Aldh8a1 (aldehyde dehydrogenase 8 family member A1)

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Gene: Aldh8a1 (aldehyde dehydrogenase 8 family member A1) Ictidomys tridecemlineatus

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Symbol:

Aldh8a1

Name:

aldehyde dehydrogenase 8 family member A1

RGD ID:

12602522

Description:

ENCODES a protein that exhibits oxidoreductase activity (inferred); oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor (inferred); retinal dehydrogenase activity (inferred); INVOLVED IN 9-cis-retinoic acid biosynthetic process (ortholog); ASSOCIATED WITH cholestasis (ortholog); Familial Behcet-Like Autoinflammatory Syndrome (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

2-aminomuconic semialdehyde dehydrogenase; aldehyde dehydrogenase 8 family member A1, transcript variant X1; aldehyde dehydrogenase 8 family member A1, transcript variant X2; aldehyde dehydrogenase 8 family member A1, transcript variant X3; aldehyde dehydrogenase family 8 member A1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	122,783,100 - 122,801,109 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936560	2,562,748 - 2,580,201 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936560	2,562,394 - 2,580,261 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cholestasis (ISO)

Familial Behcet-Like Autoinflammatory Syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

9-cis-retinoic acid biosynthetic process (IEA,ISO)

retinal metabolic process (IEA)

retinoic acid metabolic process (IEA)

Molecular Function

oxidoreductase activity (IEA)

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor (IEA)

retinal dehydrogenase activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Aldh8a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	122,783,100 - 122,801,109 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936560	2,562,748 - 2,580,201 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936560	2,562,394 - 2,580,261 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ALDH8A1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	134,917,393 - 134,950,101 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	134,917,393 - 134,950,115 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	135,238,531 - 135,271,239 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	135,280,221 - 135,312,937 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	135,280,221 - 135,312,937	NCBI
Celera	6	135,978,855 - 136,011,613 (-)	NCBI		Celera
Cytogenetic Map	6	q23.3	NCBI
HuRef	6	132,802,624 - 132,835,473 (-)	NCBI		HuRef
CHM1_1	6	135,500,243 - 135,532,981 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	136,105,650 - 136,138,351 (-)	NCBI		T2T-CHM13v2.0

Aldh8a1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	21,253,199 - 21,272,477 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	21,253,190 - 21,272,484 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	21,377,300 - 21,396,578 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	21,377,291 - 21,396,585 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	21,097,106 - 21,116,384 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	21,066,707 - 21,085,994 (+)	NCBI		MGSCv36	mm8
Celera	10	21,271,834 - 21,291,207 (+)	NCBI		Celera
Cytogenetic Map	10	A3	NCBI
cM Map	10	9.75	NCBI

Aldh8a1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	18,003,507 - 18,022,952 (+)	NCBI		GRCr8
mRatBN7.2	1	16,183,940 - 16,203,385 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	16,183,940 - 16,203,385 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	15,939,802 - 15,967,859 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	21,941,695 - 21,969,752 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	16,165,019 - 16,193,076 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	16,910,043 - 16,929,465 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	16,910,069 - 16,930,481 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	18,065,355 - 18,084,421 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	16,750,783 - 16,769,899 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	14,601,982 - 14,621,191 (+)	NCBI		Celera
Cytogenetic Map	1	p12	NCBI

Aldh8a1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955439	1,773,861 - 1,794,328 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955439	1,773,884 - 1,794,325 (+)	NCBI	ChiLan1.0	ChiLan1.0

ALDH8A1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	154,892,189 - 154,939,701 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	152,790,595 - 152,847,608 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	132,685,904 - 132,732,194 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	136,782,957 - 136,815,611 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	136,782,957 - 136,815,611 (-)	Ensembl	panpan1.1		panPan2

ALDH8A1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	27,672,422 - 27,695,029 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	27,673,024 - 27,694,868 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	28,553,032 - 28,575,378 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	27,830,092 - 27,852,485 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	27,830,696 - 27,852,360 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	27,714,409 - 27,736,977 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	27,594,758 - 27,617,127 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	27,905,932 - 27,928,311 (-)	NCBI		UU_Cfam_GSD_1.0

