Pc (pyruvate carboxylase) - Rat Genome Database

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Gene: Pc (pyruvate carboxylase) Ictidomys tridecemlineatus
Analyze
Symbol: Pc
Name: pyruvate carboxylase
RGD ID: 12604455
Description: ENCODES a protein that exhibits ATP binding (ortholog); biotin binding (ortholog); carboxylic acid binding (ortholog); INVOLVED IN gluconeogenesis (ortholog); oxaloacetate metabolic process (ortholog); positive regulation of phospholipid biosynthetic process (ortholog); PARTICIPATES IN alanine metabolic pathway; citric acid cycle pathway; fructose-1,6-bisphosphatase deficiency pathway; ASSOCIATED WITH bipolar disorder (ortholog); Burkitt lymphoma (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: pyruvate carboxylase, mitochondrial; pyruvate carboxylase, transcript variant X1; pyruvate carboxylase, transcript variant X2; pyruvate carboxylase, transcript variant X3; pyruvate carboxylase, transcript variant X4; pyruvate carboxylase, transcript variant X5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049476,235,346 - 6,350,686 (+)NCBI
SpeTri2.0NW_0049365992,677,770 - 2,793,033 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
mitochondrion  (IEA,ISO)

Molecular Function

References

Genomics

Comparative Map Data
Pc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049476,235,346 - 6,350,686 (+)NCBI
SpeTri2.0NW_0049365992,677,770 - 2,793,033 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1166,848,417 - 66,958,386 (-)EnsemblGRCh38hg38GRCh38
GRCh381166,848,420 - 66,958,418 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371166,615,891 - 66,725,854 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361166,372,573 - 66,482,423 (-)NCBINCBI36hg18NCBI36
Build 341166,372,572 - 66,431,998NCBI
Celera1163,944,403 - 64,054,124 (-)NCBI
Cytogenetic Map11q13.2NCBI
HuRef1162,944,043 - 63,053,644 (-)NCBIHuRef
CHM1_11166,499,596 - 66,607,614 (-)NCBICHM1_1
Pcx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39194,560,500 - 4,671,780 (+)NCBIGRCm39mm39
GRCm39 Ensembl194,560,500 - 4,671,780 (+)Ensembl
GRCm38194,510,472 - 4,621,752 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl194,510,472 - 4,621,752 (+)EnsemblGRCm38mm10GRCm38
MGSCv37194,510,472 - 4,621,752 (+)NCBIGRCm37mm9NCBIm37
MGSCv36194,594,346 - 4,621,698 (+)NCBImm8
Celera194,381,239 - 4,492,934 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.07NCBI
Pc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21201,799,374 - 201,898,412 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1201,804,267 - 201,898,380 (+)Ensembl
Rnor_6.01219,759,157 - 219,859,854 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,759,183 - 219,859,848 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,626,831 - 226,726,350 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41207,112,853 - 207,212,737 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11207,266,305 - 207,366,189 (+)NCBI
Celera1199,343,224 - 199,439,273 (+)NCBICelera
RH 3.4 Map11554.4RGD
Cytogenetic Map1q43NCBI
Pc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542218,420,596 - 18,536,436 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542218,421,100 - 18,536,591 (+)NCBIChiLan1.0ChiLan1.0
PC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11165,527,285 - 65,639,533 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1165,527,662 - 65,551,396 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01162,205,644 - 62,317,917 (-)NCBIMhudiblu_PPA_v0panPan3
PC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11850,406,994 - 50,507,677 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1850,412,272 - 50,507,669 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1849,016,958 - 49,117,517 (+)NCBI
ROS_Cfam_1.01851,357,399 - 51,457,857 (+)NCBI
ROS_Cfam_1.0 Ensembl1851,357,414 - 51,457,857 (+)Ensembl
UMICH_Zoey_3.11850,541,749 - 50,642,299 (+)NCBI
UNSW_CanFamBas_1.01850,121,287 - 50,221,660 (+)NCBI
UU_Cfam_GSD_1.01850,910,958 - 51,011,409 (+)NCBI
PC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl25,518,430 - 5,587,797 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.125,566,608 - 5,587,797 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.224,594,815 - 4,609,731 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2p17NCBI
PC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.117,310,738 - 7,418,357 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl17,357,246 - 7,417,998 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038104,598,850 - 104,705,939 (+)NCBIVero_WHO_p1.0
Pc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476719,481,158 - 19,601,036 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005333362   ⟹   XP_005333419
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049476,235,392 - 6,350,686 (+)NCBI
SpeTri2.0NW_0049365992,677,770 - 2,793,033 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013361995   ⟹   XP_013217449
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049476,266,808 - 6,350,686 (+)NCBI
SpeTri2.0NW_0049365992,709,002 - 2,793,033 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021731750   ⟹   XP_021587425
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049476,275,157 - 6,350,686 (+)NCBI
SpeTri2.0NW_0049365992,717,593 - 2,793,033 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021731752   ⟹   XP_021587427
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049476,235,346 - 6,350,686 (+)NCBI
SpeTri2.0NW_0049365992,677,770 - 2,793,033 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040284039   ⟹   XP_040139973
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049476,240,943 - 6,350,686 (+)NCBI
RefSeq Acc Id: XM_040284041   ⟹   XP_040139975
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049476,235,420 - 6,350,686 (+)NCBI
RefSeq Acc Id: XM_040284042   ⟹   XP_040139976
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049476,235,852 - 6,350,686 (+)NCBI
RefSeq Acc Id: XM_040284043   ⟹   XP_040139977
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049476,318,294 - 6,350,686 (+)NCBI
RefSeq Acc Id: XM_040284044   ⟹   XP_040139978
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049476,256,568 - 6,350,686 (+)NCBI
RefSeq Acc Id: XM_040284045   ⟹   XP_040139979
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049476,235,554 - 6,350,686 (+)NCBI
RefSeq Acc Id: XM_040284046   ⟹   XP_040139980
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049476,235,761 - 6,350,686 (+)NCBI
RefSeq Acc Id: XM_040284048   ⟹   XP_040139982
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049476,236,926 - 6,350,686 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_005333419   ⟸   XM_005333362
- Peptide Label: isoform X2
- UniProtKB: A0A287DD93 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013217449   ⟸   XM_013361995
- Peptide Label: isoform X2
- UniProtKB: A0A287DD93 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021587427   ⟸   XM_021731752
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_021587425   ⟸   XM_021731750
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_040139975   ⟸   XM_040284041
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040139979   ⟸   XM_040284045
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040139980   ⟸   XM_040284046
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040139976   ⟸   XM_040284042
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040139982   ⟸   XM_040284048
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040139973   ⟸   XM_040284039
- Peptide Label: isoform X1
RefSeq Acc Id: XP_040139978   ⟸   XM_040284044
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040139977   ⟸   XM_040284043
- Peptide Label: isoform X2

