28,388,622 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	28,377,911 - 28,388,632 (+)	NCBI		MGSCv36	mm8
Celera	6	28,434,941 - 28,445,662 (+)	NCBI		Celera
Cytogenetic Map	6	A3.3	NCBI
cM Map	6	11.99	NCBI

Fscn3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	58,008,124 - 58,017,674 (+)	NCBI		GRCr8
mRatBN7.2	4	57,042,797 - 57,052,224 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	57,042,797 - 57,052,404 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	62,026,051 - 62,035,423 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	57,942,002 - 57,951,372 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	56,344,097 - 56,353,471 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	55,719,976 - 55,729,442 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	55,720,010 - 55,729,457 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	55,467,449 - 55,476,891 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	55,298,103 - 55,307,523 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	55,548,259 - 55,557,678 (+)	NCBI
Celera	4	52,154,383 - 52,163,752 (+)	NCBI		Celera
Cytogenetic Map	4	q22	NCBI

Fscn3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955479	8,648,582 - 8,654,493 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955479	8,649,022 - 8,656,899 (+)	NCBI	ChiLan1.0	ChiLan1.0

FSCN3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	164,452,844 - 164,461,849 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	16,463,095 - 16,471,201 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	119,589,219 - 119,597,360 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	132,244,268 - 132,252,312 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	132,244,268 - 132,250,913 (+)	Ensembl	panpan1.1		panPan2

FSCN3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	8,719,857 - 8,730,881 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	8,722,069 - 8,730,729 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	8,412,681 - 8,423,700 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	8,493,397 - 8,504,409 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	8,498,393 - 8,504,258 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	8,697,622 - 8,708,643 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	8,431,978 - 8,443,113 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	8,585,848 - 8,596,872 (-)	NCBI		UU_Cfam_GSD_1.0

FSCN3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	20,686,746 - 20,693,552 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	20,684,621 - 20,693,552 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	21,688,295 - 21,697,317 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FSCN3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	96,407,983 - 96,416,313 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	96,409,005 - 96,414,922 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666042	6,990,607 - 6,999,054 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fscn3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624783	8,350,201 - 8,356,189 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624783	8,345,467 - 8,356,973 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005319411	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040291630	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040291631	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040291632	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000177	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000002113 ⟹ ENSSTOP00000001883

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936479	14,795,129 - 14,801,401 (+)	Ensembl

RefSeq Acc Id:

XM_005319411 ⟹ XP_005319468

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405118	53,671,359 - 53,679,780 (+)	NCBI
SpeTri2.0	NW_004936479	14,794,876 - 14,803,549 (+)	NCBI

Sequence:

show sequence

TAAAAAAATACTTAAAACCACAAGAGAGTCAGACAGAACATACTTTCTGGGAAGAAAGCGGTTG
ATTTCTATCCCATTAATGAGAAACAGGTAAAGAAACGGAAGGACATGGCTAAAGTTGCAAGTTA
TGGTTCTAATTCCCAGTTAGCTCAGCCTACCTCATTGCCTGGAATGACACGGGGAGGCAAATGC
TAGAGGCTTTAGACCCTCCTCCTCTGGACCGTGGATTGATGGTGCTGGGCCAGTGCCCTTTCCC
CACTGTGTTGGGATAAGAGGCAACCATCACAGTCACAATGCTCCCGGGTCACAGAGGTGCCAGG
CCGTAGGCCAACCTCTTTTGAGAAGTTCCCTCTGGGAACATCTTCTGGTGGGTACTACAGACCT
TATTCGGGGCCCTATGGCCTGTGGAACCTCACCGCTGGGGGGAAGGCTGGGCCTGTCGGAGTCA
TCATCTGTAGCACTAGCCTCATGGATGAAATGGAATGGACAACCAGACATCCTAAGGCAGAGGA
TCTAAGGGTTGGGCTCATCAACTGGGCAGGAACTTACCTCACTTTTGAAGCATACAAAAATACA
GTTACAACTACTGCAAAGAGTTTGGGCAGAAAACAGACCTGGGAGCTCCTGGTTAGCAATGAAC
ATGAGGCACAGGCTGTGATACGACTAAAGAGCTTGCAGGGTCTCTACCTTCTCTGTGAGGCAGA
TGGCACTGTGAGCTATGGTCGGCCAAAGAACAGCCACCATGGATGCTTCCTACTCCGTTTCCAC
CGGAATGGCAAGTGGACCCTCCAGTGCATAATCTCTGGTCGTTATCTGGAGTCTGATGGTGAGG
ATGTGTTCTGCAACTCCCAGGTCCTCTCTGCTTACCATATGTGGACCCCCCGGCCAGCCCTGCA
TGTCCACGTGACCCTGTACAGCCCTGTCTACCACAGCTACGCCCGGGCTGACCACACTGTGGGC
CGCATCTGGGTGGATGCAGCAGTCCCCTGCCTAGAAGAATGTGGCTTCTTGTTGCACTTCCAAG
ATGGATGCTACCACCTGGAAACCTCTACTCACCACTTCTTGTCCCATGTAGACCGACTGGTTGC
CCAAACATCACCACAAACAGCTTTTCATATGCAAGTACGGCCTGGAGGGCTTGTGGCACTGTGC
GATGGAGAAGGTGGTTCATTATATCCACATGGTGCACATATGCTCCTGGGCCTGGGCTCCAATC
CCATGAAGGGCCAGGAGTGGTTCATCCTACAGCACTTCCCAACCTGGGTCAGCCTCAGGTCAAA
GGCTCGGAAATTCATTTCAGTCATCTATGATGCTGAGGTGTGTGCTGCCTCTGAGCAATTGACC
CCAATGTCATTGTTCCAGTTTGAATGTGACTGTGAGAACCCCATCTTGCAGCTTCGTTCAGCCA
ATGGCTACTACCTAGCCCAGCGGCGCCACAAGTCATTGATGGCTGATGGCCATCCAATGGAGTC
TGATACCTTCTTCCGTGTACACTGGAATTGTGGCAAGATTATCCTGCAGTCTTCCAATGGGCGC
TTTTTGACTACTGCTGCCAATGGCCTGCTGATGGCCAGTGCTACCATTCCAGGTCCAAATGAGG
AGCTGGGGATTCGATTTGCCAACCGCCCTTTCCTTGTTTTGCGAGGTCGGTATGGGTATGTGGG
CTCCTCATCAGAGCATGACCTCATACAGTGCAATATGGATGAACCCGACTGCATTCACCTTCTG
CCCTGCCGTCAGGGCATCTACCACTTCCAGGCACAGGGTGGATCCTTCTGGTCAATAACATCCT
TTGGCTCCTTCCGCCCTTGGGGAAAATTTGCCCTCAACTTCTGCATAGAACTTCATGGAAGCAA
CTTGCTCACAGTGCTGGCACCCAATGGCTTTTACATTCGAGCCGACCGAAGTGGCACCCTAATG
GCAGACAGCGAAGATGTTACCAAAGAGTGTATCTGGGAATTTTAGGCCAACAGGATGCCACCTG
CCAAACTCCAAATCCTCCAGAAAAATACTACTGCACTAAACAGAACAGGAACCCCAGAGTCAAG
ATCCGAGAGAAGAATATCTGTTACACAACTTTTCCTACCCAGTTTAGCAAAACACCTGTTTTGA
GCAACAATACATCACAACAGGCCACC

