Gls2 (glutaminase 2) - Rat Genome Database

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Gene: Gls2 (glutaminase 2) Ictidomys tridecemlineatus
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Symbol: Gls2
Name: glutaminase 2
RGD ID: 12611556
Description: ENCODES a protein that exhibits glutaminase activity (inferred); hydrolase activity (inferred); INVOLVED IN reactive oxygen species metabolic process (ortholog); regulation of apoptotic process (ortholog); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; argininosuccinic aciduria pathway; carbamoyl phosphate synthetase I deficiency pathway; ASSOCIATED WITH cataract 15 multiple types (ortholog); Charcot-Marie-Tooth disease axonal type 2U (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: glutaminase 2, transcript variant X1; glutaminase 2, transcript variant X2; glutaminase 2, transcript variant X3; glutaminase 2, transcript variant X4; glutaminase 2, transcript variant X5; glutaminase 2, transcript variant X6; glutaminase 2, transcript variant X7; glutaminase liver isoform, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,028,150 - 58,044,275 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646823,682 - 842,199 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936646825,957 - 842,184 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Gls2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,028,150 - 58,044,275 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646823,682 - 842,199 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936646825,957 - 842,184 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,470,952 - 56,488,161 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,470,944 - 56,488,414 (-)EnsemblGRCh38hg38GRCh38
GRCh371256,864,736 - 56,881,945 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,151,003 - 55,168,448 (-)NCBINCBI36Build 36hg18NCBI36
Celera1256,518,105 - 56,535,542 (-)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1253,903,771 - 53,921,163 (-)NCBIHuRef
CHM1_11256,832,389 - 56,849,813 (-)NCBICHM1_1
T2T-CHM13v2.01256,438,665 - 56,455,831 (-)NCBIT2T-CHM13v2.0
Gls2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,030,504 - 128,045,873 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,030,326 - 128,045,873 (+)EnsemblGRCm39 Ensembl
GRCm3810128,194,635 - 128,210,004 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,194,457 - 128,210,004 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710127,631,691 - 127,647,060 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610127,597,639 - 127,612,883 (+)NCBIMGSCv36mm8
Celera10130,589,515 - 130,604,841 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1076.44NCBI
Gls2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,201,757 - 1,218,014 (+)NCBIGRCr8
mRatBN7.27617,252 - 633,424 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7617,288 - 633,426 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,375,756 - 3,391,882 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,251,772 - 5,267,898 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,553,463 - 5,569,719 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,605,679 - 2,621,853 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,605,719 - 2,621,852 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,584,594 - 2,600,729 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,484,397 - 1,495,283 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,484,396 - 1,495,283 (+)NCBI
Celera7495,890 - 511,971 (+)NCBICelera
Cytogenetic Map7q11NCBI
Gls2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554584,050,674 - 4,065,322 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554584,055,088 - 4,065,307 (-)NCBIChiLan1.0ChiLan1.0
GLS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21037,842,942 - 37,861,603 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11237,839,707 - 37,858,368 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,426,264 - 32,443,690 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11232,678,814 - 32,696,694 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,678,814 - 32,696,694 (+)Ensemblpanpan1.1panPan2
GLS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110722,105 - 737,857 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10722,202 - 737,753 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10785,318 - 800,983 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010731,085 - 746,763 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10731,091 - 746,792 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110708,149 - 723,814 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010951,254 - 966,922 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0101,074,979 - 1,090,642 (-)NCBIUU_Cfam_GSD_1.0
GLS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,806,406 - 21,820,001 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,806,405 - 21,820,001 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2523,529,902 - 23,543,618 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GLS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,430,345 - 52,448,572 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1152,427,919 - 52,448,463 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037193,533,565 - 193,552,090 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gls2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480211,545,142 - 11,561,942 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480211,545,196 - 11,559,851 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000019743   ⟹   ENSSTOP00000018235
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936646826,434 - 841,905 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000036685   ⟹   ENSSTOP00000031755
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936646823,682 - 842,199 (-)Ensembl
RefSeq Acc Id: XM_005335638   ⟹   XP_005335695
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494558,028,150 - 58,043,968 (+)NCBI
SpeTri2.0NW_004936646825,957 - 842,184 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005335639   ⟹   XP_005335696
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494558,028,533 - 58,043,968 (+)NCBI
SpeTri2.0NW_004936646825,957 - 841,717 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021733498   ⟹   XP_021589173
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494558,028,184 - 58,044,275 (+)NCBI
SpeTri2.0NW_004936646825,957 - 841,974 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021733500   ⟹   XP_021589175
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494558,028,369 - 58,043,968 (+)NCBI
SpeTri2.0NW_004936646825,957 - 841,788 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021733501   ⟹   XP_021589176
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494558,028,771 - 58,043,968 (+)NCBI
SpeTri2.0NW_004936646825,957 - 841,460 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021733502   ⟹   XP_021589177
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494558,028,286 - 58,043,968 (+)NCBI
SpeTri2.0NW_004936646825,957 - 841,910 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040280460   ⟹   XP_040136394
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494558,035,511 - 58,043,968 (+)NCBI
RefSeq Acc Id: XP_005335695   ⟸   XM_005335638
- Peptide Label: isoform X2
- UniProtKB: A0A287DDW6 (UniProtKB/TrEMBL),   I3N1I9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005335696   ⟸   XM_005335639
- Peptide Label: isoform X3
- UniProtKB: I3N1I9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021589173   ⟸   XM_021733498
- Peptide Label: isoform X1
- UniProtKB: I3N1I9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021589177   ⟸   XM_021733502
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_021589175   ⟸   XM_021733500
- Peptide Label: isoform X4
- UniProtKB: I3N1I9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021589176   ⟸   XM_021733501
- Peptide Label: isoform X4
- UniProtKB: I3N1I9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040136394   ⟸   XM_040280460
- Peptide Label: isoform X5
Ensembl Acc Id: ENSSTOP00000031755   ⟸   ENSSTOT00000036685
Ensembl Acc Id: ENSSTOP00000018235   ⟸   ENSSTOT00000019743
Protein Domains
Glutaminase EF-hand


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000020896 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000019743.2 UniProtKB/TrEMBL
  ENSSTOT00000036685.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.238.210 UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/TrEMBL
  3.40.710.10 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  Beta-lactam/transpept-like UniProtKB/TrEMBL
  Glutaminase UniProtKB/TrEMBL
  Glutaminase_EF-hand UniProtKB/TrEMBL
NCBI Gene Gls2 ENTREZGENE
PANTHER GLUTAMINASE LIVER ISOFORM, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR12544 UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
  EF-hand_14 UniProtKB/TrEMBL
  Glutaminase UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/TrEMBL
  SSF56601 UniProtKB/TrEMBL
UniProt A0A287DDW6 ENTREZGENE, UniProtKB/TrEMBL
  I3N1I9 ENTREZGENE, UniProtKB/TrEMBL