Rbpj (recombination signal binding protein for immunoglobulin kappa J region) - Rat Genome Database

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Gene: Rbpj (recombination signal binding protein for immunoglobulin kappa J region) Ictidomys tridecemlineatus
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Symbol: Rbpj
Name: recombination signal binding protein for immunoglobulin kappa J region
RGD ID: 12618486
Description: ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN angiogenesis (ortholog); artery morphogenesis (ortholog); auditory receptor cell fate commitment (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH Adams-Oliver syndrome (ortholog); Adams-Oliver Syndrome 3 (ortholog); aortic valve disease (ortholog); FOUND IN protein-containing complex (ortholog); protein-DNA complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: recombination signal binding protein for immunoglobulin kappa J region, transcript variant X1; recombination signal binding protein for immunoglobulin kappa J region, transcript variant X2; recombination signal binding protein for immunoglobulin kappa J region, transcript variant X3; recombining binding protein suppressor of hairless
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528549,648,938 - 49,859,262 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364773,349,627 - 3,461,797 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364773,354,336 - 3,445,248 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
aortic valve development  (IEA)
arterial endothelial cell fate commitment  (IEA)
artery morphogenesis  (IEA,ISO)
atrioventricular canal development  (IEA)
auditory receptor cell fate commitment  (IEA,ISO)
B cell differentiation  (IEA,ISO)
blood vessel endothelial cell fate specification  (IEA)
blood vessel lumenization  (IEA)
blood vessel remodeling  (IEA)
cardiac left ventricle morphogenesis  (IEA)
cardiac muscle cell myoblast differentiation  (IEA)
cell differentiation  (IEA,ISO)
cell fate commitment  (IEA,ISO)
cell population proliferation  (IEA,ISO)
club cell differentiation  (IEA,ISO)
defense response to bacterium  (IEA,ISO)
dorsal aorta morphogenesis  (IEA)
endocardium development  (IEA)
endocardium morphogenesis  (IEA)
epidermal cell fate specification  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO)
epithelial to mesenchymal transition  (IEA,ISO)
epithelial to mesenchymal transition involved in endocardial cushion formation  (IEA)
hair follicle maturation  (IEA,ISO)
heart development  (IEA,ISO)
hemopoiesis  (IEA,ISO)
humoral immune response  (IEA,ISO)
inflammatory response to antigenic stimulus  (IEA,ISO)
keratinocyte differentiation  (IEA,ISO)
labyrinthine layer blood vessel development  (IEA)
myeloid dendritic cell differentiation  (IEA,ISO)
negative regulation of cell differentiation  (IEA,ISO)
negative regulation of cold-induced thermogenesis  (IEA)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of ossification  (IEA)
negative regulation of smooth muscle cell apoptotic process  (ISO)
negative regulation of smooth muscle cell migration  (ISO)
negative regulation of stem cell proliferation  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
neuron differentiation  (IEA,ISO)
Notch signaling pathway  (IEA,ISO)
outflow tract morphogenesis  (IEA)
pituitary gland development  (IEA,ISO)
positive regulation of BMP signaling pathway  (IEA)
positive regulation of canonical Wnt signaling pathway  (IEA,ISO)
positive regulation of cardiac muscle cell proliferation  (IEA)
positive regulation of cell proliferation involved in heart morphogenesis  (IEA)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of ephrin receptor signaling pathway  (IEA)
positive regulation of epithelial cell proliferation  (IEA,ISO)
positive regulation of ERBB signaling pathway  (IEA)
positive regulation of gene expression  (IEA,ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of transcription of Notch receptor target  (IEA,ISO)
pulmonary valve development  (IEA)
regulation of cell adhesion involved in heart morphogenesis  (IEA)
regulation of DNA-templated transcription  (IEA)
regulation of epithelial cell proliferation  (IEA,ISO)
regulation of gene expression  (IEA,ISO)
regulation of generation of precursor metabolites and energy  (IEA)
regulation of timing of cell differentiation  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
sebaceous gland development  (IEA,ISO)
secondary heart field specification  (IEA,ISO)
somatic stem cell population maintenance  (IEA,ISO)
somitogenesis  (IEA,ISO)
stem cell proliferation  (IEA,ISO)
ventricular septum morphogenesis  (IEA)
ventricular trabecula myocardium morphogenesis  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Rbpj