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000009227 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000008290 ENTREZGENE, UniProtKB/TrEMBL
  ENSSTOP00000029479 UniProtKB/TrEMBL
  ENSSTOP00000031545 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000009241 UniProtKB/TrEMBL
  ENSSTOT00000030868 UniProtKB/TrEMBL
  ENSSTOT00000040281 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/TrEMBL
InterPro Aldolase_TIM UniProtKB/TrEMBL
  ATP-grasp UniProtKB/TrEMBL
  BC-like_N UniProtKB/TrEMBL
  Biotin_BS UniProtKB/TrEMBL
  Biotin_carboxylation_dom UniProtKB/TrEMBL
  Biotin_COase_C UniProtKB/TrEMBL
  Biotin_lipoyl UniProtKB/TrEMBL
  Carboxylase_cons_dom UniProtKB/TrEMBL
  CbamoylP_synth_lsu-like_ATP-bd UniProtKB/TrEMBL
  PreATP-grasp_dom_sf UniProtKB/TrEMBL
  PYR_CT UniProtKB/TrEMBL
  Pyruv_COase UniProtKB/TrEMBL
  Rudment_hybrid_motif UniProtKB/TrEMBL
  Single_hybrid_motif UniProtKB/TrEMBL
NCBI Gene Pc ENTREZGENE
Pfam Biotin_carb_C UniProtKB/TrEMBL
  Biotin_carb_N UniProtKB/TrEMBL
  Biotin_lipoyl UniProtKB/TrEMBL
  CPSase_L_D2 UniProtKB/TrEMBL
  HMGL-like UniProtKB/TrEMBL
  PYC_OADA UniProtKB/TrEMBL
PIRSF Pyruv_carbox UniProtKB/TrEMBL
PROSITE ATP_GRASP UniProtKB/TrEMBL
  BIOTIN UniProtKB/TrEMBL
  BIOTINYL_LIPOYL UniProtKB/TrEMBL
  PS50979 UniProtKB/TrEMBL
  PYR_CT UniProtKB/TrEMBL
SMART Biotin_carb_C UniProtKB/TrEMBL
Superfamily-SCOP SSF51230 UniProtKB/TrEMBL
  SSF51246 UniProtKB/TrEMBL
  SSF52440 UniProtKB/TrEMBL
TIGRFAMs pyruv_carbox UniProtKB/TrEMBL
UniProt A0A287DD93 ENTREZGENE, UniProtKB/TrEMBL
  I3MD71_ICTTR UniProtKB/TrEMBL