Spcs3 (signal peptidase complex subunit 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Spcs3 (signal peptidase complex subunit 3) Ictidomys tridecemlineatus
Analyze
Symbol: Spcs3
Name: signal peptidase complex subunit 3
RGD ID: 12613707
Description: INVOLVED IN protein targeting to ER (inferred); proteolysis (inferred); signal peptide processing (inferred); ASSOCIATED WITH genetic disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN signal peptidase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: signal peptidase complex subunit 3 homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494326,489,021 - 26,500,942 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365166,903,332 - 6,912,728 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365166,903,337 - 6,915,232 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Spcs3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494326,489,021 - 26,500,942 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365166,903,332 - 6,912,728 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365166,903,337 - 6,915,232 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPCS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384176,319,966 - 176,332,245 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4176,319,966 - 176,332,245 (+)EnsemblGRCh38hg38GRCh38
GRCh374177,241,117 - 177,253,396 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364177,478,109 - 177,487,348 (+)NCBINCBI36Build 36hg18NCBI36
Build 344177,616,263 - 177,625,501NCBI
Celera4174,568,936 - 174,581,241 (+)NCBICelera
Cytogenetic Map4q34.2NCBI
HuRef4172,992,124 - 173,004,427 (+)NCBIHuRef
CHM1_14177,217,493 - 177,229,799 (+)NCBICHM1_1
T2T-CHM13v2.04179,659,012 - 179,671,286 (+)NCBIT2T-CHM13v2.0
Spcs3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39854,973,468 - 54,983,033 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl854,973,468 - 54,983,033 (-)EnsemblGRCm39 Ensembl
GRCm38854,520,433 - 54,529,998 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl854,520,433 - 54,529,998 (-)EnsemblGRCm38mm10GRCm38
MGSCv37855,605,787 - 55,615,351 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36855,605,787 - 55,615,351 (-)NCBIMGSCv36mm8
Celera857,233,886 - 57,243,432 (-)NCBICelera
Cytogenetic Map8B1.3NCBI
cM Map829.26NCBI
Spcs3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81644,038,421 - 44,043,855 (+)NCBIGRCr8
mRatBN7.21637,305,358 - 37,310,792 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1637,305,305 - 37,331,746 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1642,656,924 - 42,662,359 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01646,017,737 - 46,023,170 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01641,398,686 - 41,404,098 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01640,050,862 - 40,056,296 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1640,050,734 - 40,058,822 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01639,826,990 - 39,832,424 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41640,215,903 - 40,221,337 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1635,430,705 - 35,436,020 (+)NCBICelera
Cytogenetic Map16p11NCBI
Spcs3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540331,454,710 - 31,461,826 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540331,451,426 - 31,461,032 (-)NCBIChiLan1.0ChiLan1.0
SPCS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23174,024,438 - 174,048,466 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14174,413,671 - 174,430,287 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04168,502,522 - 168,514,965 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14180,738,416 - 180,749,063 (+)NCBIpanpan1.1PanPan1.1panPan2
SPCS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11653,258,714 - 53,266,191 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1653,258,714 - 53,267,034 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1648,756,658 - 48,769,237 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01655,569,334 - 55,582,729 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1655,561,201 - 55,582,665 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11653,463,220 - 53,476,366 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01654,059,627 - 54,072,563 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01654,297,870 - 54,310,703 (-)NCBIUU_Cfam_GSD_1.0
SPCS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1538,790,655 - 38,802,635 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11538,790,605 - 38,802,641 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21544,496,106 - 44,508,096 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPCS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17122,390,408 - 122,403,870 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7122,391,738 - 122,400,189 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037102,476,928 - 102,489,330 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spcs3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247697,317,201 - 7,324,769 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247697,317,201 - 7,328,244 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005325534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000013677   ⟹   ENSSTOP00000012256
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365166,903,332 - 6,912,728 (+)Ensembl
RefSeq Acc Id: XM_005325534   ⟹   XP_005325591
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494326,489,021 - 26,500,942 (+)NCBI
SpeTri2.0NW_0049365166,903,337 - 6,915,232 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005325591 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000012256.3
GenBank Protein KAG3294540 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005325591   ⟸   XM_005325534
- UniProtKB: I3MLG9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000012256   ⟸   ENSSTOT00000013677


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000013678 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000013677.3 UniProtKB/TrEMBL
InterPro SPC3 UniProtKB/TrEMBL
NCBI Gene Spcs3 ENTREZGENE
PANTHER PTHR12804 UniProtKB/TrEMBL
  SIGNAL PEPTIDASE COMPLEX SUBUNIT 3 UniProtKB/TrEMBL
Pfam SPC22 UniProtKB/TrEMBL
PIRSF SPC22 UniProtKB/TrEMBL
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
UniProt I3MLG9 ENTREZGENE, UniProtKB/TrEMBL