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528549,648,938 - 49,859,262 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364773,349,627 - 3,461,797 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364773,354,336 - 3,445,248 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RBPJ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38426,105,449 - 26,435,131 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl426,163,455 - 26,435,131 (+)EnsemblGRCh38hg38GRCh38
GRCh37426,165,080 - 26,436,753 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36425,930,430 - 26,042,376 (+)NCBINCBI36Build 36hg18NCBI36
Celera426,771,681 - 26,884,040 (+)NCBICelera
Cytogenetic Map4p15.2NCBI
HuRef425,659,979 - 25,775,063 (+)NCBIHuRef
CHM1_1426,322,549 - 26,437,875 (+)NCBICHM1_1
T2T-CHM13v2.0426,087,631 - 26,420,111 (+)NCBIT2T-CHM13v2.0
Rbpj
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39553,713,121 - 53,814,787 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl553,623,494 - 53,814,704 (+)EnsemblGRCm39 Ensembl
GRCm38553,555,779 - 53,657,445 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl553,466,152 - 53,657,362 (+)EnsemblGRCm38mm10GRCm38
MGSCv37553,947,018 - 54,048,684 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36553,878,593 - 53,944,281 (+)NCBIMGSCv36mm8
Celera550,938,216 - 51,041,035 (+)NCBICelera
Cytogenetic Map5C1NCBI
cM Map529.37NCBI
Rbpj
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81461,551,366 - 61,736,220 (-)NCBIGRCr8
mRatBN7.21457,338,493 - 57,523,330 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1457,338,507 - 57,523,353 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1461,746,363 - 61,809,045 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01463,048,700 - 63,111,484 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01459,445,481 - 59,508,257 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01459,657,738 - 59,865,427 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1459,658,935 - 59,735,450 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01459,785,053 - 59,859,229 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1456,447,546 - 56,510,235 (-)NCBICelera
Cytogenetic Map14q11NCBI
Rbpj
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544318,783,061 - 18,910,228 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544318,783,061 - 19,029,441 (-)NCBIChiLan1.0ChiLan1.0
RBPJ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2326,573,771 - 26,689,708 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1426,766,523 - 26,881,531 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0420,719,548 - 20,835,439 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1425,996,223 - 26,107,683 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl425,995,263 - 26,107,683 (+)Ensemblpanpan1.1panPan2
RBPJ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1384,060,417 - 84,286,008 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl384,064,440 - 84,286,360 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha386,572,469 - 86,797,897 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0385,030,006 - 85,255,529 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl385,034,041 - 85,255,924 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1384,151,949 - 84,377,265 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0384,271,690 - 84,496,976 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0384,656,440 - 84,881,337 (-)NCBIUU_Cfam_GSD_1.0
RBPJ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl819,922,779 - 20,166,754 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1819,933,035 - 20,166,746 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2820,306,820 - 20,540,623 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RBPJ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12723,911,084 - 24,023,856 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604770,424,032 - 70,537,613 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rbpj
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247556,176,497 - 6,298,225 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247556,176,497 - 6,298,034 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000004552   ⟹   ENSSTOP00000004084
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364773,354,511 - 3,394,097 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000030918   ⟹   ENSSTOP00000029614
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364773,349,627 - 3,445,043 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000033136   ⟹   ENSSTOP00000030329
