Itgb6 (integrin subunit beta 6) - Rat Genome Database

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Pathways
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Gene: Itgb6 (integrin subunit beta 6) Ictidomys tridecemlineatus
Analyze
Symbol: Itgb6
Name: integrin subunit beta 6
RGD ID: 12608694
Description: ENCODES a protein that exhibits integrin binding (inferred); molecular function activator activity (inferred); INVOLVED IN bone development (ortholog); bronchiole development (ortholog); cell morphogenesis (ortholog); PARTICIPATES IN integrin mediated signaling pathway; ASSOCIATED WITH amelogenesis imperfecta type 1H (ortholog); asthma (ortholog); autistic disorder (ortholog); FOUND IN integrin alphav-beta6 complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: integrin beta-6; integrin subunit beta 6, transcript variant X1; integrin subunit beta 6, transcript variant X2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303122,961,499 - 123,089,078 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646918,581,840 - 18,650,123 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646918,581,855 - 18,650,109 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Itgb6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303122,961,499 - 123,089,078 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646918,581,840 - 18,650,123 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646918,581,855 - 18,650,109 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGB6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382160,099,671 - 160,200,272 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2160,099,667 - 160,200,313 (-)EnsemblGRCh38hg38GRCh38
GRCh372160,956,182 - 161,056,783 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362160,666,479 - 160,764,836 (-)NCBINCBI36Build 36hg18NCBI36
Build 342160,783,739 - 160,882,097NCBI
Celera2154,569,718 - 154,668,069 (-)NCBICelera
Cytogenetic Map2q24.2NCBI
HuRef2152,841,567 - 152,939,796 (-)NCBIHuRef
CHM1_12160,964,913 - 161,062,919 (-)NCBICHM1_1
T2T-CHM13v2.02160,557,539 - 160,657,754 (-)NCBIT2T-CHM13v2.0
Itgb6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39260,428,636 - 60,553,005 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl260,428,636 - 60,552,987 (-)EnsemblGRCm39 Ensembl
GRCm38260,598,292 - 60,722,603 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl260,598,292 - 60,722,643 (-)EnsemblGRCm38mm10GRCm38
MGSCv37260,436,349 - 60,560,660 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36260,399,131 - 60,474,500 (-)NCBIMGSCv36mm8
Celera262,295,485 - 62,419,857 (-)NCBICelera
Cytogenetic Map2C1.1- C1.2NCBI
cM Map234.81NCBI
Itgb6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8365,454,964 - 65,579,179 (-)NCBIGRCr8
mRatBN7.2345,046,295 - 45,170,532 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl345,048,044 - 45,121,671 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx348,404,699 - 48,477,782 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0356,988,255 - 57,061,340 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0354,757,778 - 54,831,418 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0346,652,624 - 46,775,362 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl346,652,623 - 46,726,958 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0351,760,871 - 51,883,770 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4342,286,140 - 42,360,793 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1342,182,533 - 42,257,165 (-)NCBI
Celera344,745,206 - 44,817,710 (-)NCBICelera
Cytogenetic Map3q21NCBI
Itgb6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544913,448,084 - 13,520,879 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544913,387,013 - 13,520,879 (+)NCBIChiLan1.0ChiLan1.0
ITGB6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21362,791,601 - 62,961,884 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B62,806,572 - 62,909,714 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B47,386,913 - 47,496,491 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B164,757,913 - 164,867,426 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B164,764,251 - 164,867,426 (-)Ensemblpanpan1.1panPan2