ALDH8A1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	29,060,701 - 29,083,143 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	29,060,682 - 29,083,815 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	32,551,894 - 32,561,317 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ALDH8A1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	38,489,459 - 38,521,983 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	38,490,181 - 38,522,087 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	10,689,605 - 10,721,369 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Aldh8a1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624886	2,702,960 - 2,722,357 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624886	2,702,328 - 2,721,954 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013360511	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021729466	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021729467	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000007531 ⟹ ENSSTOP00000006731

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936560	2,562,748 - 2,580,201 (-)	Ensembl

RefSeq Acc Id:

XM_013360511 ⟹ XP_013215965

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404946	122,783,100 - 122,801,109 (-)	NCBI
SpeTri2.0	NW_004936560	2,562,394 - 2,580,261 (-)	NCBI

Sequence:

show sequence

ATGTGGATATTGGGACTGGAAAAGGAGAGAACAGCTCAGCACTGGGGGCAAAGTTGGGGACAAC
TCAGGGAACAATTGTGAAGGGAAAGGCAGCAGCACTTCTTCTCTGTTCTGGAACAATGGAACTT
TTGATGCTGGAAAACTTCATAGATGGGAAATTTTTACCTTGTCACTCCTATATAGATTCTTATG
ATCCATCCACAGGAGAAGTGTACTGCAAAGTGCCAGATAGTGGGAAAGAAGAGATCGAGGTCGC
AGTGGAGGCGGCCAGAAAGGCCTTTCCCAGCTGGTCATCCCGCAGCCCCCAGGAGCGCTCCCAG
GTCCTGAACCGACTGGCAGACTTGCTGGAGCAGTCCCTTGAGGAGTTGGCCCAGGCAGAATCTA
AAGACCAAGGGAAAACCCTGACGATGGCAAGAACTATAGACATTCCCCGGTCTGTGCAGAACTT
CCGGTTCTTCGCTTCCTCCATCCTGCACCACACGACAGAGAGCACACAGATGGATCACCTGGGC
TGTCTGCACTACACAGTGCGGACTCCGGTGGGAATCGCGGGTCTGATTAGTCCTTGGAATTTGC
CCCTCTACTTGCTGACCTGGAAGATAGCTCCGGCCATCGCTGCTGGGAACACTGTGATAGCAAA
GCCCAGTGAGCTAACTTCAGTGACTGCGTGGATGTTATGCAAGTTCCTGAATAAAGCAGGTGTT
CCACCAGGTGTGGTCAATATTGTGTTTGGAACAGGGCCCAAGGTAGGTGAGGCCCTGGTGACCC
ACCCAGAGGTGCCCTTGATCTCCTTTACTGGGAGTCAACCCACAGCTGAGCGGATCACCCAGCT
GAGTGCTCCCTTCTGTAAGAAGCTCTCCCTGGAGCTGGGGGGCAAGAATCCTGCCATCATTTTT
GAGGATGCCAATCTAGAGGACTGTATTCCAGCAACTGTCAGATCCAGCTTTGCCAACCAGGGTG
AAATCTGTCTCTGCACCAGCAGGATCTTTGTTCAGAGGAGCATCTATAATGAATTTTTAAAGAG
GTTTGTAGAAGCTAGCAGAAAGTGGAAGGTCGGCATTCCTTCTGATCCATCAGCCAGCATGGGT
GCTCTGATAAGTAAAGCACATTTGGAGAAAGTCAGAAGTTACATCAAGAAGGCTCGTGCTGAAG
GGGCCCAAATCCTGTGTGGCGAGGGGGTAGATAGGTTGAGCCTGCCCCCCAGGAATCAGGCAGG
CTACTTCATGCTTCCCACGGTGATAACAGACATTAAGGATGAGTCCTGCTGTATGAAGGAAGAG
ATATTTGGTCCAGTGACGTGTGTTGTCCCTTTTGATAGCGAAGAGGAAGTGATTAGAAGGGCCA
ACAGTGTTAAATACGGGCTGGCGGCTACGGTATGGTCAGGCCACGTGGGGCGCATCCACCGGGT
GGCTCAGAAGCTGCAGTCGGGCTTGGTCTGGACCAACTGCTGGCTGATCAGAGAGCTGAACCTG
CCTTTTGGGGGGATGAAGTATTCTGGGATAGGAAGGGAGGGAGCCAAGGACTCTCATGACTTCT
TTACTGAAATCAAAACCATCACAGTTAAGTACTGAACTTCGCCCATGGGGAAGCTGCTGTCGTC
ACTGCCTTGGGCAGAGACCCTGCTGTCCAGTGTGATGAAGGAAGTGCAGGTGTCCATCGCAGCA
CATCCTGACGGCAGGAGGCTCTCTCTAGCTTACCTTGGAAGGCTCGCGAGATGCTACCTATTTT
CAATGTGGACTCAGAAGAGAATACTTCTGAATAGGAAGTCACAACAAGGAGGCCACACGATCAT
CATGTCATGCCTTTCATAGTATTTTTTTCATCATCTAGATTGAATTCTTGGAATCCTCAGTAAT
CAGATATTTTCATTTACAAATATGGAGTAAAAAATCCGCAAAGCTGAAGAGAAACAACTCAGCA
TAATTCCCTGCCTTTAAGGGGACTGTGGAGATGTTCTCCTGGTCCATTAGCTACCTGTGTGGCT
AAGTGATAACTGGATACTCCTCATTATGTGTGGGGGTGTCGAATGTTTCTGCACTTTGTTAGAG
GAGGTCTATGTGGTAGGTTGGGCTAAATATATCTATACAGGGACAAAGAACAATAAAATTGCTA
CCACTTTTAGAGGAAGCTTGGAACAAGAAGAGAAAACTAATCCATTTCCACTGTC

