Cacnb1 (calcium voltage-gated channel auxiliary subunit beta 1) - Rat Genome Database

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Pathways
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Gene: Cacnb1 (calcium voltage-gated channel auxiliary subunit beta 1) Ictidomys tridecemlineatus
Analyze
Symbol: Cacnb1
Name: calcium voltage-gated channel auxiliary subunit beta 1
RGD ID: 12600878
Description: ENCODES a protein that exhibits high voltage-gated calcium channel activity (ortholog); identical protein binding (ortholog); phosphoprotein binding (ortholog); INVOLVED IN calcium ion transport (ortholog); protein targeting to membrane (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; FOUND IN glutamatergic synapse (ortholog); postsynapse (ortholog); presynapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: calcium voltage-gated channel auxiliary subunit beta 1, transcript variant X1; calcium voltage-gated channel auxiliary subunit beta 1, transcript variant X2; calcium voltage-gated channel auxiliary subunit beta 1, transcript variant X3; calcium voltage-gated channel auxiliary subunit beta 1, transcript variant X4; voltage-dependent L-type calcium channel subunit beta-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560222,606,360 - 22,626,845 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649014,448,258 - 14,468,785 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649014,448,305 - 14,468,785 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
alfentanil pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway   (ISO)
calcium transport pathway   (ISO)
calcium/calcium-mediated signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
felodipine pharmacokinetics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
gliclazide pharmacodynamics pathway  (ISO)
glyburide pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway   (ISO)
potassium channel inhibitors pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Cacnb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560222,606,360 - 22,626,845 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649014,448,258 - 14,468,785 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649014,448,305 - 14,468,785 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CACNB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381739,173,453 - 39,197,669 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1739,173,453 - 39,197,702 (-)EnsemblGRCh38hg38GRCh38
GRCh371737,329,706 - 37,353,922 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361734,583,235 - 34,607,427 (-)NCBINCBI36Build 36hg18NCBI36
Build 341734,586,914 - 34,607,427NCBI
Celera1733,990,617 - 34,014,805 (-)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1733,125,170 - 33,149,131 (-)NCBIHuRef
CHM1_11737,565,987 - 37,590,231 (-)NCBICHM1_1
T2T-CHM13v2.01740,037,330 - 40,061,546 (-)NCBIT2T-CHM13v2.0
Cacnb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391197,892,339 - 97,913,860 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1197,892,334 - 97,913,860 (-)EnsemblGRCm39 Ensembl
GRCm381198,001,508 - 98,023,034 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,001,508 - 98,023,034 (-)EnsemblGRCm38mm10GRCm38
MGSCv371197,864,215 - 97,883,941 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361197,818,991 - 97,839,113 (-)NCBIMGSCv36mm8
Celera11107,653,222 - 107,676,228 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1161.5NCBI
Cacnb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81083,494,509 - 83,515,164 (-)NCBIGRCr8
mRatBN7.21082,998,182 - 83,018,838 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1082,998,182 - 83,018,694 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1087,946,204 - 87,966,793 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01087,444,288 - 87,464,877 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01082,836,918 - 82,857,509 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01085,954,138 - 85,974,764 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1085,954,138 - 85,974,651 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01085,742,631 - 85,763,268 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41086,764,283 - 86,784,791 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11086,778,652 - 86,799,161 (-)NCBI
Celera1081,751,498 - 81,772,006 (-)NCBICelera
Cytogenetic Map10q31NCBI
Cacnb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,038,668 - 14,059,848 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,041,848 - 14,059,740 (-)NCBIChiLan1.0ChiLan1.0
CACNB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21925,740,744 - 25,765,311 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11727,634,877 - 27,659,438 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01718,073,818 - 18,098,400 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11718,349,146 - 18,373,338 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1718,349,146 - 18,373,338 (+)Ensemblpanpan1.1panPan2
CACNB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1923,182,407 - 23,197,035 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl923,180,554 - 23,195,673 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha922,649,781 - 22,668,495 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0923,972,610 - 23,991,331 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,972,594 - 23,991,326 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1922,744,505 - 22,763,217 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0923,005,588 - 23,024,294 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0923,130,733 - 23,149,448 (+)NCBIUU_Cfam_GSD_1.0
CACNB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1223,037,810 - 23,060,490 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11223,038,185 - 23,060,504 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21223,491,054 - 23,513,338 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CACNB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11666,971,379 - 66,994,031 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1666,971,459 - 66,996,095 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607737,916,094 - 37,941,343 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cacnb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247953,732,320 - 3,747,717 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247953,732,201 - 3,747,731 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000011109   ⟹   ENSSTOP00000009965
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493649014,448,260 - 14,468,785 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000033912   ⟹   ENSSTOP00000029342
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493649014,451,700 - 14,464,564 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000034819   ⟹   ENSSTOP00000024702
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493649014,448,258 - 14,468,785 (-)Ensembl
RefSeq Acc Id: XM_005321765   ⟹   XP_005321822
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560222,606,360 - 22,626,845 (+)NCBI
SpeTri2.0NW_00493649014,448,305 - 14,468,785 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005321766   ⟹   XP_005321823
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560222,606,360 - 22,626,845 (+)NCBI
SpeTri2.0NW_00493649014,448,305 - 14,468,785 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040268835   ⟹   XP_040124769
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560222,606,759 - 22,626,845 (+)NCBI
RefSeq Acc Id: XM_040268836   ⟹   XP_040124770
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560222,606,759 - 22,626,845 (+)NCBI
RefSeq Acc Id: XM_040268837   ⟹   XP_040124771
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560222,606,759 - 22,623,439 (+)NCBI
RefSeq Acc Id: XP_005321823   ⟸   XM_005321766
- Peptide Label: isoform X4
- UniProtKB: A0A287CTT8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005321822   ⟸   XM_005321765
- Peptide Label: isoform X2
- UniProtKB: I3MGP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040124769   ⟸   XM_040268835
- Peptide Label: isoform X1
RefSeq Acc Id: XP_040124770   ⟸   XM_040268836
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040124771   ⟸   XM_040268837
- Peptide Label: isoform X5
- UniProtKB: A0A287D6Z0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000024702   ⟸   ENSSTOT00000034819
Ensembl Acc Id: ENSSTOP00000009965   ⟸   ENSSTOT00000011109
Ensembl Acc Id: ENSSTOP00000029342   ⟸   ENSSTOT00000033912
Protein Domains
SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000011107 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000011109.3 UniProtKB/TrEMBL
  ENSSTOT00000033912.1 UniProtKB/TrEMBL
  ENSSTOT00000034819.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro CAB1-4_N_A-dom UniProtKB/TrEMBL
  GK/Ca_channel_bsu UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  VDCC_L_b1su UniProtKB/TrEMBL
  VDCC_L_bsu UniProtKB/TrEMBL
NCBI Gene Cacnb1 ENTREZGENE
PANTHER VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT UniProtKB/TrEMBL
  VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1 UniProtKB/TrEMBL
Pfam Guanylate_kin UniProtKB/TrEMBL
  VGCC_beta4Aa_N UniProtKB/TrEMBL
PRINTS LCACHANNELB UniProtKB/TrEMBL
  LCACHANNELB1 UniProtKB/TrEMBL
PROSITE SH3 UniProtKB/TrEMBL
SMART GuKc UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A287CTT8 ENTREZGENE, UniProtKB/TrEMBL
  A0A287D6Z0 ENTREZGENE, UniProtKB/TrEMBL
  I3MGP4 ENTREZGENE, UniProtKB/TrEMBL