ITGB6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1365,833,206 - 5,962,699 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl365,834,638 - 5,962,633 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha365,972,263 - 6,101,021 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0365,957,679 - 6,086,682 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl365,957,684 - 6,086,586 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1365,974,904 - 6,103,502 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0366,018,081 - 6,146,821 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0366,127,531 - 6,256,234 (-)NCBIUU_Cfam_GSD_1.0
ITGB6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1567,041,522 - 67,175,234 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11567,041,516 - 67,175,409 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21574,181,822 - 74,276,814 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITGB6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11045,506,355 - 45,650,979 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1045,504,987 - 45,595,543 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040153,971,887 - 154,066,448 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itgb6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247325,403,956 - 5,499,855 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247325,348,589 - 5,499,826 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000008227   ⟹   ENSSTOP00000007370
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493646918,581,840 - 18,650,123 (+)Ensembl
RefSeq Acc Id: XM_013356878   ⟹   XP_013212332
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303122,967,598 - 123,035,581 (-)NCBI
SpeTri2.0NW_00493646918,582,139 - 18,650,109 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021730299   ⟹   XP_021585974
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303122,967,598 - 123,089,077 (-)NCBI
SpeTri2.0NW_00493646918,581,855 - 18,650,109 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040294364   ⟹   XP_040150298
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303122,967,598 - 123,089,077 (-)NCBI
RefSeq Acc Id: XR_005737969
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303122,961,499 - 123,089,078 (-)NCBI
RefSeq Acc Id: XR_005737970
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303122,961,499 - 123,089,078 (-)NCBI
Protein Sequences
Protein RefSeqs XP_013212332 (Get FASTA)   NCBI Sequence Viewer  
  XP_021585974 (Get FASTA)   NCBI Sequence Viewer  
  XP_040150298 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000007370.3
GenBank Protein KAG3274560 (Get FASTA)   NCBI Sequence Viewer  
  KAG3274561 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_013212332   ⟸   XM_013356878
- Peptide Label: isoform X2
- UniProtKB: I3MB92 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021585974   ⟸   XM_021730299
- Peptide Label: isoform X1
- UniProtKB: I3MB92 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040150298   ⟸   XM_040294364
- Peptide Label: isoform X1
- UniProtKB: I3MB92 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000007370   ⟸   ENSSTOT00000008227
Protein Domains
Integrin beta subunit cytoplasmic   Integrin beta subunit tail   Integrin beta subunit VWA   PSI


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000008224 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000008227.3 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.410 UniProtKB/TrEMBL
  4.10.1240.30 UniProtKB/TrEMBL
  Cytochrome c1, transmembrane anchor, C-terminal UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
  ligand-binding face of the semaphorins, domain 2 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/TrEMBL
InterPro EGF_extracell UniProtKB/TrEMBL
  I-EGF_1 UniProtKB/TrEMBL
  Integrin_beta_N UniProtKB/TrEMBL
  Integrin_bsu UniProtKB/TrEMBL
  Integrin_bsu_cyt_dom UniProtKB/TrEMBL
  Integrin_bsu_tail UniProtKB/TrEMBL
  Integrin_bsu_tail_dom_sf UniProtKB/TrEMBL
  Integrin_bsu_VWA UniProtKB/TrEMBL
  Integrin_dom_sf UniProtKB/TrEMBL
  PSI UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
NCBI Gene Itgb6 ENTREZGENE
PANTHER PTHR10082 UniProtKB/TrEMBL
  PTHR10082:SF11 UniProtKB/TrEMBL
Pfam EGF_2 UniProtKB/TrEMBL
  I-EGF_1 UniProtKB/TrEMBL
  Integrin_b_cyt UniProtKB/TrEMBL
  Integrin_B_tail UniProtKB/TrEMBL
  Integrin_beta UniProtKB/TrEMBL
  PSI_integrin UniProtKB/TrEMBL
PIRSF Integrin_B UniProtKB/TrEMBL
PRINTS INTEGRINB UniProtKB/TrEMBL
PROSITE INTEGRIN_BETA UniProtKB/TrEMBL
SMART INB UniProtKB/TrEMBL
  Integrin_b_cyt UniProtKB/TrEMBL
  Integrin_B_tail UniProtKB/TrEMBL
  PSI UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  Plexin repeat UniProtKB/TrEMBL
  SSF53300 UniProtKB/TrEMBL
  SSF69179 UniProtKB/TrEMBL
  SSF69687 UniProtKB/TrEMBL
UniProt I3MB92 ENTREZGENE, UniProtKB/TrEMBL