Slc48a1 (solute carrier family 48 member 1)

Gene: Slc48a1 (solute carrier family 48 member 1) Ictidomys tridecemlineatus

Analyze

Symbol:

Slc48a1

Name:

solute carrier family 48 member 1

RGD ID:

12583952

Description:

ENCODES a protein that exhibits heme binding (inferred); heme transmembrane transporter activity (inferred); INVOLVED IN erythrocyte differentiation (ortholog); heme transport (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN phagolysosome membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

heme transporter HRG1

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	67,484,328 - 67,505,445 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936512	5,672,952 - 5,684,113 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936512	5,672,952 - 5,680,502 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

erythrocyte differentiation (IEA,ISO)

heme export (IEA)

heme export from vacuole to cytoplasm (IEA)

heme metabolic process (IEA)

heme transport (IEA,ISO)

localization of cell (IEA)

lysosomal transport (IEA)

phagocytosis (IEA)

Cellular Component

cytoplasm (IEA)

endolysosome (IEA)

endosome (IEA)

endosome membrane (IEA)

lysosomal membrane (IEA)

membrane (IEA)

phagocytic vesicle membrane (IEA)

phagolysosome membrane (IEA,ISO)

plasma membrane (IEA)

Molecular Function

heme binding (IEA)

heme transmembrane transporter activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Slc48a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	67,484,328 - 67,505,445 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936512	5,672,952 - 5,684,113 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936512	5,672,952 - 5,680,502 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC48A1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	47,753,934 - 47,782,751 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	47,753,916 - 47,782,751 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	48,167,021 - 48,176,534 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	46,453,258 - 46,461,720 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	46,964,517 - 46,974,086 (+)	NCBI		Celera
Cytogenetic Map	12	q13.11	NCBI
HuRef	12	45,198,127 - 45,207,696 (+)	NCBI		HuRef
CHM1_1	12	48,132,870 - 48,142,439 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	47,715,158 - 47,744,144 (+)	NCBI		T2T-CHM13v2.0

Slc48a1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	97,682,246 - 97,690,573 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	97,676,401 - 97,690,573 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	97,784,365 - 97,792,692 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	97,778,520 - 97,792,692 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	97,614,796 - 97,623,123 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	97,612,399 - 97,620,722 (+)	NCBI		MGSCv36	mm8
Celera	15	99,911,999 - 99,920,320 (+)	NCBI		Celera
Cytogenetic Map	15	F1	NCBI
cM Map	15	53.78	NCBI

Slc48a1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	130,794,233 - 130,802,119 (+)	NCBI		GRCr8
mRatBN7.2	7	128,915,136 - 128,923,929 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	128,915,195 - 128,923,024 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	130,712,333 - 130,720,120 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	132,937,868 - 132,945,655 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	132,850,334 - 132,858,120 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	139,271,698 - 139,279,499 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	139,271,698 - 139,279,499 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	139,463,280 - 139,471,081 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	136,492,421 - 136,500,222 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	7	125,406,532 - 125,414,333 (+)	NCBI		Celera
Cytogenetic Map	7	q36	NCBI

Slc48a1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955500	6,679,908 - 6,691,942 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955500	6,675,631 - 6,691,942 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLC48A1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	46,384,862 - 46,394,495 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	46,381,620 - 46,391,246 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	40,950,511 - 40,977,994 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	41,825,080 - 41,852,173 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

SLC48A1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	6,970,510 - 6,978,837 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	6,971,402 - 6,978,942 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	39,328,772 - 39,337,048 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	7,037,538 - 7,045,841 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	7,037,538 - 7,045,938 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	6,974,515 - 6,982,758 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	7,009,903 - 7,018,204 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	39,617,239 - 39,625,518 (+)	NCBI		UU_Cfam_GSD_1.0

SLC48A1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	78,141,236 - 78,150,583 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	78,141,220 - 78,150,584 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

SLC48A1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	43,979,255 - 44,001,567 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	43,993,272 - 44,000,177 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	202,379,991 - 202,407,693 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc48a1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624816	4,476,491 - 4,485,030 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624816	4,476,502 - 4,496,641 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013358516	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040280764	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040280765	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040280766	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000028115 ⟹ ENSSTOP00000019093

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936512	5,672,952 - 5,684,113 (+)	Ensembl

RefSeq Acc Id:

XM_013358516 ⟹ XP_013213970

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404945	67,484,328 - 67,491,872 (-)	NCBI
SpeTri2.0	NW_004936512	5,672,952 - 5,680,502 (+)	NCBI

Sequence:

show sequence

GTGGCTCGGGCTCCGGCTGGGGCTCCGGACCCTGCACCTGTGACTCGGCCACGTTCGCGCTCAG
TCCTCCTGGCGCCGCAGCCCCATGGCCCCGTCCCGGCTGCAGCTTGGCCTCCGTGCCGCCTACT
CGGGCATCAGCTCGGTGGCCGGCTTCTCCATCTTCCTGGTCTGGACGGTGGTCTACAGACAGCC
AGGAACTGCGGCGATGGGGGGTCTCGCAGGTGTGCTGGCGCTATGGGTCCTGGTGACGCACGTG
ATGTACATGCAGGATTACTGGAGAACCTGGCTTAAGGGACTACGTGGCTTCTTCCTTGTGGGCA
TTCTCTTCTCGGCCGTCTCCATTGCTGCCTTCTGCACCTTCCTCACATTGGCCATCACCCGGCA
CCAGAGCCTCACAGACCCAACCAGCTACTACCTCTCCTGCGTCTGGAGCTTCATTTCCTTCAAG
TGGGCCTTCCTGCTCAGCCTCTACGCCCACCGATACAGGGCCGACTTTGCCGACATCAGCATCC
TCAGTGATTTCTGACCCAGGGAGTGAGGTCACTGTGGTCCGGGGGGCCCTCAGGACCTGGACTT
GGCCTTTGAGGCATCAGGAGGCTCTGCCCCCACCCCCTGGGGACCCAGAACTGTGTCAAAAGGA
ACATAGCAGTTTGAGTGCAGTTTCCCGGGAAACTGCCTGGTCCCTTTGGGGGGGAGACCTGGGT
GCAGTGGAAAGGAGGTCCAGCCAGGTAGCTCATCGGCCTGGCTGGAGGGCAGCTTTAGACCTTT
TCAAATGGATCTATTTTCTTAGCACTTGGTGAGCAATCTTTGTAAGTAGGACCAGGGCAACAAA
GTCAAAGGGTCAAGGGTAGGACCGTGAGGCCTTGACCTATGCCTGGTGCCAAGGGCTAGGGGCA
AGTGGTTTGGTCCCTGCCACTCCAGGCCCTCTCCCTGAGGCTGGGGGCGGAACCTGGTGAGGTC
ACATCAAGGGAGAAATCGCTAATGGAGACCTCTCGCTTCCCACCCCAGCACCCCAACCTGTTAT
TCCTCAAGGGTCAAGTAGCTGAAGTTATCAGTCATAGGCAACTTTTGGCTCTTTCCCCAAAGCC
TGGGGAGTTGAGAGAAGAGTTCTGTGTCCTTCTTCCCACCCTTTCTCCCAGAGCTGGACTTCTG
AAAGTACACTATAGCCAGACCCATTCTCCCCTCCACCCCCTGTCACATGCACACATCTACACAC
CCCAGAGCAGGCCTGTTTGAACTAAGGGCCACAGGGATCACACTCCTACCCCCAGAAGGGTATT
GGGAAGTGGGTAACACGGTGCAGGCTGAAAAGGAGCCCTAGACCTTGTGATTCCTCCTGTTCCT
CATTGCACCAGACTAGCCCCAGCCATGAGACCTTCTCCCCCAACTCCAGCCCCTGCTCACTGCC
CTTCAACTAGAGCTTTTATCTTTCTAAATCTCTCTCCTGAATCTCCCTACACTGGCCCAAGGGC
TCACCTAACTTGGGAGGGAAGGGGCTGTTACATGTATCTTTTTTATATTAGGTTGCCATTTTGC
ACGTCTCCTCCTTCTCCACTGCCCCCAGCTCTTTGCCTTATCTGTGTCACTGTCACTTTAGCGG
AAATACAGCGGCCATTTATATCAAA

hide sequence

RefSeq Acc Id:

XM_040280764 ⟹ XP_040136698

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404945	67,484,328 - 67,498,083 (-)	NCBI

RefSeq Acc Id:

XM_040280765 ⟹ XP_040136699

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404945	67,498,148 - 67,505,428 (-)	NCBI

RefSeq Acc Id:

XM_040280766 ⟹ XP_040136700

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404945	67,484,328 - 67,505,445 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_013213970	(Get FASTA)	NCBI Sequence Viewer
	XP_040136698	(Get FASTA)	NCBI Sequence Viewer
	XP_040136699	(Get FASTA)	NCBI Sequence Viewer
	XP_040136700	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000019093.1

RefSeq Acc Id:	XP_013213970 ⟸ XM_013358516
- Peptide Label:	isoform X3
- UniProtKB:	I3N3Z7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAPSRLQLGLRAAYSGISSVAGFSIFLVWTVVYRQPGTAAMGGLAGVLALWVLVTHVMYMQDYW RTWLKGLRGFFLVGILFSAVSIAAFCTFLTLAITRHQSLTDPTSYYLSCVWSFISFKWAFLLSL YAHRYRADFADISILSDF hide sequence

RefSeq Acc Id:	XP_040136700 ⟸ XM_040280766
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_040136698 ⟸ XM_040280764
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_040136699 ⟸ XM_040280765
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSSTOP00000019093 ⟸ ENSSTOT00000028115

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000027173	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000028115.2	UniProtKB/TrEMBL
InterPro	HRG	UniProtKB/TrEMBL
NCBI Gene	Slc48a1	ENTREZGENE
PANTHER	HEME TRANSPORTER HRG1	UniProtKB/TrEMBL
	PTHR31525	UniProtKB/TrEMBL
Pfam	HRG	UniProtKB/TrEMBL
PRINTS	TRNSPORTRHRG	UniProtKB/TrEMBL
UniProt	I3N3Z7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar