Maml2 (mastermind like transcriptional coactivator 2) - Rat Genome Database

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Pathways
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Gene: Maml2 (mastermind like transcriptional coactivator 2) Ictidomys tridecemlineatus
Analyze
Symbol: Maml2
Name: mastermind like transcriptional coactivator 2
RGD ID: 12599077
Description: ENCODES a protein that exhibits transcription coactivator activity (inferred); INVOLVED IN Notch signaling pathway (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH ataxia telangiectasia (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC101959658; mastermind-like protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494780,800,736 - 80,903,483 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367001,642,203 - 1,743,573 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (IEA)
nucleus  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Maml2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494780,800,736 - 80,903,483 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367001,642,203 - 1,743,573 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAML2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381195,976,598 - 96,343,195 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1195,976,598 - 96,343,195 (-)EnsemblGRCh38hg38GRCh38
GRCh371195,709,762 - 96,076,359 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361195,351,088 - 95,715,992 (-)NCBINCBI36Build 36hg18NCBI36
Build 341195,351,087 - 95,715,992NCBI
Celera1193,009,819 - 93,376,547 (-)NCBICelera
Cytogenetic Map11q21NCBI
HuRef1191,777,209 - 92,143,064 (-)NCBIHuRef
CHM1_11195,594,431 - 95,959,701 (-)NCBICHM1_1
T2T-CHM13v2.01195,983,995 - 96,349,198 (-)NCBIT2T-CHM13v2.0
Maml2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39913,296,547 - 13,620,829 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl913,298,306 - 13,620,684 (+)EnsemblGRCm39 Ensembl
GRCm38913,296,561 - 13,709,533 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl913,297,957 - 13,709,388 (+)EnsemblGRCm38mm10GRCm38
MGSCv37913,424,433 - 13,513,977 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36913,580,260 - 13,675,171 (+)NCBIMGSCv36mm8
MGSCv36913,367,586 - 13,459,930 (+)NCBIMGSCv36mm8
Celera910,656,583 - 10,988,064 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map93.33NCBI
Maml2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8818,552,480 - 18,869,923 (+)NCBIGRCr8
mRatBN7.2810,268,611 - 10,588,307 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl810,268,665 - 10,587,107 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0811,929,238 - 12,253,991 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl811,931,767 - 12,251,099 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0811,887,662 - 12,204,230 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4810,161,588 - 10,523,668 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera811,766,442 - 12,088,805 (+)NCBICelera
Cytogenetic Map8q11NCBI
Maml2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955412847,977 - 952,259 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955412849,367 - 1,038,341 (-)NCBIChiLan1.0ChiLan1.0
MAML2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2996,822,483 - 97,190,799 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11197,911,426 - 98,282,235 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01190,982,013 - 91,350,289 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11194,509,513 - 94,875,263 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1194,511,873 - 94,873,977 (-)Ensemblpanpan1.1panPan2
MAML2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1214,824,377 - 5,166,859 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl214,783,712 - 5,163,540 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha214,835,079 - 5,178,107 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0214,994,635 - 5,339,158 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl214,994,666 - 5,336,245 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1214,783,514 - 5,136,428 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0214,855,134 - 5,198,035 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0214,902,938 - 5,245,712 (+)NCBIUU_Cfam_GSD_1.0
MAML2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl927,997,887 - 28,371,397 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1927,993,319 - 28,372,982 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2931,938,299 - 31,982,581 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAML2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1187,237,786 - 87,615,305 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl187,239,780 - 87,358,648 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604338,190,991 - 38,583,927 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Maml2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473540,826,790 - 40,935,346 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473540,826,386 - 41,179,154 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005338016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_005338016   ⟹   XP_005338073
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494780,800,736 - 80,903,483 (-)NCBI
SpeTri2.0NW_0049367001,642,203 - 1,743,573 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005338073 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000031202.1
GenBank Protein KAG3286400 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005338073   ⟸   XM_005338016
- UniProtKB: A0A287DCA5 (UniProtKB/TrEMBL)
- Sequence:


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000033445 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000031256.1 UniProtKB/TrEMBL
InterPro MAML1-3 UniProtKB/TrEMBL
NCBI Gene LOC101959658 ENTREZGENE
PANTHER MASTERMIND-LIKE UniProtKB/TrEMBL
  MASTERMIND-LIKE PROTEIN 2 UniProtKB/TrEMBL
UniProt A0A287DCA5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-26 Maml2  mastermind like transcriptional coactivator 2  LOC101959658  mastermind-like protein 2  Symbol and/or name change 5135510 APPROVED