hide sequence

RefSeq Acc Id:

XM_040291630 ⟹ XP_040147564

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405118	53,671,414 - 53,680,429 (+)	NCBI

RefSeq Acc Id:

XM_040291631 ⟹ XP_040147565

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405118	53,671,407 - 53,680,421 (+)	NCBI

RefSeq Acc Id:

XM_040291632 ⟹ XP_040147566

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405118	53,671,416 - 53,679,720 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005319468	(Get FASTA)	NCBI Sequence Viewer
	XP_040147564	(Get FASTA)	NCBI Sequence Viewer
	XP_040147565	(Get FASTA)	NCBI Sequence Viewer
	XP_040147566	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000001883.2
GenBank Protein	KAG3277740	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005319468 ⟸ XM_005319411
- Peptide Label:	isoform X4
- UniProtKB:	I3LZT2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDEMEWTTRHPKAEDLRVGLINWAGTYLTFEAYKNTVTTTAKSLGRKQTWELLVSNEHEAQAVI RLKSLQGLYLLCEADGTVSYGRPKNSHHGCFLLRFHRNGKWTLQCIISGRYLESDGEDVFCNSQ VLSAYHMWTPRPALHVHVTLYSPVYHSYARADHTVGRIWVDAAVPCLEECGFLLHFQDGCYHLE TSTHHFLSHVDRLVAQTSPQTAFHMQVRPGGLVALCDGEGGSLYPHGAHMLLGLGSNPMKGQEW FILQHFPTWVSLRSKARKFISVIYDAEVCAASEQLTPMSLFQFECDCENPILQLRSANGYYLAQ RRHKSLMADGHPMESDTFFRVHWNCGKIILQSSNGRFLTTAANGLLMASATIPGPNEELGIRFA NRPFLVLRGRYGYVGSSSEHDLIQCNMDEPDCIHLLPCRQGIYHFQAQGGSFWSITSFGSFRPW GKFALNFCIELHGSNLLTVLAPNGFYIRADRSGTLMADSEDVTKECIWEF hide sequence

RefSeq Acc Id:	XP_040147565 ⟸ XM_040291631
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_040147564 ⟸ XM_040291630
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_040147566 ⟸ XM_040291632
- Peptide Label:	isoform X3

Ensembl Acc Id:

ENSSTOP00000001883 ⟸ ENSSTOT00000002113

Protein Domains

Fascin

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000002115	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000002113.3	UniProtKB/TrEMBL
Gene3D-CATH	2.80.10.50	UniProtKB/TrEMBL
InterPro	Actin-crosslinking	UniProtKB/TrEMBL
	Fascin	UniProtKB/TrEMBL
	Fascin-domain	UniProtKB/TrEMBL
	Fascin_metazoans	UniProtKB/TrEMBL
NCBI Gene	Fscn3	ENTREZGENE
PANTHER	PTHR10551	UniProtKB/TrEMBL
	PTHR10551:SF1	UniProtKB/TrEMBL
Pfam	Fascin	UniProtKB/TrEMBL
PIRSF	Fascin	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50405	UniProtKB/TrEMBL
UniProt	I3LZT2	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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