Trim32 (tripartite motif containing 32) - Rat Genome Database

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Gene: Trim32 (tripartite motif containing 32) Ictidomys tridecemlineatus
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Symbol: Trim32
Name: tripartite motif containing 32
RGD ID: 12619020
Description: ENCODES a protein that exhibits identical protein binding (inferred); metal ion binding (inferred); myosin binding (inferred); INVOLVED IN actin ubiquitination (ortholog); axon development (ortholog); muscle cell cellular homeostasis (ortholog); ASSOCIATED WITH autosomal recessive limb-girdle muscular dystrophy (ortholog); autosomal recessive limb-girdle muscular dystrophy type 2H (ortholog); Bardet-Biedl syndrome (ortholog); FOUND IN autophagosome (ortholog); centrosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 ubiquitin-protein ligase TRIM32; tripartite motif containing 32, transcript variant X1; tripartite motif containing 32, transcript variant X2; tripartite motif containing 32, transcript variant X3; tripartite motif containing 32, transcript variant X4; tripartite motif containing 32, transcript variant X5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947185,838,158 - 185,861,448 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364875,606,693 - 5,619,856 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364875,606,690 - 5,619,856 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin ubiquitination  (IEA,ISO)
axon development  (IEA,ISO)
fat cell differentiation  (IEA)
free ubiquitin chain polymerization  (IEA)
innate immune response  (IEA)
muscle cell cellular homeostasis  (IEA,ISO)
negative regulation of cilium assembly  (IEA)
negative regulation of fibroblast proliferation  (IEA)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  (IEA)
negative regulation of toll-like receptor 4 signaling pathway  (IEA)
negative regulation of viral transcription  (IEA)
positive regulation of autophagosome assembly  (ISO)
positive regulation of autophagy  (IEA)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of cell cycle  (IEA)
positive regulation of cell growth  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of cell motility  (IEA)
positive regulation of chemokine (C-C motif) ligand 20 production  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of interleukin-17-mediated signaling pathway  (IEA,ISO)
positive regulation of neurogenesis  (IEA)
positive regulation of neuron differentiation  (IEA)
positive regulation of protein catabolic process  (IEA,ISO)
positive regulation of proteolysis  (IEA)
positive regulation of striated muscle cell differentiation  (IEA,ISO)
positive regulation of tumor necrosis factor-mediated signaling pathway  (IEA,ISO)
protein K48-linked ubiquitination  (IEA)
protein K63-linked ubiquitination  (ISO)
protein polyubiquitination  (IEA,ISO)
protein ubiquitination  (IEA,ISO)
response to oxidative stress  (ISO)
response to starvation  (ISO)
response to tumor necrosis factor  (IEA)
response to UV  (IEA)
suppression of viral release by host  (IEA)
tissue homeostasis  (IEA,ISO)
ubiquitin-dependent protein catabolic process  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Trim32
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947185,838,158 - 185,861,448 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364875,606,693 - 5,619,856 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364875,606,690 - 5,619,856 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRIM32
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389116,687,305 - 116,701,299 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9116,687,305 - 116,701,300 (+)EnsemblGRCh38hg38GRCh38
GRCh379119,449,584 - 119,463,578 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369118,489,402 - 118,503,400 (+)NCBINCBI36Build 36hg18NCBI36
Build 349116,529,162 - 116,542,582NCBI
Celera990,097,223 - 90,111,221 (+)NCBICelera
Cytogenetic Map9q33.1NCBI
HuRef989,054,928 - 89,068,929 (+)NCBIHuRef
CHM1_19119,596,015 - 119,610,013 (+)NCBICHM1_1
T2T-CHM13v2.09128,880,322 - 128,894,320 (+)NCBIT2T-CHM13v2.0
Trim32
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39465,523,223 - 65,534,477 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl465,523,223 - 65,534,475 (+)EnsemblGRCm39 Ensembl
GRCm38465,604,986 - 65,616,240 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl465,604,986 - 65,616,238 (+)EnsemblGRCm38mm10GRCm38
MGSCv37465,266,020 - 65,277,274 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36465,091,379 - 65,102,599 (+)NCBIMGSCv36mm8
Celera464,238,387 - 64,249,387 (+)NCBICelera
Cytogenetic Map4C1NCBI
cM Map434.43NCBI
Trim32
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8584,020,604 - 84,031,483 (+)NCBIGRCr8
mRatBN7.2579,005,139 - 79,016,615 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl578,999,389 - 79,022,018 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx581,389,235 - 81,400,062 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0583,206,527 - 83,217,355 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0583,182,098 - 83,192,925 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0581,431,554 - 81,449,023 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl581,431,600 - 81,442,451 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0585,530,347 - 85,541,240 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4582,380,439 - 82,391,290 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1582,385,551 - 82,396,402 (+)NCBI
