Ago4 (argonaute RISC component 4) - Rat Genome Database

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Gene: Ago4 (argonaute RISC component 4) Ictidomys tridecemlineatus
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Symbol: Ago4
Name: argonaute RISC component 4
RGD ID: 12614601
Description: ENCODES a protein that exhibits double-stranded RNA binding (inferred); miRNA binding (inferred); nucleic acid binding (inferred); INVOLVED IN male gonad development (ortholog); male meiotic nuclear division (ortholog); miRNA metabolic process (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH Charcot-Marie-Tooth disease dominant intermediate C (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); cytoplasmic ribonucleoprotein granule (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: argonaute 4, RISC catalytic component; argonaute RISC catalytic component 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505852,510,754 - 52,548,926 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647418,335,531 - 18,370,077 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647418,335,536 - 18,371,398 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Ago4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505852,510,754 - 52,548,926 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647418,335,531 - 18,370,077 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647418,335,536 - 18,371,398 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGO4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38135,807,636 - 35,857,890 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl135,808,016 - 35,857,890 (+)EnsemblGRCh38hg38GRCh38
GRCh37136,273,237 - 36,323,491 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36136,046,415 - 36,093,775 (+)NCBINCBI36Build 36hg18NCBI36
Build 34135,942,920 - 35,990,281NCBI
Celera134,548,288 - 34,595,633 (+)NCBICelera
Cytogenetic Map1p34.3NCBI
HuRef134,391,417 - 34,441,140 (+)NCBIHuRef
CHM1_1136,390,239 - 36,439,851 (+)NCBICHM1_1
T2T-CHM13v2.0135,670,525 - 35,720,783 (+)NCBIT2T-CHM13v2.0
Ago4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394126,383,280 - 126,427,379 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4126,383,334 - 126,427,265 (-)EnsemblGRCm39 Ensembl
GRCm384126,489,487 - 126,533,586 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4126,489,541 - 126,533,472 (-)EnsemblGRCm38mm10GRCm38
MGSCv374126,166,785 - 126,210,702 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364125,994,456 - 126,035,544 (-)NCBIMGSCv36mm8
Celera4124,826,342 - 124,870,087 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map460.9NCBI
Ago4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85144,064,949 - 144,110,422 (-)NCBIGRCr8
mRatBN7.25138,780,446 - 138,825,898 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5138,783,069 - 138,825,632 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5141,477,953 - 141,523,412 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05143,247,944 - 143,293,406 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05143,248,730 - 143,294,206 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05144,501,875 - 144,557,165 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5144,504,938 - 144,556,889 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05148,269,991 - 148,328,500 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45145,857,594 - 145,902,950 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15145,866,645 - 145,932,628 (-)NCBI
Celera5137,279,250 - 137,322,143 (-)NCBICelera
Cytogenetic Map5q36NCBI
Ago4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545213,882,416 - 13,922,590 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545213,882,416 - 13,922,590 (+)NCBIChiLan1.0ChiLan1.0
LOC100977537
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21190,990,660 - 191,040,727 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11190,111,850 - 190,161,908 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0135,072,045 - 35,122,418 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1136,249,040 - 36,299,259 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl136,249,038 - 36,299,259 (+)Ensemblpanpan1.1panPan2
AGO4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1156,325,899 - 6,351,748 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl156,329,413 - 6,356,676 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha156,569,069 - 6,608,633 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0156,462,261 - 6,501,884 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl156,281,474 - 6,502,020 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1156,315,003 - 6,354,575 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0156,383,741 - 6,423,313 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0156,398,098 - 6,437,686 (-)NCBIUU_Cfam_GSD_1.0
AGO4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl691,973,119 - 92,012,990 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1691,967,499 - 92,013,030 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2685,255,835 - 85,296,920 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AGO4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12097,001,484 - 97,056,131 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2097,003,566 - 97,056,051 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603319,672,650 - 19,725,326 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ago4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476418,838,920 - 18,883,894 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476418,838,887 - 18,883,915 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSSTOT00000004749   ⟹   ENSSTOP00000004264
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647418,335,531 - 18,370,077 (+)Ensembl
RefSeq Acc Id: XM_021735510   ⟹   XP_021591185
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505852,510,754 - 52,548,926 (+)NCBI
SpeTri2.0NW_00493647418,335,536 - 18,371,398 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040288370   ⟹   XP_040144304
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505852,516,281 - 52,548,926 (+)NCBI
Protein Sequences
Protein RefSeqs XP_021591185 (Get FASTA)   NCBI Sequence Viewer  
  XP_040144304 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000004264.3
GenBank Protein KAG3282733 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021591185   ⟸   XM_021735510
- UniProtKB: I3M4T7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040144304   ⟸   XM_040288370
- UniProtKB: I3M4T7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000004264   ⟸   ENSSTOT00000004749
Protein Domains
PAZ   Piwi


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000004725 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000004749.3 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.10 UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/TrEMBL
  paz domain UniProtKB/TrEMBL
InterPro AGO4 UniProtKB/TrEMBL
  ArgoL1 UniProtKB/TrEMBL
  ArgoL2 UniProtKB/TrEMBL
  Argonaute_Mid_dom UniProtKB/TrEMBL
  Argonaute_N UniProtKB/TrEMBL
  PAZ_dom UniProtKB/TrEMBL
  PAZ_dom_sf UniProtKB/TrEMBL
  Piwi UniProtKB/TrEMBL
  Piwi_ago-like UniProtKB/TrEMBL
  RNaseH-like_sf UniProtKB/TrEMBL
  RNaseH_sf UniProtKB/TrEMBL
NCBI Gene Ago4 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 2C UniProtKB/TrEMBL
  PROTEIN ARGONAUTE-4 UniProtKB/TrEMBL
Pfam ArgoL1 UniProtKB/TrEMBL
  ArgoL2 UniProtKB/TrEMBL
  ArgoMid UniProtKB/TrEMBL
  ArgoN UniProtKB/TrEMBL
  PAZ UniProtKB/TrEMBL
  Piwi UniProtKB/TrEMBL
PROSITE PAZ UniProtKB/TrEMBL
  PIWI UniProtKB/TrEMBL
SMART DUF1785 UniProtKB/TrEMBL
  PAZ UniProtKB/TrEMBL
  Piwi UniProtKB/TrEMBL
Superfamily-SCOP SSF101690 UniProtKB/TrEMBL
  SSF53098 UniProtKB/TrEMBL
UniProt I3M4T7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-06-04 Ago4  argonaute RISC component 4  Ago4  argonaute RISC catalytic component 4  Symbol and/or name change 5135510 APPROVED
2018-11-29 Ago4  argonaute RISC catalytic component 4    argonaute 4, RISC catalytic component  Symbol and/or name change 5135510 APPROVED