Cmpk1 (cytidine/uridine monophosphate kinase 1)

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Gene: Cmpk1 (cytidine/uridine monophosphate kinase 1) Ictidomys tridecemlineatus

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Symbol:

Cmpk1

Name:

cytidine/uridine monophosphate kinase 1

RGD ID:

12600649

Description:

ENCODES a protein that exhibits CMP kinase activity (ortholog); nucleoside monophosphate kinase activity (ortholog); UMP/dUMP kinase activity (ortholog); INVOLVED IN CDP biosynthetic process (ortholog); dCDP biosynthetic process (ortholog); dUDP biosynthetic process (ortholog); PARTICIPATES IN de novo pyrimidine biosynthetic pathway; gemcitabine pharmacodynamics pathway; gemcitabine pharmacokinetics pathway; ASSOCIATED WITH congenital aphakia (ortholog); lung non-small cell carcinoma (ortholog); FOUND IN cytoplasm (inferred); nucleolus (inferred); nucleoplasm (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

UMP-CMP kinase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	62,322,681 - 62,355,997 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	28,147,085 - 28,182,043 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	28,147,459 - 28,180,779 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital aphakia (ISO)

lung non-small cell carcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

'de novo' pyrimidine nucleobase biosynthetic process (IEA)

CDP biosynthetic process (ISO)

dCDP biosynthetic process (ISO)

dUDP biosynthetic process (ISO)

nucleoside monophosphate phosphorylation (IEA)

ovulation cycle process (ISO)

phthalate metabolic process (ISO)

pyrimidine nucleotide biosynthetic process (IEA)

pyrimidine-containing compound biosynthetic process (IEA)

UDP biosynthetic process (IEA,ISO)

Cellular Component

cytoplasm (IEA)

nucleolus (IEA)

nucleoplasm (IEA)

nucleus (IEA)

Molecular Function

(d)CMP kinase activity (IEA)

ATP binding (IEA)

CMP kinase activity (IEA,ISO)

dCMP kinase activity (IEA)

kinase activity (IEA)

nucleoside diphosphate kinase activity (IEA)

nucleoside monophosphate kinase activity (ISO)

protein binding (ISO)

UMP kinase activity (IEA)

UMP/dUMP kinase activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

de novo pyrimidine biosynthetic pathway (ISO)

gemcitabine pharmacodynamics pathway (ISO)

gemcitabine pharmacokinetics pathway (ISO)

Glut1 deficiency syndrome pathway (ISO)

lactose biosynthetic pathway (ISO)

lamivudine pharmacokinetics pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Cmpk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	62,322,681 - 62,355,997 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	28,147,085 - 28,182,043 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	28,147,459 - 28,180,779 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CMPK1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	47,333,790 - 47,378,839 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	47,333,790 - 47,394,866 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	47,799,462 - 47,844,511 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	47,572,175 - 47,617,098 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	46,085,741 - 46,130,781 (+)	NCBI		Celera
Cytogenetic Map	1	p33	NCBI
HuRef	1	45,915,968 - 45,960,944 (+)	NCBI		HuRef
CHM1_1	1	47,916,317 - 47,961,359 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	47,212,232 - 47,257,303 (+)	NCBI		T2T-CHM13v2.0

Cmpk1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	114,817,810 - 114,844,425 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	114,816,533 - 114,844,438 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	114,960,613 - 114,987,228 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	114,959,336 - 114,987,241 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	114,633,218 - 114,659,833 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	114,458,570 - 114,485,076 (-)	NCBI		MGSCv36	mm8
Celera	4	113,708,548 - 113,734,653 (-)	NCBI		Celera
Cytogenetic Map	4	D1	NCBI
cM Map	4	52.73	NCBI

Cmpk1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	133,717,073 - 133,744,623 (-)	NCBI		GRCr8
mRatBN7.2	5	128,480,301 - 128,507,830 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	128,480,301 - 128,507,830 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	131,169,403 - 131,196,989 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	132,899,052 - 132,926,636 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	132,920,733 - 132,948,328 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	133,759,722 - 133,786,452 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	133,759,735 - 133,786,452 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	137,551,825 - 137,578,247 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	135,320,845 - 135,348,973 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	135,326,070 - 135,354,120 (-)	NCBI
Celera	5	127,132,281 - 127,159,748 (-)	NCBI		Celera
Cytogenetic Map	5	q35	NCBI

Cmpk1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955464	11,179,432 - 11,213,147 (-)	NCBI	ChiLan1.0	ChiLan1.0

CMPK1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	179,437,907 - 179,468,944 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	178,579,344 - 178,610,662 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	46,642,602 - 46,673,568 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	48,156,641 - 48,186,778 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

CMPK1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	13,324,235 - 13,357,387 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	13,326,185 - 13,358,152 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	13,476,565 - 13,509,755 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	13,473,206 - 13,506,434 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	13,456,379 - 13,506,417 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	13,273,274 - 13,306,477 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	13,341,002 - 13,374,200 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	13,410,462 - 13,443,720 (-)	NCBI		UU_Cfam_GSD_1.0

CMPK1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	164,162,518 - 164,197,379 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	164,161,439 - 164,197,429 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	151,714,202 - 151,748,280 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CMPK1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	85,541,796 - 85,584,167 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	85,541,205 - 85,584,068 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	31,498,081 - 31,540,968 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cmpk1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624859	5,452,694 - 5,495,840 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005318008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000007700 ⟹ ENSSTOP00000006887

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936474	28,147,085 - 28,182,043 (+)	Ensembl

RefSeq Acc Id:

XM_005318008 ⟹ XP_005318065

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	62,322,681 - 62,355,997 (+)	NCBI
SpeTri2.0	NW_004936474	28,147,459 - 28,180,779 (+)	NCBI

Sequence:

show sequence

TCCGGCCTCGGCGGACGCCCGGGCAGCTACCGCGGCGGGGCCGCGGCGCCCACTCGGCCCGCCC
CTTTCTCCACCGGCTCCCGCCCCGCCCCGTTCCGTTCTGCCCCCGCCGCGCCGGGCGCTGTCAG
AGACTCGGTGTATGCTGAGGCGCTGCTGCGGCCGGTTGCTGCACGTCCTGGGCCCAAGCTCCCC
GCTGCTGATCCGCCTGCCACTTCTCTGCCCTCGCAGCCTCATGAAGCCGCTGGTCGTGTTCGTC
CTCGGCGGTCCCGGCGCCGGCAAGGGGACCCAGTGCGCCCGCATCGTCGAGAAATATGGCTACA
CCCACCTCTCTGCAGGAGAACTTCTTCGTGATGAAAGGAAGAACCCAGATTCACAGTATGGTGA
ACTCATTGAAAAGTACATTAAAGATGGAAAGATTGTGCCAGTTGAGATAACCATCAGTTTATTA
AAGAGGGAAATGGATCAAACAATGGCTGCCAATGCCGAGAAGAATAAGTTCTTGATTGATGGAT
TTCCAAGAAATCAAGACAATCTTCAAGGTTGGAACAAGACCATGGATGGGAAGGCAGATGTATC
TTTTGTTCTGTTTTTTGACTGTGATAATGAGATCTGTATCGAACGATGTCTTGAGAGGGGAAAG
AGTAGTGGTAGGAGTGATGACAACAGAGAGAGCTTGGAAAAGAGAATTCAGACTTACCTTCAGT
CAACAAAGCCAATTATTGACTTATATGAAGAAATGGGGAAAGTCAAGAAAATAGACGCTTCTAA
GTCTGTTGATGAAGTTTTTGATGAAGTTGTGAAGATTTTTGACAAAGAAGGCTAACTCTAAACC
TGAAAGCATCCTTGAAATCATGCTTGAATATTGCTTTGATAGCTGCTATTACAACCCCTTTTAA
AGGCAATTTTAATCTTCAAAATTACATCTCAATTAATGACTAGAAAATACATAGTAAGACAAGA
CAAAGTAAATTTTTATGGTGTTTTTTCTTTTTGATTTGTTTTTGGTCACAGGAGTAGACAGTGA
ATTCAGGTTTAATTACTTCTTAGTTATTATGGTGCTCACAAAACAAAGAAGGGTATCAGCTAGT
TCTTTGTTTTTATTAATGACTGTCCTTTTTATAGTTTGTGCCTTCTGTGAGCAAAATTTTTTAG
TATGCATGTACATCCCTTTAGAAATTACAACATATCAGAATTAAGGATTCCCACTTCTTTTCTT
GCAGGTTTTAAATTTCTAACCTCTCAATTGAATTTGTGGACCAAATTTCAAAGGAATTATTTTG
TGTAGTCAGTTCTTGTGCAAGGTGTTTGGTAAACAAACTCATAAAATGGATTCAAACAGCGTTT
TAGTATTTATGAAATAACTGACCATTTCCTACAGTAAGATGGGAAAACTTAGGCTTTGATTTAC
TTCAGCTTGCACAAAGTTGTGTGTCAGGGCTTCCAGGGTTTGGGTTGGGGGCAGGAGGGGTTCA
GAGCCTGGAGGAATTGTCAGTTTTATTCTGACATAATCCAAGGATATGGAGCAAGGATCACATC
TAATGGCTTGTGTTCCTTATGCTCAATTGTACAGTGCTGTTCATTTAGTAAACTGATCTTAACA
CAATTCCTAGCAGTGGAACCTTGAAATGCATGTGCTAGATTTATACTAAAATGATTCAGTTCTC
ATTTTAGCAACGCTTCCAAGTCTTTGTTTTTTTTTGAGACTAAATATAGGGATAAGATAAATTG
TAAAACAACCTAATGATTAAAGTTCCCATTTGCATTTTATTTTCTGAAATACTTTTTCATAGTT
ACTTGTTTTAAAAGATTTTAAAAATCATTGCACTTTGGTCAGAAAAATAATAAATTTATCTTAC
AAATGTT

hide sequence

Protein Sequences


Protein RefSeqs	XP_005318065	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000006887.2
GenBank Protein	KAG3283100	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005318065 ⟸ XM_005318008

- UniProtKB:

I3MA90 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLRRCCGRLLHVLGPSSPLLIRLPLLCPRSLMKPLVVFVLGGPGAGKGTQCARIVEKYGYTHLS
AGELLRDERKNPDSQYGELIEKYIKDGKIVPVEITISLLKREMDQTMAANAEKNKFLIDGFPRN
QDNLQGWNKTMDGKADVSFVLFFDCDNEICIERCLERGKSSGRSDDNRESLEKRIQTYLQSTKP
IIDLYEEMGKVKKIDASKSVDEVFDEVVKIFDKEG

hide sequence

Ensembl Acc Id:

ENSSTOP00000006887 ⟸ ENSSTOT00000007700

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000007706	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000007700.3	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/TrEMBL
InterPro	Adenylat/UMP-CMP_kin	UniProtKB/TrEMBL
	Adenylat_kinase_CS	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	UMP_CMP_kinase	UniProtKB/TrEMBL
NCBI Gene	Cmpk1	ENTREZGENE
PANTHER	PTHR23359	UniProtKB/TrEMBL
	UMP-CMP KINASE	UniProtKB/TrEMBL
Pfam	ADK	UniProtKB/TrEMBL
PRINTS	ADENYLTKNASE	UniProtKB/TrEMBL
PROSITE	ADENYLATE_KINASE	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	I3MA90	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - SMPDB