Celera577,919,712 - 77,930,564 (+)NCBICelera
Cytogenetic Map5q24NCBI
Trim32
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541911,151,751 - 11,168,041 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541911,151,751 - 11,168,046 (-)NCBIChiLan1.0ChiLan1.0
TRIM32
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21122,644,786 - 22,658,273 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1922,647,147 - 22,660,624 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0987,819,723 - 87,838,684 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19116,173,546 - 116,187,300 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9116,183,746 - 116,185,707 (+)Ensemblpanpan1.1panPan2
TRIM32
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11170,453,130 - 70,465,030 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1170,462,007 - 70,463,974 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1168,861,539 - 68,873,667 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01171,578,469 - 71,590,603 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1171,578,495 - 71,590,597 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11170,098,438 - 70,110,545 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01170,132,364 - 70,144,497 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01170,863,600 - 70,875,730 (+)NCBIUU_Cfam_GSD_1.0
TRIM32
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1257,054,228 - 257,066,909 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11257,051,421 - 257,066,911 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21288,450,251 - 288,461,926 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TRIM32
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11222,893,689 - 22,906,913 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1222,894,886 - 22,896,847 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603519,970,768 - 19,983,855 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trim32
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476018,585,279 - 18,599,659 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476018,577,764 - 18,600,869 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSSTOT00000020197   ⟹   ENSSTOP00000016129
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364875,616,580 - 5,618,793 (+)Ensembl
RefSeq Acc Id: ENSSTOT00000041197   ⟹   ENSSTOP00000025507
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364875,606,693 - 5,619,856 (+)Ensembl
RefSeq Acc Id: XM_005320886   ⟹   XP_005320943
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947185,838,158 - 185,861,448 (+)NCBI
SpeTri2.0NW_0049364875,606,692 - 5,619,856 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005320887   ⟹   XP_005320944
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947185,838,160 - 185,861,448 (+)NCBI
SpeTri2.0NW_0049364875,606,690 - 5,619,856 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013356747   ⟹   XP_013212201
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947185,838,384 - 185,861,448 (+)NCBI
SpeTri2.0NW_0049364875,606,929 - 5,619,856 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021723470   ⟹   XP_021579145
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947185,838,410 - 185,861,448 (+)NCBI
SpeTri2.0NW_0049364875,606,939 - 5,619,856 (+)NCBI
Sequence:
RefSeq Acc Id: XP_005320944   ⟸   XM_005320887
- UniProtKB: A0A287CW27 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005320943   ⟸   XM_005320886
- UniProtKB: A0A287CW27 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013212201   ⟸   XM_013356747
- UniProtKB: A0A287CW27 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021579145   ⟸   XM_021723470
- UniProtKB: A0A287CW27 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000016129   ⟸   ENSSTOT00000020197
RefSeq Acc Id: ENSSTOP00000025507   ⟸   ENSSTOT00000041197
Protein Domains
B box-type   RING-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000020349 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000020197.2 UniProtKB/TrEMBL
  ENSSTOT00000041197.1 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/TrEMBL
  NHL_repeat UniProtKB/TrEMBL
  TRIM32_Bbox1_Znf UniProtKB/TrEMBL
  Znf-RING_LisH UniProtKB/TrEMBL
  Znf_B-box UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
NCBI Gene Trim32 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE TRIM32 UniProtKB/TrEMBL
  TRIPARTITE MOTIF-CONTAINING PROTEIN 2-LIKE PROTEIN UniProtKB/TrEMBL
Pfam NHL UniProtKB/TrEMBL
  zf-RING_UBOX UniProtKB/TrEMBL
PROSITE NHL UniProtKB/TrEMBL
  ZF_BBOX UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
SMART BBOX UniProtKB/TrEMBL
  RING UniProtKB/TrEMBL
Superfamily-SCOP B-box zinc-binding domain UniProtKB/TrEMBL
  NHL repeat UniProtKB/TrEMBL
  RING/U-box UniProtKB/TrEMBL
UniProt A0A287CW27 ENTREZGENE, UniProtKB/TrEMBL
  I3MVI4_ICTTR UniProtKB/TrEMBL