hide sequence

Protein Sequences


Protein RefSeqs	XP_013215965	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000006731.3
GenBank Protein	KAG3290290	(Get FASTA)	NCBI Sequence Viewer
	KAG3290291	(Get FASTA)	NCBI Sequence Viewer
	KAG3290292	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_013215965 ⟸ XM_013360511

- UniProtKB:

I3M9X5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MELLMLENFIDGKFLPCHSYIDSYDPSTGEVYCKVPDSGKEEIEVAVEAARKAFPSWSSRSPQE
RSQVLNRLADLLEQSLEELAQAESKDQGKTLTMARTIDIPRSVQNFRFFASSILHHTTESTQMD
HLGCLHYTVRTPVGIAGLISPWNLPLYLLTWKIAPAIAAGNTVIAKPSELTSVTAWMLCKFLNK
AGVPPGVVNIVFGTGPKVGEALVTHPEVPLISFTGSQPTAERITQLSAPFCKKLSLELGGKNPA
IIFEDANLEDCIPATVRSSFANQGEICLCTSRIFVQRSIYNEFLKRFVEASRKWKVGIPSDPSA
SMGALISKAHLEKVRSYIKKARAEGAQILCGEGVDRLSLPPRNQAGYFMLPTVITDIKDESCCM
KEEIFGPVTCVVPFDSEEEVIRRANSVKYGLAATVWSGHVGRIHRVAQKLQSGLVWTNCWLIRE
LNLPFGGMKYSGIGREGAKDSHDFFTEIKTITVKY

hide sequence

Ensembl Acc Id:

ENSSTOP00000006731 ⟸ ENSSTOT00000007531

Protein Domains

Aldehyde dehydrogenase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000007535	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000007531.3	UniProtKB/TrEMBL
InterPro	Ald_DH/histidinol_DH	UniProtKB/TrEMBL
	Ald_DH_C	UniProtKB/TrEMBL
	Ald_DH_CS_CYS	UniProtKB/TrEMBL
	Ald_DH_CS_GLU	UniProtKB/TrEMBL
	Ald_DH_N	UniProtKB/TrEMBL
	Aldehyde_DH_dom	UniProtKB/TrEMBL
NCBI Gene	Aldh8a1	ENTREZGENE
PANTHER	2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE	UniProtKB/TrEMBL
	2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE	UniProtKB/TrEMBL
Pfam	Aldedh	UniProtKB/TrEMBL
PROSITE	ALDEHYDE_DEHYDR_CYS	UniProtKB/TrEMBL
	ALDEHYDE_DEHYDR_GLU	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53720	UniProtKB/TrEMBL
UniProt	I3M9X5	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD