Snta1 (syntrophin alpha 1) - Rat Genome Database

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Pathways
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Gene: Snta1 (syntrophin alpha 1) Ictidomys tridecemlineatus
Analyze
Symbol: Snta1
Name: syntrophin alpha 1
RGD ID: 12591548
Description: ENCODES a protein that exhibits PDZ domain binding (ortholog); INVOLVED IN neuromuscular junction development (ortholog); regulation of vasoconstriction by circulating norepinephrine (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH atrial fibrillation (ortholog); Becker muscular dystrophy (ortholog); Brugada syndrome (ortholog); FOUND IN neuromuscular junction (ortholog); sarcolemma (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alpha-1-syntrophin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640171,615,021 - 171,653,713 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365617,101,654 - 7,133,988 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365617,101,654 - 7,134,529 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
fosphenytoin pharmacokinetics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Snta1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640171,615,021 - 171,653,713 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365617,101,654 - 7,133,988 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365617,101,654 - 7,134,529 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SNTA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382033,407,957 - 33,443,763 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2033,407,957 - 33,443,763 (-)EnsemblGRCh38hg38GRCh38
GRCh372031,995,763 - 32,031,569 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362031,459,424 - 31,495,359 (-)NCBINCBI36Build 36hg18NCBI36
Build 342031,459,423 - 31,495,359NCBI
Celera2028,749,527 - 28,785,451 (-)NCBICelera
Cytogenetic Map20q11.21NCBI
HuRef2028,783,561 - 28,819,451 (-)NCBIHuRef
CHM1_12031,896,842 - 31,932,765 (-)NCBICHM1_1
T2T-CHM13v2.02035,135,186 - 35,170,977 (-)NCBIT2T-CHM13v2.0
Snta1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392154,218,234 - 154,250,004 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2154,218,233 - 154,250,019 (-)EnsemblGRCm39 Ensembl
GRCm382154,376,313 - 154,408,107 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2154,376,313 - 154,408,099 (-)EnsemblGRCm38mm10GRCm38
MGSCv372154,202,050 - 154,233,820 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362154,067,769 - 154,099,522 (-)NCBIMGSCv36mm8
Celera2160,280,592 - 160,313,658 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map276.52NCBI
Snta1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83163,336,509 - 163,366,954 (-)NCBIGRCr8
mRatBN7.23142,876,285 - 142,906,737 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3142,876,296 - 142,906,709 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3146,743,646 - 146,773,763 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03155,361,813 - 155,391,929 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03153,101,175 - 153,131,287 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03149,874,023 - 149,905,980 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3149,874,030 - 149,905,944 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03156,245,190 - 156,278,486 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43144,843,678 - 144,874,238 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13144,749,301 - 144,779,860 (-)NCBI
Celera3141,611,616 - 141,641,783 (-)NCBICelera
Cytogenetic Map3q41NCBI
Snta1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542227,844,853 - 27,871,547 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542227,844,699 - 27,872,104 (+)NCBIChiLan1.0ChiLan1.0
SNTA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22139,099,698 - 39,135,847 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12039,092,798 - 39,128,921 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02029,696,137 - 29,732,258 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12030,810,787 - 30,844,472 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2030,810,787 - 30,844,476 (-)Ensemblpanpan1.1panPan2
SNTA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12422,636,716 - 22,665,828 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2422,636,756 - 22,665,741 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2422,281,583 - 22,313,637 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02423,322,134 - 23,354,134 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2423,322,133 - 23,354,191 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12422,597,383 - 22,628,609 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02422,708,067 - 22,740,033 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02423,139,650 - 23,170,903 (-)NCBIUU_Cfam_GSD_1.0
CDK5RAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1736,915,953 - 36,946,187 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11736,917,276 - 36,946,232 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21741,867,614 - 41,896,571 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SNTA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1237,703,002 - 37,737,529 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl237,702,971 - 37,737,423 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605089,152,431 - 89,194,359 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Snta1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248425,805,342 - 5,834,022 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248425,805,409 - 5,834,553 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000021196   ⟹   ENSSTOP00000015897
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365617,101,654 - 7,133,988 (+)Ensembl
RefSeq Acc Id: XM_040275433   ⟹   XP_040131367
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640171,615,021 - 171,653,713 (-)NCBI
Protein Sequences
Protein RefSeqs XP_040131367 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000015897.2
Reference Protein Sequences
RefSeq Acc Id: XP_040131367   ⟸   XM_040275433
- UniProtKB: I3MUV2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000015897   ⟸   ENSSTOT00000021196
Protein Domains
PDZ   PH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000020522 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000021196.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
InterPro PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PHsplit_syntrophin UniProtKB/TrEMBL
  Syntrophin UniProtKB/TrEMBL
NCBI Gene Snta1 ENTREZGENE
PANTHER PTHR10554 UniProtKB/TrEMBL
  PTHR10554:SF6 UniProtKB/TrEMBL
Pfam PDZ UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  PH_17 UniProtKB/TrEMBL
PROSITE PDZ UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
SMART PDZ UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
UniProt I3MUV2 ENTREZGENE, UniProtKB/TrEMBL