Acot6 (acyl-CoA thioesterase 6) - Rat Genome Database

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Gene: Acot6 (acyl-CoA thioesterase 6) Ictidomys tridecemlineatus
Analyze
Symbol: Acot6
Name: acyl-CoA thioesterase 6
RGD ID: 12612139
Description: ENCODES a protein that exhibits fatty acyl-CoA hydrolase activity (inferred); thiolester hydrolase activity (inferred); INVOLVED IN acyl-CoA metabolic process (inferred); fatty acid metabolic process (inferred); ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); schizophrenia (ortholog); FOUND IN cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: putative acyl-coenzyme A thioesterase 6
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864029,130,634 - 29,138,703 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364882,930,114 - 2,939,325 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364882,930,291 - 2,938,300 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Acot6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864029,130,634 - 29,138,703 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364882,930,114 - 2,939,325 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364882,930,291 - 2,938,300 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACOT6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381473,610,945 - 73,619,888 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1473,610,945 - 73,619,888 (+)EnsemblGRCh38hg38GRCh38
GRCh371474,077,649 - 74,086,592 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361473,153,301 - 73,156,345 (+)NCBINCBI36Build 36hg18NCBI36
Celera1454,119,631 - 54,122,671 (+)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1454,251,313 - 54,254,353 (+)NCBIHuRef
CHM1_11474,023,109 - 74,026,149 (+)NCBICHM1_1
T2T-CHM13v2.01467,818,457 - 67,827,400 (+)NCBIT2T-CHM13v2.0
Acot6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391284,147,538 - 84,158,128 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1284,147,428 - 84,158,123 (+)EnsemblGRCm39 Ensembl
GRCm381284,100,654 - 84,109,783 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1284,100,654 - 84,111,349 (+)EnsemblGRCm38mm10GRCm38
MGSCv371285,441,604 - 85,450,733 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361284,990,402 - 85,001,102 (+)NCBIMGSCv36mm8
Celera1285,547,614 - 85,556,743 (+)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1239.04NCBI
Acot6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86109,463,513 - 109,472,587 (+)NCBIGRCr8
mRatBN7.26103,732,372 - 103,741,446 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6103,732,372 - 103,741,446 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6103,894,180 - 103,903,254 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06104,193,399 - 104,202,473 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06103,562,847 - 103,571,921 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06107,581,357 - 107,590,431 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6107,581,608 - 107,590,373 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06117,946,002 - 117,963,918 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46108,146,690 - 108,155,388 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16108,150,145 - 108,193,873 (+)NCBI
Celera6101,561,356 - 101,570,442 (+)NCBICelera
Cytogenetic Map6q31NCBI
ACOT6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21574,691,158 - 74,709,999 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11473,907,658 - 73,926,511 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01454,171,652 - 54,179,322 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11473,029,435 - 73,037,223 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1473,034,520 - 73,037,170 (+)Ensemblpanpan1.1panPan2
ACOT6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1846,905,354 - 46,911,627 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl846,852,880 - 46,911,640 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha846,589,770 - 46,595,919 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0847,134,480 - 47,140,629 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl847,081,692 - 47,140,579 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1846,802,068 - 46,808,222 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0846,820,344 - 46,826,490 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0847,210,706 - 47,216,944 (+)NCBIUU_Cfam_GSD_1.0
ACOT6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl796,984,716 - 96,992,873 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1796,984,547 - 96,990,400 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27102,742,804 - 102,785,288 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACOT6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12450,826,561 - 50,834,462 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605339,008,311 - 39,016,103 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acot6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473427,901,129 - 27,908,976 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005321209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010003700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000003081   ⟹   ENSSTOP00000002752
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364882,930,114 - 2,939,325 (+)Ensembl
RefSeq Acc Id: XM_005321209   ⟹   XP_005321266
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864029,130,634 - 29,138,703 (-)NCBI
SpeTri2.0NW_0049364882,930,291 - 2,938,300 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005321266 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000002752.2
GenBank Protein KAG3260728 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005321266   ⟸   XM_005321209
- UniProtKB: I3M1N1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000002752   ⟸   ENSSTOT00000003081
Protein Domains
Acyl-CoA thioester hydrolase/bile acid-CoA amino   BAAT/Acyl-CoA thioester hydrolase C-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000003091 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000003081.3 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.2240 UniProtKB/TrEMBL
  3.40.50.1820 UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  Acyl-CoA_thioEstase_long-chain UniProtKB/TrEMBL
  BAAT_C UniProtKB/TrEMBL
  Thio_Ohase/aa_AcTrfase UniProtKB/TrEMBL
  Thio_Ohase/BAAT_N UniProtKB/TrEMBL
NCBI Gene Acot6 ENTREZGENE
PANTHER ACYL-COENZYME A THIOESTERASE 6-RELATED UniProtKB/TrEMBL
  ACYL-COENZYME A THIOESTERASE-RELATED UniProtKB/TrEMBL
Pfam BAAT_C UniProtKB/TrEMBL
  Bile_Hydr_Trans UniProtKB/TrEMBL
PIRSF Acyl-CoA_hydro UniProtKB/TrEMBL
Superfamily-SCOP SSF53474 UniProtKB/TrEMBL
UniProt I3M1N1 ENTREZGENE, UniProtKB/TrEMBL