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364773,349,627 - 3,414,032 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000037720   ⟹   ENSSTOP00000028356
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364773,364,677 - 3,461,797 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000041946   ⟹   ENSSTOP00000025917
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364773,354,511 - 3,445,171 (-)Ensembl
RefSeq Acc Id: XM_005318909   ⟹   XP_005318966
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440528549,648,938 - 49,743,340 (-)NCBI
SpeTri2.0NW_0049364773,354,336 - 3,445,043 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013355888   ⟹   XP_013211342
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440528549,648,938 - 49,712,367 (-)NCBI
SpeTri2.0NW_0049364773,354,336 - 3,415,130 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021722041   ⟹   XP_021577716
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440528549,648,938 - 49,743,486 (-)NCBI
SpeTri2.0NW_0049364773,354,336 - 3,445,248 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040292569   ⟹   XP_040148503
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440528549,648,938 - 49,859,262 (-)NCBI
RefSeq Acc Id: XM_040292570   ⟹   XP_040148504
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440528549,648,938 - 49,732,652 (-)NCBI
RefSeq Acc Id: XM_040292571   ⟹   XP_040148505
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440528549,648,938 - 49,741,908 (-)NCBI
RefSeq Acc Id: XM_040292572   ⟹   XP_040148506
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440528549,648,938 - 49,742,675 (-)NCBI
RefSeq Acc Id: XM_040292573   ⟹   XP_040148507
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440528549,648,938 - 49,700,569 (-)NCBI
RefSeq Acc Id: XM_040292574   ⟹   XP_040148508
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440528549,648,938 - 49,743,488 (-)NCBI
RefSeq Acc Id: XP_005318966   ⟸   XM_005318909
- Peptide Label: isoform X3
- UniProtKB: A0A287D7V2 (UniProtKB/TrEMBL),   I3M4G5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013211342   ⟸   XM_013355888
- Peptide Label: isoform X4
- UniProtKB: A0A287D9W1 (UniProtKB/TrEMBL),   I3M4G5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021577716   ⟸   XM_021722041
- Peptide Label: isoform X1
- UniProtKB: A0A287CX86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040148503   ⟸   XM_040292569
- Peptide Label: isoform X2
- UniProtKB: I3M4G5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040148508   ⟸   XM_040292574
- Peptide Label: isoform X5
RefSeq Acc Id: XP_040148506   ⟸   XM_040292572
- Peptide Label: isoform X2
- UniProtKB: I3M4G5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040148505   ⟸   XM_040292571
- Peptide Label: isoform X2
- UniProtKB: I3M4G5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040148504   ⟸   XM_040292570
- Peptide Label: isoform X2
- UniProtKB: I3M4G5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040148507   ⟸   XM_040292573
- Peptide Label: isoform X2
- UniProtKB: I3M4G5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000025917   ⟸   ENSSTOT00000041946
Ensembl Acc Id: ENSSTOP00000029614   ⟸   ENSSTOT00000030918
Ensembl Acc Id: ENSSTOP00000004084   ⟸   ENSSTOT00000004552
Ensembl Acc Id: ENSSTOP00000030329   ⟸   ENSSTOT00000033136
Ensembl Acc Id: ENSSTOP00000028356   ⟸   ENSSTOT00000037720
Protein Domains
Beta-trefoil DNA-binding   RBP-J/Cbf11/Cbf12 DNA binding


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000004547 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000004552.3 UniProtKB/TrEMBL
  ENSSTOT00000030918.1 UniProtKB/TrEMBL
  ENSSTOT00000033136.1 UniProtKB/TrEMBL
  ENSSTOT00000037720.1 UniProtKB/TrEMBL
  ENSSTOT00000041946.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  2.60.40.1450 UniProtKB/TrEMBL
  2.80.10.50 UniProtKB/TrEMBL
InterPro Beta-trefoil_DNA-bd_dom UniProtKB/TrEMBL
  BTD_sf UniProtKB/TrEMBL
  CLS_fam UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
  p53-like_TF_DNA-bd UniProtKB/TrEMBL
  RBP-J/Cbf11/Cbf12_DNA-bd UniProtKB/TrEMBL
  RBP-J/Cbf11_DNA-bd_sf UniProtKB/TrEMBL
  RBP-Jkappa_IPT UniProtKB/TrEMBL
NCBI Gene Rbpj ENTREZGENE
PANTHER PTHR10665 UniProtKB/TrEMBL
  RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS UniProtKB/TrEMBL
Pfam BTD UniProtKB/TrEMBL
  LAG1-DNAbind UniProtKB/TrEMBL
  TIG_SUH UniProtKB/TrEMBL
SMART BTD UniProtKB/TrEMBL
  LAG1_DNAbind UniProtKB/TrEMBL
Superfamily-SCOP SSF110217 UniProtKB/TrEMBL
  SSF49417 UniProtKB/TrEMBL
  SSF81296 UniProtKB/TrEMBL
UniProt A0A287CX86 ENTREZGENE, UniProtKB/TrEMBL
  A0A287D440_ICTTR UniProtKB/TrEMBL
  A0A287D7V2 ENTREZGENE, UniProtKB/TrEMBL
  A0A287D9W1 ENTREZGENE, UniProtKB/TrEMBL
  I3M4G5 ENTREZGENE, UniProtKB/TrEMBL